{"id":"https://openalex.org/W2772982727","doi":"https://doi.org/10.1109/tbme.2017.2783238","title":"Extremum Seeking Control for Personalized Zone Adaptation in Model Predictive Control for Type 1 Diabetes","display_name":"Extremum Seeking Control for Personalized Zone Adaptation in Model Predictive Control for Type 1 Diabetes","publication_year":2017,"publication_date":"2017-12-13","ids":{"openalex":"https://openalex.org/W2772982727","doi":"https://doi.org/10.1109/tbme.2017.2783238","mag":"2772982727","pmid":"https://pubmed.ncbi.nlm.nih.gov/29989925"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2017.2783238","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2017.2783238","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6760655","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012669091","display_name":"Zhixing Cao","orcid":"https://orcid.org/0000-0003-2600-5806"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhixing Cao","raw_affiliation_strings":["Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University"],"raw_orcid":"https://orcid.org/0000-0003-2600-5806","affiliations":[{"raw_affiliation_string":"Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084562136","display_name":"Ravi Gondhalekar","orcid":"https://orcid.org/0000-0003-0797-2470"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Gondhalekar","raw_affiliation_strings":["Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007855159","display_name":"Eyal Dassau","orcid":"https://orcid.org/0000-0001-5333-6892"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eyal Dassau","raw_affiliation_strings":["Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University"],"raw_orcid":"https://orcid.org/0000-0001-5333-6892","affiliations":[{"raw_affiliation_string":"Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081288689","display_name":"Francis J. Doyle","orcid":"https://orcid.org/0000-0002-3293-9114"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis J. Doyle","raw_affiliation_strings":["Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-3293-9114","affiliations":[{"raw_affiliation_string":"Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":2.9758,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.91648187,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"65","issue":"8","first_page":"1859","last_page":"1870"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14083","display_name":"Extremum Seeking Control Systems","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T14083","display_name":"Extremum Seeking Control Systems","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10791","display_name":"Advanced Control Systems Optimization","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.7713894248008728},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.7381396293640137},{"id":"https://openalex.org/keywords/dither","display_name":"Dither","score":0.7340601682662964},{"id":"https://openalex.org/keywords/glycemic","display_name":"Glycemic","score":0.6020506024360657},{"id":"https://openalex.org/keywords/model-predictive-control","display_name":"Model predictive control","score":0.5873376131057739},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.43319547176361084},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.36939042806625366},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.27075958251953125},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2291763722896576},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.19926464557647705},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.17151710391044617},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16096389293670654},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.14152628183364868},{"id":"https://openalex.org/keywords/bandwidth","display_name":"Bandwidth (computing)","score":0.08752524852752686}],"concepts":[{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.7713894248008728},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.7381396293640137},{"id":"https://openalex.org/C70451592","wikidata":"https://www.wikidata.org/wiki/Q376493","display_name":"Dither","level":3,"score":0.7340601682662964},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.6020506024360657},{"id":"https://openalex.org/C172205157","wikidata":"https://www.wikidata.org/wiki/Q1782962","display_name":"Model predictive control","level":3,"score":0.5873376131057739},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43319547176361084},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.36939042806625366},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.27075958251953125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2291763722896576},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.19926464557647705},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.17151710391044617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16096389293670654},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.14152628183364868},{"id":"https://openalex.org/C2776257435","wikidata":"https://www.wikidata.org/wiki/Q1576430","display_name":"Bandwidth (computing)","level":2,"score":0.08752524852752686},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007332","descriptor_name":"Insulin Infusion Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007332","descriptor_name":"Insulin Infusion Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007332","descriptor_name":"Insulin Infusion Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015190","descriptor_name":"Blood Glucose Self-Monitoring","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015190","descriptor_name":"Blood Glucose Self-Monitoring","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015190","descriptor_name":"Blood Glucose Self-Monitoring","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/tbme.2017.2783238","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2017.2783238","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:29989925","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29989925","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:6760655","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6760655","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Biomed Eng","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6760655","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6760655","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Biomed Eng","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1305343510","display_name":null,"funder_award_id":"UC4 DK108483","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1385748843","display_name":null,"funder_award_id":"DP3 DK104057","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G218770630","display_name":null,"funder_award_id":"DP3DK104057","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3975915882","display_name":null,"funder_award_id":"DP3DK094331","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8794413914","display_name":null,"funder_award_id":"DP3 DK094331","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G906191584","display_name":null,"funder_award_id":"UC4DK108483","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1572161815","https://openalex.org/W1602071881","https://openalex.org/W1783970022","https://openalex.org/W1830668443","https://openalex.org/W1983929919","https://openalex.org/W1984371888","https://openalex.org/W2003047848","https://openalex.org/W2012990099","https://openalex.org/W2018771588","https://openalex.org/W2019174039","https://openalex.org/W2026529044","https://openalex.org/W2037208057","https://openalex.org/W2053529196","https://openalex.org/W2072434886","https://openalex.org/W2074952300","https://openalex.org/W2078609652","https://openalex.org/W2081055373","https://openalex.org/W2083218162","https://openalex.org/W2085890234","https://openalex.org/W2095062552","https://openalex.org/W2101901289","https://openalex.org/W2112397727","https://openalex.org/W2116088335","https://openalex.org/W2117748324","https://openalex.org/W2119971695","https://openalex.org/W2123900958","https://openalex.org/W2129995532","https://openalex.org/W2134323508","https://openalex.org/W2140147198","https://openalex.org/W2142962347","https://openalex.org/W2148395500","https://openalex.org/W2158500963","https://openalex.org/W2164640872","https://openalex.org/W2166003201","https://openalex.org/W2167830353","https://openalex.org/W2305852296","https://openalex.org/W2316722220","https://openalex.org/W2410376912","https://openalex.org/W2557289702","https://openalex.org/W2610632420","https://openalex.org/W2623842044","https://openalex.org/W2763814022","https://openalex.org/W2765210196","https://openalex.org/W3104562893","https://openalex.org/W4300443332","https://openalex.org/W6675691178"],"related_works":["https://openalex.org/W2389128124","https://openalex.org/W2364812720","https://openalex.org/W2138725603","https://openalex.org/W1984486060","https://openalex.org/W2050335563","https://openalex.org/W3001913892","https://openalex.org/W2273639645","https://openalex.org/W2050646564","https://openalex.org/W2536702343","https://openalex.org/W1507581877"],"abstract_inverted_index":{"Zone":[0],"model":[1],"predictive":[2],"control":[3],"has":[4,171,187],"proven":[5],"to":[6,12,73],"be":[7,147],"an":[8],"effective":[9],"closed-loop":[10],"method":[11,162,186],"regulate":[13],"blood":[14,81],"glucose":[15,62,67,82],"for":[16,33,37,155],"people":[17],"with":[18],"type":[19],"1":[20],"diabetes":[21],"(T1D).":[22],"In":[23],"this":[24],"paper,":[25],"we":[26],"present":[27],"a":[28,46,65,79,127,132,150],"universal":[29],"model-free":[30],"optimization":[31],"scheme":[32],"adapting":[34],"the":[35,101,116,121,142,160,164,175,184],"zone":[36,102,145,166],"T1D":[38],"patients":[39],"individually.":[40],"The":[41,69,90],"adaptation":[42,91,122],"is":[43,59,72,93,180],"based":[44,94],"on":[45,95],"clinical":[47,177],"glycemic":[48,54],"risk":[49],"index":[50,56],"named":[51],"relative":[52],"regularized":[53],"penalty":[55],"(rrGPI),":[57],"which":[58,100,170],"calculated":[60],"from":[61],"measurements":[63],"by":[64,76,106,110],"continuous":[66],"monitor.":[68],"scheme's":[70],"objective":[71],"minimize":[74],"rrGPI":[75,117],"simultaneously":[77],"modulating":[78,113],"controller's":[80],"target":[83],"zone's":[84],"upper":[85],"bound":[86],"and":[87,114,131,157],"lower":[88],"bound.":[89],"mechanism":[92],"extremum":[96],"seeking":[97],"control,":[98],"in":[99,174],"boundaries":[103],"are":[104,136],"driven":[105],"gradient":[107],"estimation":[108],"obtained":[109],"continuously":[111],"sinusoidally":[112],"demodulating":[115],"readings.":[118],"To":[119],"improve":[120],"method's":[123],"robustness":[124,189],"against":[125,190],"uncertainties,":[126],"decaying":[128],"feedback":[129],"gain":[130],"vanishing":[133],"dither":[134],"signal":[135],"employed.":[137],"in-silico":[138],"trials":[139],"suggested":[140],"that":[141,183],"personalized":[143],"optimized":[144],"can":[146],"reached":[148],"within":[149],"week":[151],"of":[152],"adaptation.":[153],"Both":[154],"announced":[156],"unannounced":[158],"meals,":[159],"proposed":[161],"outperforms":[163],"fixed":[165],"[80,":[167],"140]":[168],"mg/dL,":[169],"been":[172],"employed":[173],"authors'":[176],"trials.":[178],"It":[179],"also":[181],"shown":[182],"developed":[185],"strong":[188],"real-life":[191],"uncertainties.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
