{"id":"https://openalex.org/W4390187536","doi":"https://doi.org/10.1109/tbme.2023.3340718","title":"Integrated Time Nanosecond Pulse Irreversible Electroporation (INSPIRE): Assessment of Dose, Temperature, and Voltage on Experimental and Clinical Treatment Outcomes","display_name":"Integrated Time Nanosecond Pulse Irreversible Electroporation (INSPIRE): Assessment of Dose, Temperature, and Voltage on Experimental and Clinical Treatment Outcomes","publication_year":2023,"publication_date":"2023-12-25","ids":{"openalex":"https://openalex.org/W4390187536","doi":"https://doi.org/10.1109/tbme.2023.3340718","pmid":"https://pubmed.ncbi.nlm.nih.gov/38145519"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2023.3340718","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2023.3340718","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11035095/pdf/nihms-1979183.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049471038","display_name":"Christopher C. Fesmire","orcid":"https://orcid.org/0000-0003-2179-9790"},"institutions":[{"id":"https://openalex.org/I4210131205","display_name":"UNC/NCSU Joint Department of Biomedical Engineering","ror":"https://ror.org/03hakdk41","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177","https://openalex.org/I137902535","https://openalex.org/I4210131205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher C. Fesmire","raw_affiliation_strings":["UNC/NCSU Joint Department of Biomedical Engineering, USA"],"raw_orcid":"https://orcid.org/0000-0003-2179-9790","affiliations":[{"raw_affiliation_string":"UNC/NCSU Joint Department of Biomedical Engineering, USA","institution_ids":["https://openalex.org/I4210131205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057746727","display_name":"R. Williamson","orcid":"https://orcid.org/0000-0001-8087-4397"},"institutions":[{"id":"https://openalex.org/I4210131205","display_name":"UNC/NCSU Joint Department of Biomedical Engineering","ror":"https://ror.org/03hakdk41","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177","https://openalex.org/I137902535","https://openalex.org/I4210131205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert H. Williamson","raw_affiliation_strings":["UNC/NCSU Joint Department of Biomedical Engineering, USA"],"raw_orcid":"https://orcid.org/0000-0001-8087-4397","affiliations":[{"raw_affiliation_string":"UNC/NCSU Joint Department of Biomedical Engineering, USA","institution_ids":["https://openalex.org/I4210131205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051545944","display_name":"Ross A. Petrella","orcid":"https://orcid.org/0000-0003-2760-0084"},"institutions":[{"id":"https://openalex.org/I4210131205","display_name":"UNC/NCSU Joint Department of Biomedical Engineering","ror":"https://ror.org/03hakdk41","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177","https://openalex.org/I137902535","https://openalex.org/I4210131205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ross A. Petrella","raw_affiliation_strings":["UNC/NCSU Joint Department of Biomedical Engineering, USA"],"raw_orcid":"https://orcid.org/0000-0003-2760-0084","affiliations":[{"raw_affiliation_string":"UNC/NCSU Joint Department of Biomedical Engineering, USA","institution_ids":["https://openalex.org/I4210131205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051882128","display_name":"Jacob D. Kaufman","orcid":null},"institutions":[{"id":"https://openalex.org/I4210131205","display_name":"UNC/NCSU Joint Department of Biomedical Engineering","ror":"https://ror.org/03hakdk41","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177","https://openalex.org/I137902535","https://openalex.org/I4210131205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob D. Kaufman","raw_affiliation_strings":["UNC/NCSU Joint Department of Biomedical Engineering, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC/NCSU Joint Department of Biomedical Engineering, USA","institution_ids":["https://openalex.org/I4210131205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026233577","display_name":"Nomi Topasna","orcid":null},"institutions":[{"id":"https://openalex.org/I4210131205","display_name":"UNC/NCSU Joint Department of Biomedical Engineering","ror":"https://ror.org/03hakdk41","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177","https://openalex.org/I137902535","https://openalex.org/I4210131205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nomi Topasna","raw_affiliation_strings":["UNC/NCSU Joint Department of Biomedical Engineering, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC/NCSU Joint Department of Biomedical Engineering, USA","institution_ids":["https://openalex.org/I4210131205"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049265718","display_name":"Michael B. Sano","orcid":"https://orcid.org/0000-0003-3823-5932"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I4210131205","display_name":"UNC/NCSU Joint Department of Biomedical Engineering","ror":"https://ror.org/03hakdk41","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177","https://openalex.org/I137902535","https://openalex.org/I4210131205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael B. Sano","raw_affiliation_strings":["UNC/NCSU Joint Department of Biomedical Engineering, Raleigh, NC, USA","Department of Molecular and Biomedical Sciences, North Carolina State University, Raleigh, NC, USA"],"raw_orcid":"https://orcid.org/0000-0003-3823-5932","affiliations":[{"raw_affiliation_string":"UNC/NCSU Joint Department of Biomedical Engineering, Raleigh, NC, USA","institution_ids":["https://openalex.org/I4210131205"]},{"raw_affiliation_string":"Department of Molecular and Biomedical Sciences, North Carolina State University, Raleigh, NC, USA","institution_ids":["https://openalex.org/I137902535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0848,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.86769779,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"71","issue":"5","first_page":"1511","last_page":"1520"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11920","display_name":"Pulsed Power Technology Applications","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10642","display_name":"Plasma Applications and Diagnostics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanosecond","display_name":"Nanosecond","score":0.6419963836669922},{"id":"https://openalex.org/keywords/voltage","display_name":"Voltage","score":0.5393955111503601},{"id":"https://openalex.org/keywords/pulse","display_name":"Pulse (music)","score":0.5374529957771301},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5049646496772766},{"id":"https://openalex.org/keywords/electroporation","display_name":"Electroporation","score":0.4561324715614319},{"id":"https://openalex.org/keywords/temperature-measurement","display_name":"Temperature measurement","score":0.42175042629241943},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.36324048042297363},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.31366586685180664},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.30378061532974243},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.2136683464050293},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.19431492686271667},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.17068463563919067},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.14810577034950256},{"id":"https://openalex.org/keywords/laser","display_name":"Laser","score":0.11795079708099365}],"concepts":[{"id":"https://openalex.org/C51141536","wikidata":"https://www.wikidata.org/wiki/Q838801","display_name":"Nanosecond","level":3,"score":0.6419963836669922},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.5393955111503601},{"id":"https://openalex.org/C2780167933","wikidata":"https://www.wikidata.org/wiki/Q1550652","display_name":"Pulse (music)","level":3,"score":0.5374529957771301},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5049646496772766},{"id":"https://openalex.org/C186852380","wikidata":"https://www.wikidata.org/wiki/Q1142521","display_name":"Electroporation","level":3,"score":0.4561324715614319},{"id":"https://openalex.org/C72293138","wikidata":"https://www.wikidata.org/wiki/Q909741","display_name":"Temperature measurement","level":2,"score":0.42175042629241943},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.36324048042297363},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.31366586685180664},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30378061532974243},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2136683464050293},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.19431492686271667},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.17068463563919067},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.14810577034950256},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.11795079708099365},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004560","descriptor_name":"Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018274","descriptor_name":"Electroporation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018274","descriptor_name":"Electroporation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018274","descriptor_name":"Electroporation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018274","descriptor_name":"Electroporation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018274","descriptor_name":"Electroporation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018274","descriptor_name":"Electroporation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018274","descriptor_name":"Electroporation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018274","descriptor_name":"Electroporation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018274","descriptor_name":"Electroporation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053672","descriptor_name":"Electrochemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053672","descriptor_name":"Electrochemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053672","descriptor_name":"Electrochemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053672","descriptor_name":"Electrochemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053672","descriptor_name":"Electrochemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053672","descriptor_name":"Electrochemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053672","descriptor_name":"Electrochemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053672","descriptor_name":"Electrochemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/tbme.2023.3340718","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2023.3340718","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:38145519","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38145519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11035095","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11035095","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11035095/pdf/nihms-1979183.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Biomed Eng","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11035095","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11035095","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11035095/pdf/nihms-1979183.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Biomed Eng","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G251595499","display_name":null,"funder_award_id":"R01 CA276232","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3815288","display_name":null,"funder_award_id":"R01CA272550","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7044531603","display_name":null,"funder_award_id":"2021-TRG-6708","funder_id":"https://openalex.org/F4320308571","funder_display_name":"North Carolina Biotechnology Center"}],"funders":[{"id":"https://openalex.org/F4320308571","display_name":"North Carolina Biotechnology Center","ror":"https://ror.org/03hj4jr80"},{"id":"https://openalex.org/F4320310013","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390187536.pdf","grobid_xml":"https://content.openalex.org/works/W4390187536.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W39164354","https://openalex.org/W1968762869","https://openalex.org/W1971970281","https://openalex.org/W1972891483","https://openalex.org/W2004620568","https://openalex.org/W2011835180","https://openalex.org/W2016406973","https://openalex.org/W2019410912","https://openalex.org/W2044542264","https://openalex.org/W2044632997","https://openalex.org/W2046449631","https://openalex.org/W2066685150","https://openalex.org/W2071224732","https://openalex.org/W2076101335","https://openalex.org/W2078695541","https://openalex.org/W2080280001","https://openalex.org/W2084319978","https://openalex.org/W2089985908","https://openalex.org/W2093294263","https://openalex.org/W2094688975","https://openalex.org/W2114144028","https://openalex.org/W2122041824","https://openalex.org/W2127480875","https://openalex.org/W2132773568","https://openalex.org/W2144706342","https://openalex.org/W2146526868","https://openalex.org/W2149458424","https://openalex.org/W2160591916","https://openalex.org/W2172501680","https://openalex.org/W2175210372","https://openalex.org/W2196065821","https://openalex.org/W2197139568","https://openalex.org/W2272316879","https://openalex.org/W2489099863","https://openalex.org/W2529080716","https://openalex.org/W2574492937","https://openalex.org/W2586708534","https://openalex.org/W2592956618","https://openalex.org/W2758096856","https://openalex.org/W2789361628","https://openalex.org/W2795983134","https://openalex.org/W2841301758","https://openalex.org/W2901352282","https://openalex.org/W2972964074","https://openalex.org/W2989614000","https://openalex.org/W2998101305","https://openalex.org/W3021011356","https://openalex.org/W3022838598","https://openalex.org/W3024046297","https://openalex.org/W3024480124","https://openalex.org/W3024532598","https://openalex.org/W3025044847","https://openalex.org/W3034929865","https://openalex.org/W3166511756","https://openalex.org/W4210342432","https://openalex.org/W4254021855","https://openalex.org/W6738111629"],"related_works":["https://openalex.org/W1979717110","https://openalex.org/W4207000166","https://openalex.org/W3145994936","https://openalex.org/W2019248278","https://openalex.org/W2554612520","https://openalex.org/W2415180729","https://openalex.org/W2085582759","https://openalex.org/W4231714208","https://openalex.org/W2918092747","https://openalex.org/W2912617263"],"abstract_inverted_index":{"OBJECTIVE:":[0],"This":[1,233],"study":[2,234],"sought":[3],"to":[4,20,72,79,84,95,144,172,183],"investigate":[5],"a":[6],"novel":[7],"strategy":[8],"using":[9,42,56],"temperature-controlled":[10,197],"delivery":[11,198],"of":[12,196],"nanosecond":[13,157],"pulsed":[14],"electric":[15,61],"fields":[16],"as":[17],"an":[18],"alternative":[19],"the":[21,90,151,210,244],"50-100":[22],"microsecond":[23],"pulses":[24,116,178,220],"used":[25,71,155],"for":[26,76,92,110,212],"irreversible":[27,217],"electroporation.":[28,174,218],"METHODS:":[29],"INSPIRE":[30,77,245],"treatments":[31,78,87,94,114],"were":[32,54,64,108],"carried":[33],"out":[34],"at":[35,123],"two":[36],"temperatures":[37],"in":[38,128,131,134,250],"3D":[39],"tumor":[40],"models":[41],"doses":[43,189],"between":[44,103,117],"0.001":[45],"s":[46,113],"and":[47,59,88,105,120,153,209,247],"0.1":[48],"s.":[49],"The":[50,194],"resulting":[51],"treatment":[52,82,141,170,231],"zones":[53,83,142],"quantified":[55],"viability":[57],"staining":[58],"lethal":[60,135],"field":[62],"intensities":[63],"determined":[65],"numerically.":[66],"Computational":[67],"modeling":[68],"was":[69],"then":[70],"determine":[73],"parameters":[74],"necessary":[75],"achieve":[80,180],"equivalent":[81,169],"clinical":[85,145,173],"electroporation":[86,146,185],"evaluate":[89],"potential":[91],"these":[93,138,223],"induce":[96],"deleterious":[97],"thermal":[98,164,201],"damage.":[99],"RESULTS:":[100],"Lethal":[101],"thresholds":[102],"1109":[104],"709":[106],"V/cm":[107],"found":[109],"nominal":[111],"0.01":[112],"with":[115,156,243],"350":[118],"ns":[119,122],"2000":[121],"physiological":[124],"temperatures.":[125],"Further":[126],"increases":[127],"dose":[129,152],"resulted":[130],"significant":[132],"decreases":[133],"thresholds.":[136],"Given":[137],"experimental":[139],"results,":[140],"comparable":[143,181],"are":[147,192,253],"possible":[148,242],"by":[149],"increasing":[150],"voltage":[154],"duration":[158],"pulses.":[159],"Temperature-controlled":[160],"simulations":[161],"indicate":[162],"minimal":[163],"cell":[165],"death":[166],"while":[167],"achieving":[168],"volumes":[171,239],"CONCLUSION:":[175],"Nanosecond":[176,219],"electrical":[177,188],"can":[179,221],"outcomes":[182],"traditional":[184],"provided":[186],"sufficient":[187],"or":[190],"voltages":[191],"applied.":[193],"use":[195],"may":[199,240],"minimize":[200],"damage":[202],"during":[203],"treatment.":[204],"SIGNIFICANCE:":[205],"Intense":[206],"muscle":[207],"stimulation":[208],"need":[211],"cardiac":[213],"gating":[214],"have":[215,227],"limited":[216],"alleviate":[222],"challenges,":[224],"but":[225],"traditionally":[226],"produced":[228],"significantly":[229],"smaller":[230],"zones.":[232],"suggests":[235],"that":[236,248],"larger":[237],"ablation":[238],"be":[241],"approach":[246],"future":[249],"vivo":[251],"studies":[252],"warranted.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}