{"id":"https://openalex.org/W2998390275","doi":"https://doi.org/10.1109/tbme.2019.2963040","title":"Joint Optimization of Collimator and Reconstruction Parameters in X-Ray Fluorescence Computed Tomography Using Analytical Point Spread Function and Model Observer","display_name":"Joint Optimization of Collimator and Reconstruction Parameters in X-Ray Fluorescence Computed Tomography Using Analytical Point Spread Function and Model Observer","publication_year":2019,"publication_date":"2019-12-30","ids":{"openalex":"https://openalex.org/W2998390275","doi":"https://doi.org/10.1109/tbme.2019.2963040","mag":"2998390275","pmid":"https://pubmed.ncbi.nlm.nih.gov/31899411"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2019.2963040","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2019.2963040","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7326652","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073254926","display_name":"Hsin Wu Tseng","orcid":"https://orcid.org/0000-0002-2892-1288"},"institutions":[{"id":"https://openalex.org/I4210124665","display_name":"Banner - University Medical Center Tucson","ror":"https://ror.org/02xbk5j62","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210124665"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hsin Wu Tseng","raw_affiliation_strings":["Medical Imaging, University of Arizona, Tucson, United States"],"raw_orcid":"https://orcid.org/0000-0002-2892-1288","affiliations":[{"raw_affiliation_string":"Medical Imaging, University of Arizona, Tucson, United States","institution_ids":["https://openalex.org/I4210124665"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015178970","display_name":"Srinivasan Vedantham","orcid":"https://orcid.org/0000-0003-4123-8392"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srinivasan Vedantham","raw_affiliation_strings":["University of Arizona Arizona Health Sciences Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona Arizona Health Sciences Center","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101876696","display_name":"Sang Hyun Cho","orcid":"https://orcid.org/0000-0002-6357-5042"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sang Hyun Cho","raw_affiliation_strings":["Department of Radiation Physics, The University of Texas MD Anderson Cancer Center"],"raw_orcid":"https://orcid.org/0000-0002-6357-5042","affiliations":[{"raw_affiliation_string":"Department of Radiation Physics, The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058544467","display_name":"Andrew Karellas","orcid":"https://orcid.org/0000-0002-5877-3677"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Karellas","raw_affiliation_strings":["University of Arizona Arizona Health Sciences Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona Arizona Health Sciences Center","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5073254926"],"corresponding_institution_ids":["https://openalex.org/I4210124665"],"apc_list":null,"apc_paid":null,"fwci":0.5285,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.70878523,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"67","issue":"9","first_page":"2443","last_page":"2452"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.5812000036239624,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.5812000036239624,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12386","display_name":"Advanced X-ray and CT Imaging","score":0.1800999939441681,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11361","display_name":"Digital Radiography and Breast Imaging","score":0.09529999643564224,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/collimator","display_name":"Collimator","score":0.8206993341445923},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.5817825794219971},{"id":"https://openalex.org/keywords/imaging-phantom","display_name":"Imaging phantom","score":0.573639452457428},{"id":"https://openalex.org/keywords/iterative-reconstruction","display_name":"Iterative reconstruction","score":0.529539942741394},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.4535258412361145},{"id":"https://openalex.org/keywords/pinhole","display_name":"Pinhole (optics)","score":0.4368540644645691},{"id":"https://openalex.org/keywords/projection","display_name":"Projection (relational algebra)","score":0.4347764849662781},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.43423497676849365},{"id":"https://openalex.org/keywords/image-quality","display_name":"Image quality","score":0.4300898611545563},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.3474735617637634},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.341346800327301},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.31371456384658813},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2833392918109894},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.1668129563331604},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.12877637147903442}],"concepts":[{"id":"https://openalex.org/C2779200277","wikidata":"https://www.wikidata.org/wiki/Q1164658","display_name":"Collimator","level":2,"score":0.8206993341445923},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.5817825794219971},{"id":"https://openalex.org/C104293457","wikidata":"https://www.wikidata.org/wiki/Q28324852","display_name":"Imaging phantom","level":2,"score":0.573639452457428},{"id":"https://openalex.org/C141379421","wikidata":"https://www.wikidata.org/wiki/Q6094427","display_name":"Iterative reconstruction","level":2,"score":0.529539942741394},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4535258412361145},{"id":"https://openalex.org/C2776700484","wikidata":"https://www.wikidata.org/wiki/Q15832623","display_name":"Pinhole (optics)","level":2,"score":0.4368540644645691},{"id":"https://openalex.org/C57493831","wikidata":"https://www.wikidata.org/wiki/Q3134666","display_name":"Projection (relational algebra)","level":2,"score":0.4347764849662781},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.43423497676849365},{"id":"https://openalex.org/C55020928","wikidata":"https://www.wikidata.org/wiki/Q3813865","display_name":"Image quality","level":3,"score":0.4300898611545563},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3474735617637634},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.341346800327301},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.31371456384658813},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2833392918109894},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.1668129563331604},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.12877637147903442},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014965","descriptor_name":"X-Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014965","descriptor_name":"X-Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014965","descriptor_name":"X-Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014965","descriptor_name":"X-Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1109/tbme.2019.2963040","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2019.2963040","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:31899411","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31899411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:7326652","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7326652","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Biomed Eng","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7326652","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7326652","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Biomed Eng","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/11","score":0.47999998927116394,"display_name":"Sustainable cities and communities"}],"awards":[{"id":"https://openalex.org/G1032536759","display_name":null,"funder_award_id":"R01 EB020658","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1553683811","https://openalex.org/W1912693941","https://openalex.org/W1963589832","https://openalex.org/W1964569755","https://openalex.org/W1966084139","https://openalex.org/W1968737705","https://openalex.org/W1972730986","https://openalex.org/W1972760446","https://openalex.org/W1977849232","https://openalex.org/W1985573469","https://openalex.org/W1986323284","https://openalex.org/W1999679509","https://openalex.org/W2008830672","https://openalex.org/W2010339071","https://openalex.org/W2011531785","https://openalex.org/W2011545771","https://openalex.org/W2024912216","https://openalex.org/W2030120896","https://openalex.org/W2033555145","https://openalex.org/W2036255459","https://openalex.org/W2041259639","https://openalex.org/W2042719484","https://openalex.org/W2045554152","https://openalex.org/W2046031025","https://openalex.org/W2069629287","https://openalex.org/W2077840517","https://openalex.org/W2084267059","https://openalex.org/W2087189170","https://openalex.org/W2090149073","https://openalex.org/W2097120899","https://openalex.org/W2097841139","https://openalex.org/W2099631097","https://openalex.org/W2104476094","https://openalex.org/W2110243466","https://openalex.org/W2111445764","https://openalex.org/W2126052028","https://openalex.org/W2135534708","https://openalex.org/W2146428417","https://openalex.org/W2152589608","https://openalex.org/W2154744699","https://openalex.org/W2157193538","https://openalex.org/W2157812230","https://openalex.org/W2161366386","https://openalex.org/W2162007813","https://openalex.org/W2417517666","https://openalex.org/W2483704245","https://openalex.org/W2486421865","https://openalex.org/W2593118978","https://openalex.org/W2606627314","https://openalex.org/W2734761664","https://openalex.org/W2753804963","https://openalex.org/W2945959799","https://openalex.org/W2951304629","https://openalex.org/W4293007919","https://openalex.org/W6716635153"],"related_works":["https://openalex.org/W2141405559","https://openalex.org/W2330621873","https://openalex.org/W2527976887","https://openalex.org/W2565357299","https://openalex.org/W2807389575","https://openalex.org/W2038643721","https://openalex.org/W2413992745","https://openalex.org/W3096737162","https://openalex.org/W2568935392","https://openalex.org/W2144778520"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"jointly":[2],"optimize":[3],"collimator":[4,195],"design":[5,196],"and":[6,36,46,112,160,177,197],"image":[7,104,147,198],"reconstruction":[8,105,199],"algorithm":[9],"in":[10,26,139],"X-ray":[11],"Fluorescence":[12],"Computed":[13],"Tomography":[14],"(XFCT)":[15],"for":[16,72,88,117,175],"imaging":[17],"low":[18],"concentrations":[19],"of":[20,32,163,194,211],"high":[21,179],"atomic":[22],"number":[23],"(Z)":[24],"elements":[25],"small":[27],"animal":[28],"models.":[29],"METHODS:":[30],"voxels)":[31],"25":[33,37],"mm":[34,38,44,48,65],"diameter":[35,45],"height":[39,49],"with":[40,128,157,183,188],"a":[41,123],"central":[42],"5":[43],"12.5":[47],"cylindrical":[50],"insert":[51],"containing":[52],"gold":[53,73],"nanoparticles":[54],"(2:1":[55],"insert:":[56],"background":[57],"concentration)":[58],"was":[59,76,94,143],"modeled.":[60],"A":[61,151],"125":[62],"kVp,":[63],"2":[64],"Sn":[66],"filtered":[67],"x-ray":[68],"spectrum":[69],"(0.5":[70],"cGy/projection)":[71],"K-shell":[74],"XFCT":[75,176],"considered.":[77],"System":[78],"matrices":[79],"were":[80,115,181,204],"implemented":[81],"using":[82,106],"analytical":[83],"point":[84],"spread":[85],"functions":[86],"(PSF)":[87],"each":[89],"pinhole":[90],"collimator.":[91],"Poisson":[92],"noise":[93],"added":[95],"to":[96],"the":[97,118,136,146,166,209],"projection":[98],"data":[99],"(16":[100],"equiangular":[101],"views)":[102],"before":[103],"Maximum-Likelihood":[107],"Expectation-Maximization":[108],"(ML-EM)":[109],"algorithm.":[110],"Signal-present":[111],"signal-absent":[113],"images":[114],"generated":[116],"detection":[119],"task":[120],"performed":[121],"by":[122],"channelized":[124],"Hotelling":[125],"observer":[126],"(CHO)":[127],"10":[129],"Dense":[130],"Difference-of-Gaussian":[131],"channels.":[132],"The":[133,192],"area":[134],"under":[135],"curve":[137],"(AUC)":[138],"receiver":[140],"operating":[141],"characteristic":[142],"used":[144],"as":[145],"quality":[148],"metric.":[149],"RESULTS:":[150],"stainless":[152],"steel":[153],"focusing":[154,184],"type":[155,185],"MPH":[156,170,186],"7":[158,189],"pinholes":[159],"20":[161],"iterations":[162],"ML-EM":[164],"provided":[165],"highest":[167],"AUC.":[168],"CONCLUSION:":[169],"collimators":[171,174],"outperformed":[172],"SPH":[173],"consistently":[178],"AUCs":[180],"observed":[182],"designs":[187],"pinholes.":[190],"SIGNIFICANCE:":[191],"combinations":[193],"parameters":[200],"that":[201],"maximized":[202],"AUC":[203],"identified,":[205],"which":[206],"could":[207],"improve":[208],"performance":[210],"XFCT.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}