{"id":"https://openalex.org/W2768964688","doi":"https://doi.org/10.1109/tbme.2017.2773463","title":"A Three-Dimensional Arrayed Microfluidic Blood\u2013Brain Barrier Model With Integrated Electrical Sensor Array","display_name":"A Three-Dimensional Arrayed Microfluidic Blood\u2013Brain Barrier Model With Integrated Electrical Sensor Array","publication_year":2017,"publication_date":"2017-11-14","ids":{"openalex":"https://openalex.org/W2768964688","doi":"https://doi.org/10.1109/tbme.2017.2773463","mag":"2768964688","pmid":"https://pubmed.ncbi.nlm.nih.gov/29346110"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2017.2773463","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2017.2773463","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11233983","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073974249","display_name":"Sehoon Jeong","orcid":"https://orcid.org/0000-0003-4174-0219"},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sehoon Jeong","raw_affiliation_strings":["Department of Biomedical Engineering, Department of Healthcare Information Techno-logy, Inje University"],"raw_orcid":"https://orcid.org/0000-0003-4174-0219","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Department of Healthcare Information Techno-logy, Inje University","institution_ids":["https://openalex.org/I104338594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103285048","display_name":"Sun-Ja Kim","orcid":"https://orcid.org/0000-0002-8457-7442"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunja Kim","raw_affiliation_strings":["Department of Veterinary Integrative Biosciences, Texas A&M University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences, Texas A&M University","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042076379","display_name":"John Edward Buonocore","orcid":"https://orcid.org/0000-0002-9444-7430"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Buonocore","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Texas A&M University"],"raw_orcid":"https://orcid.org/0000-0002-9444-7430","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Texas A&M University","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064688250","display_name":"Jaewon Park","orcid":"https://orcid.org/0000-0002-5704-726X"},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jaewon Park","raw_affiliation_strings":["Department of Electrical and Electronic Engineering, Southern University of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Electronic Engineering, Southern University of Science and Technology","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017988705","display_name":"C. Jane Welsh","orcid":"https://orcid.org/0000-0001-9659-8032"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Jane Welsh","raw_affiliation_strings":["Department of Veterinary Integrative Biosciences, Texas A&M University"],"raw_orcid":"https://orcid.org/0000-0001-9659-8032","affiliations":[{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences, Texas A&M University","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100627205","display_name":"Jianrong Li","orcid":"https://orcid.org/0000-0002-8232-9322"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianrong Li","raw_affiliation_strings":["Department of Veterinary Integrative Biosciences, Texas A&M University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences, Texas A&M University","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084191089","display_name":"Arum Han","orcid":"https://orcid.org/0000-0002-9223-8301"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arum Han","raw_affiliation_strings":["Department of Biomedical Engineering and the Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, USA"],"raw_orcid":"https://orcid.org/0000-0002-9223-8301","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and the Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.3699,"has_fulltext":false,"cited_by_count":150,"citation_normalized_percentile":{"value":0.96364007,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"65","issue":"2","first_page":"431","last_page":"439"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.879800021648407,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.879800021648407,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.07530000060796738,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.7690441608428955},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.7609071731567383},{"id":"https://openalex.org/keywords/blood\u2013brain-barrier","display_name":"Blood\u2013brain barrier","score":0.7277366518974304},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4718981683254242},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.4378511905670166},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.4317145347595215},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.4114043712615967},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.29927337169647217},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.26254650950431824},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19181227684020996},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.12918564677238464},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.12888231873512268}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7690441608428955},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.7609071731567383},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.7277366518974304},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4718981683254242},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4378511905670166},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4317145347595215},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4114043712615967},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.29927337169647217},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26254650950431824},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19181227684020996},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.12918564677238464},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12888231873512268},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/tbme.2017.2773463","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2017.2773463","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:29346110","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29346110","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11233983","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11233983","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Biomed Eng","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11233983","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11233983","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Biomed Eng","raw_type":"Text"},"sustainable_development_goals":[{"score":0.5600000023841858,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G3281339790","display_name":null,"funder_award_id":"R21 EB021005","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1465270826","https://openalex.org/W1539961074","https://openalex.org/W1574424832","https://openalex.org/W1678960821","https://openalex.org/W1847104216","https://openalex.org/W1968150858","https://openalex.org/W1979770296","https://openalex.org/W1994504773","https://openalex.org/W1994812037","https://openalex.org/W2007704622","https://openalex.org/W2010546163","https://openalex.org/W2015541518","https://openalex.org/W2024170393","https://openalex.org/W2031483215","https://openalex.org/W2041848964","https://openalex.org/W2067349066","https://openalex.org/W2070634905","https://openalex.org/W2081135553","https://openalex.org/W2084256007","https://openalex.org/W2091680093","https://openalex.org/W2094091345","https://openalex.org/W2103825400","https://openalex.org/W2104209550","https://openalex.org/W2114808045","https://openalex.org/W2116759862","https://openalex.org/W2133057534","https://openalex.org/W2144754434","https://openalex.org/W2154423876","https://openalex.org/W2157700724","https://openalex.org/W2162913942","https://openalex.org/W2172084436","https://openalex.org/W2333671040","https://openalex.org/W6637355711"],"related_works":["https://openalex.org/W2138350991","https://openalex.org/W1566729005","https://openalex.org/W2409285845","https://openalex.org/W2434195791","https://openalex.org/W1994342570","https://openalex.org/W2562771455","https://openalex.org/W2054843986","https://openalex.org/W2116210813","https://openalex.org/W2440701365","https://openalex.org/W2433842723"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,142,226],"blood-brain":[2],"barrier":[3,121,146,186],"(BBB)":[4],"poses":[5],"a":[6,44,59,95,98],"unique":[7],"challenge":[8],"to":[9,18,21,79,102,148,177,202,233],"the":[10,24,66,104,120,133,145,178,213,220],"development":[11],"of":[12,23,119,180],"therapeutics":[13],"against":[14],"neurological":[15],"disorders":[16],"due":[17],"its":[19],"impermeabi-lity":[20],"most":[22],"chemical":[25],"compounds.":[26],"Most":[27],"in":[28,34,36,67,74,132,137,170,221],"vitro":[29],"BBB":[30,92,215,223,229,246],"models":[31],"have":[32],"limitations":[33],"mimicking":[35],"vivo":[37,68,75,138,171,222],"conditions":[38],"and":[39,55,127,164,183],"functions.":[40],"Here,":[41],"we":[42],"show":[43,211],"co-culture":[45],"microfluidic":[46],"BBB-on-a-chip":[47],"that":[48,212],"provides":[49],"interactions":[50],"between":[51,162],"neurovascular":[52],"endothelial":[53,125,165,199],"cells":[54,57,126,200],"neuronal":[56],"across":[58],"porous":[60],"polycarbonate":[61],"membrane,":[62],"which":[63,114],"better":[64],"mimics":[65,219],"conditions,":[69],"as":[70,72,156,158,167,169,247,249],"well":[71,157,168,248],"allows":[73,115,144],"level":[76,139,172],"shear":[77,140,173],"stress":[78,174],"be":[80,149,234],"applied.":[81],"METHODS:":[82],"A":[83],"4":[84,86],"\u00d7":[85],"intersecting":[87],"microchannel":[88],"array":[89,100],"forms":[90],"16":[91,111],"sites":[93],"on":[94],"chip,":[96],"with":[97,191],"multielectrode":[99],"integrated":[101],"measure":[103],"transendothelial":[105],"electrical":[106],"resistance":[107],"(TEER)":[108],"from":[109],"all":[110],"different":[112],"sites,":[113],"label-free":[116],"real-time":[117],"analysis":[118],"function.":[122],"Primary":[123],"mouse":[124],"primary":[128],"astrocytes":[129,163],"were":[130],"co-cultured":[131],"chip":[134,143,216,230],"while":[135],"applying":[136],"stress.":[141],"function":[147],"analyzed":[150],"through":[151,245],"TEER":[152],"measurement,":[153],"dextran":[154],"permeability,":[155],"immunostaining.":[159],"RESULTS:":[160],"Co-culture":[161],"cells,":[166],"applied,":[175],"led":[176],"formation":[179],"tighter":[181],"junctions":[182],"significantly":[184],"lower":[185],"permeability.":[187],"Moreover,":[188],"drug":[189,238],"testing":[190],"histamine":[192],"showed":[193],"increased":[194],"permeability":[195,244],"when":[196,206],"using":[197,207],"only":[198],"compared":[201],"almost":[203],"no":[204],"change":[205],"co-culture.":[208],"CONCLUSION:":[209],"Results":[210],"developed":[214,227],"more":[217,240],"closely":[218],"environment.":[224],"SIGNIFICANCE:":[225],"multisite":[228],"is":[231],"expected":[232],"used":[235],"for":[236],"screening":[237],"by":[239],"accurately":[241],"predicting":[242],"their":[243,250],"toxicity.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":24},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":5}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}