{"id":"https://openalex.org/W4400878455","doi":"https://doi.org/10.1109/tbme.2024.3431553","title":"Causal Brain Network in Clinically-Annotated Epileptogenic Zone Predicts Surgical Outcomes of Drug-Resistant Epilepsy","display_name":"Causal Brain Network in Clinically-Annotated Epileptogenic Zone Predicts Surgical Outcomes of Drug-Resistant Epilepsy","publication_year":2024,"publication_date":"2024-07-22","ids":{"openalex":"https://openalex.org/W4400878455","doi":"https://doi.org/10.1109/tbme.2024.3431553","pmid":"https://pubmed.ncbi.nlm.nih.gov/39037881"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2024.3431553","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2024.3431553","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100740827","display_name":"Yalin Wang","orcid":"https://orcid.org/0000-0002-4440-7705"},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yalin Wang","raw_affiliation_strings":["School of Information Science and Engineering, Lanzhou University, China"],"raw_orcid":"https://orcid.org/0000-0002-4440-7705","affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Lanzhou University, China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002879367","display_name":"Wentao Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wentao Lin","raw_affiliation_strings":["School of Information Science and Technology, Fudan University, China"],"raw_orcid":"https://orcid.org/0009-0009-0465-9754","affiliations":[{"raw_affiliation_string":"School of Information Science and Technology, Fudan University, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000250608","display_name":"Yuanfeng Zhou","orcid":"https://orcid.org/0000-0002-2731-6609"},"institutions":[{"id":"https://openalex.org/I4210159329","display_name":"Children's Hospital of Fudan University","ror":"https://ror.org/05n13be63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159329"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanfeng Zhou","raw_affiliation_strings":["Children's Hospital of Fudan University, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-2731-6609","affiliations":[{"raw_affiliation_string":"Children's Hospital of Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I4210159329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035557835","display_name":"Weihao Zheng","orcid":"https://orcid.org/0000-0003-2996-5909"},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weihao Zheng","raw_affiliation_strings":["School of Information Science and Engineering, Lanzhou University, China"],"raw_orcid":"https://orcid.org/0000-0003-2996-5909","affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Lanzhou University, China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100418370","display_name":"Chen Chen","orcid":"https://orcid.org/0000-0001-7587-3314"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Chen","raw_affiliation_strings":["Human Phenome Institute, Fudan University, China"],"raw_orcid":"https://orcid.org/0000-0001-7587-3314","affiliations":[{"raw_affiliation_string":"Human Phenome Institute, Fudan University, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344582","display_name":"Wei Chen","orcid":"https://orcid.org/0000-0003-3720-718X"},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Wei Chen","raw_affiliation_strings":["School of Biomedical Engineering, University of Sydney, Camperdown, NSW, Australia"],"raw_orcid":"https://orcid.org/0000-0003-3720-718X","affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, University of Sydney, Camperdown, NSW, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100380066","display_name":"Bin Hu","orcid":"https://orcid.org/0000-0003-3514-5413"},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Hu","raw_affiliation_strings":["School of Information Science and Engineering, Lanzhou University, Lanzhou, China"],"raw_orcid":"https://orcid.org/0000-0003-3514-5413","affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Lanzhou University, Lanzhou, China","institution_ids":["https://openalex.org/I76214153"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2758,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.88051996,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"71","issue":"12","first_page":"3515","last_page":"3522"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9829999804496765,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9829999804496765,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.8083802461624146},{"id":"https://openalex.org/keywords/drug-resistant-epilepsy","display_name":"Drug Resistant Epilepsy","score":0.5916287899017334},{"id":"https://openalex.org/keywords/epilepsy-surgery","display_name":"Epilepsy surgery","score":0.553320050239563},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.504353404045105},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4688602089881897},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4599458575248718},{"id":"https://openalex.org/keywords/electrocorticography","display_name":"Electrocorticography","score":0.4510731101036072},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.4282165765762329},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.2635418176651001},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.1392110288143158}],"concepts":[{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.8083802461624146},{"id":"https://openalex.org/C2910833928","wikidata":"https://www.wikidata.org/wiki/Q18975053","display_name":"Drug Resistant Epilepsy","level":3,"score":0.5916287899017334},{"id":"https://openalex.org/C2780803581","wikidata":"https://www.wikidata.org/wiki/Q1347108","display_name":"Epilepsy surgery","level":3,"score":0.553320050239563},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.504353404045105},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4688602089881897},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4599458575248718},{"id":"https://openalex.org/C2780117969","wikidata":"https://www.wikidata.org/wiki/Q3587624","display_name":"Electrocorticography","level":3,"score":0.4510731101036072},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.4282165765762329},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2635418176651001},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1392110288143158}],"mesh":[{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbme.2024.3431553","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2024.3431553","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:39037881","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39037881","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1056251607","display_name":null,"funder_award_id":"62227807","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4305688413","display_name":null,"funder_award_id":"62001118","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1972823717","https://openalex.org/W2004177049","https://openalex.org/W2026672434","https://openalex.org/W2052066602","https://openalex.org/W2061564920","https://openalex.org/W2071044018","https://openalex.org/W2083278075","https://openalex.org/W2086612788","https://openalex.org/W2094129703","https://openalex.org/W2133776757","https://openalex.org/W2142858796","https://openalex.org/W2257913294","https://openalex.org/W2405546682","https://openalex.org/W2443718761","https://openalex.org/W2560318754","https://openalex.org/W2563036039","https://openalex.org/W2741463509","https://openalex.org/W2765545560","https://openalex.org/W3082550715","https://openalex.org/W3133560302","https://openalex.org/W3193174973","https://openalex.org/W3207836535","https://openalex.org/W4200082520","https://openalex.org/W4200245401","https://openalex.org/W4205432481","https://openalex.org/W4206719969","https://openalex.org/W4220699890","https://openalex.org/W4224234943","https://openalex.org/W4229455833","https://openalex.org/W4309662126","https://openalex.org/W4312002242","https://openalex.org/W4313413209","https://openalex.org/W4321648621","https://openalex.org/W4362601165","https://openalex.org/W4367669634","https://openalex.org/W4380684988","https://openalex.org/W4380763449","https://openalex.org/W4381331530","https://openalex.org/W4386159779","https://openalex.org/W6810423266","https://openalex.org/W6850090735"],"related_works":["https://openalex.org/W4361226145","https://openalex.org/W3032068554","https://openalex.org/W2086998976","https://openalex.org/W2624761933","https://openalex.org/W2168521352","https://openalex.org/W2327734194","https://openalex.org/W2040524797","https://openalex.org/W4324330064","https://openalex.org/W2105669039","https://openalex.org/W2097377975"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Patients":[1],"with":[2,17,125,153,182],"drug-resistant":[3],"epilepsy":[4],"(DRE)":[5],"are":[6,166],"commonly":[7],"treated":[8],"using":[9,98],"neurosurgery,":[10],"while":[11],"its":[12],"success":[13],"rate":[14],"is":[15,23,30,128,144,224,237],"limited":[16],"approximately":[18],"50%.":[19],"Predicting":[20],"surgical":[21,96,217,231],"outcomes":[22,97],"currently":[24],"a":[25,33,37,46,66,225],"prominent":[26],"topic.":[27],"The":[28,220,234],"DRE":[29,61,123,241],"recognized":[31],"as":[32],"network":[34,53,87,99,140,161,223],"disorder":[35],"involving":[36],"seizure":[38],"triggering":[39],"mechanism":[40],"within":[41],"epileptogenic":[42,86,139,221],"zone":[43],"(EZ);":[44],"however,":[45],"systematic":[47],"exploration":[48],"of":[49,91,113,137,149,213],"the":[50,78,83,107,133,138,150,154,171,207,210],"EZ":[51],"causal":[52,68,222],"remains":[54],"lacking.":[55],"METHODS:":[56],"This":[57],"paper":[58],"will":[59],"advance":[60],"study":[62],"by:":[63],"1)":[64],"developing":[65],"novel":[67],"coupling":[69,135],"algorithm,":[70],"\"full":[71],"convergent":[72],"cross":[73,205],"mapping":[74],"(FCCM)\"":[75],"to":[76,239],"improve":[77],"quantization":[79,110],"performance;":[80],"2)":[81],"characterizing":[82],"DRE's":[84,230],"multi-frequency":[85],"by":[88],"FCCM":[89,201],"calculation":[90],"ictal":[92],"iEEG;":[93],"3)":[94],"predicting":[95,216],"features":[100,202],"and":[101,116,169,179,183,186,191,198,203],"machine":[102],"learning.":[103],"Numerical":[104],"validations":[105],"demonstrate":[106,174],"FCCM's":[108],"superior":[109],"in":[111,141,159,215],"terms":[112],"nonlinearity,":[114],"accuracy,":[115],"stability.":[117],"A":[118],"multicenter":[119],"cohort":[120],"containing":[121],"22":[122],"patients":[124],"81":[126],"seizures":[127],"included.":[129],"RESULT:":[130],"Based":[131],"on":[132],"Mann-Whitney-U-test,":[134],"strength":[136],"successful":[142,178],"surgeries":[143],"significantly":[145],"higher":[146],"than":[147],"that":[148],"failed":[151,180],"group,":[152],"most":[155],"significant":[156],"difference":[157],"observed":[158],"-iEEG":[160,172],"().":[162],"Other":[163],"clinical":[164,194],"covariates":[165],"also":[167],"considered":[168],"all":[170],"networks":[173],"consistent":[175],"differences":[176],"comparing":[177],"groups,":[181],"for":[184,192,228],"lesional":[185],"non-lesional":[187],"DRE,":[188],",":[189,190],"three":[193],"centers":[195],"CHFU,":[196],"JHU":[197],"NIH.":[199],"Using":[200],"10-fold":[204],"validation,":[206],"SVM":[208],"achieves":[209],"highest":[211],"accuracy":[212],"87.65%":[214],"outcomes.":[218,232],"CONCLUSION:":[219],"reliable":[226],"biomarker":[227],"estimating":[229],"SIGNIFICANCE:":[233],"proposed":[235],"approach":[236],"promising":[238],"facilitate":[240],"precision":[242],"medicine.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6}],"updated_date":"2026-08-18T07:49:30.821534","created_date":"2025-10-10T00:00:00"}