{"id":"https://openalex.org/W2063716346","doi":"https://doi.org/10.1109/tcbb.2014.2360396","title":"Identifying Driver Nodes in the Human Signaling Network Using Structural Controllability Analysis","display_name":"Identifying Driver Nodes in the Human Signaling Network Using Structural Controllability Analysis","publication_year":2014,"publication_date":"2014-09-25","ids":{"openalex":"https://openalex.org/W2063716346","doi":"https://doi.org/10.1109/tcbb.2014.2360396","mag":"2063716346","pmid":"https://pubmed.ncbi.nlm.nih.gov/26357232"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2014.2360396","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2014.2360396","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100659709","display_name":"Xueming Liu","orcid":"https://orcid.org/0000-0003-0676-9745"},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xueming Liu","raw_affiliation_strings":["Key Laboratory of Image Information Processing and Intelligent Control, School of Automation, Huazhong University of Science and Technology, Hubei, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Image Information Processing and Intelligent Control, School of Automation, Huazhong University of Science and Technology, Hubei, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108060216","display_name":"Linqiang Pan","orcid":"https://orcid.org/0000-0002-4554-455X"},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linqiang Pan","raw_affiliation_strings":["Key Laboratory of Image Information Processing and Intelligent Control, School of Automation, Huazhong University of Science and Technology, Hubei, Wuhan, China"],"raw_orcid":"https://orcid.org/0000-0002-4554-455X","affiliations":[{"raw_affiliation_string":"Key Laboratory of Image Information Processing and Intelligent Control, School of Automation, Huazhong University of Science and Technology, Hubei, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100659709"],"corresponding_institution_ids":["https://openalex.org/I47720641"],"apc_list":null,"apc_paid":null,"fwci":1.9966,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.86345401,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"12","issue":"2","first_page":"467","last_page":"472"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/controllability","display_name":"Controllability","score":0.8148191571235657},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.5725775957107544},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.5552114844322205},{"id":"https://openalex.org/keywords/cell-signaling","display_name":"Cell signaling","score":0.5082151889801025},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3842724561691284},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3604743480682373},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.35098427534103394},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.2705826163291931},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.07318949699401855}],"concepts":[{"id":"https://openalex.org/C48209547","wikidata":"https://www.wikidata.org/wiki/Q1331104","display_name":"Controllability","level":2,"score":0.8148191571235657},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.5725775957107544},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5552114844322205},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.5082151889801025},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3842724561691284},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3604743480682373},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35098427534103394},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2705826163291931},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.07318949699401855},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2014.2360396","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2014.2360396","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26357232","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26357232","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7400000095367432}],"awards":[{"id":"https://openalex.org/G259348978","display_name":null,"funder_award_id":"61320106005","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5344687800","display_name":null,"funder_award_id":"61033003","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6236801800","display_name":null,"funder_award_id":"91130034","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6460908072","display_name":null,"funder_award_id":"61100145","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1966782492","https://openalex.org/W1969442549","https://openalex.org/W1978430385","https://openalex.org/W1978486653","https://openalex.org/W1980813857","https://openalex.org/W1996393189","https://openalex.org/W2012116432","https://openalex.org/W2019694981","https://openalex.org/W2020042644","https://openalex.org/W2029152175","https://openalex.org/W2033718639","https://openalex.org/W2061627113","https://openalex.org/W2080090262","https://openalex.org/W2082019892","https://openalex.org/W2082257952","https://openalex.org/W2101420429","https://openalex.org/W2111838183","https://openalex.org/W2116298046","https://openalex.org/W2124655218","https://openalex.org/W2136943892","https://openalex.org/W2148866736","https://openalex.org/W2157184494","https://openalex.org/W2157380840","https://openalex.org/W2157989234","https://openalex.org/W2162491170","https://openalex.org/W2296217093","https://openalex.org/W3103971085"],"related_works":["https://openalex.org/W2068787210","https://openalex.org/W4390006811","https://openalex.org/W3203208080","https://openalex.org/W3092591054","https://openalex.org/W1504782610","https://openalex.org/W2008572054","https://openalex.org/W2969388149","https://openalex.org/W2106363574","https://openalex.org/W2130108353","https://openalex.org/W1897115642"],"abstract_inverted_index":{"Cell":[0],"signaling":[1,17,48,81,101,113,129,159,181],"governs":[2],"the":[3,9,31,92,99,106,109,112,117,127,137,140,148,156,162,178],"basic":[4],"cellular":[5],"activities":[6],"and":[7,28,58,83,116],"coordinates":[8],"actions":[10],"in":[11,15,97,108,125,152,161],"cell.":[12],"Abnormal":[13],"regulations":[14],"cell":[16,39,180],"processing":[18],"are":[19,168],"responsible":[20],"for":[21,176],"many":[22],"human":[23,38,47,80,100,128,158,179],"diseases,":[24],"such":[25],"as":[26],"diabetes":[27],"cancers.":[29],"With":[30],"accumulation":[32],"of":[33,91,94,111,139],"massive":[34],"data":[35],"related":[36],"to":[37,44,68,78,154],"signaling,":[40],"it":[41],"is":[42],"feasible":[43],"obtain":[45],"a":[46,79,88,122,173],"network.":[49,102,130],"Some":[50],"studies":[51],"have":[52],"shown":[53],"that":[54,105,164],"interesting":[55],"biological":[56,69],"phenomenon":[57],"drug-targets":[59],"could":[60,143],"be":[61],"discovered":[62],"by":[63],"applying":[64],"structural":[65,76],"controllability":[66,77],"analysis":[67,90],"networks.":[70],"In":[71],"this":[72],"work,":[73],"we":[74],"apply":[75],"network":[82,160],"detect":[84],"driver":[85],"nodes,":[86],"providing":[87],"systematic":[89],"role":[93,124],"different":[95,133],"proteins":[96,107,120],"controlling":[98,126,147,177],"We":[103],"find":[104],"upstream":[110],"information":[114],"flow":[115],"low":[118],"in-degree":[119],"play":[121],"crucial":[123],"Interestingly,":[131],"inputting":[132],"control":[134,155],"signals":[135],"on":[136],"regulators":[138],"cancer-associated":[141,149],"genes":[142,150],"cost":[144],"less":[145,165],"than":[146],"directly":[151],"order":[153],"whole":[157],"sense":[163],"drive":[166],"nodes":[167],"needed.":[169],"This":[170],"research":[171],"provides":[172],"fresh":[174],"perspective":[175],"system.":[182]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
