{"id":"https://openalex.org/W3136053529","doi":"https://doi.org/10.1109/tbme.2021.3066995","title":"Integrated System for Bacterial Detection and Biofilm Treatment on Indwelling Urinary Catheters","display_name":"Integrated System for Bacterial Detection and Biofilm Treatment on Indwelling Urinary Catheters","publication_year":2021,"publication_date":"2021-03-18","ids":{"openalex":"https://openalex.org/W3136053529","doi":"https://doi.org/10.1109/tbme.2021.3066995","mag":"3136053529","pmid":"https://pubmed.ncbi.nlm.nih.gov/33735072"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2021.3066995","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2021.3066995","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002924280","display_name":"Ryan C. Huiszoon","orcid":"https://orcid.org/0000-0001-9374-6845"},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan C. Huiszoon","raw_affiliation_strings":["University of Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021975837","display_name":"Jinjing Han","orcid":"https://orcid.org/0000-0001-6664-9839"},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinjing Han","raw_affiliation_strings":["University of Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047659778","display_name":"Sangwook Chu","orcid":"https://orcid.org/0000-0002-1173-6377"},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sangwook Chu","raw_affiliation_strings":["University of Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041647288","display_name":"Justin M. Stine","orcid":"https://orcid.org/0000-0002-2693-6400"},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin M. Stine","raw_affiliation_strings":["University of Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043787728","display_name":"Luke A. Beardslee","orcid":"https://orcid.org/0000-0002-5713-5059"},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luke A. Beardslee","raw_affiliation_strings":["University of Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082285398","display_name":"Reza Ghodssi","orcid":"https://orcid.org/0000-0002-3716-4901"},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reza Ghodssi","raw_affiliation_strings":["University of Maryland, College Park, MD, USA"],"raw_orcid":"https://orcid.org/0000-0002-3716-4901","affiliations":[{"raw_affiliation_string":"University of Maryland, College Park, MD, USA","institution_ids":["https://openalex.org/I66946132"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I66946132"],"apc_list":null,"apc_paid":null,"fwci":1.8324,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.85007264,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"68","issue":"11","first_page":"3241","last_page":"3249"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.3472000062465668,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.3472000062465668,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.1826999932527542,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.02979999966919422,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biofilm","display_name":"Biofilm","score":0.7171198129653931},{"id":"https://openalex.org/keywords/catheter","display_name":"Catheter","score":0.7031220197677612},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.5106731057167053},{"id":"https://openalex.org/keywords/foley-catheter","display_name":"Foley catheter","score":0.49410417675971985},{"id":"https://openalex.org/keywords/urinary-system","display_name":"Urinary system","score":0.4105963408946991},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.32607126235961914},{"id":"https://openalex.org/keywords/surgery","display_name":"Surgery","score":0.2785399556159973},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.22207331657409668},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1626746952533722},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1066032350063324}],"concepts":[{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.7171198129653931},{"id":"https://openalex.org/C2781267111","wikidata":"https://www.wikidata.org/wiki/Q652297","display_name":"Catheter","level":2,"score":0.7031220197677612},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5106731057167053},{"id":"https://openalex.org/C2780457474","wikidata":"https://www.wikidata.org/wiki/Q3663556","display_name":"Foley catheter","level":3,"score":0.49410417675971985},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.4105963408946991},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32607126235961914},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2785399556159973},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.22207331657409668},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1626746952533722},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1066032350063324},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002408","descriptor_name":"Catheters, Indwelling","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002408","descriptor_name":"Catheters, Indwelling","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002408","descriptor_name":"Catheters, Indwelling","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014546","descriptor_name":"Urinary Catheterization","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014546","descriptor_name":"Urinary Catheterization","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014546","descriptor_name":"Urinary Catheterization","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062885","descriptor_name":"Urinary Catheters","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D062885","descriptor_name":"Urinary Catheters","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D062885","descriptor_name":"Urinary Catheters","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbme.2021.3066995","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2021.3066995","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:33735072","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33735072","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5809544665","display_name":null,"funder_award_id":"ECCS1809436","funder_id":"https://openalex.org/F4320335353","funder_display_name":"National Science Foundation of Sri Lanka"}],"funders":[{"id":"https://openalex.org/F4320335353","display_name":"National Science Foundation of Sri Lanka","ror":"https://ror.org/010xaa060"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W26450941","https://openalex.org/W46619318","https://openalex.org/W1981979777","https://openalex.org/W2007047945","https://openalex.org/W2018270773","https://openalex.org/W2020354602","https://openalex.org/W2023205645","https://openalex.org/W2040975493","https://openalex.org/W2048318076","https://openalex.org/W2060461396","https://openalex.org/W2092180709","https://openalex.org/W2093934556","https://openalex.org/W2104933486","https://openalex.org/W2111874187","https://openalex.org/W2114594973","https://openalex.org/W2120088134","https://openalex.org/W2122560605","https://openalex.org/W2123097137","https://openalex.org/W2124115339","https://openalex.org/W2137405498","https://openalex.org/W2144440398","https://openalex.org/W2150823065","https://openalex.org/W2156638731","https://openalex.org/W2267677640","https://openalex.org/W2314608485","https://openalex.org/W2332677081","https://openalex.org/W2404305780","https://openalex.org/W2502627378","https://openalex.org/W2613785804","https://openalex.org/W2618414606","https://openalex.org/W2625135270","https://openalex.org/W2748981208","https://openalex.org/W2767258316","https://openalex.org/W2791083510","https://openalex.org/W2796698134","https://openalex.org/W2896186153","https://openalex.org/W2912957596","https://openalex.org/W2916415831","https://openalex.org/W2941061023","https://openalex.org/W2969259804","https://openalex.org/W2995387126","https://openalex.org/W3019226205","https://openalex.org/W3035777783","https://openalex.org/W6737953266"],"related_works":["https://openalex.org/W2756188369","https://openalex.org/W2947973176","https://openalex.org/W2948279684","https://openalex.org/W2087552300","https://openalex.org/W4246525962","https://openalex.org/W4220932551","https://openalex.org/W2332685989","https://openalex.org/W2130763979","https://openalex.org/W93729750","https://openalex.org/W35251202"],"abstract_inverted_index":{"GOAL:":[0],"This":[1],"work":[2],"introduces":[3],"an":[4,105,179],"integrated":[5,78],"system":[6,24,80,124,159],"incorporated":[7,31],"seamlessly":[8],"with":[9,32,65,104,178,184],"a":[10,33,37,55,60,66,117,135,161,201],"commercial":[11],"Foley":[12,181],"urinary":[13,34,167],"catheter":[14,35,79,158,182],"for":[15,40,63,165],"bacterial":[16,223],"growth":[17,100],"sensing":[18,42],"and":[19,43,188],"biofilm":[20,128,144],"treatment.":[21,46],"METHODS:":[22],"The":[23,77],"is":[25,131],"comprised":[26],"of":[27,48,85,97,101,110,143,197,206,219],"flexible,":[28],"interdigitated":[29],"electrodes":[30,177],"via":[36,69],"3D-printed":[38],"insert":[39],"impedance":[41,109],"bioelectric":[44,126],"effect-based":[45,127],"Each":[47],"the":[49,82,99,123,141,150,185,195,207,217],"functions":[50,84],"were":[51],"wirelessly":[52],"controlled":[53],"using":[54,172],"custom":[56,67],"application":[57],"that":[58,139],"provides":[59],"user-friendly":[61],"interface":[62],"communicating":[64],"PCB":[68],"Bluetooth":[70],"to":[71,146],"facilitate":[72],"implementation":[73],"in":[74,108,116],"practice.":[75],"RESULTS:":[76],"maintains":[81],"primary":[83],"indwelling":[86,220],"catheters":[87,221],"-":[88,93],"urine":[89],"drainage,":[90],"balloon":[91],"inflation":[92],"while":[94],"being":[95],"capable":[96],"detecting":[98],"Escherichia":[102],"coli,":[103],"average":[106],"decrease":[107],"13.0%":[111],"after":[112],"24":[113],"hours,":[114],"tested":[115],"newly-developed":[118],"simulated":[119],"bladder":[120],"environment.":[121],"Furthermore,":[122],"enables":[125],"reduction,":[129],"which":[130],"performed":[132],"by":[133,194,216,222],"applying":[134],"low-intensity":[136],"electric":[137],"field":[138],"increases":[140],"susceptibility":[142],"bacteria":[145],"antimicrobials,":[147],"ultimately":[148],"reducing":[149],"required":[151],"antibiotic":[152],"dosage.":[153],"CONCLUSION:":[154],"Overall,":[155],"this":[156],"modified":[157],"represents":[160],"significant":[162,202],"step":[163],"forward":[164],"catheter-associated":[166],"tract":[168],"infection":[169],"(CAUTI)":[170],"management":[171],"device-based":[173],"approaches,":[174],"integrating":[175],"flexible":[176],"actual":[180],"along":[183],"control":[186],"electronics":[187],"mobile":[189],"application.":[190],"SIGNIFICANCE:":[191],"CAUTIs,":[192],"exacerbated":[193],"emergence":[196],"antibiotic-resistant":[198],"pathogens,":[199],"represent":[200],"challenge":[203],"as":[204],"one":[205],"most":[208],"prevalent":[209],"healthcare-acquired":[210],"infections.":[211],"These":[212],"infections":[213],"are":[214],"driven":[215],"colonization":[218],"biofilms.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}