{"id":"https://openalex.org/W2768695164","doi":"https://doi.org/10.1109/tbme.2017.2771943","title":"Modeling of Electroporation Induced by Pulsed Electric Fields in Irregularly Shaped Cells","display_name":"Modeling of Electroporation Induced by Pulsed Electric Fields in Irregularly Shaped Cells","publication_year":2017,"publication_date":"2017-11-13","ids":{"openalex":"https://openalex.org/W2768695164","doi":"https://doi.org/10.1109/tbme.2017.2771943","mag":"2768695164","pmid":"https://pubmed.ncbi.nlm.nih.gov/29346108"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2017.2771943","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2017.2771943","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055835548","display_name":"Luciano Mescia","orcid":"https://orcid.org/0000-0002-2339-1214"},"institutions":[{"id":"https://openalex.org/I68618741","display_name":"Polytechnic University of Bari","ror":"https://ror.org/03c44v465","country_code":"IT","type":"education","lineage":["https://openalex.org/I68618741"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Luciano Mescia","raw_affiliation_strings":["Department of Electrical and Information Engineering, Politecnico di Bari, Bari, Italy"],"raw_orcid":"https://orcid.org/0000-0002-2339-1214","affiliations":[{"raw_affiliation_string":"Department of Electrical and Information Engineering, Politecnico di Bari, Bari, Italy","institution_ids":["https://openalex.org/I68618741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110617344","display_name":"Michele Alessandro Chiapperino","orcid":null},"institutions":[{"id":"https://openalex.org/I68618741","display_name":"Polytechnic University of Bari","ror":"https://ror.org/03c44v465","country_code":"IT","type":"education","lineage":["https://openalex.org/I68618741"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele A. Chiapperino","raw_affiliation_strings":["Department of Electrical and Information Engineering, Politecnico di Bari"],"raw_orcid":"https://orcid.org/0000-0002-4536-3839","affiliations":[{"raw_affiliation_string":"Department of Electrical and Information Engineering, Politecnico di Bari","institution_ids":["https://openalex.org/I68618741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049112163","display_name":"Pietro Bia","orcid":"https://orcid.org/0000-0003-3598-2182"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pietro Bia","raw_affiliation_strings":["EmTeSys Srl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EmTeSys Srl","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037636771","display_name":"Johan Gielis","orcid":"https://orcid.org/0000-0002-4536-3839"},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Johan Gielis","raw_affiliation_strings":["Department of Bioengineering, University of Antwerp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Antwerp","institution_ids":["https://openalex.org/I149213910"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071391895","display_name":"Diego Caratelli","orcid":"https://orcid.org/0000-0003-0969-884X"},"institutions":[{"id":"https://openalex.org/I196355604","display_name":"National Research Tomsk State University","ror":"https://ror.org/02he2nc27","country_code":"RU","type":"education","lineage":["https://openalex.org/I196355604"]},{"id":"https://openalex.org/I30849647","display_name":"Tomsk Polytechnic University","ror":"https://ror.org/00a45v709","country_code":"RU","type":"education","lineage":["https://openalex.org/I30849647"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Diego Caratelli","raw_affiliation_strings":["Antenna Company Nederland BV, and also with the Institute of Cybernetics, Tomsk Polytechnic University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Antenna Company Nederland BV, and also with the Institute of Cybernetics, Tomsk Polytechnic University","institution_ids":["https://openalex.org/I196355604","https://openalex.org/I30849647"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5055835548"],"corresponding_institution_ids":["https://openalex.org/I68618741"],"apc_list":null,"apc_paid":null,"fwci":3.2744,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.91332036,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"65","issue":"2","first_page":"414","last_page":"423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11920","display_name":"Pulsed Power Technology Applications","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electroporation","display_name":"Electroporation","score":0.7682343125343323},{"id":"https://openalex.org/keywords/electric-field","display_name":"Electric field","score":0.5944638848304749},{"id":"https://openalex.org/keywords/dielectric","display_name":"Dielectric","score":0.5776786804199219},{"id":"https://openalex.org/keywords/debye","display_name":"Debye","score":0.5518591403961182},{"id":"https://openalex.org/keywords/pulse","display_name":"Pulse (music)","score":0.48216909170150757},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.4767637848854065},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4595462679862976},{"id":"https://openalex.org/keywords/dispersion","display_name":"Dispersion (optics)","score":0.44034892320632935},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.4274235665798187},{"id":"https://openalex.org/keywords/numerical-analysis","display_name":"Numerical analysis","score":0.42589807510375977},{"id":"https://openalex.org/keywords/voltage","display_name":"Voltage","score":0.4013896584510803},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.34258055686950684},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.30601298809051514},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.2540454864501953},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.20759785175323486},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.19577556848526},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.19271200895309448},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.19176098704338074},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1699405014514923},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.1528470516204834},{"id":"https://openalex.org/keywords/condensed-matter-physics","display_name":"Condensed matter physics","score":0.11493805050849915}],"concepts":[{"id":"https://openalex.org/C186852380","wikidata":"https://www.wikidata.org/wiki/Q1142521","display_name":"Electroporation","level":3,"score":0.7682343125343323},{"id":"https://openalex.org/C60799052","wikidata":"https://www.wikidata.org/wiki/Q46221","display_name":"Electric field","level":2,"score":0.5944638848304749},{"id":"https://openalex.org/C133386390","wikidata":"https://www.wikidata.org/wiki/Q184996","display_name":"Dielectric","level":2,"score":0.5776786804199219},{"id":"https://openalex.org/C40899509","wikidata":"https://www.wikidata.org/wiki/Q40603","display_name":"Debye","level":2,"score":0.5518591403961182},{"id":"https://openalex.org/C2780167933","wikidata":"https://www.wikidata.org/wiki/Q1550652","display_name":"Pulse (music)","level":3,"score":0.48216909170150757},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.4767637848854065},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4595462679862976},{"id":"https://openalex.org/C177562468","wikidata":"https://www.wikidata.org/wiki/Q182893","display_name":"Dispersion (optics)","level":2,"score":0.44034892320632935},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.4274235665798187},{"id":"https://openalex.org/C48753275","wikidata":"https://www.wikidata.org/wiki/Q11216","display_name":"Numerical analysis","level":2,"score":0.42589807510375977},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.4013896584510803},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.34258055686950684},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.30601298809051514},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2540454864501953},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.20759785175323486},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.19577556848526},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.19271200895309448},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.19176098704338074},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1699405014514923},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.1528470516204834},{"id":"https://openalex.org/C26873012","wikidata":"https://www.wikidata.org/wiki/Q214781","display_name":"Condensed matter physics","level":1,"score":0.11493805050849915},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016062","descriptor_name":"Porosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016062","descriptor_name":"Porosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016062","descriptor_name":"Porosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018274","descriptor_name":"Electroporation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018274","descriptor_name":"Electroporation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018274","descriptor_name":"Electroporation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbme.2017.2771943","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2017.2771943","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:29346108","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29346108","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W2018666833","https://openalex.org/W2018824785","https://openalex.org/W2043239560","https://openalex.org/W2072348685","https://openalex.org/W2101316489","https://openalex.org/W2107919027","https://openalex.org/W2124100122","https://openalex.org/W2131067660","https://openalex.org/W2139448638","https://openalex.org/W2141270723","https://openalex.org/W2157308816","https://openalex.org/W2166621815","https://openalex.org/W2171678352","https://openalex.org/W2223822801","https://openalex.org/W2261785050","https://openalex.org/W2275938793","https://openalex.org/W2288941897","https://openalex.org/W2318420489","https://openalex.org/W2419210035","https://openalex.org/W2557134892","https://openalex.org/W2558531492","https://openalex.org/W2606109717","https://openalex.org/W2724160455","https://openalex.org/W2889911854","https://openalex.org/W4237067690","https://openalex.org/W4300992240"],"related_works":["https://openalex.org/W1979717110","https://openalex.org/W4207000166","https://openalex.org/W3145994936","https://openalex.org/W2019248278","https://openalex.org/W2415180729","https://openalex.org/W2554612520","https://openalex.org/W3103057355","https://openalex.org/W2085582759","https://openalex.org/W4231714208","https://openalex.org/W2001301033"],"abstract_inverted_index":{"During":[0],"the":[1,4,19,37,63,70,83,87,92,99,102,118,124,152,155,158,162,168,179,189],"past":[2],"decades,":[3],"poration":[5],"of":[6,22,39,72,98,117,150,154],"cell":[7,103,119,137,143],"membrane":[8],"induced":[9],"by":[10,107,122],"pulsed":[11],"electric":[12,164],"fields":[13],"has":[14,56,104,171],"been":[15,28,57,105,145,172],"widely":[16],"investigated.":[17,146],"Since":[18],"basic":[20],"mechanisms":[21],"this":[23,46],"process":[24,170],"have":[25,144],"not":[26],"yet":[27],"fully":[29],"clarified,":[30],"many":[31],"research":[32],"activities":[33],"are":[34],"focused":[35],"on":[36,82,167],"development":[38],"suitable":[40],"theoretical":[41],"and":[42,52,59,66,86,141,161],"numerical":[43,54,175,185],"models.":[44],"To":[45],"end,":[47],"a":[48,109],"nonlinear,":[49],"nonlocal,":[50],"dispersive,":[51],"space-time":[53],"algorithm":[55],"developed":[58],"adopted":[60],"to":[61,131,187],"evaluate":[62],"transmembrane":[64],"voltage":[65],"pore":[67,93],"density":[68],"along":[69],"perimeter":[71],"realistic":[73],"irregularly":[74],"shaped":[75],"cells.":[76,194],"The":[77,95,114,174],"presented":[78],"model":[79,181],"is":[80,120,182],"based":[81],"Maxwell's":[84],"equations":[85],"asymptotic":[88],"Smoluchowski's":[89],"equation":[90],"describing":[91],"dynamics.":[94],"dielectric":[96,159],"dispersion":[97],"media":[100],"forming":[101],"modeled":[106],"using":[108,123],"general":[110],"multirelaxation":[111],"Debye-based":[112],"formulation.":[113],"irregular":[115],"shape":[116],"described":[121],"Gielis'":[125],"superformula.":[126],"Different":[127],"test":[128],"cases":[129],"pertaining":[130],"red":[132],"blood":[133],"cells,":[134,136],"muscular":[135],"in":[138,192],"mitosis":[139],"phase,":[140],"cancer-like":[142],"For":[147],"each":[148],"type":[149],"cell,":[151],"influence":[153],"relevant":[156],"shape,":[157],"properties,":[160],"external":[163],"pulse":[165],"characteristics":[166],"electroporation":[169,190],"analyzed.":[173],"results":[176],"demonstrate":[177],"that":[178],"proposed":[180],"an":[183],"efficient":[184],"tool":[186],"study":[188],"problem":[191],"arbitrary-shaped":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}