{"id":"https://openalex.org/W3178195615","doi":"https://doi.org/10.1109/tbme.2021.3096126","title":"The Translational and Regulatory Development of an Implantable Microdevice for Multiple Drug Sensitivity Measurements in Cancer Patients","display_name":"The Translational and Regulatory Development of an Implantable Microdevice for Multiple Drug Sensitivity Measurements in Cancer Patients","publication_year":2021,"publication_date":"2021-07-09","ids":{"openalex":"https://openalex.org/W3178195615","doi":"https://doi.org/10.1109/tbme.2021.3096126","mag":"3178195615","pmid":"https://pubmed.ncbi.nlm.nih.gov/34242160"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2021.3096126","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tbme.2021.3096126","pdf_url":"https://ieeexplore.ieee.org/ielx7/10/9662286/09479768.pdf","source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ieeexplore.ieee.org/ielx7/10/9662286/09479768.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027297235","display_name":"Christine Dominas","orcid":"https://orcid.org/0000-0001-6837-7603"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Dominas","raw_affiliation_strings":["Brigham and Women's Hospital in Boston, USA"],"raw_orcid":"https://orcid.org/0000-0001-6837-7603","affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital in Boston, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037958078","display_name":"Sharath K. Bhagavatula","orcid":"https://orcid.org/0000-0002-9194-0932"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharath Bhagavatula","raw_affiliation_strings":["Brigham and Women's Hospital in Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital in Boston, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062818691","display_name":"Elizabeth H. Stover","orcid":"https://orcid.org/0000-0002-6578-3216"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Stover","raw_affiliation_strings":["Brigham and Women's Hospital, USA","Dana-Farber Cancer Institute, USA"],"raw_orcid":"https://orcid.org/0000-0002-6578-3216","affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Dana-Farber Cancer Institute, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071532092","display_name":"Kyle Deans","orcid":null},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle Deans","raw_affiliation_strings":["Brigham and Women's Hospital in Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital in Boston, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062766083","display_name":"Cecilia Larocca","orcid":"https://orcid.org/0000-0002-6756-261X"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cecilia Larocca","raw_affiliation_strings":["Brigham and Women's Hospital, USA","Dana-Farber Cancer Institute, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Dana-Farber Cancer Institute, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034925727","display_name":"Yolonda L. Colson","orcid":"https://orcid.org/0000-0002-8229-5636"},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yolanda Colson","raw_affiliation_strings":["Massachusetts General Hospital, USA"],"raw_orcid":"https://orcid.org/0000-0002-8229-5636","affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012381716","display_name":"Pierpaolo Peruzzi","orcid":"https://orcid.org/0000-0001-5034-2963"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pierpaolo Peruzzi","raw_affiliation_strings":["Brigham and Women's Hospital in Boston, USA"],"raw_orcid":"https://orcid.org/0000-0001-5034-2963","affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital in Boston, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072104844","display_name":"Adam S. Kibel","orcid":"https://orcid.org/0000-0002-9446-7781"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Kibel","raw_affiliation_strings":["Brigham and Women's Hospital in Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital in Boston, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021745606","display_name":"Nobuhiko Hata","orcid":"https://orcid.org/0000-0002-6818-7700"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nobuhiko Hata","raw_affiliation_strings":["Brigham and Women's Hospital in Boston, USA"],"raw_orcid":"https://orcid.org/0000-0002-6818-7700","affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital in Boston, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007708891","display_name":"Lillian L. Tsai","orcid":"https://orcid.org/0000-0001-6890-9622"},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lillian Tsai","raw_affiliation_strings":["Massachusetts General Hospital, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039324896","display_name":"Yin P. Hung","orcid":"https://orcid.org/0000-0002-8568-1591"},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yin Hung","raw_affiliation_strings":["Massachusetts General Hospital, USA"],"raw_orcid":"https://orcid.org/0000-0002-8568-1591","affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006989477","display_name":"R. L. Packard","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Packard","raw_affiliation_strings":["Medical Device Academy, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Device Academy, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014860176","display_name":"Oliver Jonas","orcid":"https://orcid.org/0000-0003-2512-2007"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oliver Jonas","raw_affiliation_strings":["Brigham and Women's Hospital, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0003-2512-2007","affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0756,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.74028417,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"69","issue":"1","first_page":"412","last_page":"421"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.3050999939441681,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.3050999939441681,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.08500000089406967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.05090000107884407,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/workflow","display_name":"Workflow","score":0.7569656372070312},{"id":"https://openalex.org/keywords/translational-research","display_name":"Translational research","score":0.5218038558959961},{"id":"https://openalex.org/keywords/drug-development","display_name":"Drug development","score":0.5073215365409851},{"id":"https://openalex.org/keywords/food-and-drug-administration","display_name":"Food and drug administration","score":0.4720034599304199},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.46156635880470276},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.43307626247406006},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.4292800724506378},{"id":"https://openalex.org/keywords/medical-physics","display_name":"Medical physics","score":0.4167616367340088},{"id":"https://openalex.org/keywords/risk-analysis","display_name":"Risk analysis (engineering)","score":0.4073987901210785},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3784885108470917},{"id":"https://openalex.org/keywords/systems-engineering","display_name":"Systems engineering","score":0.3613335192203522},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.3075442314147949},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.2648882269859314},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.14760279655456543},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.11819517612457275},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.11631205677986145}],"concepts":[{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.7569656372070312},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.5218038558959961},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.5073215365409851},{"id":"https://openalex.org/C3018890749","wikidata":"https://www.wikidata.org/wiki/Q204711","display_name":"Food and drug administration","level":2,"score":0.4720034599304199},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.46156635880470276},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43307626247406006},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.4292800724506378},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.4167616367340088},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.4073987901210785},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3784885108470917},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.3613335192203522},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.3075442314147949},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2648882269859314},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.14760279655456543},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11819517612457275},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11631205677986145},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019736","descriptor_name":"Prostheses and Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019736","descriptor_name":"Prostheses and Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019736","descriptor_name":"Prostheses and Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/tbme.2021.3096126","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tbme.2021.3096126","pdf_url":"https://ieeexplore.ieee.org/ielx7/10/9662286/09479768.pdf","source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:34242160","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34242160","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8702455","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8702455","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Biomed Eng","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1109/tbme.2021.3096126","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tbme.2021.3096126","pdf_url":"https://ieeexplore.ieee.org/ielx7/10/9662286/09479768.pdf","source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1685034977","display_name":null,"funder_award_id":"K08 CA237871","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G323226336","display_name":null,"funder_award_id":"R37 CA224144","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3596975591","display_name":null,"funder_award_id":"K08 NS101091","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3691497352","display_name":null,"funder_award_id":"R01 EB030539","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G5987985532","display_name":null,"funder_award_id":"R01 CA232174","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7600419701","display_name":null,"funder_award_id":"P41 EB015898","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G7847992752","display_name":null,"funder_award_id":"R01 NS116144","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8317013009","display_name":null,"funder_award_id":"P41 EB028741","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G8322025468","display_name":null,"funder_award_id":"R37 CA252312","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8941304640","display_name":null,"funder_award_id":"R21 CA216796","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332705","display_name":"Brigham Research Institute","ror":"https://ror.org/04b6nzv94"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3178195615.pdf","grobid_xml":"https://content.openalex.org/works/W3178195615.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W263380825","https://openalex.org/W1969515439","https://openalex.org/W1984635063","https://openalex.org/W2007212684","https://openalex.org/W2043911652","https://openalex.org/W2051823017","https://openalex.org/W2058754065","https://openalex.org/W2079142824","https://openalex.org/W2083258699","https://openalex.org/W2084594392","https://openalex.org/W2117314282","https://openalex.org/W2150250592","https://openalex.org/W2301389244","https://openalex.org/W2337664131","https://openalex.org/W2339578380","https://openalex.org/W2387045967","https://openalex.org/W2510085761","https://openalex.org/W2564262333","https://openalex.org/W2890434658","https://openalex.org/W2946055389","https://openalex.org/W2972742918","https://openalex.org/W3016368875","https://openalex.org/W3080668573","https://openalex.org/W3084144945","https://openalex.org/W3113016995","https://openalex.org/W3120495485","https://openalex.org/W4255181203"],"related_works":["https://openalex.org/W1981780420","https://openalex.org/W2182707996","https://openalex.org/W45233828","https://openalex.org/W2964988449","https://openalex.org/W188202134","https://openalex.org/W2442880795","https://openalex.org/W2470067656","https://openalex.org/W2188607138","https://openalex.org/W2168871320","https://openalex.org/W2001995688"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1],"purpose":[2],"of":[3,12,61,65,117,128,165],"this":[4],"article":[5],"is":[6],"to":[7,81,96,119,154,167,170],"report":[8],"the":[9,21,57,160,163],"translational":[10],"process":[11],"an":[13,18],"implantable":[14],"microdevice":[15],"platform":[16],"with":[17,84,103],"emphasis":[19],"on":[20,152],"technical":[22],"and":[23,31,44,49,51,59,99,114,126,131,150],"engineering":[24,93],"adaptations":[25,41],"for":[26,42,75,135],"patient":[27,82],"use,":[28],"regulatory":[29,53,108],"advances,":[30],"successful":[32],"integration":[33],"into":[34,159],"clinical":[35,105],"workflow.":[36],"METHODS:":[37],"We":[38],"developed":[39],"design":[40,94],"implantation":[43,98],"retrieval,":[45],"established":[46],"ongoing":[47],"monitoring":[48],"testing,":[50],"facilitated":[52],"advances":[54],"that":[55,101,110],"enabled":[56,111],"administration":[58],"examination":[60],"a":[62,107,123,136,147],"large":[63],"set":[64],"cancer":[66],"therapies":[67],"simultaneously":[68],"in":[69,87,122],"individual":[70],"patients.":[71,172],"RESULTS:":[72],"Six":[73],"applications":[74,86],"oncology":[76],"studies":[77],"have":[78],"successfully":[79],"proceeded":[80],"trials,":[83],"future":[85],"progress.":[88],"CONCLUSION:":[89],"First-in-human":[90],"translation":[91],"required":[92],"changes":[95],"enable":[97],"retrieval":[100],"fit":[102],"existing":[104],"workflows,":[106],"strategy":[109],"both":[112],"delivery":[113],"response":[115],"measurement":[116],"up":[118],"20":[120],"agents":[121],"single":[124],"patient,":[125],"establishment":[127],"novel":[129],"testing":[130],"quality":[132],"control":[133],"processes":[134],"drug/device":[137],"combination":[138],"product":[139],"without":[140],"clear":[141],"precedents.":[142],"SIGNIFICANCE:":[143],"This":[144],"manuscript":[145],"provides":[146],"real-world":[148],"account":[149],"roadmap":[151],"how":[153,166],"advance":[155],"from":[156],"animal":[157],"proof-of-concept":[158],"clinic,":[161],"confronting":[162],"question":[164],"use":[168],"research":[169],"benefit":[171]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}