{"id":"https://openalex.org/W2562046671","doi":"https://doi.org/10.1109/tbme.2016.2639468","title":"Neurogenesis Enhances Response Specificity to Spatial Pattern Stimulation in Hippocampal Cultures","display_name":"Neurogenesis Enhances Response Specificity to Spatial Pattern Stimulation in Hippocampal Cultures","publication_year":2016,"publication_date":"2016-12-14","ids":{"openalex":"https://openalex.org/W2562046671","doi":"https://doi.org/10.1109/tbme.2016.2639468","mag":"2562046671","pmid":"https://pubmed.ncbi.nlm.nih.gov/28113197"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2016.2639468","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2016.2639468","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000183701","display_name":"Yukimi Tanaka","orcid":"https://orcid.org/0000-0003-3669-2099"},"institutions":[{"id":"https://openalex.org/I205924995","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I1319490839","https://openalex.org/I205924995"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yukimi Tanaka","raw_affiliation_strings":["Department of Human and Engineered Environmental Studies, Graduate School of Frontier Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan","Research Fellows with the Japan Society for the Promotion of Science"],"affiliations":[{"raw_affiliation_string":"Department of Human and Engineered Environmental Studies, Graduate School of Frontier Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Research Fellows with the Japan Society for the Promotion of Science","institution_ids":["https://openalex.org/I205924995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066085950","display_name":"Takuya Isomura","orcid":"https://orcid.org/0000-0003-2960-4919"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Isomura","raw_affiliation_strings":["Department of Human and Engineered Environmental Studies, Graduate School of Frontier Sciences, The University of Tokyo"],"affiliations":[{"raw_affiliation_string":"Department of Human and Engineered Environmental Studies, Graduate School of Frontier Sciences, The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090447356","display_name":"Kenta Shimba","orcid":"https://orcid.org/0000-0003-1156-260X"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenta Shimba","raw_affiliation_strings":["Department of Human and Engineered Environmental Studies, Graduate School of Frontier Sciences, The University of Tokyo"],"affiliations":[{"raw_affiliation_string":"Department of Human and Engineered Environmental Studies, Graduate School of Frontier Sciences, The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108832608","display_name":"Kiyoshi Kotani","orcid":null},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Kotani","raw_affiliation_strings":["Research Center for Advanced Science and Technology, The University of Tokyo"],"affiliations":[{"raw_affiliation_string":"Research Center for Advanced Science and Technology, The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032635092","display_name":"Yasuhiko Jimbo","orcid":"https://orcid.org/0009-0004-6005-5043"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiko Jimbo","raw_affiliation_strings":["Department of Precision Engineering, School of Engineering, The University of Tokyo"],"affiliations":[{"raw_affiliation_string":"Department of Precision Engineering, School of Engineering, The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5000183701"],"corresponding_institution_ids":["https://openalex.org/I205924995","https://openalex.org/I74801974"],"apc_list":null,"apc_paid":null,"fwci":0.7587,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.76254037,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"64","issue":"11","first_page":"2555","last_page":"2561"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.992900013923645,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9886999726295471,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurogenesis","display_name":"Neurogenesis","score":0.9586332440376282},{"id":"https://openalex.org/keywords/hippocampal-formation","display_name":"Hippocampal formation","score":0.7467357516288757},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.689706563949585},{"id":"https://openalex.org/keywords/hippocampus","display_name":"Hippocampus","score":0.5263838768005371},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5150353908538818},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"Basic fibroblast growth factor","score":0.47372308373451233},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.45147979259490967},{"id":"https://openalex.org/keywords/neural-stem-cell","display_name":"Neural stem cell","score":0.43685874342918396},{"id":"https://openalex.org/keywords/neural-development","display_name":"Neural development","score":0.418654203414917},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.17017319798469543},{"id":"https://openalex.org/keywords/growth-factor","display_name":"Growth factor","score":0.14994212985038757},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.09605416655540466},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.060281991958618164}],"concepts":[{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.9586332440376282},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7467357516288757},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.689706563949585},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5263838768005371},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5150353908538818},{"id":"https://openalex.org/C2777587049","wikidata":"https://www.wikidata.org/wiki/Q20969945","display_name":"Basic fibroblast growth factor","level":4,"score":0.47372308373451233},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.45147979259490967},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.43685874342918396},{"id":"https://openalex.org/C461258","wikidata":"https://www.wikidata.org/wiki/Q1345738","display_name":"Neural development","level":3,"score":0.418654203414917},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.17017319798469543},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.14994212985038757},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.09605416655540466},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.060281991958618164},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/tbme.2016.2639468","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2016.2639468","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:28113197","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28113197","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W218056410","https://openalex.org/W905650041","https://openalex.org/W1758097482","https://openalex.org/W1916207959","https://openalex.org/W1992059324","https://openalex.org/W1992268170","https://openalex.org/W2007580663","https://openalex.org/W2018023959","https://openalex.org/W2023147143","https://openalex.org/W2051173215","https://openalex.org/W2054395943","https://openalex.org/W2061690520","https://openalex.org/W2061722255","https://openalex.org/W2067856703","https://openalex.org/W2068633735","https://openalex.org/W2069785065","https://openalex.org/W2077986246","https://openalex.org/W2092284040","https://openalex.org/W2096912144","https://openalex.org/W2128780863","https://openalex.org/W2130271501","https://openalex.org/W2146316688","https://openalex.org/W2148736076","https://openalex.org/W2157485677","https://openalex.org/W2158813449","https://openalex.org/W2211598849","https://openalex.org/W6640132866"],"related_works":["https://openalex.org/W1556341684","https://openalex.org/W3145896496","https://openalex.org/W1971500244","https://openalex.org/W2019757402","https://openalex.org/W2770383780","https://openalex.org/W3088544421","https://openalex.org/W2931586626","https://openalex.org/W4213011106","https://openalex.org/W2561378381","https://openalex.org/W2153296201"],"abstract_inverted_index":{"These":[0],"results":[1],"are":[2],"the":[3,25],"first":[4],"in":[5,15],"vitro":[6,16],"demonstration":[7],"that":[8],"neurogenesis":[9,29],"improves":[10],"pattern":[11],"separation.":[12],"Our":[13],"novel":[14],"system":[17],"will":[18],"be":[19],"a":[20],"useful":[21],"tool":[22],"for":[23],"investigating":[24],"contribution":[26],"of":[27],"adult":[28],"to":[30],"cognitive":[31],"functions.":[32]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}