{"id":"https://openalex.org/W4413359424","doi":"https://doi.org/10.1109/tbme.2025.3597261","title":"From Symptomatic to Pre-Symptomatic: Adaptive Knowledge Distillation for Early Alzheimer's Detection Using Functional MRI","display_name":"From Symptomatic to Pre-Symptomatic: Adaptive Knowledge Distillation for Early Alzheimer's Detection Using Functional MRI","publication_year":2025,"publication_date":"2025-08-20","ids":{"openalex":"https://openalex.org/W4413359424","doi":"https://doi.org/10.1109/tbme.2025.3597261","pmid":"https://pubmed.ncbi.nlm.nih.gov/40833911"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2025.3597261","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2025.3597261","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yuxiang Wei","orcid":"https://orcid.org/0000-0001-6552-8912"},"institutions":[{"id":"https://openalex.org/I4210133909","display_name":"Center for Translational Research in Neuroimaging and Data Science","ror":"https://ror.org/02qx6zf82","country_code":"US","type":"facility","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I181565077","https://openalex.org/I4210133909"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yuxiang Wei","raw_affiliation_strings":["Center for Translational Research in Neuroimaging and Data Science, Georgia Institute of Technology, Georgia State University, and Emory University, USA","Center for Translational Research in Neuroimaging and Data Science (TreNDS), Georgia Institute of Technology, Georgia State University, and Emory University, USA"],"raw_orcid":"https://orcid.org/0000-0001-6552-8912","affiliations":[{"raw_affiliation_string":"Center for Translational Research in Neuroimaging and Data Science, Georgia Institute of Technology, Georgia State University, and Emory University, USA","institution_ids":["https://openalex.org/I4210133909"]},{"raw_affiliation_string":"Center for Translational Research in Neuroimaging and Data Science (TreNDS), Georgia Institute of Technology, Georgia State University, and Emory University, USA","institution_ids":["https://openalex.org/I4210133909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010748227","display_name":"Anees Abrol","orcid":"https://orcid.org/0000-0001-9223-5314"},"institutions":[{"id":"https://openalex.org/I4210133909","display_name":"Center for Translational Research in Neuroimaging and Data Science","ror":"https://ror.org/02qx6zf82","country_code":"US","type":"facility","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I181565077","https://openalex.org/I4210133909"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anees Abrol","raw_affiliation_strings":["Center for Translational Research in Neuroimaging and Data Science, Georgia Institute of Technology, Georgia State University, and Emory University, USA","Center for Translational Research in Neuroimaging and Data Science (TreNDS), Georgia Institute of Technology, Georgia State University, and Emory University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Research in Neuroimaging and Data Science, Georgia Institute of Technology, Georgia State University, and Emory University, USA","institution_ids":["https://openalex.org/I4210133909"]},{"raw_affiliation_string":"Center for Translational Research in Neuroimaging and Data Science (TreNDS), Georgia Institute of Technology, Georgia State University, and Emory University, USA","institution_ids":["https://openalex.org/I4210133909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106944724","display_name":"James J. Lah","orcid":null},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Lah","raw_affiliation_strings":["Emory University, USA"],"raw_orcid":"https://orcid.org/0000-0002-8810-620X","affiliations":[{"raw_affiliation_string":"Emory University, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023920651","display_name":"Allan I. Levey","orcid":"https://orcid.org/0000-0002-3153-502X"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allan I. Levey","raw_affiliation_strings":["Emory University, USA"],"raw_orcid":"https://orcid.org/0000-0002-3153-502X","affiliations":[{"raw_affiliation_string":"Emory University, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032850756","display_name":"Vince D. Calhoun","orcid":"https://orcid.org/0000-0001-9058-0747"},"institutions":[{"id":"https://openalex.org/I4210133909","display_name":"Center for Translational Research in Neuroimaging and Data Science","ror":"https://ror.org/02qx6zf82","country_code":"US","type":"facility","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I181565077","https://openalex.org/I4210133909"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vince D. Calhoun","raw_affiliation_strings":["Center for Translational Research in Neuroimaging and Data Science, Georgia Institute of Technology, Georgia State University, and Emory University, Atlanta, GA, USA","Center for Translational Research in Neuroimaging and Data Science (TreNDS), Georgia Institute of Technology, Georgia State University, and Emory University, USA"],"raw_orcid":"https://orcid.org/0000-0001-9058-0747","affiliations":[{"raw_affiliation_string":"Center for Translational Research in Neuroimaging and Data Science, Georgia Institute of Technology, Georgia State University, and Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I4210133909"]},{"raw_affiliation_string":"Center for Translational Research in Neuroimaging and Data Science (TreNDS), Georgia Institute of Technology, Georgia State University, and Emory University, USA","institution_ids":["https://openalex.org/I4210133909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210133909"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25777299,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"3","first_page":"1024","last_page":"1038"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.8853999972343445,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.8853999972343445,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.7775999903678894,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.7674000263214111,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4943807125091553},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.48246198892593384},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.43610087037086487},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.39786553382873535},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3485282063484192},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3340722322463989},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3166983723640442},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.2868121564388275},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.17063510417938232}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4943807125091553},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.48246198892593384},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.43610087037086487},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.39786553382873535},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3485282063484192},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3340722322463989},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3166983723640442},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2868121564388275},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.17063510417938232}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbme.2025.3597261","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2025.3597261","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:40833911","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40833911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.5299999713897705,"id":"https://metadata.un.org/sdg/2"}],"awards":[{"id":"https://openalex.org/G3685796033","display_name":null,"funder_award_id":"R01EB006841","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6414683537","display_name":null,"funder_award_id":"2112455","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7402052029","display_name":null,"funder_award_id":"1R01AG090597","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1731081199","https://openalex.org/W1770528888","https://openalex.org/W1985327120","https://openalex.org/W2010216178","https://openalex.org/W2049609468","https://openalex.org/W2106080677","https://openalex.org/W2131427446","https://openalex.org/W2148143831","https://openalex.org/W2255685744","https://openalex.org/W2302255633","https://openalex.org/W2531958295","https://openalex.org/W2737784620","https://openalex.org/W2798054687","https://openalex.org/W2905339609","https://openalex.org/W2931005391","https://openalex.org/W2936503027","https://openalex.org/W2944824748","https://openalex.org/W2962687275","https://openalex.org/W2963140444","https://openalex.org/W2963691377","https://openalex.org/W2965717703","https://openalex.org/W2967967941","https://openalex.org/W2970056174","https://openalex.org/W2982157312","https://openalex.org/W2982242214","https://openalex.org/W2987861506","https://openalex.org/W2998968185","https://openalex.org/W3000333866","https://openalex.org/W3004009719","https://openalex.org/W3046768359","https://openalex.org/W3048396787","https://openalex.org/W3140093204","https://openalex.org/W3168608201","https://openalex.org/W3178994677","https://openalex.org/W4206471589","https://openalex.org/W4211172995","https://openalex.org/W4213104374","https://openalex.org/W4225275145","https://openalex.org/W4280618724","https://openalex.org/W4281679704","https://openalex.org/W4293036553","https://openalex.org/W4294324801","https://openalex.org/W4295925510","https://openalex.org/W4308601243","https://openalex.org/W4310490264","https://openalex.org/W4312527924","https://openalex.org/W4312980183","https://openalex.org/W4313029060","https://openalex.org/W4384284015","https://openalex.org/W4386952189","https://openalex.org/W4390873603","https://openalex.org/W4394641960","https://openalex.org/W4400721967","https://openalex.org/W4402727337","https://openalex.org/W4403759655","https://openalex.org/W4405221117","https://openalex.org/W4405490362"],"related_works":["https://openalex.org/W2961085424","https://openalex.org/W4306674287","https://openalex.org/W4387369504","https://openalex.org/W4394896187","https://openalex.org/W3170094116","https://openalex.org/W4386462264","https://openalex.org/W3107602296","https://openalex.org/W4364306694","https://openalex.org/W4312192474","https://openalex.org/W2033914206"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1,140,216],"(AD)":[2],"progresses":[3],"from":[4,91,136],"asymptomatic":[5],"changes":[6],"to":[7,17,35,41,120,123,138,149],"clinical":[8],"symptoms,":[9],"underscoring":[10],"the":[11,156,180,202],"critical":[12],"need":[13],"for":[14,29,117],"early":[15,215],"detection":[16],"facilitate":[18],"timely":[19],"treatment.":[20],"Functional":[21],"magnetic":[22],"resonance":[23],"imaging":[24],"(fMRI)":[25],"offers":[26],"non-invasive":[27],"biomarkers":[28],"detection,":[30],"but":[31],"current":[32],"methods":[33],"fail":[34],"reliably":[36],"identify":[37],"pre-symptomatic":[38,52,75,96,188],"individuals":[39],"due":[40],"two":[42,108],"key":[43],"challenges:":[44],"(1)":[45,110],"Subtle,":[46],"anatomically":[47],"distinct":[48,166],"fMRI":[49],"patterns":[50,128],"in":[51,67,126,186],"cases":[53,94],"that":[54],"resemble":[55],"healthy":[56,71],"controls":[57,72],"more":[58,205,223],"than":[59],"symptomatic":[60,93],"patients,":[61],"and":[62,132,169,209,225],"(2)":[63,142],"Severe":[64],"class":[65,151],"imbalance":[66,152],"real-world":[68],"data,":[69],"where":[70,89],"vastly":[73],"outnumber":[74],"subjects.":[76],"To":[77],"address":[78],"this,":[79],"we":[80,178],"reconceptualize":[81],"AD":[82,227],"diagnosis":[83],"as":[84,190,192],"a":[85,100,211,219],"multi-stage":[86],"distillation":[87,104,135],"task,":[88],"insights":[90],"easier-to-detect":[92],"guide":[95],"detection.":[97],"We":[98,111,143,159],"propose":[99,144],"novel":[101],"margin-aware":[102],"knowledge":[103],"(KD)":[105],"framework":[106,163],"with":[107,146],"innovations:":[109],"leverage":[112],"Unbalanced":[113],"Optimal":[114],"Transport":[115],"(UOT)":[116],"Feature":[118],"Distillation":[119],"flexibly":[121],"adapt":[122],"anatomical":[124],"differences":[125],"brain":[127,184],"caused":[129],"by":[130,153],"neurodegeneration":[131],"ensure":[133],"effective":[134],"later":[137],"earlier":[139,226],"stages.":[141],"Self-Distillation":[145],"Dynamic":[147],"Margins":[148],"combat":[150],"adaptively":[154],"refining":[155],"classification":[157],"boundary.":[158],"evaluate":[160],"our":[161],"proposed":[162],"across":[164],"four":[165],"base":[167],"models":[168],"demonstrate":[170],"its":[171],"superiority":[172],"over":[173],"state-of-the-art":[174],"KD":[175],"methods.":[176],"Additionally,":[177],"show":[179],"significance":[181],"of":[182,204,214],"various":[183],"regions":[185],"identifying":[187],"subjects,":[189],"well":[191],"how":[193],"features":[194],"are":[195],"transferred":[196],"during":[197],"distillation.":[198],"These":[199],"contributions":[200],"advance":[201],"development":[203],"precise":[206],"diagnostic":[207],"tools":[208],"foster":[210],"deeper":[212],"understanding":[213],"manifestations,":[217],"marking":[218],"significant":[220],"stride":[221],"towards":[222],"reliable":[224],"diagnosis.":[228]},"counts_by_year":[],"updated_date":"2026-05-05T08:41:31.759640","created_date":"2025-10-10T00:00:00"}