{"id":"https://openalex.org/W1983451318","doi":"https://doi.org/10.1109/tcbb.2015.2407407","title":"Stable Gene Signature Selection for Prediction of Breast Cancer Recurrence Using Joint Mutual Information","display_name":"Stable Gene Signature Selection for Prediction of Breast Cancer Recurrence Using Joint Mutual Information","publication_year":2015,"publication_date":"2015-03-02","ids":{"openalex":"https://openalex.org/W1983451318","doi":"https://doi.org/10.1109/tcbb.2015.2407407","mag":"1983451318","pmid":"https://pubmed.ncbi.nlm.nih.gov/26671813"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2015.2407407","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2015.2407407","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043","2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072092537","display_name":"Mohammadreza Sehhati","orcid":"https://orcid.org/0000-0002-7316-5645"},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammadreza Sehhati","raw_affiliation_strings":["Department of Biomedical Engineering, Isfahan University of Medical Sciences, Isfahan, Iran","Department of Biomedical Eng., Isfahan University of Medical Sciences, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]},{"raw_affiliation_string":"Department of Biomedical Eng., Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042724473","display_name":"Alireza Mehridehnavi","orcid":"https://orcid.org/0000-0002-7964-0478"},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Alireza Mehridehnavi","raw_affiliation_strings":["Department of Biomedical Engineering, Isfahan University of Medical Sciences, Isfahan, Iran","Department of Biomedical Eng., Isfahan University of Medical Sciences, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]},{"raw_affiliation_string":"Department of Biomedical Eng., Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052490368","display_name":"Hossein Rabbani","orcid":"https://orcid.org/0000-0002-0551-3636"},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hossein Rabbani","raw_affiliation_strings":["Department of Biomedical Engineering, Isfahan University of Medical Sciences, Isfahan, Iran","Department of Biomedical Eng., Isfahan University of Medical Sciences, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]},{"raw_affiliation_string":"Department of Biomedical Eng., Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046749798","display_name":"Meraj Pourhossein","orcid":"https://orcid.org/0000-0002-9627-8589"},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]},{"id":"https://openalex.org/I39268498","display_name":"University of Isfahan","ror":"https://ror.org/05h9t7759","country_code":"IR","type":"education","lineage":["https://openalex.org/I39268498"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Meraj Pourhossein","raw_affiliation_strings":["Department of Genetic and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran","Department of Genetic and Molecular Biology, School of Medicine, Isfahan, Iran#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]},{"raw_affiliation_string":"Department of Genetic and Molecular Biology, School of Medicine, Isfahan, Iran#TAB#","institution_ids":["https://openalex.org/I39268498"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2645,"currency":"USD","value_usd":2645},"apc_paid":null,"fwci":1.6512,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.83328764,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"12","issue":"6","first_page":"1440","last_page":"1448"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.982699990272522,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.6388121843338013},{"id":"https://openalex.org/keywords/gene-signature","display_name":"Gene signature","score":0.6054635047912598},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.5215016007423401},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.5166338086128235},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.516576886177063},{"id":"https://openalex.org/keywords/mutual-information","display_name":"Mutual information","score":0.49436211585998535},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.4700160324573517},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45593446493148804},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.44639384746551514},{"id":"https://openalex.org/keywords/cross-validation","display_name":"Cross-validation","score":0.43144920468330383},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.42117446660995483},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3810121715068817},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.34783411026000977},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3115946054458618},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2591657340526581},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.24261441826820374},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1287752091884613}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6388121843338013},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.6054635047912598},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.5215016007423401},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.5166338086128235},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.516576886177063},{"id":"https://openalex.org/C152139883","wikidata":"https://www.wikidata.org/wiki/Q252973","display_name":"Mutual information","level":2,"score":0.49436211585998535},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.4700160324573517},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45593446493148804},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44639384746551514},{"id":"https://openalex.org/C27181475","wikidata":"https://www.wikidata.org/wiki/Q541014","display_name":"Cross-validation","level":2,"score":0.43144920468330383},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.42117446660995483},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3810121715068817},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34783411026000977},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3115946054458618},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2591657340526581},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.24261441826820374},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1287752091884613}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2015.2407407","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2015.2407407","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043","2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26671813","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26671813","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/1","display_name":"No poverty","score":0.7200000286102295}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W144440563","https://openalex.org/W1607267312","https://openalex.org/W1976173969","https://openalex.org/W1995875735","https://openalex.org/W2038894244","https://openalex.org/W2043772506","https://openalex.org/W2060749612","https://openalex.org/W2082315464","https://openalex.org/W2085256503","https://openalex.org/W2088160256","https://openalex.org/W2097554668","https://openalex.org/W2097664282","https://openalex.org/W2104921948","https://openalex.org/W2117004913","https://openalex.org/W2118413367","https://openalex.org/W2121141592","https://openalex.org/W2134672568","https://openalex.org/W2137028370","https://openalex.org/W2139345901","https://openalex.org/W2143426320","https://openalex.org/W2145259857","https://openalex.org/W2146739527","https://openalex.org/W2150533948","https://openalex.org/W2150671673","https://openalex.org/W2151990594","https://openalex.org/W2153635508","https://openalex.org/W2154053567","https://openalex.org/W2154947819","https://openalex.org/W2155344811","https://openalex.org/W2156504490","https://openalex.org/W2157132621","https://openalex.org/W2160450758","https://openalex.org/W2162371443","https://openalex.org/W2163563958","https://openalex.org/W2165374837","https://openalex.org/W2165432359","https://openalex.org/W2165580920","https://openalex.org/W2168546553","https://openalex.org/W2998216295","https://openalex.org/W4206803374","https://openalex.org/W4285719527","https://openalex.org/W6605866200","https://openalex.org/W6682686508","https://openalex.org/W6683024897","https://openalex.org/W7066667914"],"related_works":["https://openalex.org/W2277968882","https://openalex.org/W2622163206","https://openalex.org/W2577953983","https://openalex.org/W2370807923","https://openalex.org/W4285815724","https://openalex.org/W2001073520","https://openalex.org/W2093543968","https://openalex.org/W2897968225","https://openalex.org/W1535637645","https://openalex.org/W1983451318"],"abstract_inverted_index":{"In":[0,24],"this":[1,25],"experiment,":[2],"a":[3,11,27,94,161],"gene":[4,13,107],"selection":[5,98],"technique":[6],"was":[7,31,165],"proposed":[8,91,179],"to":[9,100,127,170],"select":[10,101],"robust":[12],"signature":[14],"from":[15,105,167,191],"microarray":[16,109],"data":[17,130],"for":[18,64],"prediction":[19],"of":[20,36,70,115,138],"breast":[21,132],"cancer":[22,133],"recurrence.":[23],"regard,":[26],"hybrid":[28,95],"scoring":[29],"criterion":[30],"designed":[32],"as":[33],"linear":[34],"combinations":[35],"the":[37,43,53,57,61,68,73,77,81,90,102,106,116,150,178],"scores":[38],"that":[39],"were":[40,86,120,189],"determined":[41],"in":[42,72,93,149,153,173],"mutual":[44],"information":[45,59],"(MI)":[46],"domain":[47],"and":[48,67,113,140],"protein-protein":[49],"interactions":[50],"network.":[51],"Whereas,":[52],"MI-based":[54],"score":[55],"represents":[56],"complementary":[58],"between":[60,76,185],"selected":[62,78,118,166,190],"genes":[63,79,85],"outcome":[65],"prediction;":[66],"number":[69],"connections":[71],"PPI":[74],"network":[75],"builds":[80],"PPI-based":[82],"score.":[83],"All":[84],"scored":[87],"by":[88,122],"using":[89,123],"function":[92],"forward-backward":[96],"gene-set":[97],"process":[99],"optimum":[103],"biomarker-set":[104],"expression":[108],"data.":[110],"The":[111,143],"accuracy":[112,152],"stability":[114],"finally":[117],"biomarkers":[119],"evaluated":[121],"five-fold":[124],"cross-validation":[125],"(CV)":[126],"classify":[128],"available":[129],"on":[131],"patients":[134],"into":[135],"two":[136],"cohorts":[137],"poor":[139],"good":[141],"prognosis.":[142],"results":[144],"showed":[145],"an":[146],"appealing":[147],"improvement":[148],"cross-dataset":[151],"comparison":[154],"with":[155],"similar":[156],"studies":[157],"whenever":[158],"we":[159],"applied":[160],"primary":[162],"signature,":[163],"which":[164,188],"one":[168],"dataset,":[169],"predict":[171],"survival":[172],"other":[174],"independent":[175,193],"datasets.":[176],"Moreover,":[177],"method":[180],"demonstrated":[181],"58-92":[182],"percent":[183],"overlap":[184],"50-genes":[186],"signatures,":[187],"seven":[192],"datasets":[194],"individually.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}