{"id":"https://openalex.org/W4410359206","doi":"https://doi.org/10.1109/tbme.2025.3568593","title":"Non-Intrusive Reduced Order Modeling of Patient-Specific Cochlear Implantations","display_name":"Non-Intrusive Reduced Order Modeling of Patient-Specific Cochlear Implantations","publication_year":2025,"publication_date":"2025-05-14","ids":{"openalex":"https://openalex.org/W4410359206","doi":"https://doi.org/10.1109/tbme.2025.3568593","pmid":"https://pubmed.ncbi.nlm.nih.gov/40366824"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2025.3568593","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2025.3568593","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058388061","display_name":"Fynn Bensel","orcid":"https://orcid.org/0000-0003-3889-1200"},"institutions":[{"id":"https://openalex.org/I114112103","display_name":"Leibniz University Hannover","ror":"https://ror.org/0304hq317","country_code":"DE","type":"education","lineage":["https://openalex.org/I114112103"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fynn Bensel","raw_affiliation_strings":["Institute of Mechanics and Numerical Mechanics, Leibniz University Hannover, Germany"],"raw_orcid":"https://orcid.org/0000-0003-3889-1200","affiliations":[{"raw_affiliation_string":"Institute of Mechanics and Numerical Mechanics, Leibniz University Hannover, Germany","institution_ids":["https://openalex.org/I114112103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037395743","display_name":"Daniel Kipping","orcid":"https://orcid.org/0000-0001-8371-6132"},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Kipping","raw_affiliation_strings":["Department of Otorhinolaryngology, Hannover Medical School (MHH), Germany"],"raw_orcid":"https://orcid.org/0000-0001-8371-6132","affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, Hannover Medical School (MHH), Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002395420","display_name":"Marlis Reiber","orcid":"https://orcid.org/0000-0003-3042-0199"},"institutions":[{"id":"https://openalex.org/I114112103","display_name":"Leibniz University Hannover","ror":"https://ror.org/0304hq317","country_code":"DE","type":"education","lineage":["https://openalex.org/I114112103"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marlis Reiber","raw_affiliation_strings":["Institute of Mechanics and Numerical Mechanics, Leibniz University Hannover, Germany"],"raw_orcid":"https://orcid.org/0000-0003-3042-0199","affiliations":[{"raw_affiliation_string":"Institute of Mechanics and Numerical Mechanics, Leibniz University Hannover, Germany","institution_ids":["https://openalex.org/I114112103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039035491","display_name":"Y. Zhang","orcid":"https://orcid.org/0009-0008-7615-5996"},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Yixuan Zhang","raw_affiliation_strings":["Department of Otorhinolaryngology, Hannover Medical School (MHH), Germany"],"raw_orcid":"https://orcid.org/0009-0008-7615-5996","affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, Hannover Medical School (MHH), Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029492857","display_name":"Udo Nackenhorst","orcid":"https://orcid.org/0000-0002-8964-2346"},"institutions":[{"id":"https://openalex.org/I114112103","display_name":"Leibniz University Hannover","ror":"https://ror.org/0304hq317","country_code":"DE","type":"education","lineage":["https://openalex.org/I114112103"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Udo Nackenhorst","raw_affiliation_strings":["Institute of Mechanics and Numerical Mechanics, Leibniz University Hannover, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8964-2346","affiliations":[{"raw_affiliation_string":"Institute of Mechanics and Numerical Mechanics, Leibniz University Hannover, Germany","institution_ids":["https://openalex.org/I114112103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055615467","display_name":"Waldo Nogueira","orcid":"https://orcid.org/0000-0001-7224-7617"},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Waldo Nogueira","raw_affiliation_strings":["Department of Otorhinolaryngology, Hannover Medical School (MHH), Hannover, Germany","Department of Otorhinolaryngology, Hannover Medical School (MHH), Germany"],"raw_orcid":"https://orcid.org/0000-0001-7224-7617","affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, Hannover Medical School (MHH), Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Department of Otorhinolaryngology, Hannover Medical School (MHH), Germany","institution_ids":["https://openalex.org/I34809795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07545111,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"11","first_page":"3391","last_page":"3403"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.982699990272522,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.982699990272522,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10860","display_name":"Speech and Audio Processing","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/1711","display_name":"Signal Processing"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/order","display_name":"Order (exchange)","score":0.5027821063995361},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4398883283138275},{"id":"https://openalex.org/keywords/speech-recognition","display_name":"Speech recognition","score":0.4214437007904053},{"id":"https://openalex.org/keywords/audiology","display_name":"Audiology","score":0.3974950313568115},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2074059247970581},{"id":"https://openalex.org/keywords/business","display_name":"Business","score":0.09184074401855469}],"concepts":[{"id":"https://openalex.org/C182306322","wikidata":"https://www.wikidata.org/wiki/Q1779371","display_name":"Order (exchange)","level":2,"score":0.5027821063995361},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4398883283138275},{"id":"https://openalex.org/C28490314","wikidata":"https://www.wikidata.org/wiki/Q189436","display_name":"Speech recognition","level":1,"score":0.4214437007904053},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.3974950313568115},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2074059247970581},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.09184074401855469},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D003054","descriptor_name":"Cochlear Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003054","descriptor_name":"Cochlear Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003054","descriptor_name":"Cochlear Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003054","descriptor_name":"Cochlear Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019929","descriptor_name":"Cochlear Implantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019929","descriptor_name":"Cochlear Implantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019929","descriptor_name":"Cochlear Implantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019929","descriptor_name":"Cochlear Implantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D066230","descriptor_name":"Patient-Specific Modeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066230","descriptor_name":"Patient-Specific Modeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066230","descriptor_name":"Patient-Specific Modeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066230","descriptor_name":"Patient-Specific Modeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbme.2025.3568593","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2025.3568593","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:40366824","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40366824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.4099999964237213,"id":"https://metadata.un.org/sdg/2"}],"awards":[{"id":"https://openalex.org/G1082280812","display_name":"TRR 298: Sicherheitsintegrierte und infektionsreaktive Implantate","funder_award_id":"426335750","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2541310843","display_name":null,"funder_award_id":"INST 187/742-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2658354878","display_name":"GRK 2657: Methoden der numerischen Mechanik in h\u00f6heren Dimensionen","funder_award_id":"433082294","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W32681052","https://openalex.org/W976432831","https://openalex.org/W1488757481","https://openalex.org/W1547166419","https://openalex.org/W1556083071","https://openalex.org/W1983923475","https://openalex.org/W2004026774","https://openalex.org/W2016977813","https://openalex.org/W2024000425","https://openalex.org/W2047454737","https://openalex.org/W2049753327","https://openalex.org/W2066381443","https://openalex.org/W2100199575","https://openalex.org/W2127689830","https://openalex.org/W2133041109","https://openalex.org/W2135706067","https://openalex.org/W2145475762","https://openalex.org/W2152896489","https://openalex.org/W2168314908","https://openalex.org/W2323980249","https://openalex.org/W2328145002","https://openalex.org/W2333312111","https://openalex.org/W2471220021","https://openalex.org/W2513132427","https://openalex.org/W2524098303","https://openalex.org/W2553428522","https://openalex.org/W2769831802","https://openalex.org/W2772709428","https://openalex.org/W2911862538","https://openalex.org/W2995060535","https://openalex.org/W3006936886","https://openalex.org/W3151180121","https://openalex.org/W3209298262","https://openalex.org/W4280628391","https://openalex.org/W4281975224","https://openalex.org/W4311781006","https://openalex.org/W4323666011","https://openalex.org/W4324030840","https://openalex.org/W4360938177","https://openalex.org/W4391799286","https://openalex.org/W4393965264","https://openalex.org/W4404311132"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Cochlear":[1],"implants":[2],"successfully":[3],"treat":[4],"severe":[5],"to":[6,45,82,95,106,142,167,187],"profound":[7],"hearing":[8],"loss":[9],"patients.":[10],"Patient-specific":[11],"numerical":[12,223],"simulations":[13,31,108],"can":[14,199],"yield":[15],"important":[16],"insights":[17],"that":[18],"could":[19,225],"guide":[20],"surgical":[21],"planning":[22],"and":[23,51,62,125,132,161,209,239],"the":[24,47,59,84,122,128,133,144,147,154,157,178,188,201,216,227,232],"interpretation":[25],"of":[26,53,89,146,177,184,218,229,234],"post-operative":[27],"measurements.":[28],"However,":[29],"these":[30],"have":[32],"a":[33,170,174,181],"high":[34,175],"computational":[35,60],"effort.":[36],"METHODS:":[37],"A":[38,137],"non-intrusive":[39,195],"reduced-order":[40,68,148],"model":[41,49,69,87,159,198],"has":[42],"been":[43],"used":[44,81,141],"replace":[46],"patient-specific":[48,158,220],"generation":[50,160],"simulation":[52,114,162],"different":[54,91],"electrical":[55,111],"stimulation":[56],"sources,":[57],"reducing":[58],"time":[61,155],"enabling":[63],"fast":[64,219],"response":[65],"simulations.":[66,221],"The":[67,79,150,193],"combines":[70],"proper":[71],"orthogonal":[72],"decomposition":[73],"with":[74,102,109,180],"radial":[75],"basis":[76],"function":[77],"interpolation.":[78],"dataset":[80],"build":[83],"reduced":[85,196],"order":[86,197],"consists":[88],"528":[90],"solutions,":[92],"also":[93],"referred":[94],"as":[96],"snapshots,":[97],"from":[98,163],"24":[99],"cochlear":[100,230],"models,":[101],"each":[103],"cochlea":[104,123],"subjected":[105],"22":[107],"varying":[110],"stimuli.":[112],"Each":[113],"is":[115],"characterized":[116],"by":[117],"five":[118],"parameters,":[119],"three":[120],"specifying":[121,127],"geometry":[124],"two":[126],"electrode":[129],"array":[130],"position":[131],"active":[134],"electrode.":[135],"RESULTS:":[136],"leave-one-out":[138],"strategy":[139],"was":[140],"verify":[143],"accuracy":[145,176],"model.":[149],"presented":[151,194],"approach":[152],"reduces":[153],"for":[156,206],"nearly":[164],"1.5":[165],"hours":[166],"less":[168],"than":[169],"second":[171],"while":[172],"providing":[173],"solutions":[179],"relative":[182],"error":[183],"2.5%":[185],"compared":[186],"finite":[189],"element":[190],"solution.":[191],"CONCLUSION:":[192],"predict":[200],"3D":[202],"intracochlear":[203],"voltage":[204],"distribution":[205],"new":[207],"patients":[208],"implant":[210],"positions.":[211],"SIGNIFICANCE:":[212],"This":[213],"work":[214],"demonstrates":[215],"feasibility":[217],"These":[222],"investigations":[224],"support":[226],"fitting":[228],"implants,":[231],"design":[233],"individualized":[235],"sound":[236],"coding":[237],"strategies":[238],"surgery-dependent":[240],"decision-making.":[241]},"counts_by_year":[],"updated_date":"2026-08-08T01:25:22.217667","created_date":"2025-10-10T00:00:00"}