{"id":"https://openalex.org/W3036731719","doi":"https://doi.org/10.1109/tbme.2020.3002980","title":"Low-Frequency Impedance-Based Cell Discrimination Considering Ion Transport Model in Cell Suspension","display_name":"Low-Frequency Impedance-Based Cell Discrimination Considering Ion Transport Model in Cell Suspension","publication_year":2020,"publication_date":"2020-06-17","ids":{"openalex":"https://openalex.org/W3036731719","doi":"https://doi.org/10.1109/tbme.2020.3002980","mag":"3036731719","pmid":"https://pubmed.ncbi.nlm.nih.gov/32746028"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2020.3002980","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2020.3002980","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056869124","display_name":"Daisuke Kawashima","orcid":"https://orcid.org/0000-0002-1523-6206"},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Kawashima","raw_affiliation_strings":["Graduate School of Engineering, Chiba University"],"raw_orcid":"https://orcid.org/0000-0002-1523-6206","affiliations":[{"raw_affiliation_string":"Graduate School of Engineering, Chiba University","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068065358","display_name":"Songshi Li","orcid":"https://orcid.org/0000-0001-6687-119X"},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Songshi Li","raw_affiliation_strings":["Graduate School of Engineering, Chiba University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Engineering, Chiba University","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085589181","display_name":"Hiromichi OBARA","orcid":"https://orcid.org/0000-0003-0662-6138"},"institutions":[{"id":"https://openalex.org/I69740276","display_name":"Tokyo Metropolitan University","ror":"https://ror.org/00ws30h19","country_code":"JP","type":"education","lineage":["https://openalex.org/I69740276"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromichi Obara","raw_affiliation_strings":["Department of Mechanical System Engineering, Tokyo Metropolitan University, Hino-shi, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0662-6138","affiliations":[{"raw_affiliation_string":"Department of Mechanical System Engineering, Tokyo Metropolitan University, Hino-shi, Japan","institution_ids":["https://openalex.org/I69740276"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091856593","display_name":"Masahiro Takei","orcid":"https://orcid.org/0000-0003-3855-7202"},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Takei","raw_affiliation_strings":["Graduate School of Engineering, Chiba University"],"raw_orcid":"https://orcid.org/0000-0003-3855-7202","affiliations":[{"raw_affiliation_string":"Graduate School of Engineering, Chiba University","institution_ids":["https://openalex.org/I159385669"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9388,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.71733965,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"68","issue":"3","first_page":"1015","last_page":"1023"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11778","display_name":"Electrical and Bioimpedance Tomography","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9921000003814697,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular","display_name":"Extracellular","score":0.7796675562858582},{"id":"https://openalex.org/keywords/electrical-impedance","display_name":"Electrical impedance","score":0.7141984105110168},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.5372794270515442},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5347954630851746},{"id":"https://openalex.org/keywords/ion","display_name":"Ion","score":0.530503511428833},{"id":"https://openalex.org/keywords/suspension","display_name":"Suspension (topology)","score":0.5208835601806641},{"id":"https://openalex.org/keywords/analytical-chemistry","display_name":"Analytical Chemistry (journal)","score":0.46345043182373047},{"id":"https://openalex.org/keywords/low-frequency","display_name":"Low frequency","score":0.4516996741294861},{"id":"https://openalex.org/keywords/electrode","display_name":"Electrode","score":0.44368353486061096},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.37298083305358887},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.35517948865890503},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.15394073724746704},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10502421855926514},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.07997158169746399},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.07907280325889587},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.06442531943321228},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.0580810010433197}],"concepts":[{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.7796675562858582},{"id":"https://openalex.org/C17829176","wikidata":"https://www.wikidata.org/wiki/Q179043","display_name":"Electrical impedance","level":2,"score":0.7141984105110168},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5372794270515442},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5347954630851746},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.530503511428833},{"id":"https://openalex.org/C105341887","wikidata":"https://www.wikidata.org/wiki/Q1307987","display_name":"Suspension (topology)","level":3,"score":0.5208835601806641},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.46345043182373047},{"id":"https://openalex.org/C104892082","wikidata":"https://www.wikidata.org/wiki/Q17156810","display_name":"Low frequency","level":2,"score":0.4516996741294861},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.44368353486061096},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37298083305358887},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35517948865890503},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.15394073724746704},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10502421855926514},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07997158169746399},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07907280325889587},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06442531943321228},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0580810010433197},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C5961521","wikidata":"https://www.wikidata.org/wiki/Q746083","display_name":"Homotopy","level":2,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017097","descriptor_name":"Electric Impedance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017097","descriptor_name":"Electric Impedance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017097","descriptor_name":"Electric Impedance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017136","descriptor_name":"Ion Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017136","descriptor_name":"Ion Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017136","descriptor_name":"Ion Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbme.2020.3002980","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2020.3002980","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:32746028","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32746028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","score":0.6299999952316284,"display_name":"Reduced inequalities"}],"awards":[{"id":"https://openalex.org/G6011628281","display_name":"\u30a4\u30aa\u30f3\u8f38\u9001\u4fc2\u6570\u30c6\u30f3\u30bd\u30eb\u8a08\u6e2c\u306b\u57fa\u3065\u304f\u30de\u30a4\u30af\u30ed\u6d41\u8def\u3092\u5229\u7528\u3057\u305f\u304c\u3093\u5316\u7d30\u80de\u89e3\u6790\u6cd5\u306e\u78ba\u7acb","funder_award_id":"19J00240","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W111315243","https://openalex.org/W166269271","https://openalex.org/W1663378747","https://openalex.org/W1701869895","https://openalex.org/W2000966873","https://openalex.org/W2011474048","https://openalex.org/W2016017539","https://openalex.org/W2017923672","https://openalex.org/W2026480149","https://openalex.org/W2040979770","https://openalex.org/W2069821109","https://openalex.org/W2077110701","https://openalex.org/W2091621956","https://openalex.org/W2098489734","https://openalex.org/W2125872855","https://openalex.org/W2169530852","https://openalex.org/W2286340588","https://openalex.org/W2314921421","https://openalex.org/W2557154838","https://openalex.org/W2736865651","https://openalex.org/W2747097292","https://openalex.org/W2750482762","https://openalex.org/W2794852757","https://openalex.org/W2797096615","https://openalex.org/W2802988350","https://openalex.org/W2884582038","https://openalex.org/W2892988186","https://openalex.org/W2899412763","https://openalex.org/W2919447042","https://openalex.org/W2969442974"],"related_works":["https://openalex.org/W1984947713","https://openalex.org/W190756422","https://openalex.org/W4243524043","https://openalex.org/W4318357236","https://openalex.org/W2110998913","https://openalex.org/W2012001430","https://openalex.org/W2366595807","https://openalex.org/W1979534999","https://openalex.org/W2117551213","https://openalex.org/W2071562112"],"abstract_inverted_index":{"Low-frequency":[0],"impedance-based":[1],"(LFI)":[2],"cell":[3,11,16,20,29,35,60,130,145,149,195,201,210,215],"discrimination":[4,12,17,211],"as":[5],"a":[6,143,198],"novel":[7],"non-destructive":[8],"and":[9,136],"non-invasive":[10],"is":[13,37,63,88,169],"proposed.":[14],"LFI":[15,209],"discriminates":[18,213],"the":[19,40,48,57,66,95,103,108,172,182,214],"type":[21,202],"by":[22],"considering":[23],"an":[24,72,77,133,137],"ion":[25,52,67,78,96,183],"transport":[26,32,68],"model":[27,33,69],"in":[28,34,47,80,98,129,161,185,188],"suspension.":[30],"Ion":[31],"suspension":[36,131],"constructed":[38],"on":[39,152],"basis":[41],"of":[42,45,59,110,193],"Fick's":[43],"laws":[44],"diffusion":[46],"extracellular":[49,81,99,127,186],"region":[50,82,125,187],"under":[51],"permeability":[53],"P":[54,62,192],"which":[55,87,158,179],"represents":[56],"characteristics":[58],"type.":[61,196,216],"achieved":[64],"using":[65,132],"equation":[70],"through":[71],"iterative":[73],"curve":[74,167],"fitting":[75,168],"to":[76,90,94,113,126,190],"concentration":[79,97,184],"obtained":[83],"from":[84,107,123],"low-frequency":[85,173],"impedance":[86,105,134,174,180],"assumed":[89],"be":[91],"linearly":[92],"related":[93],"region.":[100],"In":[101],"experiment,":[102],"electrical":[104],"spectra":[106],"frequency":[109],"200":[111,176],"kHz":[112,177],"2.0":[114],"MHz":[115],"are":[116,159,164],"measured":[117],"over":[118],"time":[119],"during":[120],"producing":[121],"ions":[122],"intracellular":[124,162],"one":[128],"analyzer":[135],"interdigitated":[138],"array":[139],"electrode":[140],"system.":[141],"As":[142,197],"target":[144],"type,":[146],"two":[147],"different":[148,160],"types":[150],"based":[151],"Medical":[153],"Research":[154],"Council":[155],"5":[156],"(MRC-5),":[157],"component":[163],"used.":[165],"The":[166,207],"performed":[170],"for":[171],"at":[175,178],"reflects":[181],"order":[189],"obtain":[191],"each":[194,200],"result,":[199],"has":[203],"its":[204],"own":[205],"P.":[206],"proposed":[208],"successfully":[212]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}