{"id":"https://openalex.org/W2489617990","doi":"https://doi.org/10.1109/tbme.2016.2590498","title":"Modeling Day-to-Day Variability of Glucose\u2013Insulin Regulation Over 12-Week Home Use of Closed-Loop Insulin Delivery","display_name":"Modeling Day-to-Day Variability of Glucose\u2013Insulin Regulation Over 12-Week Home Use of Closed-Loop Insulin Delivery","publication_year":2016,"publication_date":"2016-09-08","ids":{"openalex":"https://openalex.org/W2489617990","doi":"https://doi.org/10.1109/tbme.2016.2590498","mag":"2489617990","pmid":"https://pubmed.ncbi.nlm.nih.gov/28113240"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2016.2590498","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tbme.2016.2590498","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1109/tbme.2016.2590498","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015976716","display_name":"Yue Ruan","orcid":"https://orcid.org/0000-0003-3498-2543"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Yue Ruan","raw_affiliation_strings":["Department of Paediatrics, University of Cambridge","Wellcome Trust-MRC Institute of Metabolic of Science"],"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, University of Cambridge","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Wellcome Trust-MRC Institute of Metabolic of Science","institution_ids":["https://openalex.org/I4210116691","https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018911748","display_name":"Malgorzata E. Wilinska","orcid":"https://orcid.org/0000-0002-1564-8083"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Malgorzata E. Wilinska","raw_affiliation_strings":["Department of Paediatrics, University of Cambridge","Wellcome Trust-MRC Institute of Metabolic of Science"],"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, University of Cambridge","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Wellcome Trust-MRC Institute of Metabolic of Science","institution_ids":["https://openalex.org/I4210116691","https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027935204","display_name":"Hood Thabit","orcid":"https://orcid.org/0000-0001-6076-6997"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hood Thabit","raw_affiliation_strings":["Department of Paediatrics, University of Cambridge","Wellcome Trust-MRC Institute of Metabolic of Science"],"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, University of Cambridge","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Wellcome Trust-MRC Institute of Metabolic of Science","institution_ids":["https://openalex.org/I4210116691","https://openalex.org/I87048295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012170772","display_name":"Roman Hovorka","orcid":"https://orcid.org/0000-0003-2901-461X"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Roman Hovorka","raw_affiliation_strings":["Department of Paediatrics, University of Cambridge, Cambridge, U.K"],"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, University of Cambridge, Cambridge, U.K","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5015976716"],"corresponding_institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210116691","https://openalex.org/I87048295"],"apc_list":null,"apc_paid":{"value":1804,"currency":"EUR","value_usd":1945},"fwci":3.7157,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.93443042,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"64","issue":"6","first_page":"1412","last_page":"1419"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin","display_name":"Insulin","score":0.8123389482498169},{"id":"https://openalex.org/keywords/insulin-delivery","display_name":"Insulin delivery","score":0.6863566637039185},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"Type 1 diabetes","score":0.5859227776527405},{"id":"https://openalex.org/keywords/artificial-pancreas","display_name":"Artificial pancreas","score":0.4569961428642273},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.42941418290138245},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.4276775121688843},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4038671553134918},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.39915916323661804}],"concepts":[{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.8123389482498169},{"id":"https://openalex.org/C2994527087","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin delivery","level":4,"score":0.6863566637039185},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.5859227776527405},{"id":"https://openalex.org/C2780353609","wikidata":"https://www.wikidata.org/wiki/Q1569064","display_name":"Artificial pancreas","level":4,"score":0.4569961428642273},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.42941418290138245},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4276775121688843},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4038671553134918},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39915916323661804}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004040","descriptor_name":"Dietary Carbohydrates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004040","descriptor_name":"Dietary Carbohydrates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004040","descriptor_name":"Dietary Carbohydrates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004360","descriptor_name":"Drug Therapy, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004360","descriptor_name":"Drug Therapy, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004360","descriptor_name":"Drug Therapy, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/tbme.2016.2590498","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tbme.2016.2590498","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:28113240","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28113240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:pure.atira.dk:openaire/06e73b9e-fac4-484f-b6b6-9b87e2e71f1d","is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/06e73b9e-fac4-484f-b6b6-9b87e2e71f1d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ruan, Y, Wilinska, M E, Thabit, H & Hovorka, R 2017, 'Modeling Day-to-Day Variability of Glucose-Insulin Regulation Over 12-Week Home Use of Closed-Loop Insulin Delivery', IEEE transactions on bio-medical engineering, vol. 64, no. 6, pp. 1412-1419. https://doi.org/10.1109/TBME.2016.2590498","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.1109/tbme.2016.2590498","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tbme.2016.2590498","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2125290529","display_name":null,"funder_award_id":"247138","funder_id":"https://openalex.org/F4320334960","funder_display_name":"Seventh Framework Programme"},{"id":"https://openalex.org/G368246489","display_name":null,"funder_award_id":"22\u20132011\u2013668","funder_id":"https://openalex.org/F4320310820","funder_display_name":"Juvenile Diabetes Research Foundation United States of America"},{"id":"https://openalex.org/G8475365295","display_name":null,"funder_award_id":"100574/Z/12/Z","funder_id":"https://openalex.org/F4320307874","funder_display_name":"Wellcome"}],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307874","display_name":"Wellcome","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320310820","display_name":"Juvenile Diabetes Research Foundation United States of America","ror":"https://ror.org/00vqxjy61"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334960","display_name":"Seventh Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1517555081","https://openalex.org/W1897095928","https://openalex.org/W1964693647","https://openalex.org/W1997112242","https://openalex.org/W2001747862","https://openalex.org/W2001875222","https://openalex.org/W2020102996","https://openalex.org/W2021578874","https://openalex.org/W2023792256","https://openalex.org/W2027667549","https://openalex.org/W2044877664","https://openalex.org/W2056760934","https://openalex.org/W2064258708","https://openalex.org/W2072612455","https://openalex.org/W2085479895","https://openalex.org/W2098735230","https://openalex.org/W2099719924","https://openalex.org/W2125624587","https://openalex.org/W2127177370","https://openalex.org/W2130738181","https://openalex.org/W2134293572","https://openalex.org/W2145278812","https://openalex.org/W2146757477","https://openalex.org/W2151065137","https://openalex.org/W2153151143","https://openalex.org/W2167160009","https://openalex.org/W2168814550","https://openalex.org/W2170006529","https://openalex.org/W2181256817","https://openalex.org/W2236315019","https://openalex.org/W2332531077","https://openalex.org/W2334498247","https://openalex.org/W4241354775","https://openalex.org/W4242554702","https://openalex.org/W6678663635","https://openalex.org/W6689285219"],"related_works":["https://openalex.org/W2328909424","https://openalex.org/W2980786759","https://openalex.org/W2754950093","https://openalex.org/W3131588449","https://openalex.org/W2995903277","https://openalex.org/W4309021794","https://openalex.org/W1591480440","https://openalex.org/W2180802545","https://openalex.org/W2999680199","https://openalex.org/W4210657104"],"abstract_inverted_index":{"Parameters":[0],"of":[1,4,21,27,98,106,133,156,164,173,206],"physiological":[2],"models":[3],"glucose-insulin":[5,189],"regulation":[6],"in":[7,161,199],"type":[8,73],"1":[9,74],"diabetes":[10,75],"have":[11],"previously":[12],"been":[13],"estimated":[14,114,160],"using":[15,115,191],"data":[16,57],"collected":[17],"over":[18,48],"short":[19],"periods":[20],"time":[22],"and":[23,41,64,145,148,169],"lack":[24],"the":[25,116,162,204],"quantification":[26],"day-to-day":[28,53],"variability.":[29,54],"We":[30],"developed":[31],"a":[32,94,123,130,178,187],"new":[33],"hierarchical":[34,124,181],"model":[35,104,111,126,134,150,157,196],"to":[36,44,185,202],"relate":[37],"subcutaneous":[38],"insulin":[39,61,100,137,140,167,174,208],"delivery":[40,63,209],"carbohydrate":[42,146],"intake":[43,66],"continuous":[45],"glucose":[46,56],"monitoring":[47],"12":[49],"weeks":[50],"while":[51],"describing":[52],"Sensor":[55],"sampled":[58],"every":[59],"10-min,":[60],"aspart":[62],"meal":[65],"were":[67,113,152],"analyzed":[68],"from":[69],"eight":[70],"adults":[71],"with":[72],"(male/female":[76],"5/3,":[77],"age":[78],"39.9":[79],"\u00b1":[80,85,89],"9.5":[81],"years,":[82],"BMI":[83],"25.4":[84],"4.4kg/m<sup>2</sup>,":[86],"HbA1c":[87],"8.4":[88],"0.6%":[90],")":[91],"who":[92],"underwent":[93],"12-week":[95,188],"home":[96],"study":[97],"closed-loop":[99,207],"delivery.":[101],"A":[102],"compartment":[103],"comprised":[105],"five":[107],"linear":[108,179],"differential":[109],"equations;":[110],"parameters":[112,135,158],"Markov":[117],"chain":[118],"Monte":[119],"Carlo":[120],"approach":[121,182],"within":[122],"Bayesian":[125,180],"framework.":[127],"Physiologically,":[128],"plausible":[129],"posteriori":[131],"distributions":[132],"including":[136],"sensitivity,":[138],"time-to-peak":[139,142,172],"action,":[141],"gut":[143],"absorption,":[144],"bioavailability,":[147],"good":[149],"fit":[151],"observed.":[153],"Day-to-day":[154],"variability":[155],"was":[159],"range":[163],"38-79%":[165],"for":[166,171],"sensitivity":[168],"27-48%":[170],"action.":[175],"In":[176],"conclusion,":[177],"is":[183],"feasible":[184],"describe":[186],"relationship":[190],"conventional":[192],"clinical":[193],"data.":[194],"The":[195],"may":[197],"facilitate":[198],"silico":[200],"testing":[201],"aid":[203],"development":[205],"systems.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
