{"id":"https://openalex.org/W4293105575","doi":"https://doi.org/10.1109/tbme.2022.3201709","title":"Mechanical High-Intensity Focused Ultrasound (Histotripsy) in Dogs With Spontaneously Occurring Soft Tissue Sarcomas","display_name":"Mechanical High-Intensity Focused Ultrasound (Histotripsy) in Dogs With Spontaneously Occurring Soft Tissue Sarcomas","publication_year":2022,"publication_date":"2022-08-25","ids":{"openalex":"https://openalex.org/W4293105575","doi":"https://doi.org/10.1109/tbme.2022.3201709","pmid":"https://pubmed.ncbi.nlm.nih.gov/36006886"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2022.3201709","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tbme.2022.3201709","pdf_url":"https://ieeexplore.ieee.org/ielx7/10/10048704/09866853.pdf","source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ieeexplore.ieee.org/ielx7/10/10048704/09866853.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088412261","display_name":"Lauren Ruger","orcid":null},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lauren Ruger","raw_affiliation_strings":["Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, USA"],"raw_orcid":"https://orcid.org/0000-0002-7291-4907","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076353019","display_name":"Ester Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I39822340","display_name":"Virginia\u2013Maryland College of Veterinary Medicine","ror":"https://ror.org/010prmy50","country_code":"US","type":"education","lineage":["https://openalex.org/I39822340","https://openalex.org/I66946132","https://openalex.org/I859038795"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ester Yang","raw_affiliation_strings":["Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, USA","Virginia Tech Animal Cancer Care and Research Center, Virginia-Maryland Regional College of Veterinary Medicine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, USA","institution_ids":["https://openalex.org/I39822340"]},{"raw_affiliation_string":"Virginia Tech Animal Cancer Care and Research Center, Virginia-Maryland Regional College of Veterinary Medicine, USA","institution_ids":["https://openalex.org/I39822340","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072876624","display_name":"Jessica M. Gannon","orcid":"https://orcid.org/0000-0003-0762-4054"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Gannon","raw_affiliation_strings":["Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006552417","display_name":"Hannah Sheppard","orcid":"https://orcid.org/0000-0001-9319-7807"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Sheppard","raw_affiliation_strings":["Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, USA"],"raw_orcid":"https://orcid.org/0000-0001-9319-7807","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067570838","display_name":"Sheryl Coutermarsh\u2010Ott","orcid":"https://orcid.org/0000-0001-7385-3969"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheryl Coutermarsh-Ott","raw_affiliation_strings":["Department of Biological Sciences and Pathobiology, Virginia Polytechnic Institute and State University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences and Pathobiology, Virginia Polytechnic Institute and State University, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019396835","display_name":"Timothy J. Ziemlewicz","orcid":"https://orcid.org/0000-0002-7033-1062"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy J. Ziemlewicz","raw_affiliation_strings":["Department of Radiology, University of Wisconsin-Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Wisconsin-Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058723984","display_name":"Nikolaos Dervisis","orcid":"https://orcid.org/0000-0003-2869-1483"},"institutions":[{"id":"https://openalex.org/I39822340","display_name":"Virginia\u2013Maryland College of Veterinary Medicine","ror":"https://ror.org/010prmy50","country_code":"US","type":"education","lineage":["https://openalex.org/I39822340","https://openalex.org/I66946132","https://openalex.org/I859038795"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikolaos Dervisis","raw_affiliation_strings":["Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, USA","Virginia Tech Animal Cancer Care and Research Center, Virginia-Maryland Regional College of Veterinary Medicine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, USA","institution_ids":["https://openalex.org/I39822340"]},{"raw_affiliation_string":"Virginia Tech Animal Cancer Care and Research Center, Virginia-Maryland Regional College of Veterinary Medicine, USA","institution_ids":["https://openalex.org/I39822340","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008179003","display_name":"Irving C. Allen","orcid":"https://orcid.org/0000-0001-9573-5250"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irving C. Allen","raw_affiliation_strings":["Department of Biological Sciences and Pathobiology, Virginia Polytechnic Institute and State University, USA"],"raw_orcid":"https://orcid.org/0000-0001-9573-5250","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences and Pathobiology, Virginia Polytechnic Institute and State University, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052076804","display_name":"Gregory B. Daniel","orcid":"https://orcid.org/0000-0002-7313-7425"},"institutions":[{"id":"https://openalex.org/I39822340","display_name":"Virginia\u2013Maryland College of Veterinary Medicine","ror":"https://ror.org/010prmy50","country_code":"US","type":"education","lineage":["https://openalex.org/I39822340","https://openalex.org/I66946132","https://openalex.org/I859038795"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory B. Daniel","raw_affiliation_strings":["Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, USA","Virginia Tech Animal Cancer Care and Research Center, Virginia-Maryland Regional College of Veterinary Medicine, USA"],"raw_orcid":"https://orcid.org/0000-0002-7313-7425","affiliations":[{"raw_affiliation_string":"Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, USA","institution_ids":["https://openalex.org/I39822340"]},{"raw_affiliation_string":"Virginia Tech Animal Cancer Care and Research Center, Virginia-Maryland Regional College of Veterinary Medicine, USA","institution_ids":["https://openalex.org/I39822340","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047064091","display_name":"Joanne Tuohy","orcid":"https://orcid.org/0000-0003-1516-3841"},"institutions":[{"id":"https://openalex.org/I39822340","display_name":"Virginia\u2013Maryland College of Veterinary Medicine","ror":"https://ror.org/010prmy50","country_code":"US","type":"education","lineage":["https://openalex.org/I39822340","https://openalex.org/I66946132","https://openalex.org/I859038795"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanne Tuohy","raw_affiliation_strings":["Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, USA","Virginia Tech Animal Cancer Care and Research Center, Virginia-Maryland Regional College of Veterinary Medicine, USA"],"raw_orcid":"https://orcid.org/0000-0003-1516-3841","affiliations":[{"raw_affiliation_string":"Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, USA","institution_ids":["https://openalex.org/I39822340"]},{"raw_affiliation_string":"Virginia Tech Animal Cancer Care and Research Center, Virginia-Maryland Regional College of Veterinary Medicine, USA","institution_ids":["https://openalex.org/I39822340","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071475167","display_name":"Eli Vlaisavljevich","orcid":null},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eli Vlaisavljevich","raw_affiliation_strings":["Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA"],"raw_orcid":"https://orcid.org/0000-0002-4097-6257","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085281601","display_name":"Shawna Klahn","orcid":"https://orcid.org/0000-0002-7001-7698"},"institutions":[{"id":"https://openalex.org/I39822340","display_name":"Virginia\u2013Maryland College of Veterinary Medicine","ror":"https://ror.org/010prmy50","country_code":"US","type":"education","lineage":["https://openalex.org/I39822340","https://openalex.org/I66946132","https://openalex.org/I859038795"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shawna Klahn","raw_affiliation_strings":["Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, VA, USA","Virginia Tech Animal Cancer Care and Research Center, Virginia-Maryland Regional College of Veterinary Medicine, Roanoke, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, VA, USA","institution_ids":["https://openalex.org/I39822340"]},{"raw_affiliation_string":"Virginia Tech Animal Cancer Care and Research Center, Virginia-Maryland Regional College of Veterinary Medicine, Roanoke, VA, USA","institution_ids":["https://openalex.org/I39822340","https://openalex.org/I859038795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5088412261"],"corresponding_institution_ids":["https://openalex.org/I859038795"],"apc_list":null,"apc_paid":null,"fwci":1.9617,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.85460202,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"70","issue":"3","first_page":"768","last_page":"779"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.957099974155426,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.957099974155426,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-intensity-focused-ultrasound","display_name":"High-intensity focused ultrasound","score":0.511006236076355},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.4505288898944855},{"id":"https://openalex.org/keywords/ablation","display_name":"Ablation","score":0.42645758390426636},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.39716482162475586},{"id":"https://openalex.org/keywords/ultrasound","display_name":"Ultrasound","score":0.3863161504268646},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.3567832112312317},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.2664821743965149},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25224408507347107},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.19215518236160278}],"concepts":[{"id":"https://openalex.org/C2777365067","wikidata":"https://www.wikidata.org/wiki/Q564897","display_name":"High-intensity focused ultrasound","level":3,"score":0.511006236076355},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4505288898944855},{"id":"https://openalex.org/C2778902805","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Ablation","level":2,"score":0.42645758390426636},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39716482162475586},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.3863161504268646},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3567832112312317},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2664821743965149},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25224408507347107},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19215518236160278},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D057086","descriptor_name":"High-Intensity Focused Ultrasound Ablation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057086","descriptor_name":"High-Intensity Focused Ultrasound Ablation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057086","descriptor_name":"High-Intensity Focused Ultrasound Ablation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057086","descriptor_name":"High-Intensity Focused Ultrasound Ablation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057086","descriptor_name":"High-Intensity Focused Ultrasound Ablation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057086","descriptor_name":"High-Intensity Focused Ultrasound Ablation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057086","descriptor_name":"High-Intensity Focused Ultrasound Ablation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057086","descriptor_name":"High-Intensity Focused Ultrasound Ablation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1109/tbme.2022.3201709","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tbme.2022.3201709","pdf_url":"https://ieeexplore.ieee.org/ielx7/10/10048704/09866853.pdf","source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:36006886","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36006886","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9969335","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9969335","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9969335/pdf/nihms-1867754.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Biomed Eng","raw_type":"Text"},{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/114018","is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/114018","pdf_url":null,"source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1109/tbme.2022.3201709","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tbme.2022.3201709","pdf_url":"https://ieeexplore.ieee.org/ielx7/10/10048704/09866853.pdf","source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"awards":[{"id":"https://openalex.org/G1556479175","display_name":null,"funder_award_id":"453047","funder_id":"https://openalex.org/F4320309171","funder_display_name":"Focused Ultrasound Foundation"},{"id":"https://openalex.org/G2227493124","display_name":null,"funder_award_id":"P30 CA138313","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G3281754969","display_name":null,"funder_award_id":"P30 CA138313","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G464710589","display_name":null,"funder_award_id":"KL2TR003016","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G4796340452","display_name":null,"funder_award_id":"CA138313","funder_id":"https://openalex.org/F4320310846","funder_display_name":"University of South Carolina"},{"id":"https://openalex.org/G630495520","display_name":null,"funder_award_id":"CA138313","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6650788924","display_name":null,"funder_award_id":"UL1TR003015 and KL2TR003016","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G7312491463","display_name":null,"funder_award_id":"UL1TR003015","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G788917307","display_name":null,"funder_award_id":"KL2TR003016","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8045097710","display_name":null,"funder_award_id":"UL1TR003015","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G8068576878","display_name":null,"funder_award_id":"P30 CA138313","funder_id":"https://openalex.org/F4320332464","funder_display_name":"Hollings Cancer Center, Medical University of South Carolina"}],"funders":[{"id":"https://openalex.org/F4320309171","display_name":"Focused Ultrasound Foundation","ror":"https://ror.org/04qjbd269"},{"id":"https://openalex.org/F4320310846","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332464","display_name":"Hollings Cancer Center, Medical University of South Carolina","ror":"https://ror.org/00w52vt71"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4293105575.pdf","grobid_xml":"https://content.openalex.org/works/W4293105575.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1978310805","https://openalex.org/W1978432461","https://openalex.org/W1980595856","https://openalex.org/W1981243220","https://openalex.org/W1988557615","https://openalex.org/W2028549018","https://openalex.org/W2040883398","https://openalex.org/W2084289098","https://openalex.org/W2110971583","https://openalex.org/W2112916982","https://openalex.org/W2114677264","https://openalex.org/W2116455804","https://openalex.org/W2117713428","https://openalex.org/W2118213324","https://openalex.org/W2119791583","https://openalex.org/W2130658267","https://openalex.org/W2135428178","https://openalex.org/W2150014101","https://openalex.org/W2192256483","https://openalex.org/W2219119728","https://openalex.org/W2344956073","https://openalex.org/W2403290182","https://openalex.org/W2468159549","https://openalex.org/W2510683324","https://openalex.org/W2564088374","https://openalex.org/W2604367361","https://openalex.org/W2735195563","https://openalex.org/W2755890746","https://openalex.org/W2785644051","https://openalex.org/W2896761137","https://openalex.org/W2897030523","https://openalex.org/W2899409577","https://openalex.org/W2923673138","https://openalex.org/W2953107858","https://openalex.org/W2953596834","https://openalex.org/W2960078024","https://openalex.org/W2962683357","https://openalex.org/W2970080540","https://openalex.org/W2999799781","https://openalex.org/W3015411213","https://openalex.org/W3016907174","https://openalex.org/W3026469396","https://openalex.org/W3087543026","https://openalex.org/W3119005160","https://openalex.org/W3148375137","https://openalex.org/W3156807347","https://openalex.org/W3157891137","https://openalex.org/W3166538318","https://openalex.org/W3169480290","https://openalex.org/W3183953302","https://openalex.org/W3184050496","https://openalex.org/W3195937928","https://openalex.org/W3198217899","https://openalex.org/W3205535993","https://openalex.org/W3214805747","https://openalex.org/W4220653572","https://openalex.org/W4220988338","https://openalex.org/W4285732030","https://openalex.org/W6903695515"],"related_works":["https://openalex.org/W2333115645","https://openalex.org/W2157355069","https://openalex.org/W4253921921","https://openalex.org/W2681997681","https://openalex.org/W2069460318","https://openalex.org/W4309918982","https://openalex.org/W2000584922","https://openalex.org/W2541892696","https://openalex.org/W2093309763","https://openalex.org/W2357177413"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Histotripsy":[1],"is":[2],"a":[3,193],"non-invasive":[4,195],"focused":[5],"ultrasound":[6],"therapy":[7],"that":[8],"uses":[9],"controlled":[10],"acoustic":[11],"cavitation":[12],"to":[13,37,49,77,86],"mechanically":[14],"disintegrate":[15],"tissue.":[16],"To":[17],"date,":[18],"there":[19],"are":[20],"no":[21],"reports":[22],"investigating":[23],"histotripsy":[24,47,55,73,162,175],"for":[25,197],"the":[26,39,51,58,180],"treatment":[27,103,196],"of":[28,43,53],"soft":[29],"tissue":[30],"sarcoma":[31],"(STS).":[32],"OBJECTIVE:":[33],"This":[34],"study":[35,188],"aimed":[36],"investigate":[38],"in":[40,62,130,142,168,179],"vivo":[41],"feasibility":[42],"ablating":[44],"STS":[45],"with":[46,65,81,144],"and":[48,104,111,119,133,148,155,166],"characterize":[50],"impact":[52,124],"partial":[54],"ablation":[56,163],"on":[57],"acute":[59],"immunologic":[60],"response":[61],"canine":[63],"patients":[64],"spontaneous":[66],"STS.":[67,84,198],"METHODS:":[68],"A":[69],"custom":[70],"500":[71],"kHz":[72],"system":[74],"was":[75,96,115,125,164],"used":[76],"treat":[78],"ten":[79,170],"dogs":[80],"naturally":[82],"occurring":[83],"Four":[85],"six":[87],"days":[88],"after":[89],"histotripsy,":[90],"tumors":[91],"were":[92,137],"surgically":[93],"resected.":[94],"Safety":[95],"determined":[97],"by":[98,127,139],"monitoring":[99],"vital":[100],"signs":[101],"during":[102],"post-treatment":[105],"physical":[106],"examinations,":[107],"routine":[108],"lab":[109],"work,":[110],"owners'":[112],"reports.":[113],"Ablation":[114],"characterized":[116],"using":[117,152],"radiologic":[118],"histopathologic":[120],"analyses.":[121],"Systemic":[122],"immunological":[123],"evaluated":[126,138],"measuring":[128],"changes":[129,136,141,178],"cytokine":[131],"concentrations,":[132],"tumor":[134,181],"microenvironment":[135],"characterizing":[140],"infiltration":[143],"tumor-associated":[145],"macrophages":[146],"(TAMs)":[147],"tumor-infiltrating":[149],"lymphocytes":[150],"(TILs)":[151],"multiplex":[153],"immunohistochemistry":[154],"differential":[156],"gene":[157],"expression.":[158],"RESULTS:":[159],"Results":[160],"showed":[161,174],"achievable":[165],"well-tolerated":[167],"all":[169],"dogs.":[171],"Immunological":[172],"results":[173],"induced":[176],"pro-inflammatory":[177],"microenvironment.":[182],"Conclusion":[183],"&":[184],"Significance:":[185],"Overall,":[186],"this":[187],"demonstrates":[189],"histotripsy's":[190],"potential":[191],"as":[192],"precise,":[194]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":11}],"updated_date":"2026-05-07T13:39:58.223016","created_date":"2025-10-10T00:00:00"}
