{"id":"https://openalex.org/W2753476744","doi":"https://doi.org/10.1109/tbme.2017.2748798","title":"Identification of Ion Currents Components Generating Field Potential Recorded in MEA From hiPSC-CM","display_name":"Identification of Ion Currents Components Generating Field Potential Recorded in MEA From hiPSC-CM","publication_year":2017,"publication_date":"2017-09-04","ids":{"openalex":"https://openalex.org/W2753476744","doi":"https://doi.org/10.1109/tbme.2017.2748798","mag":"2753476744","pmid":"https://pubmed.ncbi.nlm.nih.gov/28880155"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2017.2748798","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2017.2748798","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hal.science/hal-01570341","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052433374","display_name":"Fabien Raphel","orcid":"https://orcid.org/0000-0002-3994-7555"},"institutions":[{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fabien Raphel","raw_affiliation_strings":["Inria Paris and Sorbonne Universit\u00e9s UPMC","REO - Numerical simulation of biological flows (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inria Paris and Sorbonne Universit\u00e9s UPMC","institution_ids":["https://openalex.org/I39804081"]},{"raw_affiliation_string":"REO - Numerical simulation of biological flows (France)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083874563","display_name":"Muriel Boulakia","orcid":"https://orcid.org/0000-0001-8087-9075"},"institutions":[{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Muriel Boulakia","raw_affiliation_strings":["Inria Paris and Sorbonne Universit\u00e9s UPMC","REO - Numerical simulation of biological flows (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inria Paris and Sorbonne Universit\u00e9s UPMC","institution_ids":["https://openalex.org/I39804081"]},{"raw_affiliation_string":"REO - Numerical simulation of biological flows (France)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018473282","display_name":"N\u00e9jib Zemzemi","orcid":"https://orcid.org/0000-0002-1212-8090"},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4210126950","display_name":"Laboratoire de recherche en cardiovasculaire, m\u00e9tabolisme, diab\u00e9tologie et nutrition","ror":"https://ror.org/03bbjky47","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210088668","https://openalex.org/I4210100596","https://openalex.org/I4210126950"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nejib Zemzemi","raw_affiliation_strings":["Inria Bordeaux, Universit\u00e9 Bordeaux 1","CARMEN - Mod\u00e9lisation et calculs pour l'\u00e9lectrophysiologie cardiaque (200, avenue de la Vieille Tour \r\n33405 Talence cedex - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inria Bordeaux, Universit\u00e9 Bordeaux 1","institution_ids":["https://openalex.org/I15057530"]},{"raw_affiliation_string":"CARMEN - Mod\u00e9lisation et calculs pour l'\u00e9lectrophysiologie cardiaque (200, avenue de la Vieille Tour \r\n33405 Talence cedex - France)","institution_ids":["https://openalex.org/I4210126950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062037573","display_name":"Yves Coudi\u00e8re","orcid":"https://orcid.org/0000-0003-2687-3232"},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4210126950","display_name":"Laboratoire de recherche en cardiovasculaire, m\u00e9tabolisme, diab\u00e9tologie et nutrition","ror":"https://ror.org/03bbjky47","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210088668","https://openalex.org/I4210100596","https://openalex.org/I4210126950"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yves Coudiere","raw_affiliation_strings":["Inria Bordeaux, Universit\u00e9 Bordeaux 1","CARMEN - Mod\u00e9lisation et calculs pour l'\u00e9lectrophysiologie cardiaque (200, avenue de la Vieille Tour \r\n33405 Talence cedex - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inria Bordeaux, Universit\u00e9 Bordeaux 1","institution_ids":["https://openalex.org/I15057530"]},{"raw_affiliation_string":"CARMEN - Mod\u00e9lisation et calculs pour l'\u00e9lectrophysiologie cardiaque (200, avenue de la Vieille Tour \r\n33405 Talence cedex - France)","institution_ids":["https://openalex.org/I4210126950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110445510","display_name":"Jean\u2010Michel Guillon","orcid":null},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Michel Guillon","raw_affiliation_strings":["Sanofi R&D, Preclinical Safety","Sanofi-Aventis R&D (France)"],"raw_orcid":"https://orcid.org/0000-0002-4522-4329","affiliations":[{"raw_affiliation_string":"Sanofi R&D, Preclinical Safety","institution_ids":["https://openalex.org/I3018075036"]},{"raw_affiliation_string":"Sanofi-Aventis R&D (France)","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062303486","display_name":"Philippe Zitoun","orcid":null},"institutions":[{"id":"https://openalex.org/I4210116453","display_name":"H\u00f4pital Ren\u00e9 Huguenin","ror":"https://ror.org/0263jp665","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210116453"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philippe Zitoun","raw_affiliation_strings":["LIPZ, La Celle Saint Cloud","LIPZ [La Celle Saint-Cloud] (11 all\u00e9e de Pavillonne 78170 La Celle Saint-Cloud - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LIPZ, La Celle Saint Cloud","institution_ids":[]},{"raw_affiliation_string":"LIPZ [La Celle Saint-Cloud] (11 all\u00e9e de Pavillonne 78170 La Celle Saint-Cloud - France)","institution_ids":["https://openalex.org/I4210116453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030634379","display_name":"Jean-Fr\u00e9d\u00e9ric Gerbeau","orcid":"https://orcid.org/0000-0002-4522-4329"},"institutions":[{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Frederic Gerbeau","raw_affiliation_strings":["Sorbonne Universit\u00e9s UPMC, Paris, France","REO - Numerical simulation of biological flows (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorbonne Universit\u00e9s UPMC, Paris, France","institution_ids":["https://openalex.org/I39804081"]},{"raw_affiliation_string":"REO - Numerical simulation of biological flows (France)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7962,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.86965578,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"65","issue":"6","first_page":"1311","last_page":"1319"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.803600013256073,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.803600013256073,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.03799999877810478,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.026599999517202377,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/safety-pharmacology","display_name":"Safety pharmacology","score":0.7845933437347412},{"id":"https://openalex.org/keywords/cardiac-electrophysiology","display_name":"Cardiac electrophysiology","score":0.5855647921562195},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49563491344451904},{"id":"https://openalex.org/keywords/reliability","display_name":"Reliability (semiconductor)","score":0.421468585729599},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4150928854942322},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.4010753035545349},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.33650970458984375},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.2687710225582123},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.23915061354637146},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.21573451161384583},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.19543179869651794},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.14086538553237915},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.09949824213981628}],"concepts":[{"id":"https://openalex.org/C2776190711","wikidata":"https://www.wikidata.org/wiki/Q7398663","display_name":"Safety pharmacology","level":3,"score":0.7845933437347412},{"id":"https://openalex.org/C61381695","wikidata":"https://www.wikidata.org/wiki/Q3302130","display_name":"Cardiac electrophysiology","level":3,"score":0.5855647921562195},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49563491344451904},{"id":"https://openalex.org/C43214815","wikidata":"https://www.wikidata.org/wiki/Q7310987","display_name":"Reliability (semiconductor)","level":3,"score":0.421468585729599},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4150928854942322},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.4010753035545349},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.33650970458984375},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.2687710225582123},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.23915061354637146},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.21573451161384583},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.19543179869651794},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.14086538553237915},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09949824213981628},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022062","descriptor_name":"Electrophysiologic Techniques, Cardiac","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D022062","descriptor_name":"Electrophysiologic Techniques, Cardiac","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D022062","descriptor_name":"Electrophysiologic Techniques, Cardiac","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1109/tbme.2017.2748798","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2017.2748798","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:28880155","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28880155","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:HAL:hal-01570341v1","is_oa":true,"landing_page_url":"https://hal.science/hal-01570341","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Transactions on Biomedical Engineering, 2018, 65 (6), pp.1311-1319. ⟨10.1109/TBME.2017.2748798⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:oskar-bordeaux.fr:20.500.12278/10093","is_oa":false,"landing_page_url":"https://oskar-bordeaux.fr/handle/20.500.12278/10093","pdf_url":null,"source":{"id":"https://openalex.org/S4306402569","display_name":"Oskar-Bordeaux (Universite de Bordeaux)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article de revue"},{"id":"pmh:oai:oskar-bordeaux.fr:20.500.12278/193603","is_oa":false,"landing_page_url":"https://oskar-bordeaux.fr/handle/20.500.12278/193603","pdf_url":null,"source":{"id":"https://openalex.org/S4306402569","display_name":"Oskar-Bordeaux (Universite de Bordeaux)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article de revue"}],"best_oa_location":{"id":"pmh:oai:HAL:hal-01570341v1","is_oa":true,"landing_page_url":"https://hal.science/hal-01570341","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Transactions on Biomedical Engineering, 2018, 65 (6), pp.1311-1319. ⟨10.1109/TBME.2017.2748798⟩","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5400000214576721,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G3691427375","display_name":"Modeling, simulation and signal processing in cardiac electrophysiology","funder_award_id":"ANR-13-LAB1-0007","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G3898789594","display_name":"Agency for mathematics in interaction with enterprise and society","funder_award_id":"ANR-10-LABX-0002","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W770729784","https://openalex.org/W1537346681","https://openalex.org/W1875475552","https://openalex.org/W1967691413","https://openalex.org/W1974119618","https://openalex.org/W1988921083","https://openalex.org/W1996054423","https://openalex.org/W2026373503","https://openalex.org/W2041417176","https://openalex.org/W2050186707","https://openalex.org/W2073642788","https://openalex.org/W2112036188","https://openalex.org/W2115765852","https://openalex.org/W2117861704","https://openalex.org/W2130139165","https://openalex.org/W2130321115","https://openalex.org/W2166751342","https://openalex.org/W2301766505","https://openalex.org/W2408343415","https://openalex.org/W2564910367","https://openalex.org/W2745870743","https://openalex.org/W4206852369","https://openalex.org/W6730726465","https://openalex.org/W6806735319"],"related_works":["https://openalex.org/W2547209687","https://openalex.org/W4386031580","https://openalex.org/W4388455436","https://openalex.org/W4386027199","https://openalex.org/W4388455513","https://openalex.org/W4388455419","https://openalex.org/W4386027200","https://openalex.org/W4386027210","https://openalex.org/W4388455503","https://openalex.org/W4388463295"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Multi":[1],"electrodes":[2],"arrays":[3],"(MEAs)":[4],"combined":[5],"with":[6,155],"cardiomyocytes":[7],"derived":[8],"from":[9,36],"human-induced":[10],"pluripotent":[11],"stem":[12],"cells":[13],"(hiPSC-CMs)":[14],"can":[15],"enable":[16],"high-":[17],"or":[18],"medium-throughput":[19],"drug":[20,206],"screening":[21],"in":[22,34,98,151],"safety":[23,175],"pharmacology.":[24,176],"This":[25],"technology":[26,193],"has":[27],"recently":[28],"attracted":[29],"a":[30,57,86,163,167,179],"lot":[31],"of":[32,111,174,183,205],"attention,":[33],"particular":[35],"an":[37,93,109],"international":[38],"initiative":[39],"named":[40],"CiPA.":[41],"But":[42],"it":[43],"is":[44,80,115],"currently":[45],"limited":[46],"by":[47,64,74,118,171],"the":[48,52,61,65,71,75,83,89,145,172,184,192],"difficulty":[49],"to":[50,59,68,131,166,190],"analyze":[51,60],"measured":[53],"signals.":[54],"We":[55],"propose":[56],"strategy":[58,161],"signals":[62,101,121],"acquired":[63],"MEA":[66,90,100,196],"and":[67,92,108,138,143,147,197,203],"automatically":[69],"deduce":[70],"channels":[72],"affected":[73],"drug.":[76],"METHODS:":[77],"Our":[78],"method":[79],"based":[81,194],"on":[82,195],"bidomain":[84],"equations,":[85],"model":[87],"for":[88,104,123,135],"electrodes,":[91],"inverse":[94],"problem":[95],"strategy.":[96],"RESULTS:":[97],"silico":[99],"are":[102,150],"obtained":[103,122],"two":[105],"commercial":[106],"devices":[107],"example":[110],"early":[112],"after":[113],"depolarization":[114],"presented.":[116],"Then,":[117],"processing":[119],"real":[120],"four":[124],"different":[125],"compounds,":[126],"our":[127,186],"algorithm":[128],"was":[129],"able":[130],"provide":[132],"dose-response":[133,148],"curves":[134,149],"potassium,":[136],"sodium,":[137],"calcium":[139],"channels.":[140],"For":[141],"ivabradine":[142],"moxifloxacin,":[144],"IC50":[146],"very":[152],"good":[153],"agreement":[154],"known":[156],"values.":[157],"SIGNIFICANCE:":[158],"The":[159],"proposed":[160],"offers":[162],"possible":[164],"answer":[165],"major":[168],"question":[169],"raised":[170],"community":[173],"By":[177],"allowing":[178],"more":[180],"automated":[181],"analysis":[182],"signals,":[185],"approach":[187],"could":[188],"contribute":[189],"promote":[191],"hiPSC-CMs":[198],"and,":[199],"therefore,":[200],"improve":[201],"reliability":[202],"efficiency":[204],"screening.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}