{"id":"https://openalex.org/W2998171860","doi":"https://doi.org/10.1109/tbme.2019.2910733","title":"Multi-Parametric Standardization of Fluorescence Imaging Systems Based on a Composite Phantom","display_name":"Multi-Parametric Standardization of Fluorescence Imaging Systems Based on a Composite Phantom","publication_year":2019,"publication_date":"2019-12-24","ids":{"openalex":"https://openalex.org/W2998171860","doi":"https://doi.org/10.1109/tbme.2019.2910733","mag":"2998171860","pmid":"https://pubmed.ncbi.nlm.nih.gov/30990172"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2019.2910733","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2019.2910733","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=57772","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039766474","display_name":"Dimitris Gorpas","orcid":"https://orcid.org/0000-0001-9576-8087"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4387155950","display_name":"Institute of Biological and Medical Imaging","ror":"https://ror.org/05g95eg64","country_code":null,"type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672","https://openalex.org/I4387155950","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dimitris Gorpas","raw_affiliation_strings":["Chair of Biological Imaging and TranslaTUM, Technische Universit\u00e4t M\u00fcnchen","Institute of Biological and Medical Imaging, Helmholtz Zentrum M\u00fcnchen"],"raw_orcid":"https://orcid.org/0000-0001-9576-8087","affiliations":[{"raw_affiliation_string":"Chair of Biological Imaging and TranslaTUM, Technische Universit\u00e4t M\u00fcnchen","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Institute of Biological and Medical Imaging, Helmholtz Zentrum M\u00fcnchen","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4387155950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101866410","display_name":"Maximilian Koch","orcid":"https://orcid.org/0000-0003-4355-5922"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4387155950","display_name":"Institute of Biological and Medical Imaging","ror":"https://ror.org/05g95eg64","country_code":null,"type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672","https://openalex.org/I4387155950","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maximilian Koch","raw_affiliation_strings":["Chair of Biological Imaging and TranslaTUM, Technische Universit\u00e4t M\u00fcnchen","Institute of Biological and Medical Imaging, Helmholtz Zentrum M\u00fcnchen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Biological Imaging and TranslaTUM, Technische Universit\u00e4t M\u00fcnchen","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Institute of Biological and Medical Imaging, Helmholtz Zentrum M\u00fcnchen","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4387155950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023004939","display_name":"Maria Anastasopoulou","orcid":"https://orcid.org/0000-0003-2999-7775"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4387155950","display_name":"Institute of Biological and Medical Imaging","ror":"https://ror.org/05g95eg64","country_code":null,"type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672","https://openalex.org/I4387155950","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maria Anastasopoulou","raw_affiliation_strings":["Chair of Biological Imaging and TranslaTUM, Technische Universit\u00e4t M\u00fcnchen","Institute of Biological and Medical Imaging, Helmholtz Zentrum M\u00fcnchen"],"raw_orcid":"https://orcid.org/0000-0003-2999-7775","affiliations":[{"raw_affiliation_string":"Chair of Biological Imaging and TranslaTUM, Technische Universit\u00e4t M\u00fcnchen","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Institute of Biological and Medical Imaging, Helmholtz Zentrum M\u00fcnchen","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4387155950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008102023","display_name":"Dmitry Bozhko","orcid":"https://orcid.org/0000-0002-6151-8896"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4387155950","display_name":"Institute of Biological and Medical Imaging","ror":"https://ror.org/05g95eg64","country_code":null,"type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672","https://openalex.org/I4387155950","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dmitry Bozhko","raw_affiliation_strings":["Chair of Biological Imaging and TranslaTUM, Technische Universit\u00e4t M\u00fcnchen","Institute of Biological and Medical Imaging, Helmholtz Zentrum M\u00fcnchen"],"raw_orcid":"https://orcid.org/0000-0002-6151-8896","affiliations":[{"raw_affiliation_string":"Chair of Biological Imaging and TranslaTUM, Technische Universit\u00e4t M\u00fcnchen","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Institute of Biological and Medical Imaging, Helmholtz Zentrum M\u00fcnchen","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4387155950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031782465","display_name":"Uwe Klemm","orcid":"https://orcid.org/0000-0002-8768-5289"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4387155950","display_name":"Institute of Biological and Medical Imaging","ror":"https://ror.org/05g95eg64","country_code":null,"type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672","https://openalex.org/I4387155950","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Uwe Klemm","raw_affiliation_strings":["Chair of Biological Imaging and TranslaTUM, Technische Universit\u00e4t M\u00fcnchen","Institute of Biological and Medical Imaging, Helmholtz Zentrum M\u00fcnchen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Biological Imaging and TranslaTUM, Technische Universit\u00e4t M\u00fcnchen","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Institute of Biological and Medical Imaging, Helmholtz Zentrum M\u00fcnchen","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4387155950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047346468","display_name":"Markus Nieberler","orcid":null},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Nieberler","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, University Hospital Rechts der Isar, Technische Universit\u00e4t M\u00fcnchen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, University Hospital Rechts der Isar, Technische Universit\u00e4t M\u00fcnchen","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059881887","display_name":"Vasilis Ntziachristos","orcid":"https://orcid.org/0000-0002-9988-0233"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4387155950","display_name":"Institute of Biological and Medical Imaging","ror":"https://ror.org/05g95eg64","country_code":null,"type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672","https://openalex.org/I4387155950","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Vasilis Ntziachristos","raw_affiliation_strings":["Chair of Biological Imaging and TranslaTUM, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany","Institute of Biological and Medical Imaging, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9988-0233","affiliations":[{"raw_affiliation_string":"Chair of Biological Imaging and TranslaTUM, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Institute of Biological and Medical Imaging, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4387155950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2847,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.88520343,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"67","issue":"1","first_page":"185","last_page":"192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.738099992275238,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.738099992275238,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.23999999463558197,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/imaging-phantom","display_name":"Imaging phantom","score":0.8392249345779419},{"id":"https://openalex.org/keywords/benchmarking","display_name":"Benchmarking","score":0.6288061738014221},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6134477853775024},{"id":"https://openalex.org/keywords/standardization","display_name":"Standardization","score":0.5705470442771912},{"id":"https://openalex.org/keywords/medical-physics","display_name":"Medical physics","score":0.5200902223587036},{"id":"https://openalex.org/keywords/image-quality","display_name":"Image quality","score":0.48022252321243286},{"id":"https://openalex.org/keywords/image-resolution","display_name":"Image resolution","score":0.46376630663871765},{"id":"https://openalex.org/keywords/digital-imaging","display_name":"Digital imaging","score":0.45177170634269714},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.4348219633102417},{"id":"https://openalex.org/keywords/fidelity","display_name":"Fidelity","score":0.4343799948692322},{"id":"https://openalex.org/keywords/parametric-statistics","display_name":"Parametric statistics","score":0.43075665831565857},{"id":"https://openalex.org/keywords/fluorescence-lifetime-imaging-microscopy","display_name":"Fluorescence-lifetime imaging microscopy","score":0.41622278094291687},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3780311942100525},{"id":"https://openalex.org/keywords/image-processing","display_name":"Image processing","score":0.35808229446411133},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.32183706760406494},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.22509557008743286},{"id":"https://openalex.org/keywords/digital-image","display_name":"Digital image","score":0.2093788981437683},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.18668338656425476},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.17179879546165466},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.15245014429092407},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.1307242214679718},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1063685417175293},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.09249594807624817}],"concepts":[{"id":"https://openalex.org/C104293457","wikidata":"https://www.wikidata.org/wiki/Q28324852","display_name":"Imaging phantom","level":2,"score":0.8392249345779419},{"id":"https://openalex.org/C86251818","wikidata":"https://www.wikidata.org/wiki/Q816754","display_name":"Benchmarking","level":2,"score":0.6288061738014221},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6134477853775024},{"id":"https://openalex.org/C188087704","wikidata":"https://www.wikidata.org/wiki/Q369577","display_name":"Standardization","level":2,"score":0.5705470442771912},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.5200902223587036},{"id":"https://openalex.org/C55020928","wikidata":"https://www.wikidata.org/wiki/Q3813865","display_name":"Image quality","level":3,"score":0.48022252321243286},{"id":"https://openalex.org/C205372480","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Image resolution","level":2,"score":0.46376630663871765},{"id":"https://openalex.org/C112416745","wikidata":"https://www.wikidata.org/wiki/Q974213","display_name":"Digital imaging","level":5,"score":0.45177170634269714},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.4348219633102417},{"id":"https://openalex.org/C2776459999","wikidata":"https://www.wikidata.org/wiki/Q2119376","display_name":"Fidelity","level":2,"score":0.4343799948692322},{"id":"https://openalex.org/C117251300","wikidata":"https://www.wikidata.org/wiki/Q1849855","display_name":"Parametric statistics","level":2,"score":0.43075665831565857},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.41622278094291687},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3780311942100525},{"id":"https://openalex.org/C9417928","wikidata":"https://www.wikidata.org/wiki/Q1070689","display_name":"Image processing","level":3,"score":0.35808229446411133},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.32183706760406494},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.22509557008743286},{"id":"https://openalex.org/C42781572","wikidata":"https://www.wikidata.org/wiki/Q1250322","display_name":"Digital image","level":4,"score":0.2093788981437683},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.18668338656425476},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17179879546165466},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.15245014429092407},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.1307242214679718},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1063685417175293},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09249594807624817},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C162853370","wikidata":"https://www.wikidata.org/wiki/Q39809","display_name":"Marketing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D012015","descriptor_name":"Reference Standards","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012015","descriptor_name":"Reference Standards","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012015","descriptor_name":"Reference Standards","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D057054","descriptor_name":"Molecular Imaging","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D057054","descriptor_name":"Molecular Imaging","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D057054","descriptor_name":"Molecular Imaging","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D057054","descriptor_name":"Molecular Imaging","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D057054","descriptor_name":"Molecular Imaging","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D057054","descriptor_name":"Molecular Imaging","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1109/tbme.2019.2910733","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2019.2910733","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:30990172","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30990172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:mediatum.ub.tum.de:node/1588299","is_oa":false,"landing_page_url":"https://ieeexplore.ieee.org/document/8688475","pdf_url":null,"source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:57772","is_oa":true,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=57772","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans. Bio. Med. Eng. 67, 185-192 (2020)","raw_type":"Text"},{"id":"pmh:oai:push-zb.helmholtz-munich.de:57772","is_oa":false,"landing_page_url":"https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=57772","pdf_url":null,"source":{"id":"https://openalex.org/S7407055352","display_name":"PuSH - Publication Server of Helmholtz Zentrum M\u00fcnchen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans. Bio. Med. Eng. 67, 185-192 (2020)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:57772","is_oa":true,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=57772","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans. Bio. Med. Eng. 67, 185-192 (2020)","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5657306566","display_name":null,"funder_award_id":"NT 3/10-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8234889483","display_name":null,"funder_award_id":"01KT1809","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W164261674","https://openalex.org/W1976056487","https://openalex.org/W2025749961","https://openalex.org/W2029548232","https://openalex.org/W2032240642","https://openalex.org/W2041323004","https://openalex.org/W2063429363","https://openalex.org/W2063461906","https://openalex.org/W2074255456","https://openalex.org/W2106173789","https://openalex.org/W2112579958","https://openalex.org/W2136413862","https://openalex.org/W2147906777","https://openalex.org/W2157132786","https://openalex.org/W2194632500","https://openalex.org/W2316581203","https://openalex.org/W2422399389","https://openalex.org/W2515781873","https://openalex.org/W2519930924","https://openalex.org/W2554295594","https://openalex.org/W2564389970","https://openalex.org/W2587652742","https://openalex.org/W2772882676","https://openalex.org/W2885266984"],"related_works":["https://openalex.org/W4238897586","https://openalex.org/W435179959","https://openalex.org/W2619091065","https://openalex.org/W2059640416","https://openalex.org/W1490753184","https://openalex.org/W2284465472","https://openalex.org/W2291782699","https://openalex.org/W2002789908","https://openalex.org/W2012504994","https://openalex.org/W2321582776"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Fluorescence":[1],"molecular":[2],"imaging":[3,130,201,235,244,249],"(FMI)":[4],"has":[5,211],"emerged":[6],"as":[7],"a":[8,39,58,64,94,194,199,229],"promising":[9],"tool":[10],"for":[11,82,112,127,144,173,232,241],"surgical":[12,195],"guidance":[13],"in":[14,189,237],"oncology,":[15],"with":[16],"one":[17],"of":[18,38,68,73,78,107,117,135,156,193,198,225],"the":[19,24,36,104,113,118,191,208,212,226],"few":[20],"remaining":[21],"challenges":[22],"being":[23],"ability":[25],"to":[26,43,137,149,153,214],"offer":[27],"quality":[28],"control":[29],"and":[30,45,76,85,96,158,161,171,197,220,240,247],"data":[31,180],"referencing.":[32,181],"This":[33,50],"paper":[34,51],"investigates":[35],"use":[37,188],"novel":[40],"composite":[41,186],"phantom":[42,59,187,210],"correct":[44],"benchmark":[46],"FMI":[47,69,217,227],"systems.":[48],"METHODS:":[49],"extends":[52],"on":[53],"previous":[54],"work":[55],"by":[56],"describing":[57],"design":[60],"that":[61,124,207],"can":[62,131,167],"provide":[63],"more":[65],"complete":[66],"assessment":[67],"systems":[70,125,142],"through":[71,218],"quantification":[72],"dynamic":[74],"range":[75],"determination":[77],"spatial":[79],"illumination":[80,160],"patterns":[81],"both":[83],"reflectance":[84],"fluorescence":[86,129],"imaging.":[87],"Various":[88],"performance":[89,192],"metrics":[90],"are":[91,147],"combined":[92],"into":[93],"robust":[95],"descriptive":[97],"\"system":[98],"benchmarking":[99,133,219],"score,\"":[100],"enabling":[101,242],"not":[102],"only":[103],"comprehensive":[105],"comparison":[106],"different":[108],"systems,":[109],"but":[110],"also":[111,168],"first":[114],"time,":[115],"correction":[116],"acquired":[119],"data.":[120],"RESULTS:":[121],"We":[122],"show":[123],"developed":[126],"targeted":[128],"achieve":[132],"scores":[134],"up":[136],"70%,":[138],"while":[139],"clinically":[140],"available":[141],"optimized":[143],"indocyanine":[145],"green":[146],"limited":[148],"50%,":[150],"mostly":[151],"due":[152],"greater":[154],"leakage":[155],"ambient":[157],"excitation":[159],"lower":[162],"resolution.":[163],"The":[164],"image":[165,174,221],"uniformity":[166],"be":[169],"approximated":[170],"employed":[172],"flat-fielding,":[175],"an":[176],"important":[177],"milestone":[178],"toward":[179],"In":[182],"addition,":[183],"we":[184],"demonstrate":[185],"assessing":[190],"microscope":[196],"raster-scan":[200],"system.":[202],"CONCLUSION:":[203],"Our":[204],"results":[205],"suggest":[206],"new":[209],"potential":[213],"support":[215],"high-fidelity":[216,243],"correction.":[222],"SIGNIFICANCE:":[223],"Standardization":[224],"is":[228],"necessary":[230],"process":[231],"establishing":[233],"good":[234],"practices":[236],"clinical":[238],"environments":[239],"across":[245],"patients":[246],"multi-center":[248],"studies.":[250]},"counts_by_year":[{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}