{"id":"https://openalex.org/W2946293106","doi":"https://doi.org/10.1109/tbme.2019.2917212","title":"Cardiac Electrical Modeling for Closed-Loop Validation of Implantable Devices","display_name":"Cardiac Electrical Modeling for Closed-Loop Validation of Implantable Devices","publication_year":2019,"publication_date":"2019-05-16","ids":{"openalex":"https://openalex.org/W2946293106","doi":"https://doi.org/10.1109/tbme.2019.2917212","mag":"2946293106","pmid":"https://pubmed.ncbi.nlm.nih.gov/31095474"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2019.2917212","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2019.2917212","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054349747","display_name":"Weiwei Ai","orcid":"https://orcid.org/0000-0001-5602-5707"},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":true,"raw_author_name":"Weiwei Ai","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Auckland, Auckland, New Zealand"],"raw_orcid":"https://orcid.org/0000-0001-5602-5707","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032512352","display_name":"Nitish Patel","orcid":"https://orcid.org/0000-0002-3459-5407"},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Nitish D. Patel","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Auckland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Auckland","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076621370","display_name":"Partha S. Roop","orcid":"https://orcid.org/0000-0001-9654-5678"},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Partha S. Roop","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Auckland"],"raw_orcid":"https://orcid.org/0000-0001-9654-5678","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Auckland","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007782699","display_name":"Avinash Malik","orcid":"https://orcid.org/0000-0002-7524-8292"},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Avinash Malik","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Auckland"],"raw_orcid":"https://orcid.org/0000-0002-7524-8292","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Auckland","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073737510","display_name":"Mark L. Trew","orcid":"https://orcid.org/0000-0003-4296-8231"},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Mark L. Trew","raw_affiliation_strings":["Auckland Bioengineering Institute, University of Auckland"],"raw_orcid":"https://orcid.org/0000-0003-4296-8231","affiliations":[{"raw_affiliation_string":"Auckland Bioengineering Institute, University of Auckland","institution_ids":["https://openalex.org/I154130895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5054349747"],"corresponding_institution_ids":["https://openalex.org/I154130895"],"apc_list":null,"apc_paid":null,"fwci":2.7909,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.91601151,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"67","issue":"2","first_page":"536","last_page":"544"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9333999752998352,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9333999752998352,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.028999999165534973,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-electrophysiology","display_name":"Cardiac electrophysiology","score":0.6877385377883911},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6590023636817932},{"id":"https://openalex.org/keywords/sinus-rhythm","display_name":"Sinus rhythm","score":0.4932231307029724},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.45078790187835693},{"id":"https://openalex.org/keywords/reentry","display_name":"Reentry","score":0.43388238549232483},{"id":"https://openalex.org/keywords/simulation","display_name":"Simulation","score":0.3893764615058899},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"Atrial fibrillation","score":0.2430785894393921},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1514497995376587},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.1395619809627533},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.10397693514823914}],"concepts":[{"id":"https://openalex.org/C61381695","wikidata":"https://www.wikidata.org/wiki/Q3302130","display_name":"Cardiac electrophysiology","level":3,"score":0.6877385377883911},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6590023636817932},{"id":"https://openalex.org/C2775914520","wikidata":"https://www.wikidata.org/wiki/Q12335414","display_name":"Sinus rhythm","level":3,"score":0.4932231307029724},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.45078790187835693},{"id":"https://openalex.org/C2777720157","wikidata":"https://www.wikidata.org/wiki/Q7306947","display_name":"Reentry","level":2,"score":0.43388238549232483},{"id":"https://openalex.org/C44154836","wikidata":"https://www.wikidata.org/wiki/Q45045","display_name":"Simulation","level":1,"score":0.3893764615058899},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.2430785894393921},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1514497995376587},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.1395619809627533},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10397693514823914}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010138","descriptor_name":"Pacemaker, Artificial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010138","descriptor_name":"Pacemaker, Artificial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010138","descriptor_name":"Pacemaker, Artificial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013611","descriptor_name":"Tachycardia, Atrioventricular Nodal Reentry","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013611","descriptor_name":"Tachycardia, Atrioventricular Nodal Reentry","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013611","descriptor_name":"Tachycardia, Atrioventricular Nodal Reentry","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054849","descriptor_name":"Cardiac Electrophysiology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D054849","descriptor_name":"Cardiac Electrophysiology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D054849","descriptor_name":"Cardiac Electrophysiology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/tbme.2019.2917212","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2019.2917212","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:31095474","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31095474","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:researchspace.auckland.ac.nz:2292/48518","is_oa":false,"landing_page_url":"http://hdl.handle.net/2292/48518","pdf_url":null,"source":{"id":"https://openalex.org/S7407055463","display_name":"ResearchSpace (University of Auckland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I154130895","host_organization_name":"University of Auckland","host_organization_lineage":["https://openalex.org/I154130895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5699999928474426}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320890","display_name":"Fondation Leducq","ror":"https://ror.org/01czwga19"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W164184961","https://openalex.org/W206970439","https://openalex.org/W1508695273","https://openalex.org/W1574124831","https://openalex.org/W1575242179","https://openalex.org/W1843007637","https://openalex.org/W1895507721","https://openalex.org/W1979343524","https://openalex.org/W1993099746","https://openalex.org/W1994322021","https://openalex.org/W1995146104","https://openalex.org/W1995281013","https://openalex.org/W1995339685","https://openalex.org/W2011052746","https://openalex.org/W2047224650","https://openalex.org/W2052600736","https://openalex.org/W2053398545","https://openalex.org/W2079604837","https://openalex.org/W2081324807","https://openalex.org/W2099091817","https://openalex.org/W2100078256","https://openalex.org/W2101072502","https://openalex.org/W2101508170","https://openalex.org/W2104749146","https://openalex.org/W2117305411","https://openalex.org/W2119872725","https://openalex.org/W2122931628","https://openalex.org/W2130139165","https://openalex.org/W2130321115","https://openalex.org/W2138036714","https://openalex.org/W2138951514","https://openalex.org/W2142830159","https://openalex.org/W2143182748","https://openalex.org/W2143738377","https://openalex.org/W2147340401","https://openalex.org/W2155157732","https://openalex.org/W2165895237","https://openalex.org/W2166277504","https://openalex.org/W2203772677","https://openalex.org/W2256006760","https://openalex.org/W2291989804","https://openalex.org/W2346361143","https://openalex.org/W2514747239","https://openalex.org/W2547245610","https://openalex.org/W2566006602","https://openalex.org/W2586664265","https://openalex.org/W2597821080","https://openalex.org/W2608425165","https://openalex.org/W2757974192","https://openalex.org/W2883045357","https://openalex.org/W2884170599","https://openalex.org/W2885341929","https://openalex.org/W3011730451"],"related_works":["https://openalex.org/W2086609101","https://openalex.org/W2274750791","https://openalex.org/W3044098214","https://openalex.org/W2055549109","https://openalex.org/W1968555577","https://openalex.org/W2748521320","https://openalex.org/W2006154469","https://openalex.org/W203924752","https://openalex.org/W2119568772","https://openalex.org/W2070106059"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Evaluating":[1],"and":[2,65,87,102,106,144,151,162,195,227],"testing":[3,25],"cardiac":[4,36,71,163],"electrical":[5],"devices":[6],"in":[7,22,153,167,174],"a":[8,54,77,81,128,171],"closed-physiologic-loop":[9],"can":[10,123,197,221],"help":[11],"design":[12,229],"safety,":[13],"but":[14],"this":[15],"is":[16,63,114],"rarely":[17],"practical":[18],"or":[19],"comprehensive.":[20],"Furthermore,":[21],"silico":[23],"closed-loop":[24],"with":[26,91,170],"biophysical":[27],"computer":[28],"models":[29,41],"cannot":[30],"meet":[31],"the":[32,48,154,177,199,204,209],"requirements":[33,44],"of":[34,111,130,203],"time-critical":[35,43,64],"device":[37,173,210,225],"systems,":[38],"while":[39,120],"simplified":[40],"meeting":[42],"may":[45],"not":[46],"have":[47,191],"necessary":[49],"dynamic":[50,160],"features.":[51],"We":[52],"propose":[53],"new":[55],"high-level":[56],"(abstracted)":[57],"physiologically-based":[58],"computational":[59],"heart":[60,205,219],"model":[61,69,79,146,155,178,206,220],"that":[62,94,207],"dynamic.":[66],"METHODS:":[67],"The":[68,84,109],"comprises":[70],"regional":[72,85],"cellular-electrophysiology":[73],"types":[74],"connected":[75],"by":[76],"path":[78],"along":[80],"conduction":[82,103],"network.":[83],"electrophysiology":[86,150],"paths":[88,152],"are":[89,139],"modeled":[90],"hybrid":[92],"automata":[93],"capture":[95],"non-linear":[96],"dynamics,":[97],"such":[98,132,182],"as":[99,133,183],"action":[100,158],"potential":[101],"velocity":[104],"restitution":[105],"overdrive":[107],"suppression.":[108],"hierarchy":[110],"pacemaker":[112],"functions":[113],"incorporated":[115],"to":[116,126,228],"generate":[117],"sinus":[118],"rhythms,":[119],"abnormal":[121],"automaticity":[122],"be":[124,222],"introduced":[125],"form":[127],"variety":[129],"arrhythmias":[131],"escape":[134],"ectopic":[135],"rhythms.":[136],"Model":[137],"parameters":[138],"calibrated":[140],"using":[141],"experimental":[142],"data":[143],"prior":[145],"simulations.":[147],"CONCLUSION:":[148],"Regional":[149],"match":[156],"human":[157],"potentials,":[159],"behavior,":[161],"activation":[164],"sequences.":[165],"Connected":[166],"closed":[168],"loop":[169],"pacing":[172],"DDD":[175],"mode,":[176],"generates":[179],"complex":[180],"arrhythmia":[181],"atrioventricular":[184],"nodal":[185],"reentry":[186],"tachycardia.":[187],"Such":[188],"device-induced":[189],"outcomes":[190],"been":[192],"observed":[193],"clinically":[194],"we":[196],"establish":[198],"key":[200],"physiological":[201],"features":[202],"influence":[208],"operation.":[211],"SIGNIFICANCE:":[212],"These":[213],"findings":[214],"demonstrate":[215],"how":[216],"an":[217],"abstract":[218],"used":[223],"for":[224],"validation":[226],"personalized":[230],"treatment.":[231]},"counts_by_year":[{"year":2025,"cited_by_count":26},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}