{"id":"https://openalex.org/W2081810802","doi":"https://doi.org/10.1109/tcbb.2014.2326860","title":"Molecular Modeling and Evaluation of Novel Dibenzopyrrole Derivatives as Telomerase Inhibitors and Potential Drug for Cancer Therapy","display_name":"Molecular Modeling and Evaluation of Novel Dibenzopyrrole Derivatives as Telomerase Inhibitors and Potential Drug for Cancer Therapy","publication_year":2014,"publication_date":"2014-05-29","ids":{"openalex":"https://openalex.org/W2081810802","doi":"https://doi.org/10.1109/tcbb.2014.2326860","mag":"2081810802","pmid":"https://pubmed.ncbi.nlm.nih.gov/26357055"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2014.2326860","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2014.2326860","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002833815","display_name":"Umesh Kalathiya","orcid":"https://orcid.org/0000-0001-7757-6962"},"institutions":[{"id":"https://openalex.org/I169333911","display_name":"Gda\u0144sk University of Technology","ror":"https://ror.org/006x4sc24","country_code":"PL","type":"education","lineage":["https://openalex.org/I169333911"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Umesh Kalathiya","raw_affiliation_strings":["Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Narutowicza, Gdansk, Poland","The Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Gdansk, Poland#TAB#"],"raw_orcid":"https://orcid.org/0000-0001-7757-6962","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Narutowicza, Gdansk, Poland","institution_ids":["https://openalex.org/I169333911"]},{"raw_affiliation_string":"The Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Gdansk, Poland#TAB#","institution_ids":["https://openalex.org/I169333911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087875575","display_name":"Monikaben Padariya","orcid":"https://orcid.org/0000-0002-9132-8620"},"institutions":[{"id":"https://openalex.org/I169333911","display_name":"Gda\u0144sk University of Technology","ror":"https://ror.org/006x4sc24","country_code":"PL","type":"education","lineage":["https://openalex.org/I169333911"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Monikaben Padariya","raw_affiliation_strings":["Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Narutowicza, Gdansk, Poland","The Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Gdansk, Poland#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Narutowicza, Gdansk, Poland","institution_ids":["https://openalex.org/I169333911"]},{"raw_affiliation_string":"The Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Gdansk, Poland#TAB#","institution_ids":["https://openalex.org/I169333911"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075050584","display_name":"Maciej Bagi\u0144ski","orcid":"https://orcid.org/0000-0002-6795-7515"},"institutions":[{"id":"https://openalex.org/I169333911","display_name":"Gda\u0144sk University of Technology","ror":"https://ror.org/006x4sc24","country_code":"PL","type":"education","lineage":["https://openalex.org/I169333911"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Maciej Baginski","raw_affiliation_strings":["Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Narutowicza, Gdansk, Poland","The Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Gdansk, Poland#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Narutowicza, Gdansk, Poland","institution_ids":["https://openalex.org/I169333911"]},{"raw_affiliation_string":"The Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Gdansk, Poland#TAB#","institution_ids":["https://openalex.org/I169333911"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I169333911"],"apc_list":null,"apc_paid":null,"fwci":1.4687,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.8303273,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"11","issue":"6","first_page":"1196","last_page":"1207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.9692999720573425,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyrazole","display_name":"Pyrazole","score":0.8670382499694824},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.7849552631378174},{"id":"https://openalex.org/keywords/telomerase","display_name":"Telomerase","score":0.7500820159912109},{"id":"https://openalex.org/keywords/autodock","display_name":"AutoDock","score":0.7115824222564697},{"id":"https://openalex.org/keywords/combinatorial-chemistry","display_name":"Combinatorial chemistry","score":0.5978314876556396},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5585435628890991},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.5055937767028809},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3417358994483948},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22512885928153992},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.21730929613113403},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.19142994284629822},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.07046794891357422}],"concepts":[{"id":"https://openalex.org/C2777682936","wikidata":"https://www.wikidata.org/wiki/Q408908","display_name":"Pyrazole","level":2,"score":0.8670382499694824},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.7849552631378174},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.7500820159912109},{"id":"https://openalex.org/C2780152424","wikidata":"https://www.wikidata.org/wiki/Q4826062","display_name":"AutoDock","level":4,"score":0.7115824222564697},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5978314876556396},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5585435628890991},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5055937767028809},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3417358994483948},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22512885928153992},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21730929613113403},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.19142994284629822},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07046794891357422},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002227","descriptor_name":"Carbazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002227","descriptor_name":"Carbazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002227","descriptor_name":"Carbazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002227","descriptor_name":"Carbazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002227","descriptor_name":"Carbazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002227","descriptor_name":"Carbazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2014.2326860","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2014.2326860","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26357055","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26357055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.800000011920929}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W1510314201","https://openalex.org/W1553934596","https://openalex.org/W1582109070","https://openalex.org/W1656114533","https://openalex.org/W1829553711","https://openalex.org/W1949583200","https://openalex.org/W1964652416","https://openalex.org/W1977437036","https://openalex.org/W1980240132","https://openalex.org/W1980470053","https://openalex.org/W1982103602","https://openalex.org/W1983304433","https://openalex.org/W1983673827","https://openalex.org/W1984021058","https://openalex.org/W1986240377","https://openalex.org/W1987952795","https://openalex.org/W1988111902","https://openalex.org/W1990630639","https://openalex.org/W1992842240","https://openalex.org/W1993006130","https://openalex.org/W1993403967","https://openalex.org/W2000971601","https://openalex.org/W2004561527","https://openalex.org/W2012084558","https://openalex.org/W2016876678","https://openalex.org/W2022507419","https://openalex.org/W2030976397","https://openalex.org/W2031372687","https://openalex.org/W2038182421","https://openalex.org/W2042377388","https://openalex.org/W2043609191","https://openalex.org/W2044430178","https://openalex.org/W2044606083","https://openalex.org/W2048574852","https://openalex.org/W2050960249","https://openalex.org/W2051090838","https://openalex.org/W2052351457","https://openalex.org/W2057483675","https://openalex.org/W2060896826","https://openalex.org/W2066622170","https://openalex.org/W2072192279","https://openalex.org/W2082227489","https://openalex.org/W2083715474","https://openalex.org/W2092324565","https://openalex.org/W2098085059","https://openalex.org/W2100215079","https://openalex.org/W2105668062","https://openalex.org/W2109270528","https://openalex.org/W2110419228","https://openalex.org/W2119085025","https://openalex.org/W2127539269","https://openalex.org/W2128332459","https://openalex.org/W2130479394","https://openalex.org/W2132262459","https://openalex.org/W2136687298","https://openalex.org/W2137889982","https://openalex.org/W2142820798","https://openalex.org/W2148496296","https://openalex.org/W2152829009","https://openalex.org/W2155524113","https://openalex.org/W2156053468","https://openalex.org/W2157445042","https://openalex.org/W2158534713","https://openalex.org/W2160037672","https://openalex.org/W2160185049","https://openalex.org/W2163498131","https://openalex.org/W2168536356","https://openalex.org/W2433169728","https://openalex.org/W2950450753","https://openalex.org/W2952663663","https://openalex.org/W3148651560","https://openalex.org/W3187658540","https://openalex.org/W4211057601","https://openalex.org/W4230274588","https://openalex.org/W4250830547","https://openalex.org/W4254759378","https://openalex.org/W6798962545"],"related_works":["https://openalex.org/W2058674645","https://openalex.org/W1594539819","https://openalex.org/W2007257620","https://openalex.org/W2766845742","https://openalex.org/W2130867670","https://openalex.org/W4213038553","https://openalex.org/W1984029386","https://openalex.org/W4312202637","https://openalex.org/W2136513242","https://openalex.org/W2336040088"],"abstract_inverted_index":{"During":[0],"previous":[1],"years,":[2],"many":[3],"studies":[4],"on":[5,10],"synthesis,":[6],"as":[7,9,69,82,168],"well":[8],"anti-tumor,":[11],"anti-inflammatory":[12],"and":[13,30,87,128,133,149,156],"anti-bacterial":[14],"activities":[15,29],"of":[16,42,50,59,89,98,154,158],"the":[17,48,103,144],"pyrazole":[18,24,43,62,155],"derivatives":[19,25,116],"have":[20,31],"been":[21],"described.":[22],"Certain":[23],"exhibit":[26],"important":[27],"pharmacological":[28],"proved":[32],"to":[33,139],"be":[34],"useful":[35],"template":[36],"in":[37,45,102,137,146,150,160],"drug":[38],"research.":[39],"Considering":[40],"importance":[41],"template,":[44],"current":[46],"work":[47],"series":[49],"novel":[51,84],"inhibitors":[52,90,142],"were":[53,67,117],"designed":[54,100,141],"by":[55,93,119],"replacing":[56],"central":[57],"ring":[58],"acridine":[60],"with":[61],"ring.":[63],"These":[64],"heterocyclic":[65],"compounds":[66,101,161],"proposed":[68],"a":[70,83],"new":[71],"potential":[72,169],"base":[73],"for":[74],"telomerase":[75,104,170],"inhibitors.":[76,171],"Obtained":[77],"dibenzopyrrole":[78,115,159],"structure":[79,86],"was":[80,91,111],"used":[81],"scaffold":[85],"extension":[88,157],"done":[92],"different":[94],"functional":[95],"groups.":[96],"Docking":[97],"newly":[99],"active":[105],"site":[106],"(telomerase":[107],"catalytic":[108],"subunit":[109],"TERT)":[110],"carried":[112],"out.":[113],"All":[114],"evaluated":[118],"three":[120],"docking":[121,125,145],"programs:":[122],"CDOCKER,":[123],"Ligandfit":[124],"(Scoring":[126],"Functions)":[127],"AutoDock.":[129],"Compound":[130],"C_9g,":[131],"C_9k":[132],"C_9l":[134],"performed":[135],"best":[136],"comparison":[138],"all":[140,147],"during":[143],"methods":[148],"interaction":[151],"analysis.":[152],"Introduction":[153],"confirm":[162],"that":[163],"such":[164],"compound":[165],"may":[166],"act":[167]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}