{"id":"https://openalex.org/W3187902288","doi":"https://doi.org/10.1109/tbme.2021.3102416","title":"A Numerical Model of the Acute Cardiac Effects Provoked by Cervical Vagus Nerve Stimulation","display_name":"A Numerical Model of the Acute Cardiac Effects Provoked by Cervical Vagus Nerve Stimulation","publication_year":2021,"publication_date":"2021-08-06","ids":{"openalex":"https://openalex.org/W3187902288","doi":"https://doi.org/10.1109/tbme.2021.3102416","mag":"3187902288","pmid":"https://pubmed.ncbi.nlm.nih.gov/34357860"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2021.3102416","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2021.3102416","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Max Haberbusch","orcid":"https://orcid.org/0000-0003-0712-4893"},"institutions":[{"id":"https://openalex.org/I4210151154","display_name":"Ludwig Boltzmann Institute for Cancer Research","ror":"https://ror.org/04abv6630","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4210151154"]},{"id":"https://openalex.org/I4403928418","display_name":"Ludwig Boltzmann Institute for Digital Health and Prevention","ror":"https://ror.org/00a2syk23","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4403928418"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Max Haberbusch","raw_affiliation_strings":["Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria","Ludwig Boltzmann Institute for Cardiovascular Research, Vienna, Austria"],"raw_orcid":"https://orcid.org/0000-0003-0712-4893","affiliations":[{"raw_affiliation_string":"Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Ludwig Boltzmann Institute for Cardiovascular Research, Vienna, Austria","institution_ids":["https://openalex.org/I4210151154","https://openalex.org/I4403928418"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Silvia Frullini","orcid":null},"institutions":[{"id":"https://openalex.org/I121760703","display_name":"University of Applied Sciences Technikum Wien","ror":"https://ror.org/04jsx0x49","country_code":"AT","type":"education","lineage":["https://openalex.org/I121760703"]},{"id":"https://openalex.org/I177477856","display_name":"Politecnico di Torino","ror":"https://ror.org/00bgk9508","country_code":"IT","type":"education","lineage":["https://openalex.org/I177477856"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","IT"],"is_corresponding":false,"raw_author_name":"Silvia Frullini","raw_affiliation_strings":["Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria","Department of Life Science Engineering, UAS FH Technikum Wien, Austria","Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Department of Life Science Engineering, UAS FH Technikum Wien, Austria","institution_ids":["https://openalex.org/I121760703"]},{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Italy","institution_ids":["https://openalex.org/I177477856"]}]},{"author_position":"last","author":{"id":null,"display_name":"Francesco Moscato","orcid":"https://orcid.org/0000-0003-0279-6615"},"institutions":[{"id":"https://openalex.org/I4210163309","display_name":"Austrian Cluster for Tissue Regeneration","ror":"https://ror.org/052f3yd19","country_code":"AT","type":"other","lineage":["https://openalex.org/I4210163309"]},{"id":"https://openalex.org/I4403928418","display_name":"Ludwig Boltzmann Institute for Digital Health and Prevention","ror":"https://ror.org/00a2syk23","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4403928418"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Francesco Moscato","raw_affiliation_strings":["Austrian Cluster for Tissue Regeneration, Austria","Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria","Ludwig Boltzmann Institute for Cardiovascular Research, Austria"],"raw_orcid":"https://orcid.org/0000-0003-0279-6615","affiliations":[{"raw_affiliation_string":"Austrian Cluster for Tissue Regeneration, Austria","institution_ids":["https://openalex.org/I4210163309"]},{"raw_affiliation_string":"Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Ludwig Boltzmann Institute for Cardiovascular Research, Austria","institution_ids":["https://openalex.org/I4403928418"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210151154","https://openalex.org/I4403928418","https://openalex.org/I76134821"],"apc_list":null,"apc_paid":null,"fwci":1.2947,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.79454806,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"69","issue":"2","first_page":"613","last_page":"623"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.9934999942779541,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.9934999942779541,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13381","display_name":"Heart rate and cardiovascular health","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vagus-nerve","display_name":"Vagus nerve","score":0.5321000218391418},{"id":"https://openalex.org/keywords/vagus-nerve-stimulation","display_name":"Vagus nerve stimulation","score":0.45509999990463257},{"id":"https://openalex.org/keywords/electrocardiography","display_name":"Electrocardiography","score":0.3919999897480011},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.31839999556541443},{"id":"https://openalex.org/keywords/heart-rate","display_name":"Heart rate","score":0.3102000057697296},{"id":"https://openalex.org/keywords/numerical-models","display_name":"Numerical models","score":0.29109999537467957}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6935999989509583},{"id":"https://openalex.org/C2781404750","wikidata":"https://www.wikidata.org/wiki/Q190140","display_name":"Vagus nerve","level":3,"score":0.5321000218391418},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.49079999327659607},{"id":"https://openalex.org/C2780087125","wikidata":"https://www.wikidata.org/wiki/Q2062293","display_name":"Vagus nerve stimulation","level":4,"score":0.45509999990463257},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.43369999527931213},{"id":"https://openalex.org/C2780040984","wikidata":"https://www.wikidata.org/wiki/Q79785","display_name":"Electrocardiography","level":2,"score":0.3919999897480011},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3197999894618988},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.31839999556541443},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.3102000057697296},{"id":"https://openalex.org/C2986605239","wikidata":"https://www.wikidata.org/wiki/Q925667","display_name":"Numerical models","level":3,"score":0.29109999537467957},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.2856000065803528},{"id":"https://openalex.org/C152478114","wikidata":"https://www.wikidata.org/wiki/Q660910","display_name":"Neurophysiology","level":2,"score":0.28049999475479126},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.26840001344680786},{"id":"https://openalex.org/C79752029","wikidata":"https://www.wikidata.org/wiki/Q808732","display_name":"Baroreceptor","level":4,"score":0.2651999890804291}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009333","descriptor_name":"Neck","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009333","descriptor_name":"Neck","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009333","descriptor_name":"Neck","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009333","descriptor_name":"Neck","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014630","descriptor_name":"Vagus Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014630","descriptor_name":"Vagus Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014630","descriptor_name":"Vagus Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014630","descriptor_name":"Vagus Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055536","descriptor_name":"Vagus Nerve Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055536","descriptor_name":"Vagus Nerve Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055536","descriptor_name":"Vagus Nerve Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055536","descriptor_name":"Vagus Nerve Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbme.2021.3102416","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2021.3102416","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:34357860","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34357860","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W96847431","https://openalex.org/W999207820","https://openalex.org/W1483704015","https://openalex.org/W1526545443","https://openalex.org/W1599037430","https://openalex.org/W1599810882","https://openalex.org/W1965019913","https://openalex.org/W1968710842","https://openalex.org/W1971482087","https://openalex.org/W1973492181","https://openalex.org/W2004890004","https://openalex.org/W2007233535","https://openalex.org/W2021060449","https://openalex.org/W2023626397","https://openalex.org/W2049108855","https://openalex.org/W2060718012","https://openalex.org/W2062596174","https://openalex.org/W2063773170","https://openalex.org/W2065292698","https://openalex.org/W2086939968","https://openalex.org/W2096688703","https://openalex.org/W2101397237","https://openalex.org/W2120723181","https://openalex.org/W2123221516","https://openalex.org/W2127729103","https://openalex.org/W2129823797","https://openalex.org/W2133325032","https://openalex.org/W2140259596","https://openalex.org/W2147510452","https://openalex.org/W2163017714","https://openalex.org/W2171565404","https://openalex.org/W2173348671","https://openalex.org/W2179717202","https://openalex.org/W2181006531","https://openalex.org/W2254718226","https://openalex.org/W2280141967","https://openalex.org/W2328693094","https://openalex.org/W2337818477","https://openalex.org/W2343078689","https://openalex.org/W2397167071","https://openalex.org/W2468671092","https://openalex.org/W2481969851","https://openalex.org/W2525609606","https://openalex.org/W2586672809","https://openalex.org/W2590461770","https://openalex.org/W2799381945","https://openalex.org/W2914190779","https://openalex.org/W2945648942","https://openalex.org/W2994718216","https://openalex.org/W3003178367","https://openalex.org/W3007271119","https://openalex.org/W3033887562","https://openalex.org/W3045660812","https://openalex.org/W3087092343","https://openalex.org/W3095110852","https://openalex.org/W3097511959","https://openalex.org/W3128815104"],"related_works":[],"abstract_inverted_index":{"OBJECTIVE:":[0],"Today,":[1],"the":[2,26,34,70,83,102,110,121,132,147,164,168],"diverse":[3],"acute":[4,27,111,169],"cardiac":[5,28,76,112,122,148,170],"effects":[6,113,149],"of":[7,45,74,91,114,134,150,161,163,167],"vagus":[8,142],"nerve":[9,47,56,143],"stimulation":[10],"(VNS)":[11],"are":[12],"still":[13],"not":[14],"fully":[15],"understood.":[16],"Therefore,":[17],"we":[18],"propose":[19],"a":[20,43,59,156],"numerical":[21],"model":[22,44,84,103,118,154],"that":[23],"can":[24,119],"predict":[25,106],"responses":[29,123,171],"to":[30,68,124,138,172],"VNS":[31,125],"and":[32,50,82,141],"explain":[33,120],"underlying":[35,165],"mechanisms":[36,166],"on":[37,88,109,126],"different":[38],"levels.":[39,128],"METHODS:":[40],"We":[41],"integrated":[42],"vagal":[46,55,75],"fiber":[48],"recruitment":[49],"acetylcholine":[51],"(ACh)":[52],"kinetics":[53],"at":[54],"terminals":[57],"into":[58],"cardiovascular":[60],"system":[61],"model.":[62],"A":[63],"sensitivity":[64],"analysis":[65],"was":[66,85],"performed":[67],"identify":[69],"most":[71],"important":[72],"parameters":[73,79,136],"pathways.":[77],"These":[78],"were":[80],"tuned,":[81],"validated":[86],"based":[87],"published":[89,107],"data":[90,108],"experiments":[92],"in":[93,159],"anesthetized":[94],"sheep.":[95],"RESULTS:":[96],",":[97],"respectively.":[98],"With":[99],"this":[100],"parameterization,":[101],"could":[104],"accurately":[105],"VNS.":[115,151,173],"CONCLUSIONS:":[116],"The":[117,129,153],"multiple":[127],"results":[130],"highlight":[131],"importance":[133],"four":[135],"tied":[137],"ACh":[139],"dynamics":[140],"anatomy":[144],"for":[145],"predicting":[146],"SIGNIFICANCE:":[152],"represents":[155],"substantial":[157],"improvement":[158],"terms":[160],"comprehensibility":[162]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4}],"updated_date":"2026-04-28T14:05:53.105641","created_date":"2021-08-16T00:00:00"}