{"id":"https://openalex.org/W4306909624","doi":"https://doi.org/10.1109/tbme.2022.3216231","title":"Quantifying the Morphology and Mechanisms of Cancer Progression in 3D In-Vitro Environments: Integrating Experiments and Multiscale Models","display_name":"Quantifying the Morphology and Mechanisms of Cancer Progression in 3D In-Vitro Environments: Integrating Experiments and Multiscale Models","publication_year":2022,"publication_date":"2022-11-03","ids":{"openalex":"https://openalex.org/W4306909624","doi":"https://doi.org/10.1109/tbme.2022.3216231","pmid":"https://pubmed.ncbi.nlm.nih.gov/36264745"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2022.3216231","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2022.3216231","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034205194","display_name":"Nikolaos M. Dimitriou","orcid":"https://orcid.org/0000-0001-5002-202X"},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nikolaos M. Dimitriou","raw_affiliation_strings":["Department of Bioengineering, McGill University, Montreal, QC, Canada"],"raw_orcid":"https://orcid.org/0000-0001-5002-202X","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001945902","display_name":"Salvador Flores-Torres","orcid":"https://orcid.org/0000-0002-2947-9786"},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Salvador Flores-Torres","raw_affiliation_strings":["Department of Bioengineering, McGill University, Canada"],"raw_orcid":"https://orcid.org/0000-0002-2947-9786","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, McGill University, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009309705","display_name":"Joseph M. Kinsella","orcid":"https://orcid.org/0000-0002-3052-0782"},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Joseph Matthew Kinsella","raw_affiliation_strings":["Department of Bioengineering, McGill University, Canada"],"raw_orcid":"https://orcid.org/0000-0002-3052-0782","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, McGill University, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062820435","display_name":"Georgios D. Mitsis","orcid":"https://orcid.org/0000-0001-9975-5128"},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Georgios D. Mitsis","raw_affiliation_strings":["Department of Bioengineering, McGill University, Canada"],"raw_orcid":"https://orcid.org/0000-0001-9975-5128","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, McGill University, Canada","institution_ids":["https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I5023651"],"apc_list":null,"apc_paid":null,"fwci":1.0826,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.73928523,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"70","issue":"4","first_page":"1318","last_page":"1329"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9902999997138977,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.6078575253486633},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5525467991828918},{"id":"https://openalex.org/keywords/matrigel","display_name":"Matrigel","score":0.5304678678512573},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.49680855870246887},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.4302843511104584},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.31030404567718506},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"Angiogenesis","score":0.11740759015083313},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.11598357558250427}],"concepts":[{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.6078575253486633},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5525467991828918},{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.5304678678512573},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49680855870246887},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4302843511104584},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31030404567718506},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.11740759015083313},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.11598357558250427},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbme.2022.3216231","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2022.3216231","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:36264745","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36264745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2510329497","display_name":null,"funder_award_id":"34362","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"}],"funders":[{"id":"https://openalex.org/F4320331257","display_name":"Alliance de recherche num\u00e9rique du Canada","ror":"https://ror.org/010r6td27"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W79392631","https://openalex.org/W200447247","https://openalex.org/W1131320503","https://openalex.org/W1224802987","https://openalex.org/W1818937361","https://openalex.org/W1877687928","https://openalex.org/W1975817152","https://openalex.org/W1985320029","https://openalex.org/W2006067863","https://openalex.org/W2009913017","https://openalex.org/W2012376126","https://openalex.org/W2018439279","https://openalex.org/W2018669757","https://openalex.org/W2020168202","https://openalex.org/W2028249595","https://openalex.org/W2032413258","https://openalex.org/W2036959910","https://openalex.org/W2044066240","https://openalex.org/W2045484383","https://openalex.org/W2049161806","https://openalex.org/W2061245907","https://openalex.org/W2071122929","https://openalex.org/W2071867803","https://openalex.org/W2082447375","https://openalex.org/W2087752560","https://openalex.org/W2101191265","https://openalex.org/W2105667333","https://openalex.org/W2112548197","https://openalex.org/W2120038224","https://openalex.org/W2127225632","https://openalex.org/W2145876651","https://openalex.org/W2153464267","https://openalex.org/W2165754185","https://openalex.org/W2193448558","https://openalex.org/W2285581648","https://openalex.org/W2299806323","https://openalex.org/W2510729796","https://openalex.org/W2569818561","https://openalex.org/W2582743722","https://openalex.org/W2595599881","https://openalex.org/W2603809684","https://openalex.org/W2692620042","https://openalex.org/W2744396587","https://openalex.org/W2771775464","https://openalex.org/W2831738876","https://openalex.org/W2898582484","https://openalex.org/W2919520822","https://openalex.org/W2949880289","https://openalex.org/W2950278368","https://openalex.org/W2963398318","https://openalex.org/W2987901253","https://openalex.org/W3007653373","https://openalex.org/W3010371906","https://openalex.org/W3024379478","https://openalex.org/W3081134611","https://openalex.org/W3081288452","https://openalex.org/W3104298728","https://openalex.org/W3108628588","https://openalex.org/W3164314236","https://openalex.org/W3217680342","https://openalex.org/W4200603279","https://openalex.org/W4234794606","https://openalex.org/W4241971838","https://openalex.org/W4288052227","https://openalex.org/W6733261796"],"related_works":["https://openalex.org/W2082860237","https://openalex.org/W1990804418","https://openalex.org/W2130076355","https://openalex.org/W1993764875","https://openalex.org/W1641042124","https://openalex.org/W2013243191","https://openalex.org/W2972872313","https://openalex.org/W2750777328","https://openalex.org/W2418239294","https://openalex.org/W2805185066"],"abstract_inverted_index":{"Mathematical":[0],"models":[1,74],"of":[2,21,31,50,58,71,75,106,109,123,139,144,159,187,202,205,218],"cancer":[3,59,76,140,206,227],"growth":[4,77,207,228],"have":[5],"become":[6],"increasingly":[7],"more":[8],"accurate":[9],"both":[10],"in":[11,27,61,116,208],"the":[12,18,38,48,51,55,69,89,104,107,121,156,160,183,199,203,216],"space":[13],"and":[14,54,84,119,146,163,214,229],"time":[15,185],"domains.":[16],"However,":[17],"limited":[19],"amount":[20],"data":[22],"typically":[23],"available":[24],"has":[25],"resulted":[26],"a":[28,127,176],"larger":[29],"number":[30],"qualitative":[32],"rather":[33],"than":[34],"quantitative":[35,200],"studies.":[36],"In":[37],"present":[39],"study,":[40],"we":[41],"provide":[42],"an":[43],"integrated":[44],"experimental-computational":[45],"framework":[46,66,102,191],"for":[47,68],"quantification":[49],"morphological":[52,92],"characteristics":[53,158],"mechanistic":[56],"modelling":[57],"progression":[60],"3D":[62,80,209],"environments.":[63],"The":[64,132,149,189],"proposed":[65,150],"allows":[67],"calibration":[70],"multiscale,":[72,128],"spatiotemporal":[73],"using":[78,94,126,211],"state-of-the-art":[79],"cell":[81],"culture":[82],"data,":[83],"their":[85],"validation":[86],"based":[87],"on":[88],"resulting":[90],"experimental":[91,161],"patterns":[93],"spatial":[95,137],"point-pattern":[96,212],"analysis":[97],"techniques.":[98],"We":[99],"applied":[100],"this":[101],"to":[103,154,174,180,194],"study":[105],"development":[108],"Triple":[110],"Negative":[111],"Breast":[112],"Cancer":[113],"cells":[114,141],"cultured":[115],"Matrigel":[117],"scaffolds,":[118],"validated":[120],"hypothesis":[122],"chemotactic":[124,166],"migration":[125,167],"hybrid":[129],"Keller-Segel":[130],"model.":[131],"results":[133],"revealed":[134],"transient,":[135],"non-random":[136],"distributions":[138],"that":[142,165,225],"consist":[143],"clustered,":[145],"dispersion":[147],"patterns.":[148],"model":[151],"was":[152,172],"able":[153],"describe":[155],"general":[157],"observations":[162],"suggests":[164],"together":[168],"with":[169,221],"random":[170],"motion":[171],"found":[173],"be":[175],"plausible":[177],"mechanism":[178],"leading":[179],"accumulation,":[181],"during":[182],"examined":[184],"period":[186],"development.":[188],"developed":[190],"enabled":[192],"us":[193],"pursue":[195],"two":[196],"goals;":[197],"first,":[198],"description":[201],"morphology":[204,220],"cultures":[210],"analysis,":[213],"second,":[215],"relation":[217],"tumour":[219],"underlying":[222],"biophysical":[223],"mechanisms":[224],"govern":[226],"migration.":[230]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
