{"id":"https://openalex.org/W2969100648","doi":"https://doi.org/10.1109/tbme.2019.2934682","title":"Towards Personalized Closed-Loop Mechanical CPR: A Model Relating Carotid Blood Flow to Chest Compression Rate and Duration","display_name":"Towards Personalized Closed-Loop Mechanical CPR: A Model Relating Carotid Blood Flow to Chest Compression Rate and Duration","publication_year":2019,"publication_date":"2019-08-12","ids":{"openalex":"https://openalex.org/W2969100648","doi":"https://doi.org/10.1109/tbme.2019.2934682","mag":"2969100648","pmid":"https://pubmed.ncbi.nlm.nih.gov/31403405"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2019.2934682","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2019.2934682","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053812510","display_name":"Joshua W. Lampe","orcid":"https://orcid.org/0000-0001-6036-535X"},"institutions":[{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua W. Lampe","raw_affiliation_strings":["Feinstein Institute for Medical Research, Manhasset, USA","Zoll, Chelmsford, USA"],"raw_orcid":"https://orcid.org/0000-0001-6036-535X","affiliations":[{"raw_affiliation_string":"Feinstein Institute for Medical Research, Manhasset, USA","institution_ids":["https://openalex.org/I1327576362"]},{"raw_affiliation_string":"Zoll, Chelmsford, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044193063","display_name":"Subash Padmanaban","orcid":"https://orcid.org/0000-0003-2879-3113"},"institutions":[{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Subash Padmanaban","raw_affiliation_strings":["Feinstein Institute for Medical Research","Interaxon Inc"],"raw_orcid":"https://orcid.org/0000-0003-2879-3113","affiliations":[{"raw_affiliation_string":"Feinstein Institute for Medical Research","institution_ids":["https://openalex.org/I1327576362"]},{"raw_affiliation_string":"Interaxon Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083278720","display_name":"Lance B. Becker","orcid":"https://orcid.org/0000-0001-7051-8778"},"institutions":[{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lance B. Becker","raw_affiliation_strings":["Feinstein Institute for Medical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Feinstein Institute for Medical Research","institution_ids":["https://openalex.org/I1327576362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068492860","display_name":"Theodoros P. Zanos","orcid":"https://orcid.org/0000-0002-9204-9551"},"institutions":[{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodoros P. Zanos","raw_affiliation_strings":["Institute of Bioelectronic Medicine, Feinstein Institute for Medical Research, Manhasset, USA"],"raw_orcid":"https://orcid.org/0000-0002-9204-9551","affiliations":[{"raw_affiliation_string":"Institute of Bioelectronic Medicine, Feinstein Institute for Medical Research, Manhasset, USA","institution_ids":["https://openalex.org/I1327576362"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1327576362"],"apc_list":null,"apc_paid":null,"fwci":0.5581,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.70499529,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"67","issue":"5","first_page":"1253","last_page":"1262"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11238","display_name":"Simulation-Based Education in Healthcare","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiopulmonary-resuscitation","display_name":"Cardiopulmonary resuscitation","score":0.767964243888855},{"id":"https://openalex.org/keywords/blood-flow","display_name":"Blood flow","score":0.6766987442970276},{"id":"https://openalex.org/keywords/compression","display_name":"Compression (physics)","score":0.581430971622467},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5575260519981384},{"id":"https://openalex.org/keywords/pulseless-electrical-activity","display_name":"Pulseless electrical activity","score":0.5370361804962158},{"id":"https://openalex.org/keywords/data-compression-ratio","display_name":"Data compression ratio","score":0.51677405834198},{"id":"https://openalex.org/keywords/return-of-spontaneous-circulation","display_name":"Return of spontaneous circulation","score":0.4466639459133148},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.4218495190143585},{"id":"https://openalex.org/keywords/resuscitation","display_name":"Resuscitation","score":0.3815561830997467},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.35848158597946167},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.28858909010887146},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.21020227670669556}],"concepts":[{"id":"https://openalex.org/C2777055891","wikidata":"https://www.wikidata.org/wiki/Q185325","display_name":"Cardiopulmonary resuscitation","level":3,"score":0.767964243888855},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.6766987442970276},{"id":"https://openalex.org/C180016635","wikidata":"https://www.wikidata.org/wiki/Q2712821","display_name":"Compression (physics)","level":2,"score":0.581430971622467},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5575260519981384},{"id":"https://openalex.org/C2777205947","wikidata":"https://www.wikidata.org/wiki/Q1326997","display_name":"Pulseless electrical activity","level":4,"score":0.5370361804962158},{"id":"https://openalex.org/C94835093","wikidata":"https://www.wikidata.org/wiki/Q3113333","display_name":"Data compression ratio","level":5,"score":0.51677405834198},{"id":"https://openalex.org/C2778619729","wikidata":"https://www.wikidata.org/wiki/Q7317197","display_name":"Return of spontaneous circulation","level":4,"score":0.4466639459133148},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4218495190143585},{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.3815561830997467},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35848158597946167},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.28858909010887146},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.21020227670669556},{"id":"https://openalex.org/C9417928","wikidata":"https://www.wikidata.org/wiki/Q1070689","display_name":"Image processing","level":3,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C13481523","wikidata":"https://www.wikidata.org/wiki/Q412438","display_name":"Image compression","level":4,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006323","descriptor_name":"Heart Arrest","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006323","descriptor_name":"Heart Arrest","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006323","descriptor_name":"Heart Arrest","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011312","descriptor_name":"Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011312","descriptor_name":"Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011312","descriptor_name":"Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013909","descriptor_name":"Thorax","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013909","descriptor_name":"Thorax","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013909","descriptor_name":"Thorax","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016887","descriptor_name":"Cardiopulmonary Resuscitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016887","descriptor_name":"Cardiopulmonary Resuscitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016887","descriptor_name":"Cardiopulmonary Resuscitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbme.2019.2934682","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2019.2934682","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:31403405","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31403405","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320315735","display_name":"ZOLL Medical Corporation","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1800251357","https://openalex.org/W1981362599","https://openalex.org/W1994193077","https://openalex.org/W1999782276","https://openalex.org/W2023802187","https://openalex.org/W2041853587","https://openalex.org/W2046543648","https://openalex.org/W2057413381","https://openalex.org/W2072208404","https://openalex.org/W2083589454","https://openalex.org/W2086632167","https://openalex.org/W2106659642","https://openalex.org/W2116179239","https://openalex.org/W2118436419","https://openalex.org/W2134125121","https://openalex.org/W2139916084","https://openalex.org/W2142046230","https://openalex.org/W2176568680","https://openalex.org/W2595557058","https://openalex.org/W2766037853","https://openalex.org/W2885990087","https://openalex.org/W3144877909","https://openalex.org/W4245785529","https://openalex.org/W4319308453"],"related_works":["https://openalex.org/W4206281649","https://openalex.org/W2889684667","https://openalex.org/W101351176","https://openalex.org/W4391089756","https://openalex.org/W2082118526","https://openalex.org/W2001814951","https://openalex.org/W2589143988","https://openalex.org/W4289594428","https://openalex.org/W2128949083","https://openalex.org/W4389786882"],"abstract_inverted_index":{"OBJECTIVE:":[0],"There":[1],"is":[2,44,49,337],"a":[3,33,66,156,168,325,338],"growing":[4],"interest":[5],"in":[6,148,216,237,249,275,307],"the":[7,30,53,56,82,88,96,100,105,124,134,143,194,197,213,242,246,290,295,308,315],"personalization":[8],"of":[9,32,41,55,68,95,98,126,196,218,227,260,264,292],"chest":[10,62,90,101,256,319],"compressions":[11],"to":[12,28,45,51,60,80,145,150,193,224,300,318],"increase":[13],"blood":[14,58,84,109,137,153,233,251,266,284,305],"flow":[15,59,85,138,154,234,252,306],"during":[16,70],"cardiopulmonary":[17],"resuscitation":[18,71,293],"(CPR),":[19],"but":[20,178],"there":[21],"has":[22],"been":[23],"very":[24],"little":[25],"systematic":[26],"work":[27,76],"test":[29],"feasibility":[31],"closed":[34,333],"loop":[35,334],"mechanical":[36,335],"CPR":[37,127,336],"system.":[38],"The":[39,199],"purpose":[40],"this":[42],"study":[43],"determine":[46],"if":[47],"it":[48],"possible":[50],"model":[52,147,201,244,301],"response":[54,317],"carotid":[57,83,108,136,152,232,250,265,283,304],"different":[61,272],"compression":[63,91,102,129,131,236,257,296,320],"waveforms":[64],"as":[65,142],"function":[67],"time":[69],"from":[72,117,167,176,324],"cardiac":[73,119],"arrest.":[74],"This":[75,312,330],"tests":[77],"several":[78],"approaches":[79],"predict":[81,151,303],"generated":[86,253],"by":[87,254],"next":[89,309],"based":[92],"on":[93,207,212],"knowledge":[94],"duration":[97,291],"resuscitation,":[99],"rate,":[103,132],"and":[104,133,139,171,210,294,302],"last":[106],"compression's":[107],"flow.":[110],"METHODS:":[111],"Using":[112],"an":[113,225],"existing":[114],"physiological":[115,281,316],"database":[116],"swine":[118],"arrest":[120],"studies,":[121],"we":[122],"computed":[123],"features":[125],"epoch,":[128],"index,":[130],"previous":[135],"used":[140],"them":[141],"inputs":[144],"our":[146],"order":[149],"using":[155],"Random":[157],"Forest":[158],"algorithm.":[159],"We":[160],"tested":[161,211],"animal":[162],"specific":[163,186],"(estimated":[164,173],"with":[165,174,287],"data":[166,175,328],"single":[169,280],"animal)":[170],"global":[172,200,243],"all":[177],"one":[179],"animals)":[180],"models":[181,187],"for":[182],"effectiveness.":[183],"RESULTS:":[184],"Animal":[185],"did":[188],"not":[189],"generalize":[190],"when":[191,205],"applied":[192],"rest":[195],"animals.":[198,277],"performed":[202],"reasonably":[203],"well":[204],"trained":[206],"six":[208],"animals":[209],"7th,":[214],"resulting":[215],"errors":[217],"40-160":[219],"\u03bcL":[220,230],"per":[221,235],"compression,":[222],"compared":[223],"average":[226],"approximately":[228],"400":[229],"net":[231],"early":[238],"compressions.":[239],"In":[240],"addition,":[241],"highlighted":[245],"inter-animal":[247],"variability":[248],"identical":[255],"waveforms.":[258],"Generation":[259],"probability":[261],"distribution":[262,273],"functions":[263],"flows":[267],"suggested":[268],"at":[269],"least":[270],"three":[271],"profiles":[274],"seven":[276],"CONCLUSION:":[278],"A":[279],"metric,":[282],"flow,":[285],"combined":[286],"information":[288],"about":[289],"rate":[297],"was":[298],"sufficient":[299],"compression.":[310],"SIGNIFICANCE:":[311],"demonstrates":[313],"that":[314,332],"can":[321],"be":[322],"predicted":[323],"relatively":[326],"modest":[327],"set.":[329],"suggests":[331],"viable":[339],"medical":[340],"device":[341],"target.":[342]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}