{"id":"https://openalex.org/W4224246909","doi":"https://doi.org/10.1109/tbme.2022.3168402","title":"Towards Patient-Specific Optimization of Neoadjuvant Treatment Protocols for Breast Cancer Based on Image-Guided Fluid Dynamics","display_name":"Towards Patient-Specific Optimization of Neoadjuvant Treatment Protocols for Breast Cancer Based on Image-Guided Fluid Dynamics","publication_year":2022,"publication_date":"2022-04-19","ids":{"openalex":"https://openalex.org/W4224246909","doi":"https://doi.org/10.1109/tbme.2022.3168402","pmid":"https://pubmed.ncbi.nlm.nih.gov/35439121"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2022.3168402","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2022.3168402","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9640301","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Chengyue Wu","orcid":"https://orcid.org/0000-0002-3789-404X"},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chengyue Wu","raw_affiliation_strings":["Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, TX, USA"],"raw_orcid":"https://orcid.org/0000-0002-3789-404X","affiliations":[{"raw_affiliation_string":"Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, TX, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David A. Hormuth","orcid":"https://orcid.org/0000-0002-9643-1694"},"institutions":[{"id":"https://openalex.org/I1305023659","display_name":"Livestrong Foundation","ror":"https://ror.org/04ndvz759","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305023659"]},{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Hormuth","raw_affiliation_strings":["Oden Institute for Computational Engineering and Sciences, and Livestrong Cancer Institutes, The University of Texas at Austin, USA"],"raw_orcid":"https://orcid.org/0000-0002-9643-1694","affiliations":[{"raw_affiliation_string":"Oden Institute for Computational Engineering and Sciences, and Livestrong Cancer Institutes, The University of Texas at Austin, USA","institution_ids":["https://openalex.org/I1305023659","https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Guillermo Lorenzo","orcid":"https://orcid.org/0000-0001-9090-190X"},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guillermo Lorenzo","raw_affiliation_strings":["Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, USA"],"raw_orcid":"https://orcid.org/0000-0001-9090-190X","affiliations":[{"raw_affiliation_string":"Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Angela M. Jarrett","orcid":null},"institutions":[{"id":"https://openalex.org/I1305023659","display_name":"Livestrong Foundation","ror":"https://ror.org/04ndvz759","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305023659"]},{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela M. Jarrett","raw_affiliation_strings":["Oden Institute for Computational Engineering and Sciences, and Livestrong Cancer Institutes, The University of Texas at Austin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oden Institute for Computational Engineering and Sciences, and Livestrong Cancer Institutes, The University of Texas at Austin, USA","institution_ids":["https://openalex.org/I1305023659","https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Federico Pineda","orcid":null},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Federico Pineda","raw_affiliation_strings":["Department of Radiology, The University of Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The University of Chicago, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Frederick M. Howard","orcid":null},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick M. Howard","raw_affiliation_strings":["Section of Hematology&#x002F;Oncology-Department of Medicine, The University of Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hematology&#x002F;Oncology-Department of Medicine, The University of Chicago, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gregory S. Karczmar","orcid":null},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory S. Karczmar","raw_affiliation_strings":["Department of Radiology, The University of Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The University of Chicago, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":null,"display_name":"Thomas E. Yankeelov","orcid":"https://orcid.org/0000-0001-6201-3913"},"institutions":[{"id":"https://openalex.org/I1305023659","display_name":"Livestrong Foundation","ror":"https://ror.org/04ndvz759","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305023659"]},{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas E. Yankeelov","raw_affiliation_strings":["Department of Biomedical Engineering, Department of Diagnostic Medicine, Department of Oncology, Oden Institute for Computational Engineering and Sciences, and Livestrong Cancer Institutes, The University of Texas at Austin, USA"],"raw_orcid":"https://orcid.org/0000-0001-6201-3913","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Department of Diagnostic Medicine, Department of Oncology, Oden Institute for Computational Engineering and Sciences, and Livestrong Cancer Institutes, The University of Texas at Austin, USA","institution_ids":["https://openalex.org/I1305023659","https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3033,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.92979102,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"69","issue":"11","first_page":"3334","last_page":"3344"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.1858000010251999,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.1858000010251999,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.10429999977350235,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.09529999643564224,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.7405999898910522},{"id":"https://openalex.org/keywords/neoadjuvant-therapy","display_name":"Neoadjuvant therapy","score":0.5752000212669373},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.4106000065803528},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.2858000099658966},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.2842000126838684}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7405999898910522},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6324999928474426},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.5752000212669373},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4571000039577484},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4106000065803528},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3073999881744385},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2858000099658966},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2856000065803528},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.2842000126838684},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.26089999079704285}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057446","descriptor_name":"Hydrodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057446","descriptor_name":"Hydrodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057446","descriptor_name":"Hydrodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057446","descriptor_name":"Hydrodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/tbme.2022.3168402","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2022.3168402","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:35439121","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35439121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9640301","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9640301","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Biomed Eng","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9640301","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9640301","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Biomed Eng","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1061422990","display_name":null,"funder_award_id":"U01 CA253540","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2373080777","display_name":null,"funder_award_id":"R01 CA218700","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3051959199","display_name":null,"funder_award_id":"P30CA014599","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4055805275","display_name":null,"funder_award_id":"R01 CA228036","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4267969883","display_name":null,"funder_award_id":"U01 CA174706","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4429254488","display_name":null,"funder_award_id":"R01 CA172801","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4678155734","display_name":null,"funder_award_id":"U01 CA142565","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5274261483","display_name":null,"funder_award_id":"R01CA172801","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5575932833","display_name":null,"funder_award_id":"U01CA142565","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5603744340","display_name":null,"funder_award_id":"P30 CA014599","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5941128670","display_name":"Recruitment of Established Investigators","funder_award_id":"RR160005","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G5977230749","display_name":null,"funder_award_id":"U24 CA226110","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6425450718","display_name":null,"funder_award_id":"U01CA174706","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6976185267","display_name":null,"funder_award_id":"R01CA218700","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7016240052","display_name":null,"funder_award_id":"U01CA253540","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7290378863","display_name":null,"funder_award_id":"No. 838786","funder_id":"https://openalex.org/F4320338337","funder_display_name":"H2020 Marie Sk\u0142odowska-Curie Actions"},{"id":"https://openalex.org/G8531030779","display_name":null,"funder_award_id":"U24CA226110","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320338337","display_name":"H2020 Marie Sk\u0142odowska-Curie Actions","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W109056630","https://openalex.org/W1492360552","https://openalex.org/W1842248410","https://openalex.org/W1978831940","https://openalex.org/W1979482187","https://openalex.org/W1983763758","https://openalex.org/W2006816753","https://openalex.org/W2020893327","https://openalex.org/W2023125141","https://openalex.org/W2068072750","https://openalex.org/W2073216552","https://openalex.org/W2101760255","https://openalex.org/W2108082333","https://openalex.org/W2111578514","https://openalex.org/W2114397636","https://openalex.org/W2116780500","https://openalex.org/W2118605519","https://openalex.org/W2123591186","https://openalex.org/W2125562614","https://openalex.org/W2127276782","https://openalex.org/W2132060393","https://openalex.org/W2134539328","https://openalex.org/W2136802843","https://openalex.org/W2148847151","https://openalex.org/W2283816551","https://openalex.org/W2337000942","https://openalex.org/W2338021849","https://openalex.org/W2340000092","https://openalex.org/W2754374743","https://openalex.org/W2768458828","https://openalex.org/W2786689981","https://openalex.org/W2890692562","https://openalex.org/W2898583962","https://openalex.org/W2903044532","https://openalex.org/W2912070541","https://openalex.org/W2913286462","https://openalex.org/W2985137783","https://openalex.org/W3004461112","https://openalex.org/W3005915104","https://openalex.org/W3006134372","https://openalex.org/W3008925325","https://openalex.org/W3015654211","https://openalex.org/W3031939267","https://openalex.org/W3102789433","https://openalex.org/W3108628588","https://openalex.org/W3127010631","https://openalex.org/W3167698219","https://openalex.org/W6604475230","https://openalex.org/W6840507498","https://openalex.org/W6903797826"],"related_works":[],"abstract_inverted_index":{"OBJECTIVE:":[0],"This":[1],"study":[2],"establishes":[3],"a":[4,102,112,117,199,216],"fluid":[5,176],"dynamics":[6,177],"model":[7,70],"personalized":[8],"with":[9],"patient-specific":[10,51,200,217],"imaging":[11,45],"data":[12,46],"to":[13,49,58,137,158,178,209],"optimize":[14],"neoadjuvant":[15,185,229],"therapy":[16,186,230],"(i.e.,":[17],"doxorubicin)":[18],"protocols":[19,231],"for":[20,90,222,232],"breast":[21,233],"cancers.":[22,234],"METHODS:":[23],"Ten":[24],"patients":[25],"recruited":[26],"at":[27,227],"the":[28,60,72,77,82,94,132,140,147,180,190,207],"University":[29],"of":[30,68,116,153,184,193,212],"Chicago":[31],"were":[32],"included":[33],"in":[34],"this":[35,69],"study.":[36],"Quantitative":[37],"dynamic":[38],"contrast-enhanced":[39],"and":[40,107,174,182,219],"diffusion":[41],"weighted":[42],"magnetic":[43],"resonance":[44],"are":[47,55],"leveraged":[48],"estimate":[50],"hemodynamic":[52],"properties,":[53],"which":[54,100],"then":[56],"used":[57],"constrain":[59],"mechanism-based":[61],"drug":[62,74],"delivery":[63],"model.":[64],"Then,":[65],"computer":[66],"simulations":[67],"yield":[71],"subsequent":[73],"distribution":[75],"throughout":[76],"breast.":[78],"By":[79],"systematically":[80],"varying":[81],"dosing":[83],"schedule,":[84],"we":[85],"identify":[86],"an":[87,150,194],"optimized":[88],"regimen":[89,114,197],"each":[91],"patient":[92],"using":[93],"maximum":[95],"safe":[96],"therapeutic":[97,196,213],"duration":[98],"(MSTD),":[99],"is":[101,135],"metric":[103],"balancing":[104],"treatment":[105],"efficacy":[106,181],"toxicity.":[108],"RESULTS:":[109],"per":[110],"injection),":[111],"3-week":[113],"consisting":[115],"uniform":[118],"daily":[119],"injection":[120],"significantly":[121,138],"outperforms":[122],"all":[123],"other":[124],"scheduling":[125],"strategies":[126],"(P":[127,143],"<":[128,144],"0.001).":[129],"In":[130],"particular,":[131],"optimal":[133,195],"protocol":[134,142],"predicted":[136],"outperform":[139],"standard":[141],"0.001),":[145],"improving":[146],"MSTD":[148],"by":[149,166],"average":[151],"factor":[152],"9.93":[154],"(range":[155],"=":[156],"6.63":[157],"14.17).":[159],"CONCLUSION:":[160],"A":[161],"clinical-mathematical":[162],"framework":[163],"was":[164],"developed":[165],"integrating":[167],"quantitative":[168],"MRI":[169],"data,":[170],"advanced":[171],"image":[172],"processing,":[173],"computational":[175],"predict":[179],"toxicity":[183],"protocols,":[187],"thus":[188],"enabling":[189],"rational":[191],"identification":[192],"on":[198,215],"basis.":[201],"SIGNIFICANCE:":[202],"Our":[203],"clinical-computational":[204],"approach":[205],"has":[206],"potential":[208],"enable":[210],"optimization":[211],"regimens":[214],"basis":[218],"provide":[220],"guidance":[221],"prospective":[223],"clinical":[224],"trials":[225],"aimed":[226],"refining":[228]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2022-04-26T00:00:00"}
