{"id":"https://openalex.org/W2996327200","doi":"https://doi.org/10.1109/tbme.2019.2960049","title":"Understanding Factors Governing Distribution Volume of Ethyl Cellulose-Ethanol to Optimize Ablative Therapy in the Liver","display_name":"Understanding Factors Governing Distribution Volume of Ethyl Cellulose-Ethanol to Optimize Ablative Therapy in the Liver","publication_year":2019,"publication_date":"2019-12-16","ids":{"openalex":"https://openalex.org/W2996327200","doi":"https://doi.org/10.1109/tbme.2019.2960049","mag":"2996327200","pmid":"https://pubmed.ncbi.nlm.nih.gov/31841399"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2019.2960049","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tbme.2019.2960049","pdf_url":"https://ieeexplore.ieee.org/ielx7/10/9142461/08933449.pdf","source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ieeexplore.ieee.org/ielx7/10/9142461/08933449.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086623578","display_name":"Robert Morhard","orcid":"https://orcid.org/0000-0001-8875-471X"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Morhard","raw_affiliation_strings":["Biomedical Engineering, Duke University, Durham, USA"],"raw_orcid":"https://orcid.org/0000-0001-8875-471X","affiliations":[{"raw_affiliation_string":"Biomedical Engineering, Duke University, Durham, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079219278","display_name":"Jenna L. Mueller","orcid":"https://orcid.org/0000-0001-5198-8491"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenna L. Mueller","raw_affiliation_strings":["Biomedical Engineering, Duke University, Durham, USA"],"raw_orcid":"https://orcid.org/0000-0001-5198-8491","affiliations":[{"raw_affiliation_string":"Biomedical Engineering, Duke University, Durham, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024039823","display_name":"Qishun Tang","orcid":"https://orcid.org/0000-0003-0687-0237"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4210132461","display_name":"Applied Physical Sciences (United States)","ror":"https://ror.org/03gf10a58","country_code":"US","type":"company","lineage":["https://openalex.org/I4210132461"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qishun Tang","raw_affiliation_strings":["Applied Physical Sciences, University of North Carolina at Chapel Hill"],"raw_orcid":"https://orcid.org/0000-0003-0687-0237","affiliations":[{"raw_affiliation_string":"Applied Physical Sciences, University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4210132461"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008045445","display_name":"Corrine A. Nief","orcid":"https://orcid.org/0000-0003-3870-4786"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corrine Nief","raw_affiliation_strings":["Biomedical Engineering, Duke University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, Duke University","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070534033","display_name":"Erika Chelales","orcid":"https://orcid.org/0000-0002-8860-7143"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erika Chelales","raw_affiliation_strings":["Biomedical Engineering, Duke University"],"raw_orcid":"https://orcid.org/0000-0002-8860-7143","affiliations":[{"raw_affiliation_string":"Biomedical Engineering, Duke University","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013318922","display_name":"Christopher T. Lam","orcid":"https://orcid.org/0000-0002-8491-8702"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher T. Lam","raw_affiliation_strings":["Biomedical Engineering, Duke University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, Duke University","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109843969","display_name":"Daniel \u00c1lvarez","orcid":null},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Adrianzen Alvarez","raw_affiliation_strings":["Biomedical Engineering, Duke University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, Duke University","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018026577","display_name":"Michael Rubinstein","orcid":"https://orcid.org/0000-0002-5455-0951"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Rubinstein","raw_affiliation_strings":["Biomedical Engineering, Duke University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, Duke University","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060992832","display_name":"David F. Katz","orcid":"https://orcid.org/0000-0002-1440-8416"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David F. Katz","raw_affiliation_strings":["Biomedical Engineering, Duke University"],"raw_orcid":"https://orcid.org/0000-0002-1440-8416","affiliations":[{"raw_affiliation_string":"Biomedical Engineering, Duke University","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022593092","display_name":"Nirmala Ramanujam","orcid":"https://orcid.org/0000-0001-7319-8415"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nimmi Ramanujam","raw_affiliation_strings":["Biomedical Engineering, Duke University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, Duke University","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2045,"currency":"USD","value_usd":2045},"apc_paid":{"value":2045,"currency":"USD","value_usd":2045},"fwci":1.9399,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.86637785,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"67","issue":"8","first_page":"2337","last_page":"2348"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.8140000104904175,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.8140000104904175,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.0203000009059906,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12548","display_name":"Hemostasis and retained surgical items","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethanol","display_name":"Ethanol","score":0.7261506915092468},{"id":"https://openalex.org/keywords/ethyl-cellulose","display_name":"Ethyl cellulose","score":0.4774130582809448},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4119076728820801},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.37514767050743103},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.17326214909553528}],"concepts":[{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.7261506915092468},{"id":"https://openalex.org/C2776035855","wikidata":"https://www.wikidata.org/wiki/Q420113","display_name":"Ethyl cellulose","level":3,"score":0.4774130582809448},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4119076728820801},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.37514767050743103},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17326214909553528},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002482","descriptor_name":"Cellulose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002482","descriptor_name":"Cellulose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002482","descriptor_name":"Cellulose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002482","descriptor_name":"Cellulose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017115","descriptor_name":"Catheter Ablation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017115","descriptor_name":"Catheter Ablation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017115","descriptor_name":"Catheter Ablation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017115","descriptor_name":"Catheter Ablation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1109/tbme.2019.2960049","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tbme.2019.2960049","pdf_url":"https://ieeexplore.ieee.org/ielx7/10/9142461/08933449.pdf","source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:31841399","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31841399","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7295656","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7295656","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Biomed Eng","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1109/tbme.2019.2960049","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tbme.2019.2960049","pdf_url":"https://ieeexplore.ieee.org/ielx7/10/9142461/08933449.pdf","source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1152963880","display_name":null,"funder_award_id":"EFMA-1830957","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3047363731","display_name":null,"funder_award_id":"R01CA239268","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4463749938","display_name":"Preventing Cervical Cancer in the First Mile of the Cancer Care Continuum","funder_award_id":"5r00ca234455-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5024329055","display_name":null,"funder_award_id":"F31 CA239623","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6213279519","display_name":"Enhanced ethanol ablation as a surgical-alternative for head and neck cancer treatment in resource-limited settings","funder_award_id":"1f31ca239623-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6401456091","display_name":null,"funder_award_id":"R00 CA234455","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7461271822","display_name":"Core B: Analytics for Mucolytics Core","funder_award_id":"5p01hl108808-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G770865720","display_name":"EFRI CEE : Engineering Technologies to Determine Causal Relationships Between Chromatin Structure and Gene Regulation","funder_award_id":"1830957","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G887415676","display_name":null,"funder_award_id":"P01-HL-108808","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8947872873","display_name":null,"funder_award_id":"K99 CA234455","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G947307681","display_name":"Novel see and treat strategies for cervical cancer prevention in low-resource settings","funder_award_id":"5r01ca239268-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306168","display_name":"Cystic Fibrosis Foundation","ror":"https://ror.org/00ax59295"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2996327200.pdf","grobid_xml":"https://content.openalex.org/works/W2996327200.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1498553196","https://openalex.org/W1581170315","https://openalex.org/W1969848765","https://openalex.org/W1970800786","https://openalex.org/W1971433696","https://openalex.org/W1972861065","https://openalex.org/W1973161563","https://openalex.org/W1976802607","https://openalex.org/W1978188012","https://openalex.org/W1981379718","https://openalex.org/W1984048969","https://openalex.org/W1991561238","https://openalex.org/W1993685077","https://openalex.org/W2000249913","https://openalex.org/W2018684283","https://openalex.org/W2025126236","https://openalex.org/W2032613413","https://openalex.org/W2039685983","https://openalex.org/W2041009580","https://openalex.org/W2041060696","https://openalex.org/W2041099873","https://openalex.org/W2043861297","https://openalex.org/W2044006168","https://openalex.org/W2045272150","https://openalex.org/W2054518570","https://openalex.org/W2055264482","https://openalex.org/W2055361720","https://openalex.org/W2055919556","https://openalex.org/W2061475241","https://openalex.org/W2064447850","https://openalex.org/W2074044739","https://openalex.org/W2085581249","https://openalex.org/W2097113997","https://openalex.org/W2107438504","https://openalex.org/W2116055493","https://openalex.org/W2120477004","https://openalex.org/W2120650073","https://openalex.org/W2148727825","https://openalex.org/W2153584585","https://openalex.org/W2163086303","https://openalex.org/W2170037192","https://openalex.org/W2170468591","https://openalex.org/W2182857445","https://openalex.org/W2270408904","https://openalex.org/W2279932199","https://openalex.org/W2300853570","https://openalex.org/W2321796693","https://openalex.org/W2394573937","https://openalex.org/W2417910850","https://openalex.org/W2465961915","https://openalex.org/W2509183844","https://openalex.org/W2517056294","https://openalex.org/W2529326258","https://openalex.org/W2745779832","https://openalex.org/W2757147410","https://openalex.org/W2968479145","https://openalex.org/W2975233607","https://openalex.org/W4241175378","https://openalex.org/W4242661038","https://openalex.org/W4249227673","https://openalex.org/W6634807615","https://openalex.org/W6719785201"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Ethanol":[1],"ablation,":[2],"the":[3,64,68,76,187,193,199,202,230],"injection":[4,59,73,86],"of":[5,122,135,140,177,182,204,208,213,245],"ethanol":[6,44,116],"to":[7,13,21,28,70,98,126,171,234,241],"induce":[8],"necrosis,":[9],"was":[10,113],"originally":[11],"used":[12],"treat":[14,242],"hepatocellular":[15],"carcinoma,":[16],"with":[17,43,95],"survival":[18],"rates":[19],"comparable":[20],"surgery.":[22],"However,":[23],"efficacy":[24],"is":[25,160],"limited":[26],"due":[27],"leakage":[29,112,129],"into":[30,53],"surrounding":[31],"tissue.":[32,54,155],"To":[33,55,216],"reduce":[34],"leakage,":[35,219],"we":[36],"previously":[37],"reported":[38],"incorporating":[39],"ethyl":[40],"cellulose":[41],"(EC)":[42],"as":[45,60],"this":[46],"mixture":[47],"forms":[48],"a":[49,120,161,175,180,243],"gel":[50],"when":[51],"injected":[52,77],"further":[56,217],"develop":[57],"EC-ethanol":[58,240],"an":[61],"ablative":[62],"therapy,":[63],"present":[65],"study":[66],"evaluates":[67],"extent":[69],"which":[71,166],"salient":[72],"parameters":[74,87],"govern":[75],"fluid":[78,172],"distribution.":[79],"METHODS:":[80],"Utilizing":[81],"ex":[82],"vivo":[83],"swine":[84],"liver,":[85],"(infusion":[88],"rate,":[89],"EC%,":[90],"infusion":[91,136,141,163,194,214],"volume)":[92],"were":[93,105,145,210],"examined":[94],"fluorescein":[96],"added":[97],"each":[99],"solution.":[100],"After":[101],"injection,":[102],"tissue":[103,200],"samples":[104],"frozen,":[106],"sectioned,":[107],"and":[108,117,143,152,201,229],"imaged.":[109],"RESULTS:":[110],"While":[111],"higher":[114],"for":[115,132],"3%EC-ethanol":[118],"at":[119],"rate":[121,176,195],"10":[123,178],"mL/hr":[124],"compared":[125],"1":[127],"mL/hr,":[128,179],"remained":[130,185],"low":[131],"6%EC-ethanol":[133,209],"regardless":[134,212],"rate.":[137,215],"The":[138],"impact":[139],"volume":[142,181],"pressure":[144,164],"also":[146],"investigated":[147],"first":[148],"in":[149,154],"tissue-mimicking":[150],"surrogates":[151],"then":[153],"Results":[156],"indicated":[157],"that":[158],"there":[159],"critical":[162,188],"beyond":[165],"crack":[167,205],"formation":[168],"occurs":[169],"leading":[170],"leakage.":[173],"At":[174],"50":[183],"\u03bcL":[184],"below":[186],"pressure.":[189],"CONCLUSIONS:":[190],"Although":[191],"increasing":[192],"increases":[196],"stress":[197],"on":[198],"risk":[203],"formation,":[206],"injections":[207],"localized":[211],"limit":[218],"multiple":[220],"low-volume":[221],"infusions":[222],"may":[223],"be":[224],"employed.":[225],"SIGNIFICANCE:":[226],"These":[227],"results,":[228],"experimental":[231],"framework":[232],"developed":[233],"obtain":[235],"them,":[236],"can":[237],"inform":[238],"optimizing":[239],"range":[244],"medical":[246],"conditions.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4}],"updated_date":"2026-09-08T07:41:39.490200","created_date":"2025-10-10T00:00:00"}