{"id":"https://openalex.org/W3155379283","doi":"https://doi.org/10.1109/tbme.2021.3074053","title":"The Contribution of Glycosaminoglycans/Proteoglycans to Aortic Mechanics in Health and Disease: A Critical Review","display_name":"The Contribution of Glycosaminoglycans/Proteoglycans to Aortic Mechanics in Health and Disease: A Critical Review","publication_year":2021,"publication_date":"2021-04-19","ids":{"openalex":"https://openalex.org/W3155379283","doi":"https://doi.org/10.1109/tbme.2021.3074053","mag":"3155379283","pmid":"https://pubmed.ncbi.nlm.nih.gov/33872141"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2021.3074053","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2021.3074053","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Noor M. Ghadie","orcid":"https://orcid.org/0000-0003-2616-1737"},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Noor M. Ghadie","raw_affiliation_strings":["Mechanical Engineering Department, University of Ottawa, Canada"],"raw_orcid":"https://orcid.org/0000-0003-2616-1737","affiliations":[{"raw_affiliation_string":"Mechanical Engineering Department, University of Ottawa, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jean-Philippe St-Pierre","orcid":"https://orcid.org/0000-0002-3853-3123"},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jean-Philippe St-Pierre","raw_affiliation_strings":["Chemical and Biological Engineering Department, University of Ottawa, Canada"],"raw_orcid":"https://orcid.org/0000-0002-3853-3123","affiliations":[{"raw_affiliation_string":"Chemical and Biological Engineering Department, University of Ottawa, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"last","author":{"id":null,"display_name":"Michel R. Labrosse","orcid":"https://orcid.org/0000-0002-4707-7270"},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michel R. Labrosse","raw_affiliation_strings":["Mechanical Engineering Department, University of Ottawa, Ottawa, ON, Canada"],"raw_orcid":"https://orcid.org/0000-0002-4707-7270","affiliations":[{"raw_affiliation_string":"Mechanical Engineering Department, University of Ottawa, Ottawa, ON, Canada","institution_ids":["https://openalex.org/I153718931"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I153718931"],"apc_list":null,"apc_paid":null,"fwci":3.0565,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.92064983,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"68","issue":"12","first_page":"3491","last_page":"3500"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/elastin","display_name":"Elastin","score":0.779699981212616},{"id":"https://openalex.org/keywords/abdominal-aortic-aneurysm","display_name":"Abdominal aortic aneurysm","score":0.6592000126838684},{"id":"https://openalex.org/keywords/aortic-aneurysm","display_name":"Aortic aneurysm","score":0.6022999882698059},{"id":"https://openalex.org/keywords/biomechanics","display_name":"Biomechanics","score":0.5285000205039978},{"id":"https://openalex.org/keywords/thoracic-aortic-aneurysm","display_name":"Thoracic aortic aneurysm","score":0.5013999938964844},{"id":"https://openalex.org/keywords/aneurysm","display_name":"Aneurysm","score":0.4700999855995178},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"Extracellular matrix","score":0.4214000105857849}],"concepts":[{"id":"https://openalex.org/C2779869378","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Elastin","level":2,"score":0.779699981212616},{"id":"https://openalex.org/C2779993416","wikidata":"https://www.wikidata.org/wiki/Q2256736","display_name":"Abdominal aortic aneurysm","level":3,"score":0.6592000126838684},{"id":"https://openalex.org/C2777323849","wikidata":"https://www.wikidata.org/wiki/Q616003","display_name":"Aortic aneurysm","level":3,"score":0.6022999882698059},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5573999881744385},{"id":"https://openalex.org/C170700871","wikidata":"https://www.wikidata.org/wiki/Q193378","display_name":"Biomechanics","level":2,"score":0.5285000205039978},{"id":"https://openalex.org/C2780847584","wikidata":"https://www.wikidata.org/wiki/Q3616648","display_name":"Thoracic aortic aneurysm","level":4,"score":0.5013999938964844},{"id":"https://openalex.org/C2776098176","wikidata":"https://www.wikidata.org/wiki/Q189389","display_name":"Aneurysm","level":2,"score":0.4700999855995178},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43959999084472656},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4316999912261963},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4214000105857849},{"id":"https://openalex.org/C76334062","wikidata":"https://www.wikidata.org/wiki/Q2909678","display_name":"Fibrillin","level":3,"score":0.38339999318122864},{"id":"https://openalex.org/C2780561598","wikidata":"https://www.wikidata.org/wiki/Q208562","display_name":"Marfan syndrome","level":2,"score":0.3495999872684479},{"id":"https://openalex.org/C3020090656","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Arterial wall","level":2,"score":0.32120001316070557},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.3199999928474426},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3093000054359436},{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.3059000074863434},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3043000102043152},{"id":"https://openalex.org/C163498912","wikidata":"https://www.wikidata.org/wiki/Q472287","display_name":"Respiratory physiology","level":3,"score":0.298799991607666},{"id":"https://openalex.org/C196822366","wikidata":"https://www.wikidata.org/wiki/Q270524","display_name":"Parenchyma","level":2,"score":0.26190000772476196},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2603999972343445},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.25099998712539673}],"mesh":[{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017544","descriptor_name":"Aortic Aneurysm, Abdominal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017544","descriptor_name":"Aortic Aneurysm, Abdominal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017544","descriptor_name":"Aortic Aneurysm, Abdominal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017545","descriptor_name":"Aortic Aneurysm, Thoracic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017545","descriptor_name":"Aortic Aneurysm, Thoracic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017545","descriptor_name":"Aortic Aneurysm, Thoracic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbme.2021.3074053","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2021.3074053","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:33872141","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33872141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":112,"referenced_works":["https://openalex.org/W7015111","https://openalex.org/W7338016","https://openalex.org/W113263070","https://openalex.org/W122349615","https://openalex.org/W1483256491","https://openalex.org/W1487383435","https://openalex.org/W1963977555","https://openalex.org/W1965152163","https://openalex.org/W1966686938","https://openalex.org/W1972910424","https://openalex.org/W1973546521","https://openalex.org/W1976056802","https://openalex.org/W1976562969","https://openalex.org/W1976950008","https://openalex.org/W1979837737","https://openalex.org/W1980117320","https://openalex.org/W1981467725","https://openalex.org/W1986105178","https://openalex.org/W1987603011","https://openalex.org/W1990034474","https://openalex.org/W1993068563","https://openalex.org/W1994589849","https://openalex.org/W1995088425","https://openalex.org/W1995448925","https://openalex.org/W2000333410","https://openalex.org/W2002022177","https://openalex.org/W2003914234","https://openalex.org/W2008787883","https://openalex.org/W2009001048","https://openalex.org/W2010426476","https://openalex.org/W2011247521","https://openalex.org/W2011248969","https://openalex.org/W2012028367","https://openalex.org/W2014033285","https://openalex.org/W2015062429","https://openalex.org/W2015694728","https://openalex.org/W2017886142","https://openalex.org/W2018363774","https://openalex.org/W2021196131","https://openalex.org/W2025292889","https://openalex.org/W2031684656","https://openalex.org/W2033570048","https://openalex.org/W2038541045","https://openalex.org/W2039354854","https://openalex.org/W2044937303","https://openalex.org/W2049208430","https://openalex.org/W2050030809","https://openalex.org/W2051104484","https://openalex.org/W2053340629","https://openalex.org/W2055108975","https://openalex.org/W2058229406","https://openalex.org/W2060821149","https://openalex.org/W2064742396","https://openalex.org/W2065530999","https://openalex.org/W2067017355","https://openalex.org/W2072411085","https://openalex.org/W2076250807","https://openalex.org/W2077787084","https://openalex.org/W2094521685","https://openalex.org/W2094876228","https://openalex.org/W2097777092","https://openalex.org/W2106362066","https://openalex.org/W2109232495","https://openalex.org/W2114115666","https://openalex.org/W2116463491","https://openalex.org/W2125408508","https://openalex.org/W2128531352","https://openalex.org/W2129316092","https://openalex.org/W2135962089","https://openalex.org/W2136456374","https://openalex.org/W2138063219","https://openalex.org/W2140611701","https://openalex.org/W2144259944","https://openalex.org/W2147355064","https://openalex.org/W2150838305","https://openalex.org/W2157923296","https://openalex.org/W2160727590","https://openalex.org/W2169938898","https://openalex.org/W2171931631","https://openalex.org/W2331082817","https://openalex.org/W2440233981","https://openalex.org/W2480859993","https://openalex.org/W2482421968","https://openalex.org/W2567762258","https://openalex.org/W2572182904","https://openalex.org/W2594653562","https://openalex.org/W2619561301","https://openalex.org/W2758054633","https://openalex.org/W2790164154","https://openalex.org/W2793771702","https://openalex.org/W2795375387","https://openalex.org/W2888724959","https://openalex.org/W2894806069","https://openalex.org/W2899347540","https://openalex.org/W2904964614","https://openalex.org/W2915409635","https://openalex.org/W2927490428","https://openalex.org/W2970846063","https://openalex.org/W2972321517","https://openalex.org/W2976633937","https://openalex.org/W2981680418","https://openalex.org/W2995246356","https://openalex.org/W3013821279","https://openalex.org/W3030642087","https://openalex.org/W3046808422","https://openalex.org/W3082210386","https://openalex.org/W3082421441","https://openalex.org/W3090179149","https://openalex.org/W4206708970","https://openalex.org/W4238882601","https://openalex.org/W4254911650","https://openalex.org/W6771088101"],"related_works":[],"abstract_inverted_index":{"While":[0],"elastin":[1],"and":[2,18,43,99,110,117,133,155,172,199,223,226],"collagen":[3],"have":[4],"received":[5],"a":[6,214],"lot":[7],"of":[8,61,74,77,82,93,108,124,136,143,149,165,186,213,228],"attention":[9],"as":[10,23,87,89,97],"major":[11],"contributors":[12],"to":[13,36,79,114,145,152,182,197,208],"aortic":[14,38,85,94,118,169,174,230],"biomechanics,":[15],"glycosaminoglycans":[16],"(GAGs)":[17],"proteoglycans":[19],"(PGs)":[20],"recently":[21],"emerged":[22],"additional":[24],"key":[25],"players":[26],"whose":[27],"roles":[28,164],"must":[29],"be":[30,195,209],"better":[31],"elucidated":[32],"if":[33],"one":[34],"hopes":[35],"predict":[37],"ruptures":[39],"caused":[40],"by":[41],"aneurysms":[42,98],"dissections":[44],"more":[45],"reliably.":[46],"GAGs":[47],"are":[48],"highly":[49],"negatively":[50],"charged":[51],"polysaccharide":[52],"molecules":[53,128],"that":[54],"exist":[55],"in":[56,90,131,167,188,220,232],"the":[57,62,71,75,80,83,91,104,122,137,147,184,203,217,224,229],"extracellular":[58],"matrix":[59],"(ECM)":[60],"arterial":[63],"wall.":[64],"In":[65],"this":[66],"critical":[67],"review,":[68],"we":[69,102,178],"summarize":[70],"current":[72,158],"understanding":[73],"contributions":[76,113],"GAGs/PGs":[78,109,166,187],"biomechanics":[81],"normal":[84],"wall,":[86],"well":[88],"case":[92],"diseases":[95],"such":[96],"dissections.":[100],"Specifically,":[101],"describe":[103],"fundamental":[105],"swelling":[106],"behavior":[107],"discuss":[111],"their":[112],"residual":[115],"stresses":[116],"stiffness,":[119],"thereby":[120],"highlighting":[121],"importance":[123],"taking":[125],"these":[126],"polyanionic":[127],"into":[129],"account":[130],"mathematical":[132],"numerical":[134],"models":[135],"aorta.":[138],"We":[139,160],"suggest":[140],"specific":[141],"lines":[142],"investigation":[144],"further":[146],"acquisition":[148],"experimental":[150],"data":[151],"complement":[153],"simulations":[154],"solidify":[156],"our":[157],"understanding.":[159],"underscore":[161],"different":[162],"potential":[163],"thoracic":[168],"aneurysm":[170,175],"(TAAD)":[171],"abdominal":[173],"(AAA).":[176],"Namely,":[177],"report":[179],"findings":[180],"according":[181],"which":[183,193],"accumulation":[185],"TAAD":[189],"causes":[190],"stress":[191],"concentrations":[192],"may":[194],"sufficient":[196],"initiate":[198],"propagate":[200],"delamination.":[201],"On":[202],"other":[204],"hand,":[205],"there":[206],"seems":[207],"no":[210],"clear":[211],"indication":[212],"relationship":[215],"between":[216],"marked":[218],"reduction":[219],"GAG/PG":[221],"content":[222],"stiffening":[225],"weakening":[227],"wall":[231],"AAA.":[233]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1}],"updated_date":"2026-07-14T08:27:34.040176","created_date":"2021-04-26T00:00:00"}
