{"id":"https://openalex.org/W2108120899","doi":"https://doi.org/10.1109/tcbb.2011.61","title":"An Information Theoretic Approach to Constructing Robust Boolean Gene Regulatory Networks","display_name":"An Information Theoretic Approach to Constructing Robust Boolean Gene Regulatory Networks","publication_year":2011,"publication_date":"2011-04-06","ids":{"openalex":"https://openalex.org/W2108120899","doi":"https://doi.org/10.1109/tcbb.2011.61","mag":"2108120899","pmid":"https://pubmed.ncbi.nlm.nih.gov/21464507"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2011.61","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2011.61","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040676835","display_name":"Bane Vasi\u0107","orcid":"https://orcid.org/0000-0003-2365-4106"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"B. Vasic","raw_affiliation_strings":["University of Arizona, Tucson","[Dept. of Electr. & Comput. Eng., Univ. of Arizona, Tucson, AZ, USA]"],"affiliations":[{"raw_affiliation_string":"University of Arizona, Tucson","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"[Dept. of Electr. & Comput. Eng., Univ. of Arizona, Tucson, AZ, USA]","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032995957","display_name":"Vida Ravanmehr","orcid":"https://orcid.org/0000-0002-3971-1083"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Ravanmehr","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Arizona, Tucson, AZ, USA","[Dept. of Electr. & Comput. Eng., Univ. of Arizona, Tucson, AZ, USA]"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"[Dept. of Electr. & Comput. Eng., Univ. of Arizona, Tucson, AZ, USA]","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110662883","display_name":"Anantha Raman Krishnan","orcid":null},"institutions":[{"id":"https://openalex.org/I4210121352","display_name":"Western Digital (United States)","ror":"https://ror.org/02hqwnx33","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121352"]},{"id":"https://openalex.org/I118271192","display_name":"Western Digital (Japan)","ror":"https://ror.org/0521k5n17","country_code":"JP","type":"company","lineage":["https://openalex.org/I118271192","https://openalex.org/I4210121352"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"A. R. Krishnan","raw_affiliation_strings":["Western Digital Corporation, Irvine, CA, USA","Western Digital Corp., Irvine, CA, USA"],"affiliations":[{"raw_affiliation_string":"Western Digital Corporation, Irvine, CA, USA","institution_ids":["https://openalex.org/I4210121352"]},{"raw_affiliation_string":"Western Digital Corp., Irvine, CA, USA","institution_ids":["https://openalex.org/I118271192"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5040676835"],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":null,"apc_paid":null,"fwci":1.3029,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.79470265,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"9","issue":"1","first_page":"52","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9929999709129333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/boolean-network","display_name":"Boolean network","score":0.9051394462585449},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.749290406703949},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.651403546333313},{"id":"https://openalex.org/keywords/attractor","display_name":"Attractor","score":0.6280554533004761},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.5242198705673218},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4919690787792206},{"id":"https://openalex.org/keywords/boolean-function","display_name":"Boolean function","score":0.3890973627567291},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.38104480504989624},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.37992778420448303},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3745710849761963},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3315091133117676},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24909868836402893},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.24748605489730835},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.2143857777118683},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18503153324127197},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.13761720061302185}],"concepts":[{"id":"https://openalex.org/C134444547","wikidata":"https://www.wikidata.org/wiki/Q585230","display_name":"Boolean network","level":3,"score":0.9051394462585449},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.749290406703949},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.651403546333313},{"id":"https://openalex.org/C164380108","wikidata":"https://www.wikidata.org/wiki/Q507187","display_name":"Attractor","level":2,"score":0.6280554533004761},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.5242198705673218},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4919690787792206},{"id":"https://openalex.org/C187455244","wikidata":"https://www.wikidata.org/wiki/Q942353","display_name":"Boolean function","level":2,"score":0.3890973627567291},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.38104480504989624},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37992778420448303},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3745710849761963},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3315091133117676},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24909868836402893},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.24748605489730835},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2143857777118683},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18503153324127197},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.13761720061302185},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007257","descriptor_name":"Information Theory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007257","descriptor_name":"Information Theory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007257","descriptor_name":"Information Theory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2011.61","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2011.61","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21464507","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21464507","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W105761860","https://openalex.org/W303371926","https://openalex.org/W395700585","https://openalex.org/W1513851163","https://openalex.org/W1534925464","https://openalex.org/W1573602524","https://openalex.org/W1597836871","https://openalex.org/W1897287337","https://openalex.org/W1926807800","https://openalex.org/W1965142549","https://openalex.org/W1968856189","https://openalex.org/W1969166586","https://openalex.org/W1969857637","https://openalex.org/W1978469373","https://openalex.org/W1988263223","https://openalex.org/W2001764350","https://openalex.org/W2032811716","https://openalex.org/W2046355391","https://openalex.org/W2046881634","https://openalex.org/W2048233403","https://openalex.org/W2053961182","https://openalex.org/W2054548862","https://openalex.org/W2061280979","https://openalex.org/W2065817779","https://openalex.org/W2068900887","https://openalex.org/W2069947940","https://openalex.org/W2070974284","https://openalex.org/W2080498142","https://openalex.org/W2084554663","https://openalex.org/W2086634897","https://openalex.org/W2087471103","https://openalex.org/W2097144068","https://openalex.org/W2097263107","https://openalex.org/W2097385238","https://openalex.org/W2104085672","https://openalex.org/W2104130992","https://openalex.org/W2107536713","https://openalex.org/W2108020239","https://openalex.org/W2111870329","https://openalex.org/W2114869758","https://openalex.org/W2124637492","https://openalex.org/W2125631472","https://openalex.org/W2126362591","https://openalex.org/W2128276810","https://openalex.org/W2133068391","https://openalex.org/W2133400923","https://openalex.org/W2133401281","https://openalex.org/W2136559804","https://openalex.org/W2137324353","https://openalex.org/W2137813581","https://openalex.org/W2142501768","https://openalex.org/W2146997276","https://openalex.org/W2149310258","https://openalex.org/W2150570316","https://openalex.org/W2153800196","https://openalex.org/W2154625195","https://openalex.org/W2155418451","https://openalex.org/W2156091616","https://openalex.org/W2157974112","https://openalex.org/W2160740951","https://openalex.org/W2163296727","https://openalex.org/W2171192921","https://openalex.org/W2400908863","https://openalex.org/W2414846929","https://openalex.org/W2497735908","https://openalex.org/W3101070717","https://openalex.org/W3101693422","https://openalex.org/W3103886388","https://openalex.org/W3182208082","https://openalex.org/W4211147273","https://openalex.org/W4240348657","https://openalex.org/W4252631146","https://openalex.org/W4388252848","https://openalex.org/W6666987163","https://openalex.org/W6679967613"],"related_works":["https://openalex.org/W2972653083","https://openalex.org/W2101472055","https://openalex.org/W2061235113","https://openalex.org/W1968124963","https://openalex.org/W2789889436","https://openalex.org/W2963357480","https://openalex.org/W2159176187","https://openalex.org/W2108120899","https://openalex.org/W4294329136","https://openalex.org/W4302620569"],"abstract_inverted_index":{"We":[0,68],"introduce":[1],"a":[2,24,33,70,92,121],"class":[3],"of":[4,8,14,23,36,42,91,110,116,139,149],"finite":[5,34],"systems":[6],"models":[7],"gene":[9,58,86,143],"regulatory":[10,144],"networks":[11,145],"exhibiting":[12],"behavior":[13],"the":[15,40,117,127,147],"cell":[16,48,141,155],"cycle.":[17,156],"The":[18,28,89,113,135],"model":[19],"is":[20,94,126],"an":[21,43],"extension":[22],"Boolean":[25,102,118],"network":[26,72,93,119,130],"model.":[27],"system":[29],"spontaneously":[30],"cycles":[31],"through":[32],"set":[35],"internal":[37],"states,":[38],"tracking":[39],"increase":[41],"external":[44],"factor":[45],"such":[46,132],"as":[47],"mass,":[49],"and":[50,97],"also":[51],"exhibits":[52],"checkpoints":[53],"in":[54,57,153],"which":[55,78],"errors":[56],"expression":[59,87],"levels":[60],"due":[61],"to":[62],"cellular":[63],"noise":[64],"are":[65],"automatically":[66],"corrected.":[67],"present":[69],"7-gene":[71],"based":[73],"on":[74],"Projective":[75],"Geometry":[76],"codes,":[77],"can":[79,105],"correct,":[80],"at":[81],"every":[82],"given":[83],"time,":[84],"one":[85],"error.":[88],"topology":[90],"highly":[95],"symmetric":[96],"requires":[98],"using":[99,108],"only":[100],"simple":[101],"functions":[103],"that":[104],"be":[106],"synthesized":[107],"genes":[109],"various":[111],"organisms.":[112],"attractor":[114],"structure":[115],"contains":[120],"single":[122],"cycle":[123,142],"attractor.":[124],"It":[125],"smallest":[128],"nontrivial":[129],"with":[131,146],"high":[133],"robustness.":[134],"methodology":[136],"allows":[137],"construction":[138],"artificial":[140],"number":[148],"phases":[150],"larger":[151],"than":[152],"natural":[154]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}