{"id":"https://openalex.org/W2944132893","doi":"https://doi.org/10.1109/tbme.2019.2915526","title":"Evaluation of Fluid Resuscitation Control Algorithms via a Hardware-in-the-Loop Test Bed","display_name":"Evaluation of Fluid Resuscitation Control Algorithms via a Hardware-in-the-Loop Test Bed","publication_year":2019,"publication_date":"2019-05-08","ids":{"openalex":"https://openalex.org/W2944132893","doi":"https://doi.org/10.1109/tbme.2019.2915526","mag":"2944132893","pmid":"https://pubmed.ncbi.nlm.nih.gov/31071014"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2019.2915526","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2019.2915526","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7082848","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089309660","display_name":"Hossein Mirinejad","orcid":"https://orcid.org/0000-0002-6505-2245"},"institutions":[{"id":"https://openalex.org/I1335686170","display_name":"Center for Devices and Radiological Health","ror":"https://ror.org/007x9se63","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070","https://openalex.org/I1335686170"]},{"id":"https://openalex.org/I39565521","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08","country_code":"US","type":"government","lineage":["https://openalex.org/I1330989302","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hossein Mirinejad","raw_affiliation_strings":["Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, USA"],"raw_orcid":"https://orcid.org/0000-0002-6505-2245","affiliations":[{"raw_affiliation_string":"Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, USA","institution_ids":["https://openalex.org/I1335686170","https://openalex.org/I39565521"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007040455","display_name":"Bahram Parvinian","orcid":null},"institutions":[{"id":"https://openalex.org/I1335686170","display_name":"Center for Devices and Radiological Health","ror":"https://ror.org/007x9se63","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070","https://openalex.org/I1335686170"]},{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bahram Parvinian","raw_affiliation_strings":["Department of Mechanical Engineering, University of Maryland","FDA's Center for Devices and Radiological Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Maryland","institution_ids":["https://openalex.org/I66946132"]},{"raw_affiliation_string":"FDA's Center for Devices and Radiological Health","institution_ids":["https://openalex.org/I1335686170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078158437","display_name":"Margo Ricks","orcid":null},"institutions":[{"id":"https://openalex.org/I1335686170","display_name":"Center for Devices and Radiological Health","ror":"https://ror.org/007x9se63","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070","https://openalex.org/I1335686170"]},{"id":"https://openalex.org/I39565521","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08","country_code":"US","type":"government","lineage":["https://openalex.org/I1330989302","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I4210149736","display_name":"Food and Drug Administration","ror":"https://ror.org/05hvrsg85","country_code":"TH","type":"government","lineage":["https://openalex.org/I4210149736"]}],"countries":["TH","US"],"is_corresponding":false,"raw_author_name":"Margo Ricks","raw_affiliation_strings":["Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration","institution_ids":["https://openalex.org/I1335686170","https://openalex.org/I39565521","https://openalex.org/I4210149736"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100388178","display_name":"Yi Zhang","orcid":"https://orcid.org/0000-0002-5375-360X"},"institutions":[{"id":"https://openalex.org/I1335686170","display_name":"Center for Devices and Radiological Health","ror":"https://ror.org/007x9se63","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070","https://openalex.org/I1335686170"]},{"id":"https://openalex.org/I39565521","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08","country_code":"US","type":"government","lineage":["https://openalex.org/I1330989302","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I4210149736","display_name":"Food and Drug Administration","ror":"https://ror.org/05hvrsg85","country_code":"TH","type":"government","lineage":["https://openalex.org/I4210149736"]}],"countries":["TH","US"],"is_corresponding":false,"raw_author_name":"Yi Zhang","raw_affiliation_strings":["Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration"],"raw_orcid":"https://orcid.org/0000-0002-5375-360X","affiliations":[{"raw_affiliation_string":"Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration","institution_ids":["https://openalex.org/I1335686170","https://openalex.org/I39565521","https://openalex.org/I4210149736"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019496528","display_name":"Sandy Weininger","orcid":"https://orcid.org/0000-0001-9955-1096"},"institutions":[{"id":"https://openalex.org/I1335686170","display_name":"Center for Devices and Radiological Health","ror":"https://ror.org/007x9se63","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070","https://openalex.org/I1335686170"]},{"id":"https://openalex.org/I39565521","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08","country_code":"US","type":"government","lineage":["https://openalex.org/I1330989302","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I4210149736","display_name":"Food and Drug Administration","ror":"https://ror.org/05hvrsg85","country_code":"TH","type":"government","lineage":["https://openalex.org/I4210149736"]}],"countries":["TH","US"],"is_corresponding":false,"raw_author_name":"Sandy Weininger","raw_affiliation_strings":["Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration"],"raw_orcid":"https://orcid.org/0000-0001-9955-1096","affiliations":[{"raw_affiliation_string":"Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration","institution_ids":["https://openalex.org/I1335686170","https://openalex.org/I39565521","https://openalex.org/I4210149736"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057276590","display_name":"Jin\u2010Oh Hahn","orcid":"https://orcid.org/0000-0001-5429-2836"},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin-Oh Hahn","raw_affiliation_strings":["Department of Mechanical Engineering, University of Maryland"],"raw_orcid":"https://orcid.org/0000-0001-5429-2836","affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Maryland","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079054224","display_name":"Christopher G. Scully","orcid":"https://orcid.org/0000-0001-8244-0832"},"institutions":[{"id":"https://openalex.org/I1335686170","display_name":"Center for Devices and Radiological Health","ror":"https://ror.org/007x9se63","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070","https://openalex.org/I1335686170"]},{"id":"https://openalex.org/I39565521","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08","country_code":"US","type":"government","lineage":["https://openalex.org/I1330989302","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I4210149736","display_name":"Food and Drug Administration","ror":"https://ror.org/05hvrsg85","country_code":"TH","type":"government","lineage":["https://openalex.org/I4210149736"]}],"countries":["TH","US"],"is_corresponding":false,"raw_author_name":"Christopher G. Scully","raw_affiliation_strings":["Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration"],"raw_orcid":"https://orcid.org/0000-0001-8244-0832","affiliations":[{"raw_affiliation_string":"Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration","institution_ids":["https://openalex.org/I1335686170","https://openalex.org/I39565521","https://openalex.org/I4210149736"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4143,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.9207264,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"67","issue":"2","first_page":"471","last_page":"481"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.17919999361038208,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.17919999361038208,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.16509999334812164,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.08449999988079071,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resuscitation","display_name":"Resuscitation","score":0.541032075881958},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5118900537490845},{"id":"https://openalex.org/keywords/test","display_name":"Test (biology)","score":0.4748119115829468},{"id":"https://openalex.org/keywords/loop","display_name":"Loop (graph theory)","score":0.4542728364467621},{"id":"https://openalex.org/keywords/hardware-in-the-loop-simulation","display_name":"Hardware-in-the-loop simulation","score":0.41777223348617554},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.36071354150772095},{"id":"https://openalex.org/keywords/simulation","display_name":"Simulation","score":0.2490437626838684},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.24849218130111694},{"id":"https://openalex.org/keywords/emergency-medicine","display_name":"Emergency medicine","score":0.1730961799621582},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1265827715396881},{"id":"https://openalex.org/keywords/geology","display_name":"Geology","score":0.06899797916412354}],"concepts":[{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.541032075881958},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5118900537490845},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.4748119115829468},{"id":"https://openalex.org/C184670325","wikidata":"https://www.wikidata.org/wiki/Q512604","display_name":"Loop (graph theory)","level":2,"score":0.4542728364467621},{"id":"https://openalex.org/C70587628","wikidata":"https://www.wikidata.org/wiki/Q1142371","display_name":"Hardware-in-the-loop simulation","level":2,"score":0.41777223348617554},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.36071354150772095},{"id":"https://openalex.org/C44154836","wikidata":"https://www.wikidata.org/wiki/Q45045","display_name":"Simulation","level":1,"score":0.2490437626838684},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24849218130111694},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.1730961799621582},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1265827715396881},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.06899797916412354},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001795","descriptor_name":"Blood Pressure Determination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001795","descriptor_name":"Blood Pressure Determination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001795","descriptor_name":"Blood Pressure Determination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001795","descriptor_name":"Blood Pressure Determination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005440","descriptor_name":"Fluid Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005440","descriptor_name":"Fluid Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005440","descriptor_name":"Fluid Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005440","descriptor_name":"Fluid Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012151","descriptor_name":"Resuscitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012151","descriptor_name":"Resuscitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012151","descriptor_name":"Resuscitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012151","descriptor_name":"Resuscitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1109/tbme.2019.2915526","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2019.2915526","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:31071014","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31071014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:europepmc.org:6756078","is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7082848","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7082848","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7082848","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Biomed Eng","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7082848","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7082848","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Biomed Eng","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1586159327","display_name":null,"funder_award_id":"CNS-1748762","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3050811832","display_name":null,"funder_award_id":"FD999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5413616413","display_name":null,"funder_award_id":"N000141512018","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G6894515429","display_name":null,"funder_award_id":"N000141410591","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"},{"id":"https://openalex.org/F4320332382","display_name":"Oak Ridge Institute for Science and Education","ror":"https://ror.org/0526p1y61"},{"id":"https://openalex.org/F4320337345","display_name":"Office of Naval Research","ror":"https://ror.org/00rk2pe57"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W2001131888","https://openalex.org/W2007254392","https://openalex.org/W2038873307","https://openalex.org/W2043742363","https://openalex.org/W2061986136","https://openalex.org/W2141617123","https://openalex.org/W2339453682","https://openalex.org/W2568246828","https://openalex.org/W2739927630","https://openalex.org/W2790968248","https://openalex.org/W2791132452","https://openalex.org/W2800196539","https://openalex.org/W2885971563","https://openalex.org/W2900474954","https://openalex.org/W2922820107","https://openalex.org/W2924457751"],"related_works":["https://openalex.org/W2051487156","https://openalex.org/W2365513417","https://openalex.org/W2073681303","https://openalex.org/W24774503","https://openalex.org/W2087737319","https://openalex.org/W2368125093","https://openalex.org/W1993975100","https://openalex.org/W2379999974","https://openalex.org/W2885805061","https://openalex.org/W2086754639"],"abstract_inverted_index":{"OBJECTIVE:":[0],"This":[1,203],"paper":[2],"presents":[3],"a":[4,22,77,82,243],"hardware-in-the-loop":[5],"(HIL)":[6],"testing":[7,187,206,238],"platform":[8,20],"for":[9,166,185,237],"evaluating":[10],"the":[11,51,58,69,100,108,114,121,126,147,151,155,158,164,167,171,178,181],"performance":[12,70],"of":[13,71,90,125,150,157,180,188,198,205,211,239,246],"fluid":[14,73,128],"resuscitation":[15,74,129],"control":[16,75,214],"algorithms.":[17,34],"The":[18,36,61,87,175],"proposed":[19,59],"is":[21,40,64],"cyber-physical":[23],"system":[24],"that":[25,94,113,132],"integrates":[26],"physical":[27,193],"devices":[28,194],"with":[29,195],"computational":[30,196],"models":[31,197],"and":[32,45,81,107,140,200,222,234,248],"computer-based":[33],"METHODS:":[35],"HIL":[37,101,115,172,182],"test":[38,62,91,102,116,183],"bed":[39,63,92,117,184],"evaluated":[41],"against":[42,242],"in":[43,46,57,99,104,109,170,218,230,232],"silico":[44,105],"vivo":[47,110],"data":[48],"to":[49,67,144,216,226],"ensure":[50],"hemodynamic":[52,122,136,152],"variables":[53,137],"are":[54,97],"appropriately":[55],"predicted":[56],"platform.":[60,173],"then":[65],"used":[66],"investigate":[68],"two":[72,127],"algorithms:":[76],"decision":[78],"table":[79],"(rule-based)":[80],"proportional-integral-derivative":[83],"(PID)":[84],"controller.":[85],"RESULTS:":[86],"statistical":[88],"evaluation":[89,210],"indicates":[93],"similar":[95,142],"results":[96,176],"observed":[98],"bed,":[103],"implementation,":[106],"data,":[111],"verifying":[112],"can":[118],"adequately":[119],"predict":[120],"responses.":[123],"Comparison":[124],"controllers":[130,134,190],"reveals":[131],"both":[133],"stabilized":[135],"over":[138],"time":[139],"had":[141],"speed":[143],"efficiently":[145],"achieve":[146],"target":[148],"level":[149],"endpoint.":[153],"However,":[154],"accuracy":[156],"PID":[159],"controller":[160],"was":[161],"higher":[162],"than":[163],"rule-based":[165],"scenarios":[168],"tested":[169],"CONCLUSION:":[174],"demonstrate":[177],"potential":[179],"realistic":[186],"physiologic":[189,212],"by":[191],"incorporating":[192],"physiology":[199],"disturbances.":[201],"SIGNIFICANCE:":[202],"type":[204],"enables":[207],"relatively":[208],"fast":[209],"closed-loop":[213],"systems":[215,241],"aid":[217],"iterative":[219],"design":[220],"processes":[221],"offers":[223],"complementary":[224],"means":[225],"existing":[227],"techniques":[228],"(e.g.,":[229],"silico,":[231],"vivo,":[233],"clinical":[235],"studies)":[236],"such":[240],"wide":[244],"range":[245],"disturbances":[247],"scenarios.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}