{"id":"https://openalex.org/W4406657569","doi":"https://doi.org/10.1109/tbme.2024.3467924","title":"Influence of Heart Rate on Dynamic Characteristics and Hemolytic Potential: A Study Using In-Vitro and Numerical Methods","display_name":"Influence of Heart Rate on Dynamic Characteristics and Hemolytic Potential: A Study Using In-Vitro and Numerical Methods","publication_year":2025,"publication_date":"2025-01-21","ids":{"openalex":"https://openalex.org/W4406657569","doi":"https://doi.org/10.1109/tbme.2024.3467924","pmid":"https://pubmed.ncbi.nlm.nih.gov/40031179"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2024.3467924","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2024.3467924","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036332733","display_name":"Shulei Li","orcid":"https://orcid.org/0000-0002-1802-0902"},"institutions":[{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shulei Li","raw_affiliation_strings":["School of Energy and Power Engineering, Beihang University, China"],"raw_orcid":"https://orcid.org/0000-0002-1802-0902","affiliations":[{"raw_affiliation_string":"School of Energy and Power Engineering, Beihang University, China","institution_ids":["https://openalex.org/I82880672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049414025","display_name":"Donghai Jin","orcid":"https://orcid.org/0009-0004-7569-8025"},"institutions":[{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Donghai Jin","raw_affiliation_strings":["School of Energy and Power Engineering, Beihang University, Beijing, China"],"raw_orcid":"https://orcid.org/0009-0004-7569-8025","affiliations":[{"raw_affiliation_string":"School of Energy and Power Engineering, Beihang University, Beijing, China","institution_ids":["https://openalex.org/I82880672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112427446","display_name":"Xingmin Gui","orcid":null},"institutions":[{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingmin Gui","raw_affiliation_strings":["School of Energy and Power Engineering, Beihang University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Energy and Power Engineering, Beihang University, China","institution_ids":["https://openalex.org/I82880672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071515811","display_name":"Guangmao Liu","orcid":"https://orcid.org/0000-0002-7736-4684"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guangmao Liu","raw_affiliation_strings":["State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-7736-4684","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069051956","display_name":"Jianqiang Hao","orcid":"https://orcid.org/0000-0001-9585-3230"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianqiang Hao","raw_affiliation_strings":["State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026867608","display_name":"Xihang Jiang","orcid":"https://orcid.org/0000-0002-7485-7635"},"institutions":[{"id":"https://openalex.org/I4210119975","display_name":"Beijing Institute of Power Machinery (China)","ror":"https://ror.org/02hxk7x55","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210119975"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xihang Jiang","raw_affiliation_strings":["Beijing Power Machinery Research Institute, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Power Machinery Research Institute, China","institution_ids":["https://openalex.org/I4210119975"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5036332733"],"corresponding_institution_ids":["https://openalex.org/I82880672"],"apc_list":null,"apc_paid":null,"fwci":0.5801,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.61596828,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"72","issue":"2","first_page":"689","last_page":"704"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11249","display_name":"Wireless Power Transfer Systems","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.5054628849029541},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.49313753843307495},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.43201494216918945},{"id":"https://openalex.org/keywords/heart-rate","display_name":"Heart rate","score":0.4231100082397461},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.33332687616348267},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.3185267448425293},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2580971121788025},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.23288893699645996},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.17858287692070007},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"Blood pressure","score":0.10121616721153259}],"concepts":[{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5054628849029541},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.49313753843307495},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.43201494216918945},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.4231100082397461},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33332687616348267},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.3185267448425293},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2580971121788025},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23288893699645996},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17858287692070007},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.10121616721153259},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006353","descriptor_name":"Heart-Assist Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006353","descriptor_name":"Heart-Assist Devices","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006353","descriptor_name":"Heart-Assist Devices","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006353","descriptor_name":"Heart-Assist Devices","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbme.2024.3467924","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2024.3467924","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:40031179","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40031179","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G223822229","display_name":null,"funder_award_id":"JCYJ20210324130408023","funder_id":"https://openalex.org/F4320329791","funder_display_name":"Shenzhen Fundamental Research Program"},{"id":"https://openalex.org/G8704502913","display_name":null,"funder_award_id":"52376021","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320329791","display_name":"Shenzhen Fundamental Research Program","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W99792463","https://openalex.org/W835511631","https://openalex.org/W1538581007","https://openalex.org/W1591139544","https://openalex.org/W1867938852","https://openalex.org/W1971426446","https://openalex.org/W1971656749","https://openalex.org/W1973417097","https://openalex.org/W1995021535","https://openalex.org/W1998494385","https://openalex.org/W2004816273","https://openalex.org/W2013614447","https://openalex.org/W2015790897","https://openalex.org/W2017462548","https://openalex.org/W2055992037","https://openalex.org/W2067626478","https://openalex.org/W2074646264","https://openalex.org/W2081913215","https://openalex.org/W2126185883","https://openalex.org/W2127354627","https://openalex.org/W2132234126","https://openalex.org/W2155601548","https://openalex.org/W2327306241","https://openalex.org/W2342166896","https://openalex.org/W2342322634","https://openalex.org/W2408747061","https://openalex.org/W2515415754","https://openalex.org/W2585810302","https://openalex.org/W2611646194","https://openalex.org/W2743172923","https://openalex.org/W2751541740","https://openalex.org/W2782525562","https://openalex.org/W2806068201","https://openalex.org/W2884373107","https://openalex.org/W2895444396","https://openalex.org/W2896270452","https://openalex.org/W2897975672","https://openalex.org/W2900316863","https://openalex.org/W2986327447","https://openalex.org/W3018168125","https://openalex.org/W3042759011","https://openalex.org/W3092286021","https://openalex.org/W3092908297","https://openalex.org/W3093278679","https://openalex.org/W4224007023","https://openalex.org/W4323315416","https://openalex.org/W4328048263","https://openalex.org/W6672776811"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W4404995717","https://openalex.org/W2016187641","https://openalex.org/W4404725684","https://openalex.org/W4246450666","https://openalex.org/W4388998267","https://openalex.org/W2898370298","https://openalex.org/W2137437058","https://openalex.org/W4405893659","https://openalex.org/W4404784341"],"abstract_inverted_index":{"OBJECTIVE:":[0],"This":[1,124],"study":[2,125],"investigates":[3],"the":[4,11,14,19,52,72,75,81,119,127,131,169],"influence":[5,132],"of":[6,74,133,171],"heart":[7],"rate":[8],"(HR)":[9],"on":[10,135],"pump":[12,42,76,136,163],"at":[13,58],"coupled":[15,172],"working":[16,173],"state":[17],"with":[18,111,149],"cardiovascular":[20],"system.":[21],"METHODS:":[22],"A":[23],"combined":[24],"approach":[25],"integrating":[26],"in-vitro":[27,53],"and":[28,80,99,139,168],"numerical":[29],"methods":[30],"is":[31],"employed":[32],"to":[33,96,104],"predict":[34],"cycle-average":[35,82],"hemolytic":[36,56,83],"potential":[37,57,145],"(denoted":[38],"as":[39],").":[40],"The":[41,55],"dynamic":[43,77,120,137],"characteristics":[44,138],"under":[45,156],"varying":[46],"HR":[47,69,109,134,158],"conditions":[48],"are":[49,65],"investigated":[50],"in":[51,86,165],"experiments.":[54],"different":[59],"operation":[60],"points":[61],"(represented":[62],"by":[63],")":[64],"predicted":[66],"numerically.":[67],"RESULTS:":[68],"variations":[70],"affect":[71],"shape":[73],"characteristic":[78],"loop":[79],"potential.":[84],"Specifically,":[85],"all":[87],"three":[88],"series":[89],"studied,":[90],"demonstrated":[91],"an":[92],"increase":[93],"from":[94,102],"60":[95],"80":[97],"bpm":[98],"a":[100],"decrease":[101],"100":[103],"120":[105],"bpm.":[106],"CONCLUSION:":[107],"Higher":[108],"correlates":[110],"heightened":[112],"hysteresis":[113],"effects":[114,147],"within":[115],"turbomachinery,":[116],"thereby":[117],"impacting":[118],"characteristics'":[121],"profile.":[122],"SIGNIFICANCE:":[123],"unveils":[126],"physical":[128],"mechanisms":[129],"underlying":[130],"provides":[140],"crucial":[141],"insights":[142],"for":[143],"estimating":[144],"adverse":[146],"associated":[148],"left":[150],"ventricular":[151],"assist":[152],"device":[153],"(LVAD)":[154],"implantation":[155],"diverse":[157],"conditions,":[159],"which":[160],"helps":[161],"prompt":[162],"adjustments":[164],"clinical":[166],"applications":[167],"development":[170],"models.":[174]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-05-05T08:41:31.759640","created_date":"2025-10-10T00:00:00"}