{"id":"https://openalex.org/W4307342170","doi":"https://doi.org/10.1109/tbme.2022.3217264","title":"Immunohistochemical Index Prediction of Breast Cancer by Using Hybrid Ultrasound Data","display_name":"Immunohistochemical Index Prediction of Breast Cancer by Using Hybrid Ultrasound Data","publication_year":2022,"publication_date":"2022-11-03","ids":{"openalex":"https://openalex.org/W4307342170","doi":"https://doi.org/10.1109/tbme.2022.3217264","pmid":"https://pubmed.ncbi.nlm.nih.gov/36288237"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2022.3217264","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2022.3217264","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033847087","display_name":"Fang Chen","orcid":"https://orcid.org/0000-0003-1926-3807"},"institutions":[{"id":"https://openalex.org/I9842412","display_name":"Nanjing University of Aeronautics and Astronautics","ror":"https://ror.org/01scyh794","country_code":"CN","type":"education","lineage":["https://openalex.org/I9842412"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Chen","raw_affiliation_strings":["Department of Computer Science and Engineering, Nanjing University of Aeronautics and Astronautics, MIIT Key Laboratory of Pattern Analysis and Machine Intelligence, Nanjing, China"],"raw_orcid":"https://orcid.org/0000-0003-1926-3807","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Nanjing University of Aeronautics and Astronautics, MIIT Key Laboratory of Pattern Analysis and Machine Intelligence, Nanjing, China","institution_ids":["https://openalex.org/I9842412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104102586","display_name":"Haojie Han","orcid":null},"institutions":[{"id":"https://openalex.org/I9842412","display_name":"Nanjing University of Aeronautics and Astronautics","ror":"https://ror.org/01scyh794","country_code":"CN","type":"education","lineage":["https://openalex.org/I9842412"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haojie Han","raw_affiliation_strings":["Department of Computer Science and Engineering, Nanjing University of Aeronautics and Astronautics, MIIT Key Laboratory of Pattern Analysis and Machine Intelligence, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Nanjing University of Aeronautics and Astronautics, MIIT Key Laboratory of Pattern Analysis and Machine Intelligence, China","institution_ids":["https://openalex.org/I9842412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031766048","display_name":"Guochen Ning","orcid":"https://orcid.org/0000-0003-0282-7303"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guochen Ning","raw_affiliation_strings":["Department of Biomedical Engineering, Tsinghua University, China"],"raw_orcid":"https://orcid.org/0000-0003-0282-7303","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Tsinghua University, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007565811","display_name":"Baojie Wen","orcid":"https://orcid.org/0000-0001-5692-7057"},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baojie Wen","raw_affiliation_strings":["Department of Ultrasound, Affiliated Drum Tower Hospital, Medical School of Nanjing University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ultrasound, Affiliated Drum Tower Hospital, Medical School of Nanjing University, China","institution_ids":["https://openalex.org/I4210111013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018740222","display_name":"Hongen Liao","orcid":"https://orcid.org/0000-0003-3847-9347"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongen Liao","raw_affiliation_strings":["Department of Biomedical Engineering, Tsinghua University, China"],"raw_orcid":"https://orcid.org/0000-0003-3847-9347","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Tsinghua University, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029934760","display_name":"Wentao Kong","orcid":"https://orcid.org/0000-0002-4313-6958"},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wentao Kong","raw_affiliation_strings":["Department of Ultrasound, Affiliated Drum Tower Hospital, Medical School of Nanjing University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ultrasound, Affiliated Drum Tower Hospital, Medical School of Nanjing University, China","institution_ids":["https://openalex.org/I4210111013"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018821033","display_name":"Daoqiang Zhang","orcid":"https://orcid.org/0000-0002-5658-7643"},"institutions":[{"id":"https://openalex.org/I9842412","display_name":"Nanjing University of Aeronautics and Astronautics","ror":"https://ror.org/01scyh794","country_code":"CN","type":"education","lineage":["https://openalex.org/I9842412"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Daoqiang Zhang","raw_affiliation_strings":["Department of Computer Science and Engineering, Nanjing University of Aeronautics and Astronautics, MIIT Key Laboratory of Pattern Analysis and Machine Intelligence, China"],"raw_orcid":"https://orcid.org/0000-0002-5658-7643","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Nanjing University of Aeronautics and Astronautics, MIIT Key Laboratory of Pattern Analysis and Machine Intelligence, China","institution_ids":["https://openalex.org/I9842412"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6971,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.74572691,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"70","issue":"4","first_page":"1401","last_page":"1412"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10727","display_name":"Ultrasound Imaging and Elastography","score":0.9837999939918518,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.606010377407074},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5775421261787415},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5473641157150269},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"Immunohistochemistry","score":0.5457755923271179},{"id":"https://openalex.org/keywords/ultrasound","display_name":"Ultrasound","score":0.5440264940261841},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.43400561809539795},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.39271867275238037},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.2898384928703308},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.2277231514453888},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2038639783859253},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.16959327459335327},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.13309577107429504}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.606010377407074},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5775421261787415},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5473641157150269},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5457755923271179},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.5440264940261841},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.43400561809539795},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.39271867275238037},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2898384928703308},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2277231514453888},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2038639783859253},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.16959327459335327},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13309577107429504}],"mesh":[{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbme.2022.3217264","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2022.3217264","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:36288237","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36288237","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.800000011920929,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1205941549","display_name":null,"funder_award_id":"2020Z024","funder_id":"https://openalex.org/F4320335471","funder_display_name":"Jiangsu Planned Projects for Postdoctoral Research Funds"},{"id":"https://openalex.org/G1917912769","display_name":null,"funder_award_id":"U20A20389","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2959468657","display_name":null,"funder_award_id":"2020M671484","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G4051618105","display_name":null,"funder_award_id":"62271246","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6176476365","display_name":null,"funder_award_id":"61901214","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8805908310","display_name":null,"funder_award_id":"2021T140322","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320335471","display_name":"Jiangsu Planned Projects for Postdoctoral Research Funds","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1905055296","https://openalex.org/W1964071243","https://openalex.org/W1973421681","https://openalex.org/W1984421643","https://openalex.org/W1988407776","https://openalex.org/W2002459284","https://openalex.org/W2010664411","https://openalex.org/W2014328722","https://openalex.org/W2036752075","https://openalex.org/W2049420719","https://openalex.org/W2077377510","https://openalex.org/W2087274016","https://openalex.org/W2096281534","https://openalex.org/W2124714703","https://openalex.org/W2132434084","https://openalex.org/W2132441369","https://openalex.org/W2155140373","https://openalex.org/W2155674415","https://openalex.org/W2156147303","https://openalex.org/W2260481171","https://openalex.org/W2279374661","https://openalex.org/W2310297397","https://openalex.org/W2324411677","https://openalex.org/W2328176404","https://openalex.org/W2537468337","https://openalex.org/W2560406314","https://openalex.org/W2756381840","https://openalex.org/W2791292838","https://openalex.org/W2796167672","https://openalex.org/W2887563333","https://openalex.org/W2897900737","https://openalex.org/W2898418754","https://openalex.org/W2912993657","https://openalex.org/W2915626801","https://openalex.org/W2921407870","https://openalex.org/W2963155035","https://openalex.org/W2963820951","https://openalex.org/W2972594929","https://openalex.org/W2981385151","https://openalex.org/W3023894752","https://openalex.org/W3035148740","https://openalex.org/W3109343597","https://openalex.org/W3142516134","https://openalex.org/W3153830729","https://openalex.org/W3185864722","https://openalex.org/W3217215249","https://openalex.org/W4283709076"],"related_works":["https://openalex.org/W2999877485","https://openalex.org/W2355920994","https://openalex.org/W2399421402","https://openalex.org/W2376996112","https://openalex.org/W4375867731","https://openalex.org/W2773349476","https://openalex.org/W2782824587","https://openalex.org/W2101676003","https://openalex.org/W4200568016","https://openalex.org/W2034169702"],"abstract_inverted_index":{"The":[0,113,128],"immunohistochemical":[1,57,110],"index":[2],"is":[3,51],"significant":[4],"to":[5,32,88,106],"help":[6],"the":[7,56,60,68,75,80,84,90,133,147],"selection":[8],"of":[9,27,55,65,93,109,140],"treatment":[10],"strategy":[11],"for":[12,53,142,151],"breast":[13,125],"cancer":[14,126],"patients.":[15,127],"Existing":[16],"studies":[17,38],"that":[18,132],"focus":[19],"on":[20,67],"conventional":[21],"ultrasound":[22,62,121],"features":[23],"and":[24,35,70,83,101,146],"certain":[25],"types":[26],"immunohistochemistry":[28],"expressions":[29],"are":[30],"limited":[31],"correlation":[33],"exploration,":[34],"only":[36],"few":[37],"have":[39],"built":[40,52],"predictive":[41],"models.":[42],"In":[43],"this":[44],"study,":[45],"a":[46,137],"Tri-Branch":[47,134],"deep":[48,76],"learning":[49,77,86],"network":[50],"prediction":[54,115,150],"HER2":[58,111,143,148],"using":[59,119],"hybrid":[61,94,120],"data,":[63],"instead":[64],"relying":[66],"invasive":[69],"biopsy-based":[71],"histopathological":[72],"examination.":[73],"Specifically,":[74],"model":[78,116,135],"uses":[79],"cross-model":[81],"attention":[82],"interactive":[85],"approaches":[87],"obtain":[89],"strong":[91],"complementarity":[92],"data":[95],"comprising":[96],"B-mode":[97],"US,":[98],"contrast-enhanced":[99],"ultrasound,":[100],"optical":[102],"flow":[103],"motion":[104],"information":[105],"enhance":[107],"accuracy":[108,139],"prediction.":[112],"proposed":[114],"was":[117],"evaluated":[118],"dataset":[122],"from":[123],"335":[124],"experimental":[129],"results":[130],"indicated":[131],"had":[136],"high":[138],"86.23%":[141],"status":[144,149],"prediction,":[145],"patients":[152],"with":[153],"different":[154],"pathology":[155],"grades":[156],"exhibited":[157],"some":[158],"meaningful":[159],"clinical":[160],"observations.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}
