{"id":"https://openalex.org/W4400810708","doi":"https://doi.org/10.1109/tbme.2024.3431013","title":"Synergistic Bipolar Irreversible Electroporation for Tumor Ablation Without Muscle Contraction","display_name":"Synergistic Bipolar Irreversible Electroporation for Tumor Ablation Without Muscle Contraction","publication_year":2024,"publication_date":"2024-07-19","ids":{"openalex":"https://openalex.org/W4400810708","doi":"https://doi.org/10.1109/tbme.2024.3431013","pmid":"https://pubmed.ncbi.nlm.nih.gov/39028604"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2024.3431013","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2024.3431013","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031553360","display_name":"Yancheng Wang","orcid":"https://orcid.org/0009-0004-7361-190X"},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yancheng Wang","raw_affiliation_strings":["Key Laboratory of Power Transmission Equipment Technology, School of Electrical Engineering, Chongqing University, China"],"raw_orcid":"https://orcid.org/0009-0004-7361-190X","affiliations":[{"raw_affiliation_string":"Key Laboratory of Power Transmission Equipment Technology, School of Electrical Engineering, Chongqing University, China","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061690485","display_name":"Kun Qian","orcid":"https://orcid.org/0000-0002-4798-3601"},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Qian","raw_affiliation_strings":["Key Laboratory of Power Transmission Equipment Technology, School of Electrical Engineering, Chongqing University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Power Transmission Equipment Technology, School of Electrical Engineering, Chongqing University, China","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100704584","display_name":"Xinlei Liu","orcid":"https://orcid.org/0000-0001-7216-9292"},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinlei Liu","raw_affiliation_strings":["Laboratory Animal Research Center, Stem Cell Research Center, School of Medicine, Chongqing University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Animal Research Center, Stem Cell Research Center, School of Medicine, Chongqing University, China","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100636286","display_name":"Qiang Yang","orcid":"https://orcid.org/0000-0001-5059-8360"},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Yang","raw_affiliation_strings":["Key Laboratory of Power Transmission Equipment Technology, School of Electrical Engineering, Chongqing University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Power Transmission Equipment Technology, School of Electrical Engineering, Chongqing University, China","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081781282","display_name":"Yizhen Lei","orcid":null},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yizhen Lei","raw_affiliation_strings":["Key Laboratory of Power Transmission Equipment Technology, School of Electrical Engineering, Chongqing University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Power Transmission Equipment Technology, School of Electrical Engineering, Chongqing University, China","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Liming Zhu","orcid":null},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liming Zhu","raw_affiliation_strings":["Key Laboratory of Power Transmission Equipment Technology, School of Electrical Engineering, Chongqing University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Power Transmission Equipment Technology, School of Electrical Engineering, Chongqing University, China","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087988000","display_name":"Chenguo Yao","orcid":"https://orcid.org/0000-0002-1781-2756"},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenguo Yao","raw_affiliation_strings":["Key Laboratory of Power Transmission Equipment Technology, School of Electrical Engineering, Chongqing University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Power Transmission Equipment Technology, School of Electrical Engineering, Chongqing University, China","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063157424","display_name":"Quan Zhou","orcid":"https://orcid.org/0000-0001-5441-6472"},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Quan Zhou","raw_affiliation_strings":["Key Laboratory of Power Transmission Equipment Technology, School of Electrical Engineering, Chongqing University, China"],"raw_orcid":"https://orcid.org/0000-0001-5441-6472","affiliations":[{"raw_affiliation_string":"Key Laboratory of Power Transmission Equipment Technology, School of Electrical Engineering, Chongqing University, China","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102923717","display_name":"Huawen Liu","orcid":"https://orcid.org/0000-0003-0535-4652"},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I50180762","display_name":"Chongqing Three Gorges University","ror":"https://ror.org/05rs3pv16","country_code":"CN","type":"education","lineage":["https://openalex.org/I50180762"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huawen Liu","raw_affiliation_strings":["Department of Oncology, Chongqing University Three Gorges Hospital, Chongqing University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Chongqing University Three Gorges Hospital, Chongqing University, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I50180762"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060589907","display_name":"Shoulong Dong","orcid":"https://orcid.org/0000-0001-6104-0282"},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shoulong Dong","raw_affiliation_strings":["Key Laboratory of Power Transmission Equipment Technology, School of Electrical Engineering, Chongqing University, Chongqing, China"],"raw_orcid":"https://orcid.org/0000-0001-6104-0282","affiliations":[{"raw_affiliation_string":"Key Laboratory of Power Transmission Equipment Technology, School of Electrical Engineering, Chongqing University, Chongqing, China","institution_ids":["https://openalex.org/I158842170"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7387,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.82775023,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"71","issue":"12","first_page":"3505","last_page":"3514"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12495","display_name":"Electrostatic Discharge in Electronics","score":0.9387999773025513,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11920","display_name":"Pulsed Power Technology Applications","score":0.9386000037193298,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electroporation","display_name":"Electroporation","score":0.8916071057319641},{"id":"https://openalex.org/keywords/irreversible-electroporation","display_name":"Irreversible electroporation","score":0.8294254541397095},{"id":"https://openalex.org/keywords/ablation","display_name":"Ablation","score":0.7716240882873535},{"id":"https://openalex.org/keywords/electrochemotherapy","display_name":"Electrochemotherapy","score":0.6718945503234863},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.6259243488311768},{"id":"https://openalex.org/keywords/tumor-ablation","display_name":"Tumor ablation","score":0.5907222628593445},{"id":"https://openalex.org/keywords/contraction","display_name":"Contraction (grammar)","score":0.529170036315918},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.4869557321071625},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.44381535053253174},{"id":"https://openalex.org/keywords/myocyte","display_name":"Myocyte","score":0.41520261764526367},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.35251301527023315},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.31183725595474243},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.24284228682518005},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2037559151649475},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18710485100746155}],"concepts":[{"id":"https://openalex.org/C186852380","wikidata":"https://www.wikidata.org/wiki/Q1142521","display_name":"Electroporation","level":3,"score":0.8916071057319641},{"id":"https://openalex.org/C2778716261","wikidata":"https://www.wikidata.org/wiki/Q17164846","display_name":"Irreversible electroporation","level":4,"score":0.8294254541397095},{"id":"https://openalex.org/C2778902805","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Ablation","level":2,"score":0.7716240882873535},{"id":"https://openalex.org/C2777108052","wikidata":"https://www.wikidata.org/wiki/Q3137263","display_name":"Electrochemotherapy","level":4,"score":0.6718945503234863},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6259243488311768},{"id":"https://openalex.org/C3020187634","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Tumor ablation","level":3,"score":0.5907222628593445},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.529170036315918},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4869557321071625},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.44381535053253174},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.41520261764526367},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35251301527023315},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31183725595474243},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24284228682518005},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2037559151649475},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18710485100746155},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D018274","descriptor_name":"Electroporation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018274","descriptor_name":"Electroporation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018274","descriptor_name":"Electroporation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018274","descriptor_name":"Electroporation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055011","descriptor_name":"Ablation Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055011","descriptor_name":"Ablation Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055011","descriptor_name":"Ablation Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055011","descriptor_name":"Ablation Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbme.2024.3431013","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2024.3431013","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:39028604","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39028604","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.5099999904632568}],"awards":[{"id":"https://openalex.org/G3889991094","display_name":null,"funder_award_id":"52307254","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G449648370","display_name":null,"funder_award_id":"52477229","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6811740004","display_name":null,"funder_award_id":"52237010","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8118357470","display_name":null,"funder_award_id":"2023CDJKYJH075","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G843776469","display_name":null,"funder_award_id":"2023CDJYGRH-ZD04","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1974088560","https://openalex.org/W1992729124","https://openalex.org/W2004620568","https://openalex.org/W2005288489","https://openalex.org/W2006191628","https://openalex.org/W2034791850","https://openalex.org/W2046449631","https://openalex.org/W2057710955","https://openalex.org/W2061356186","https://openalex.org/W2071224732","https://openalex.org/W2073836324","https://openalex.org/W2082781273","https://openalex.org/W2089819212","https://openalex.org/W2092845519","https://openalex.org/W2101863964","https://openalex.org/W2104393847","https://openalex.org/W2112143708","https://openalex.org/W2114367134","https://openalex.org/W2122586603","https://openalex.org/W2143059818","https://openalex.org/W2146996882","https://openalex.org/W2147314036","https://openalex.org/W2149131370","https://openalex.org/W2157421269","https://openalex.org/W2162635508","https://openalex.org/W2167880104","https://openalex.org/W2253232794","https://openalex.org/W2495119399","https://openalex.org/W2612163387","https://openalex.org/W2748568654","https://openalex.org/W2767091006","https://openalex.org/W2768431787","https://openalex.org/W2777454039","https://openalex.org/W2791149574","https://openalex.org/W2794610319","https://openalex.org/W2884289885","https://openalex.org/W2886817841","https://openalex.org/W2917550741","https://openalex.org/W2932745877","https://openalex.org/W2944561076","https://openalex.org/W2945437838","https://openalex.org/W2956361595","https://openalex.org/W2994323246","https://openalex.org/W2998101305","https://openalex.org/W3000284312","https://openalex.org/W3032761271","https://openalex.org/W3084229688","https://openalex.org/W3163087250","https://openalex.org/W3167620363","https://openalex.org/W3207676521","https://openalex.org/W3210736016","https://openalex.org/W4254021855","https://openalex.org/W4283829326","https://openalex.org/W4291377599","https://openalex.org/W4362603459","https://openalex.org/W4390357338"],"related_works":["https://openalex.org/W2124057266","https://openalex.org/W99661837","https://openalex.org/W2004469159","https://openalex.org/W2416685495","https://openalex.org/W2996517533","https://openalex.org/W197636502","https://openalex.org/W2253335250","https://openalex.org/W2110949835","https://openalex.org/W3217623804","https://openalex.org/W4254021855"],"abstract_inverted_index":{"Irreversible":[0,42],"electroporation":[1,174],"(IRE)":[2],"has":[3],"emerged":[4],"as":[5],"a":[6,36,256,266,280],"promising":[7,283],"modality":[8],"for":[9,292],"tumor":[10,48,132,153,263,286],"ablation,":[11,264],"leveraging":[12],"the":[13,24,29,51,60,136,160,167,176,183,240,260],"controlled":[14],"application":[15,62],"of":[16,55,63,162,169,242,253,262],"electrical":[17,66,98],"pulses":[18,67,99],"to":[19,82,88,114,120,129,158,179,235,244,285],"induce":[20],"cell":[21,180],"death.":[22],"However,":[23],"associated":[25,269],"muscle":[26,56,140,229,271],"contractions":[27],"during":[28,273],"procedure":[30],"pose":[31],"challenges.":[32],"This":[33,275],"study":[34],"introduces":[35],"novel":[37],"approach,":[38],"termed":[39],"Synergistic":[40],"Bipolar":[41],"Electroporation":[43],"(SBIRE),":[44],"aimed":[45],"at":[46],"achieving":[47],"ablation":[49,184],"without":[50],"undesirable":[52],"side":[53,295],"effect":[54,185],"contraction.":[57],"SBIRE":[58,170,243,254],"involves":[59],"simultaneous":[61],"nanosecond":[64],"bipolar":[65,97],"(\u00b11600":[68],"V":[69,75,101,107],"per":[70,76,102,108],"0.2":[71,103],"cm":[72,104],"or":[73,105],"\u00b18000":[74],"1":[77,85,109],"cm,":[78,110],"\u00b1500":[79],"ns,":[80],"\u201c+\u201d":[81,89,113,121],"\u201c\u2212\u201d":[83,87,115,119],"delay":[84,90,116,122],"\u00b5s,":[86,92,112,118,124],"200":[91],"5":[93],"cycles)":[94],"and":[95,148,155,182,248,282],"microsecond":[96],"(\u00b1300":[100],"\u00b11500":[106],"\u00b12":[111],"2":[117],"1000":[123],"25":[125],"cycles),":[126],"strategically":[127],"designed":[128],"synergistically":[130],"target":[131],"cells":[133,154],"while":[134],"minimizing":[135,293],"impact":[137],"on":[138],"adjacent":[139],"tissue.":[141],"The":[142,251],"experimental":[143],"setup":[144],"includes":[145],"in":[146,149,171,259],"vitro":[147],"vivo":[150],"studies":[151],"utilizing":[152],"animal":[156],"models":[157],"assess":[159],"efficacy":[161],"SBIRE.":[163],"Preliminary":[164],"results":[165],"demonstrate":[166],"effectiveness":[168],"inducing":[172],"irreversible":[173],"within":[175],"tumor,":[177],"leading":[178],"death,":[181],"is":[186,231],"better":[187],"than":[188],"other":[189],"parameter":[190],"forms":[191],"(24.41":[192],"\u00b1":[193,202,210,218],"0.23":[194,211],"mm<sup":[195,204,212,220],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[196,205,213,221,226],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</sup>":[197,206,214,222],"(SBIRE":[198],"group)":[199],"vs":[200],"12.93":[201],"0.31":[203],"(ns":[207],"group),":[208,216,224],"6.55":[209],"(\u00b5s":[215],"19.54":[217],"0.25":[219],"(ns+\u00b5s":[223],"<italic":[225],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">p</i><0.0001).":[227],"Notably,":[228],"contraction":[230,272],"significantly":[232],"reduced":[233],"compared":[234],"traditional":[236],"IRE":[237],"procedures,":[238],"highlighting":[239],"potential":[241],"enhance":[245],"patient":[246],"comfort":[247],"procedural":[249,294],"success.":[250],"development":[252],"represents":[255],"significant":[257],"advancement":[258],"field":[261],"addressing":[265],"fundamental":[267],"limitation":[268],"with":[270],"IRE.":[274],"technique":[276],"not":[277],"only":[278],"offers":[279],"valuable":[281],"approach":[284],"treatment":[287],"but":[288],"also":[289],"holds":[290],"promise":[291],"effects.":[296]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1}],"updated_date":"2026-07-26T07:53:14.480251","created_date":"2025-10-10T00:00:00"}