{"id":"https://openalex.org/W4404848909","doi":"https://doi.org/10.1109/tcad.2024.3509795","title":"Automated Design for Multiorgan-on-Chip Geometries","display_name":"Automated Design for Multiorgan-on-Chip Geometries","publication_year":2024,"publication_date":"2024-11-29","ids":{"openalex":"https://openalex.org/W4404848909","doi":"https://doi.org/10.1109/tcad.2024.3509795"},"language":"en","primary_location":{"id":"doi:10.1109/tcad.2024.3509795","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tcad.2024.3509795","pdf_url":null,"source":{"id":"https://openalex.org/S100835903","display_name":"IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems","issn_l":"0278-0070","issn":["0278-0070","1937-4151"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1109/tcad.2024.3509795","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055908357","display_name":"Maria Emmerich","orcid":"https://orcid.org/0000-0002-8456-6508"},"institutions":[{"id":"https://openalex.org/I174004417","display_name":"Munich University of Applied Sciences","ror":"https://ror.org/012k1v959","country_code":"DE","type":"education","lineage":["https://openalex.org/I174004417"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maria Emmerich","raw_affiliation_strings":["Chair for Design Automation, Technische Universitat Munchen, Munchen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8456-6508","affiliations":[{"raw_affiliation_string":"Chair for Design Automation, Technische Universitat Munchen, Munchen, Germany","institution_ids":["https://openalex.org/I174004417","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029743891","display_name":"Philipp Ebner","orcid":"https://orcid.org/0000-0001-9086-6948"},"institutions":[{"id":"https://openalex.org/I121883995","display_name":"Johannes Kepler University of Linz","ror":"https://ror.org/052r2xn60","country_code":"AT","type":"education","lineage":["https://openalex.org/I121883995"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Philipp Ebner","raw_affiliation_strings":["Institute for Integrated Circuits, Johannes Kepler University, Linz, Austria"],"raw_orcid":"https://orcid.org/0000-0001-9086-6948","affiliations":[{"raw_affiliation_string":"Institute for Integrated Circuits, Johannes Kepler University, Linz, Austria","institution_ids":["https://openalex.org/I121883995"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004214923","display_name":"Robert Wille","orcid":"https://orcid.org/0000-0002-4993-7860"},"institutions":[{"id":"https://openalex.org/I174004417","display_name":"Munich University of Applied Sciences","ror":"https://ror.org/012k1v959","country_code":"DE","type":"education","lineage":["https://openalex.org/I174004417"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Robert Wille","raw_affiliation_strings":["Chair for Design Automation, Technische Universitat Munchen, Munchen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-4993-7860","affiliations":[{"raw_affiliation_string":"Chair for Design Automation, Technische Universitat Munchen, Munchen, Germany","institution_ids":["https://openalex.org/I174004417","https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8749,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.69305602,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"44","issue":"6","first_page":"2287","last_page":"2299"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9656000137329102,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9656000137329102,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chip","display_name":"Chip","score":0.5740324258804321},{"id":"https://openalex.org/keywords/organ-on-a-chip","display_name":"Organ-on-a-chip","score":0.5693658590316772},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.464105486869812},{"id":"https://openalex.org/keywords/embedded-system","display_name":"Embedded system","score":0.41568899154663086},{"id":"https://openalex.org/keywords/engineering-drawing","display_name":"Engineering drawing","score":0.34808334708213806},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.26173484325408936},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.24016687273979187},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.1738852560520172},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.07102352380752563}],"concepts":[{"id":"https://openalex.org/C165005293","wikidata":"https://www.wikidata.org/wiki/Q1074500","display_name":"Chip","level":2,"score":0.5740324258804321},{"id":"https://openalex.org/C165932988","wikidata":"https://www.wikidata.org/wiki/Q7101746","display_name":"Organ-on-a-chip","level":3,"score":0.5693658590316772},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.464105486869812},{"id":"https://openalex.org/C149635348","wikidata":"https://www.wikidata.org/wiki/Q193040","display_name":"Embedded system","level":1,"score":0.41568899154663086},{"id":"https://openalex.org/C199639397","wikidata":"https://www.wikidata.org/wiki/Q1788588","display_name":"Engineering drawing","level":1,"score":0.34808334708213806},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.26173484325408936},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.24016687273979187},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1738852560520172},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.07102352380752563},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/tcad.2024.3509795","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tcad.2024.3509795","pdf_url":null,"source":{"id":"https://openalex.org/S100835903","display_name":"IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems","issn_l":"0278-0070","issn":["0278-0070","1937-4151"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1109/tcad.2024.3509795","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tcad.2024.3509795","pdf_url":null,"source":{"id":"https://openalex.org/S100835903","display_name":"IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems","issn_l":"0278-0070","issn":["0278-0070","1937-4151"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1092768213","display_name":null,"funder_award_id":"890068","funder_id":"https://openalex.org/F4320323031","funder_display_name":"\u00d6sterreichische Forschungsf\u00f6rderungsgesellschaft"}],"funders":[{"id":"https://openalex.org/F4320323031","display_name":"\u00d6sterreichische Forschungsf\u00f6rderungsgesellschaft","ror":"https://ror.org/028jc0449"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W152943885","https://openalex.org/W1987320854","https://openalex.org/W2008353596","https://openalex.org/W2032115883","https://openalex.org/W2076922024","https://openalex.org/W2124535624","https://openalex.org/W2132341968","https://openalex.org/W2175949414","https://openalex.org/W2208642322","https://openalex.org/W2468862097","https://openalex.org/W2499907403","https://openalex.org/W2570891323","https://openalex.org/W2582966092","https://openalex.org/W2593758551","https://openalex.org/W2613775110","https://openalex.org/W2618400336","https://openalex.org/W2791607331","https://openalex.org/W2792442441","https://openalex.org/W2793367223","https://openalex.org/W2801312105","https://openalex.org/W2902544696","https://openalex.org/W2912840511","https://openalex.org/W2972050434","https://openalex.org/W2993669487","https://openalex.org/W3021020424","https://openalex.org/W3045012209","https://openalex.org/W3083104485","https://openalex.org/W3139112400","https://openalex.org/W3209141514","https://openalex.org/W3216718125","https://openalex.org/W4205779877","https://openalex.org/W4206094525","https://openalex.org/W4220652963","https://openalex.org/W4220755377","https://openalex.org/W4225100591","https://openalex.org/W4225552085","https://openalex.org/W4243147561","https://openalex.org/W4280540675","https://openalex.org/W4286542772","https://openalex.org/W4319455971","https://openalex.org/W4388399941","https://openalex.org/W4401568730"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W2765463169"],"abstract_inverted_index":{"Multiorgans-on-chips":[0],"(multi-OoCs)":[1],"represent":[2,41],"human":[3],"or":[4,165],"other":[5],"animal":[6],"physiology":[7],"on":[8,73,136],"a":[9,34,56,93,110,128,147,157,171,193],"chip\u2014providing":[10],"testing":[11],"platforms":[12],"for":[13,97,114,162],"the":[14,64,69,77,80,122,150,197,202],"pharmaceutical,":[15],"cosmetic,":[16],"and":[17,44,75,82,126,153,170,183,199],"chemical":[18],"industries.":[19],"They":[20],"are":[21,31,174],"composed":[22],"of":[23,50,59,66,84,149,201],"miniaturized":[24],"organ":[25,28,42,67],"tissues":[26],"(so-called":[27],"modules)":[29],"that":[30,159],"connected":[32],"via":[33],"microfluidic":[35],"channel":[36],"network":[37],"and,":[38],"by":[39,179,185],"this,":[40],"functionalities":[43],"their":[45],"interactions":[46],"on-chip.":[47],"The":[48,167],"design":[49,95,111,124,131,143,148],"these":[51],"multi-OoC":[52,115],"geometries,":[53],"however,":[54],"requires":[55],"sophisticated":[57],"orchestration":[58],"numerous":[60],"aspects,":[61],"such":[62],"as":[63,190,192],"size":[65],"modules,":[68],"required":[70],"shear":[71],"stress":[72],"membranes":[74],"subsequently":[76],"flow":[78],"rate,":[79],"dimensions":[81],"geometry":[83],"channels,":[85],"pump":[86],"pressures,":[87],"etc.":[88],"Mastering":[89],"all":[90],"this":[91,106,118],"constitutes":[92],"nontrivial":[94],"task":[96],"which,":[98],"unfortunately,":[99],"no":[100],"automatic":[101,142],"support":[102],"exists":[103],"yet.":[104],"In":[105],"work,":[107],"we":[108,120,138],"propose":[109,140],"automation":[112],"solution":[113],"geometries.":[116],"To":[117],"end,":[119],"review":[121],"respective":[123],"steps":[125],"derive":[127],"corresponding":[129],"formal":[130],"specification":[132],"from":[133],"them.":[134],"Based":[135],"that,":[137],"then":[139],"an":[141],"tool,":[144],"which":[145],"generates":[146],"desired":[151],"device":[152],"exports":[154],"it":[155],"in":[156],"fashion":[158],"is":[160],"ready":[161],"subsequent":[163],"simulation":[164],"fabrication.":[166],"open-source":[168],"tool":[169],"step-by-step":[172],"tutorial":[173],"available":[175],"athttps://github.com/cda-tum/mmft-ooc-designer.":[176],"Evaluations":[177],"(inspired":[178],"real-world":[180],"use":[181],"cases":[182],"confirmed":[184],"computational":[186],"fluid":[187],"dynamic":[188],"simulations":[189],"well":[191],"fabrication":[194],"process)":[195],"demonstrate":[196],"applicability":[198],"validity":[200],"proposed":[203],"approach.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5}],"updated_date":"2026-07-29T09:40:50.615796","created_date":"2025-10-10T00:00:00"}
