{"id":"https://openalex.org/W3081487930","doi":"https://doi.org/10.1109/tbme.2020.3018173","title":"A Novel Estimation Approach of Pressure Gradient and Haemodynamic Stresses as Indicators of Pathological Aortic Flow Using Subvoxel Modelling","display_name":"A Novel Estimation Approach of Pressure Gradient and Haemodynamic Stresses as Indicators of Pathological Aortic Flow Using Subvoxel Modelling","publication_year":2020,"publication_date":"2020-08-20","ids":{"openalex":"https://openalex.org/W3081487930","doi":"https://doi.org/10.1109/tbme.2020.3018173","mag":"3081487930","pmid":"https://pubmed.ncbi.nlm.nih.gov/32816672"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2020.3018173","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2020.3018173","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052896253","display_name":"Pascal Corso","orcid":"https://orcid.org/0000-0001-7875-1080"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Pascal Corso","raw_affiliation_strings":["Institute for Environmental Engineering, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-7875-1080","affiliations":[{"raw_affiliation_string":"Institute for Environmental Engineering, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052053483","display_name":"George Giannakopoulos","orcid":"https://orcid.org/0000-0001-7427-1776"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George Giannakopoulos","raw_affiliation_strings":["Aerothermochemistry and Combustion Systems Laboratory, Swiss Federal Institute of Technology Zurich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aerothermochemistry and Combustion Systems Laboratory, Swiss Federal Institute of Technology Zurich","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024372057","display_name":"Utku G\u00fclan","orcid":"https://orcid.org/0000-0002-8639-6936"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Utku Gulan","raw_affiliation_strings":["Hi-D Imaging"],"raw_orcid":"https://orcid.org/0000-0002-8639-6936","affiliations":[{"raw_affiliation_string":"Hi-D Imaging","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063524108","display_name":"Christos E. Frouzakis","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christos Emmanouil Frouzakis","raw_affiliation_strings":["Aerothermochemistry and Combustion Systems Laboratory, Swiss Federal Institute of Technology Zurich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aerothermochemistry and Combustion Systems Laboratory, Swiss Federal Institute of Technology Zurich","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032726673","display_name":"Markus Holzner","orcid":"https://orcid.org/0000-0003-2702-8612"},"institutions":[{"id":"https://openalex.org/I2800262456","display_name":"Swiss Federal Institute for Forest, Snow and Landscape Research","ror":"https://ror.org/04bs5yc70","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I2800262456"]},{"id":"https://openalex.org/I63664421","display_name":"Swiss Federal Institute of Aquatic Science and Technology","ror":"https://ror.org/00pc48d59","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I63664421"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Markus Holzner","raw_affiliation_strings":["Swiss Federal Institute for Forest, Snow and Landscape Research WSL","Swiss Federal Institute of Aquatic Science and Technology Eawag"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swiss Federal Institute for Forest, Snow and Landscape Research WSL","institution_ids":["https://openalex.org/I2800262456"]},{"raw_affiliation_string":"Swiss Federal Institute of Aquatic Science and Technology Eawag","institution_ids":["https://openalex.org/I63664421"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5052896253"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6492,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.84124141,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"68","issue":"3","first_page":"980","last_page":"991"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.39649999141693115,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.39649999141693115,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.13230000436306,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.1096000000834465,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemodynamics","display_name":"Hemodynamics","score":0.7216759920120239},{"id":"https://openalex.org/keywords/pressure-gradient","display_name":"Pressure gradient","score":0.5945923924446106},{"id":"https://openalex.org/keywords/pathological","display_name":"Pathological","score":0.5921975374221802},{"id":"https://openalex.org/keywords/flow","display_name":"Flow (mathematics)","score":0.5084973573684692},{"id":"https://openalex.org/keywords/estimation","display_name":"Estimation","score":0.4870901107788086},{"id":"https://openalex.org/keywords/aortic-pressure","display_name":"Aortic pressure","score":0.4857688248157501},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.47958412766456604},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3666030466556549},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.331470251083374},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3130209743976593},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.2799946069717407},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.15992528200149536},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1494307518005371}],"concepts":[{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.7216759920120239},{"id":"https://openalex.org/C98156149","wikidata":"https://www.wikidata.org/wiki/Q2414143","display_name":"Pressure gradient","level":2,"score":0.5945923924446106},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.5921975374221802},{"id":"https://openalex.org/C38349280","wikidata":"https://www.wikidata.org/wiki/Q1434290","display_name":"Flow (mathematics)","level":2,"score":0.5084973573684692},{"id":"https://openalex.org/C96250715","wikidata":"https://www.wikidata.org/wiki/Q965330","display_name":"Estimation","level":2,"score":0.4870901107788086},{"id":"https://openalex.org/C39124391","wikidata":"https://www.wikidata.org/wiki/Q4778759","display_name":"Aortic pressure","level":3,"score":0.4857688248157501},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.47958412766456604},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3666030466556549},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.331470251083374},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3130209743976593},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.2799946069717407},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.15992528200149536},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1494307518005371},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011673","descriptor_name":"Pulsatile Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011673","descriptor_name":"Pulsatile Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011673","descriptor_name":"Pulsatile Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012212","descriptor_name":"Rheology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012212","descriptor_name":"Rheology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012212","descriptor_name":"Rheology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1109/tbme.2020.3018173","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2020.3018173","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:32816672","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32816672","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:dora:eawag_23966","is_oa":false,"landing_page_url":"https://www.dora.lib4ri.ch/eawag/islandora/object/eawag%3A23966","pdf_url":null,"source":{"id":"https://openalex.org/S4306400127","display_name":"DORA Eawag (Swiss Federal Institute of Aquatic Science and Technology (Eawag))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I63664421","host_organization_name":"Swiss Federal Institute of Aquatic Science and Technology","host_organization_lineage":["https://openalex.org/I63664421"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:dora:wsl_25284","is_oa":false,"landing_page_url":"https://www.dora.lib4ri.ch/wsl/islandora/object/wsl%3A25284","pdf_url":null,"source":{"id":"https://openalex.org/S4306401379","display_name":"DORA WSL (Swiss Federal Institute for Forest, Snow and Landscape Research)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2800262456","host_organization_name":"Swiss Federal Institute for Forest, Snow and Landscape Research","host_organization_lineage":["https://openalex.org/I2800262456"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2298649895","display_name":null,"funder_award_id":"159686","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W199420291","https://openalex.org/W1904411227","https://openalex.org/W1979677378","https://openalex.org/W1996285474","https://openalex.org/W1997859168","https://openalex.org/W2019890443","https://openalex.org/W2043510278","https://openalex.org/W2045030872","https://openalex.org/W2049219350","https://openalex.org/W2049956971","https://openalex.org/W2057183214","https://openalex.org/W2074088746","https://openalex.org/W2077810734","https://openalex.org/W2112823474","https://openalex.org/W2140441019","https://openalex.org/W2160337198","https://openalex.org/W2169352170","https://openalex.org/W2180382450","https://openalex.org/W2202602041","https://openalex.org/W2492667227","https://openalex.org/W2593830172","https://openalex.org/W2606513458","https://openalex.org/W2627004417","https://openalex.org/W2892722194","https://openalex.org/W2942574739","https://openalex.org/W2946262828","https://openalex.org/W2969262004","https://openalex.org/W2984888372","https://openalex.org/W2995374396","https://openalex.org/W3015515389","https://openalex.org/W3098136883","https://openalex.org/W3103452973","https://openalex.org/W4232872664"],"related_works":["https://openalex.org/W2365243064","https://openalex.org/W2386699790","https://openalex.org/W2063918854","https://openalex.org/W2373252393","https://openalex.org/W2352462806","https://openalex.org/W2373002487","https://openalex.org/W2077353105","https://openalex.org/W134178525","https://openalex.org/W2913730579","https://openalex.org/W1978683330"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,154],"flow":[2,287],"downstream":[3],"from":[4,74,82],"aortic":[5,306],"stenoses":[6],"is":[7,35,108],"characterised":[8],"by":[9,234,238],"the":[10,43,48,62,111,115,122,178,187,201,216,220,230,236,248,274],"onset":[11],"of":[12,53,196,203,250],"shear-induced":[13],"turbulence":[14],"that":[15,28,58,219,273],"leads":[16],"to":[17,40,159,171,183,224,260,280,297],"irreversible":[18,231,264],"pressure":[19,44,112,150,189,232,262,265,299],"losses.":[20],"These":[21],"extra":[22],"losses":[23],"represent":[24],"an":[25],"increased":[26,204],"resistance":[27],"impacts":[29],"cardiac":[30],"efficiency.":[31],"A":[32,105,210],"novel":[33,244],"approach":[34,222,245,275],"suggested":[36],"in":[37,66,83,86,136,145,215,225,282,284,290,304],"this":[38,207],"study":[39],"accurately":[41,185],"evaluate":[42],"gradient":[45,190],"profile":[46],"along":[47,79],"aorta":[49],"centreline":[50],"using":[51,121,133],"modelling":[52,249],"haemodynamic":[54],"stress":[55,165,252],"at":[56,93,174,200,206,239],"scales":[57],"are":[59,119,131],"smaller":[60],"than":[61],"typical":[63],"resolution":[64,296],"achieved":[65],"experiments.":[67],"METHODS:":[68],"We":[69,271],"use":[70],"benchmark":[71],"data":[72,139,148,288,292],"obtained":[73],"direct":[75],"numerical":[76],"simulation":[77],"(DNS)":[78],"with":[80,212,293],"results":[81],"silico":[84,137,291],"and":[85,102,114,124,135,140,149,256,267,301],"vitro":[87,146,226,285],"three-dimensional":[88],"particle":[89],"tracking":[90],"velocimetry":[91],"(3D-PTV)":[92],"three":[94],"voxel":[95,194,208],"sizes,":[96],"namely":[97],"750":[98],"\u03bcm,":[99],"1":[100],"mm":[101,198],"1.5":[103,197],"mm.":[104],"differential":[106],"equation":[107],"derived":[109],"for":[110,163,192],"gradient,":[113,263],"subvoxel-scale":[116],"(SVS)":[117],"stresses":[118,303],"closed":[120],"Smagorinsky":[123],"a":[125,254],"new":[126,179,221],"refined":[127],"model.":[128],"Model":[129],"constants":[130],"optimised":[132],"DNS":[134],"PTV":[138,227],"validated":[141,255],"based":[142,246],"on":[143,247],"pulsatile":[144],"3D-PTV":[147],"catheter":[151],"measurements.":[152],"RESULTS:":[153],"Smagorinsky-based":[155],"model":[156,180],"was":[157,181],"found":[158,182],"be":[160,278],"more":[161,169,184,257],"accurate":[162,258],"SVS":[164,268,302],"estimation":[166],"but":[167],"also":[168],"sensitive":[170],"errors":[172,237],"especially":[173],"lower":[175],"resolution,":[176],"whereas":[177],"estimate":[186,261],"projected":[188],"even":[191],"larger":[193],"size":[195],"albeit":[199],"cost":[202],"sensitivity":[205],"size.":[209],"comparison":[211],"other":[213],"methods":[214],"literature":[217],"shows":[218],"applied":[223,279],"measurements":[228],"estimates":[229],"drop":[233],"decreasing":[235],"least":[240],"20%.":[241],"CONCLUSION:":[242],"Our":[243],"subvoxel":[251],"offers":[253],"way":[259],"loss":[266,300],"stress.":[269],"SIGNIFICANCE:":[270],"anticipate":[272],"may":[276],"potentially":[277],"image-based":[281],"vivo,":[283],"4D":[286],"or":[289],"limited":[294],"spatial":[295],"assess":[298],"disturbed":[305],"blood":[307],"flow.":[308]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}