{"id":"https://openalex.org/W2913964535","doi":"https://doi.org/10.1109/tbme.2019.2897851","title":"Incorporating Long-Acting Insulin Glargine Into the UVA/Padova Type 1 Diabetes Simulator for<i>In Silico</i>Testing of MDI Therapies","display_name":"Incorporating Long-Acting Insulin Glargine Into the UVA/Padova Type 1 Diabetes Simulator for<i>In Silico</i>Testing of MDI Therapies","publication_year":2019,"publication_date":"2019-02-06","ids":{"openalex":"https://openalex.org/W2913964535","doi":"https://doi.org/10.1109/tbme.2019.2897851","mag":"2913964535","pmid":"https://pubmed.ncbi.nlm.nih.gov/30735983"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2019.2897851","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2019.2897851","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022115669","display_name":"R. Visentin","orcid":"https://orcid.org/0000-0002-5848-5990"},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Roberto Visentin","raw_affiliation_strings":["Department of Information Engineering, University of Padova"],"raw_orcid":"https://orcid.org/0000-0002-5848-5990","affiliations":[{"raw_affiliation_string":"Department of Information Engineering, University of Padova","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046700628","display_name":"Michele Schiavon","orcid":"https://orcid.org/0000-0003-0590-2399"},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Schiavon","raw_affiliation_strings":["Department of Information Engineering, University of Padova"],"raw_orcid":"https://orcid.org/0000-0003-0590-2399","affiliations":[{"raw_affiliation_string":"Department of Information Engineering, University of Padova","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017662160","display_name":"Clemens Giegerich","orcid":"https://orcid.org/0000-0001-6124-5915"},"institutions":[{"id":"https://openalex.org/I4210138838","display_name":"Sanofi (Germany)","ror":"https://ror.org/03ytdtb31","country_code":"DE","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210138838"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Clemens Giegerich","raw_affiliation_strings":["R&D Translational Medicine Early Development, Sanofi-Aventis Deutschland GmbH"],"raw_orcid":"https://orcid.org/0000-0001-6124-5915","affiliations":[{"raw_affiliation_string":"R&D Translational Medicine Early Development, Sanofi-Aventis Deutschland GmbH","institution_ids":["https://openalex.org/I4210138838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057888842","display_name":"Thomas Klabunde","orcid":"https://orcid.org/0000-0002-0745-4940"},"institutions":[{"id":"https://openalex.org/I4210138838","display_name":"Sanofi (Germany)","ror":"https://ror.org/03ytdtb31","country_code":"DE","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210138838"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Klabunde","raw_affiliation_strings":["R&D Translational Medicine Early Development, Sanofi-Aventis Deutschland GmbH"],"raw_orcid":"https://orcid.org/0000-0002-0745-4940","affiliations":[{"raw_affiliation_string":"R&D Translational Medicine Early Development, Sanofi-Aventis Deutschland GmbH","institution_ids":["https://openalex.org/I4210138838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068823308","display_name":"Chiara Dalla Man","orcid":"https://orcid.org/0000-0002-4908-0596"},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Dalla Man","raw_affiliation_strings":["Department of Information Engineering, University of Padova, Padova, Italy"],"raw_orcid":"https://orcid.org/0000-0002-4908-0596","affiliations":[{"raw_affiliation_string":"Department of Information Engineering, University of Padova, Padova, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026228486","display_name":"Claudio Cobelli","orcid":"https://orcid.org/0000-0002-0169-6682"},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudio Cobelli","raw_affiliation_strings":["Department of Information Engineering, University of Padova"],"raw_orcid":"https://orcid.org/0000-0002-0169-6682","affiliations":[{"raw_affiliation_string":"Department of Information Engineering, University of Padova","institution_ids":["https://openalex.org/I138689650"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5022115669"],"corresponding_institution_ids":["https://openalex.org/I138689650"],"apc_list":null,"apc_paid":null,"fwci":1.8547,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.85976483,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"66","issue":"10","first_page":"2889","last_page":"2896"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9894000291824341,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9894000291824341,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6706033945083618},{"id":"https://openalex.org/keywords/dosing","display_name":"Dosing","score":0.5861004590988159},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5564842820167542},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"Type 2 diabetes","score":0.511099636554718},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.4883260428905487},{"id":"https://openalex.org/keywords/insulin-glargine","display_name":"Insulin glargine","score":0.46369612216949463},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.4285953640937805},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3870016634464264},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.35742801427841187},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.21900376677513123},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.15537133812904358},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.10565844178199768},{"id":"https://openalex.org/keywords/biotechnology","display_name":"Biotechnology","score":0.08737695217132568},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.06999394297599792}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6706033945083618},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.5861004590988159},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5564842820167542},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.511099636554718},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4883260428905487},{"id":"https://openalex.org/C2779920387","wikidata":"https://www.wikidata.org/wiki/Q417317","display_name":"Insulin glargine","level":4,"score":0.46369612216949463},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4285953640937805},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3870016634464264},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35742801427841187},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21900376677513123},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.15537133812904358},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10565844178199768},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.08737695217132568},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06999394297599792},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069036","descriptor_name":"Insulin Glargine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000069036","descriptor_name":"Insulin Glargine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000069036","descriptor_name":"Insulin Glargine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000069036","descriptor_name":"Insulin Glargine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000069036","descriptor_name":"Insulin Glargine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000069036","descriptor_name":"Insulin Glargine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049528","descriptor_name":"Insulin, Long-Acting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049528","descriptor_name":"Insulin, Long-Acting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049528","descriptor_name":"Insulin, Long-Acting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/tbme.2019.2897851","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2019.2897851","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:30735983","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30735983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:www.research.unipd.it:11577/3317716","is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/3317716","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5400000214576721,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1849264946","https://openalex.org/W1958010439","https://openalex.org/W2061310674","https://openalex.org/W2062082544","https://openalex.org/W2065510740","https://openalex.org/W2089128745","https://openalex.org/W2099719924","https://openalex.org/W2102783853","https://openalex.org/W2145265693","https://openalex.org/W2180833524","https://openalex.org/W2211234866","https://openalex.org/W2314840118","https://openalex.org/W2322662949","https://openalex.org/W2328332657","https://openalex.org/W2473968961","https://openalex.org/W2520537712","https://openalex.org/W2572287943","https://openalex.org/W2581151970","https://openalex.org/W2596063051","https://openalex.org/W2747023271","https://openalex.org/W2749544044","https://openalex.org/W2770468706","https://openalex.org/W2775079439","https://openalex.org/W2790915589","https://openalex.org/W2946979198"],"related_works":["https://openalex.org/W1563850031","https://openalex.org/W2333605542","https://openalex.org/W2415759662","https://openalex.org/W2966688321","https://openalex.org/W4321334971","https://openalex.org/W3036934084","https://openalex.org/W2056555318","https://openalex.org/W2233866314","https://openalex.org/W4310707532","https://openalex.org/W2622781332"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Glargine":[1],"100":[2],"U/mL":[3,7],"(Gla-100)":[4],"and":[5,42,58,64,78,121,227],"300":[6],"(Gla-300)":[8],"are":[9],"long-acting":[10],"insulin":[11,15],"analogs":[12],"providing":[13],"basal":[14],"supply":[16],"in":[17,109,134,136,171,183,222,241],"multiple":[18],"daily":[19],"injection":[20],"(MDI)":[21],"therapy":[22],"of":[23,54,75,86,149,193,208],"type":[24],"1":[25],"diabetes":[26],"(T1D).":[27],"Both":[28],"insulins":[29,139],"require":[30],"extensive":[31],"testing":[32,201,207],"to":[33,102,127,144,217,230],"arrive":[34],"at":[35,47],"the":[36,83,129,190,194,218],"optimal":[37],"dosing":[38,56],"regimen,":[39],"e.g.,":[40],"timing":[41],"amount.":[43],"Here":[44],"we":[45],"aim":[46],"a":[48,91,124],"simulation":[49,242],"tool":[50],"for":[51,61,107,200],"evaluating":[52],"benefits/risks":[53],"different":[55],"schemes":[57],"up-titration":[59],"rules":[60],"both":[62,76,138],"Gla-100":[63,77,116,155],"Gla-300":[65,79,118,157],"before":[66],"clinical":[67,125,195,214,244],"testing.":[68],"METHODS:":[69],"A":[70,112],"new":[71],"pharmacokinetic":[72],"(PK)":[73],"model":[74],"was":[80,100,119],"incorporated":[81],"into":[82],"FDA-accepted":[84],"University":[85],"Virginia/Padova":[87],"T1D":[88],"simulator:":[89],"Specifically,":[90],"joint":[92],"parameter":[93,98],"distribution,":[94],"built":[95],"from":[96],"PK":[97,105],"estimates,":[99],"used":[101],"generate":[103],"individual":[104],"parametrizations":[106],"each":[108],"silico":[110,137,206,223],"subject.":[111],"virtual":[113],"trial":[114],"comparing":[115],"vs.":[117,156,164,176,243],"performed":[120,140],"assessed":[122],"against":[123],"study":[126],"validate":[128],"glargine":[130,187],"simulator.":[131],"RESULTS:":[132],"Like":[133],"vivo,":[135],"similarly":[141],"with":[142,154],"respect":[143],"glucose":[145,150],"control:":[146],"percent":[147],"time":[148],"between":[151],"[80-140]":[152],"mg/dL":[153],"(primary":[158],"endpoint)":[159],"were":[160],"41.5":[161],"\u00b1":[162,166,174,178],"1.1%":[163],"39.0":[165],"1.2%":[167],"(P":[168,180],"=":[169,181],"0.11)":[170],"silico,":[172],"31.0":[173],"1.6%":[175],"31.8":[177],"1.5%":[179],"0.73)":[182],"vivo.":[184],"CONCLUSIONS:":[185],"The":[186],"simulator":[188],"reproduced":[189],"main":[191],"findings":[192],"trial,":[196],"proving":[197],"its":[198],"validity":[199],"MDI":[202,209],"therapies.":[203],"SIGNIFICANCE:":[204],"In":[205],"therapies":[210],"can":[211],"help":[212],"designing":[213],"trials.":[215],"Due":[216],"more":[219],"standardized":[220,225],"settings":[221],"(e.g.,":[224],"meals":[226],"strict":[228],"adherence":[229],"titration":[231],"rule),":[232],"any":[233],"potential":[234],"treatment":[235],"effect":[236],"is":[237],"reaching":[238],"statistical":[239],"significance":[240],"trial.":[245]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2019-02-21T00:00:00"}
