{"id":"https://openalex.org/W3127602128","doi":"https://doi.org/10.1109/tbme.2021.3057522","title":"Model Analysis of Post-Stimulation Effect on Axonal Conduction and Block","display_name":"Model Analysis of Post-Stimulation Effect on Axonal Conduction and Block","publication_year":2021,"publication_date":"2021-02-08","ids":{"openalex":"https://openalex.org/W3127602128","doi":"https://doi.org/10.1109/tbme.2021.3057522","mag":"3127602128","pmid":"https://pubmed.ncbi.nlm.nih.gov/33544668"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2021.3057522","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2021.3057522","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8339149","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040897654","display_name":"Yihua Zhong","orcid":"https://orcid.org/0000-0001-5212-0336"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yihua Zhong","raw_affiliation_strings":["Capital Medical University, China","University of Pittsburgh, USA"],"raw_orcid":"https://orcid.org/0000-0001-5212-0336","affiliations":[{"raw_affiliation_string":"Capital Medical University, China","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"University of Pittsburgh, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100644804","display_name":"Jicheng Wang","orcid":"https://orcid.org/0000-0003-0118-5628"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jicheng Wang","raw_affiliation_strings":["University of Pittsburgh, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047216342","display_name":"Jonathan M. Beckel","orcid":"https://orcid.org/0000-0003-1390-2292"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Beckel","raw_affiliation_strings":["University of Pittsburgh, USA"],"raw_orcid":"https://orcid.org/0000-0003-1390-2292","affiliations":[{"raw_affiliation_string":"University of Pittsburgh, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113902259","display_name":"William C. de Groat","orcid":null},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William C. de Groat","raw_affiliation_strings":["University of Pittsburgh, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077974120","display_name":"Changfeng Tai","orcid":"https://orcid.org/0000-0002-7776-8611"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Changfeng Tai","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-7776-8611","affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7244,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.62423289,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"68","issue":"10","first_page":"2974","last_page":"2985"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.8507000207901001,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.8507000207901001,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.023900000378489494,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.01850000023841858,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.5594724416732788},{"id":"https://openalex.org/keywords/block","display_name":"Block (permutation group theory)","score":0.5144293904304504},{"id":"https://openalex.org/keywords/neurophysiology","display_name":"Neurophysiology","score":0.41496923565864563},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.38991695642471313},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.36688411235809326},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.3551460802555084},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.20758280158042908},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.18358945846557617},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.1379374861717224},{"id":"https://openalex.org/keywords/geometry","display_name":"Geometry","score":0.09774652123451233}],"concepts":[{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5594724416732788},{"id":"https://openalex.org/C2777210771","wikidata":"https://www.wikidata.org/wiki/Q4927124","display_name":"Block (permutation group theory)","level":2,"score":0.5144293904304504},{"id":"https://openalex.org/C152478114","wikidata":"https://www.wikidata.org/wiki/Q660910","display_name":"Neurophysiology","level":2,"score":0.41496923565864563},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38991695642471313},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.36688411235809326},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3551460802555084},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20758280158042908},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18358945846557617},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1379374861717224},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.09774652123451233}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009431","descriptor_name":"Neural Conduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009431","descriptor_name":"Neural Conduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009431","descriptor_name":"Neural Conduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1109/tbme.2021.3057522","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2021.3057522","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:33544668","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33544668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8339149","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8339149","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Biomed Eng","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8339149","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8339149","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Biomed Eng","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4938217580","display_name":null,"funder_award_id":"R01 NS109198","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6847904402","display_name":null,"funder_award_id":"R01NS109198","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1588906117","https://openalex.org/W1849732852","https://openalex.org/W1897882577","https://openalex.org/W1985940938","https://openalex.org/W2005864845","https://openalex.org/W2019549306","https://openalex.org/W2028226828","https://openalex.org/W2030798246","https://openalex.org/W2042291300","https://openalex.org/W2075518511","https://openalex.org/W2083865162","https://openalex.org/W2094137543","https://openalex.org/W2129537160","https://openalex.org/W2137237108","https://openalex.org/W2147992400","https://openalex.org/W2153031112","https://openalex.org/W2153192653","https://openalex.org/W2154291780","https://openalex.org/W2156851998","https://openalex.org/W2160621520","https://openalex.org/W2461311181","https://openalex.org/W2470035536","https://openalex.org/W2513083063","https://openalex.org/W2734552138","https://openalex.org/W2751498701","https://openalex.org/W2783280708","https://openalex.org/W2784607980","https://openalex.org/W2798214928","https://openalex.org/W2931852536","https://openalex.org/W2987316956","https://openalex.org/W3046931886","https://openalex.org/W3048473272"],"related_works":["https://openalex.org/W2915014248","https://openalex.org/W2350233123","https://openalex.org/W2055241807","https://openalex.org/W2417990286","https://openalex.org/W2886641791","https://openalex.org/W2089916170","https://openalex.org/W1975077850","https://openalex.org/W63251931","https://openalex.org/W2418587965","https://openalex.org/W2055249654"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"reveal":[2],"the":[3,71,75,81,100,104,133,168,173,179,185,196,216],"possible":[4],"contribution":[5],"of":[6,32,57,136,159,192,198,215],"changes":[7],"in":[8,74,92,123,148,176],"membrane":[9],"ion":[10,14,28,72,180],"concentration":[11],"gradients":[12],"and":[13,27,55,89,127,142,151,183],"pump":[15],"activity":[16],"to":[17,172],"axonal":[18,36,108,137,155,202],"conduction/block":[19,37,203],"induced":[20,60],"by":[21,40,61,99],"long-duration":[22,33,114,199],"electrical":[23],"stimulation.":[24],"METHODS:":[25],"concentrations":[26,73,141,181],"pumps.":[29],"The":[30,48,157],"effect":[31],"stimulation":[34,120,160,200],"on":[35,154,201],"is":[38,161],"analyzed":[39],"computer":[41],"simulation":[42],"using":[43],"this":[44],"new":[45,49,101,208],"model.":[46,78,102],"RESULTS:":[47],"model":[50,105,209],"successfully":[51,97,106],"simulates":[52,107],"initiation,":[53],"propagation,":[54],"block":[56,109,135],"action":[58,86],"potentials":[59],"short-duration":[62],"(multiple":[63,115],"milliseconds)":[64],"stimulations":[65],"that":[66],"do":[67],"not":[68],"significantly":[69,211],"change":[70],"classical":[76],"HH":[77],"In":[79],"addition,":[80],"activity-dependent":[82,152],"effects":[83,150,153,197],"such":[84],"as":[85,121],"potential":[87],"attenuation":[88],"broadening":[90],"observed":[91,122],"animal":[93,125],"studies":[94,126],"are":[95,204],"also":[96],"simulated":[98],"Finally,":[103],"occurring":[110],"after":[111],"terminating":[112],"a":[113,162],"seconds)":[116],"direct":[117],"current":[118],"(DC)":[119],"recent":[124,189],"reveals":[128],"3":[129],"different":[130,219],"mechanisms":[131,217],"for":[132],"post-DC":[134],"conduction.":[138],"CONCLUSION:":[139],"Ion":[140],"pumps":[143],"play":[144],"an":[145],"important":[146],"role":[147],"post-stimulation":[149],"conduction/block.":[156],"duration":[158],"determinant":[163],"factor":[164],"because":[165],"it":[166],"influences":[167],"total":[169],"charges":[170],"applied":[171],"axon,":[174],"which":[175],"turn":[177],"determines":[178],"inside":[182],"outside":[184],"axon.":[186],"SIGNIFICANCE:":[187],"Despite":[188],"clinical":[190],"success":[191],"many":[193],"neurostimulation":[194,220],"therapies,":[195],"poorly":[205],"understood.":[206],"This":[207],"could":[210],"impact":[212],"our":[213],"understanding":[214],"underlying":[218],"therapies.":[221]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}