{"id":"https://openalex.org/W2396959751","doi":"https://doi.org/10.1109/tbme.2016.2571624","title":"Contrast-Enhanced Ultrasound Angiogenesis Imaging by Mutual Information Analysis for Prostate Cancer Localization","display_name":"Contrast-Enhanced Ultrasound Angiogenesis Imaging by Mutual Information Analysis for Prostate Cancer Localization","publication_year":2016,"publication_date":"2016-05-22","ids":{"openalex":"https://openalex.org/W2396959751","doi":"https://doi.org/10.1109/tbme.2016.2571624","mag":"2396959751","pmid":"https://pubmed.ncbi.nlm.nih.gov/28113214"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2016.2571624","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2016.2571624","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.amsterdamumc.nl/files/178266110/Contrast-enhanced-ultrasound-angiogenesis-imaging-by-mutual-information-analysis-for-prostate-cancer-localization.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070262651","display_name":"Stefan G. Schalk","orcid":"https://orcid.org/0000-0002-5350-2288"},"institutions":[{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Stefan G. Schalk","raw_affiliation_strings":["Department of Electrical and Engineering, Eindhoven University of Technology, Eindhoven, AE, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-5350-2288","affiliations":[{"raw_affiliation_string":"Department of Electrical and Engineering, Eindhoven University of Technology, Eindhoven, AE, The Netherlands","institution_ids":["https://openalex.org/I83019370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021984927","display_name":"Libertario Demi","orcid":"https://orcid.org/0000-0002-0635-2133"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Libertario Demi","raw_affiliation_strings":["Department of Electrical and EngineeringEindhoven University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and EngineeringEindhoven University of Technology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081650177","display_name":"Nabil Bouhouch","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nabil Bouhouch","raw_affiliation_strings":["Department of Electrical and EngineeringEindhoven University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and EngineeringEindhoven University of Technology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025277061","display_name":"M.P.J. Kuenen","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maarten P. J. Kuenen","raw_affiliation_strings":["Department of Electrical and EngineeringEindhoven University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and EngineeringEindhoven University of Technology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067002701","display_name":"Arnoud W. Postema","orcid":"https://orcid.org/0000-0003-0629-871X"},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Arnoud W. Postema","raw_affiliation_strings":["Department of Urology, Academic Medical Center Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Academic Medical Center Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082495905","display_name":"Jean de la Rosette","orcid":"https://orcid.org/0000-0002-6308-1763"},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jean J. M. C. H. de la Rosette","raw_affiliation_strings":["Department of Urology, Academic Medical Center Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Academic Medical Center Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041526805","display_name":"Hessel Wijkstra","orcid":"https://orcid.org/0000-0002-4127-4169"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hessel Wijkstra","raw_affiliation_strings":["Department of Electrical and EngineeringEindhoven University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and EngineeringEindhoven University of Technology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110023303","display_name":"Tjalling Tjalkens","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tjalling J. Tjalkens","raw_affiliation_strings":["Department of Electrical and EngineeringEindhoven University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and EngineeringEindhoven University of Technology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050399847","display_name":"Massimo Mischi","orcid":"https://orcid.org/0000-0002-1179-5385"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Massimo Mischi","raw_affiliation_strings":["Department of Electrical and EngineeringEindhoven University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and EngineeringEindhoven University of Technology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8026,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.83697479,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"64","issue":"3","first_page":"661","last_page":"670"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.6787999868392944,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.6787999868392944,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10727","display_name":"Ultrasound Imaging and Elastography","score":0.20829999446868896,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.039400000125169754,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mutual-information","display_name":"Mutual information","score":0.5959091782569885},{"id":"https://openalex.org/keywords/ultrasound","display_name":"Ultrasound","score":0.5853763818740845},{"id":"https://openalex.org/keywords/contrast-enhanced-ultrasound","display_name":"Contrast-enhanced ultrasound","score":0.5623483061790466},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.5571670532226562},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"Prostate cancer","score":0.4917774498462677},{"id":"https://openalex.org/keywords/contrast","display_name":"Contrast (vision)","score":0.45011577010154724},{"id":"https://openalex.org/keywords/medical-imaging","display_name":"Medical imaging","score":0.41609278321266174},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.3930678367614746},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3834120035171509},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3797415494918823},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3614693284034729},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3523915410041809},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.3420789837837219},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.33200135827064514},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.30006635189056396},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.15438532829284668}],"concepts":[{"id":"https://openalex.org/C152139883","wikidata":"https://www.wikidata.org/wiki/Q252973","display_name":"Mutual information","level":2,"score":0.5959091782569885},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.5853763818740845},{"id":"https://openalex.org/C2779585989","wikidata":"https://www.wikidata.org/wiki/Q500458","display_name":"Contrast-enhanced ultrasound","level":3,"score":0.5623483061790466},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5571670532226562},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.4917774498462677},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.45011577010154724},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.41609278321266174},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3930678367614746},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3834120035171509},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3797415494918823},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3614693284034729},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3523915410041809},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3420789837837219},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.33200135827064514},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30006635189056396},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15438532829284668}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055420","descriptor_name":"Perfusion Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055420","descriptor_name":"Perfusion Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055420","descriptor_name":"Perfusion Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1109/tbme.2016.2571624","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2016.2571624","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:28113214","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28113214","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/bf18ce5a-d53d-405f-999f-877ad3f3de6c","is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/bf18ce5a-d53d-405f-999f-877ad3f3de6c","pdf_url":"https://pure.amsterdamumc.nl/files/178266110/Contrast-enhanced-ultrasound-angiogenesis-imaging-by-mutual-information-analysis-for-prostate-cancer-localization.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Schalk, S G, Demi, L, Bouhouch, N, Kuenen, M P J, Postema, A W, de La Rosette, J J M C H, Wijkstra, H, Tjalkens, T J & Mischi, M 2017, 'Contrast-Enhanced Ultrasound Angiogenesis Imaging by Mutual Information Analysis for Prostate Cancer Localization', IEEE transactions on bio-medical engineering, vol. 64, no. 3, pp. 661-670. https://doi.org/10.1109/TBME.2016.2571624","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.tue.nl:publications/371bc01f-1bad-4cd7-ab8e-d0f7cff37029","is_oa":true,"landing_page_url":"https://research.tue.nl/en/publications/371bc01f-1bad-4cd7-ab8e-d0f7cff37029","pdf_url":"https://research.tue.nl/files/56902645/schalkcon2016.pdf","source":{"id":"https://openalex.org/S4406922641","display_name":"TU/e Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Schalk, S G, Demi, L, Bouhouch, N, Kuenen, M P J, Postema, A W, de la Rosette, J J M C H, Wijkstra, H, Tjalkens, T J & Mischi, M 2016, 'Contrast-enhanced ultrasound Angiogenesis imaging by mutual information analysis for Prostate Cancer localization', IEEE Transactions on Biomedical Engineering, vol. 64, no. 3, pp. 661-670. https://doi.org/10.1109/TBME.2016.2571624","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:848813","is_oa":false,"landing_page_url":"http://library.tue.nl/csp/dare/LinkToRepository.csp?recordnumber=848813","pdf_url":null,"source":{"id":"https://openalex.org/S4406922641","display_name":"TU/e Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN:0018-9294","raw_type":"Article / Letter to the editor"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/e83314a9-dcb1-4278-a625-959128671af3","is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/contrastenhanced-ultrasound-angiogenesis-imaging-by-mutual-information-analysis-for-prostate-cancer-localization(e83314a9-dcb1-4278-a625-959128671af3).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE transactions on bio-medical engineering, 64(3), 661 - 670. IEEE Computer Society","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unitn.it:11572/209512","is_oa":false,"landing_page_url":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=7475875","pdf_url":null,"source":{"id":"https://openalex.org/S4306401913","display_name":"Institutional Research Information System (Universit\u00e0 degli Studi di Trento)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I193223587","host_organization_name":"University of Trento","host_organization_lineage":["https://openalex.org/I193223587"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:tue:oai:pure.tue.nl:publications/371bc01f-1bad-4cd7-ab8e-d0f7cff37029","is_oa":true,"landing_page_url":"https://research.tue.nl/nl/publications/371bc01f-1bad-4cd7-ab8e-d0f7cff37029","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Transactions on Biomedical Engineering, 64(3), 661 - 670. IEEE Computer Society","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/bf18ce5a-d53d-405f-999f-877ad3f3de6c","is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/bf18ce5a-d53d-405f-999f-877ad3f3de6c","pdf_url":"https://pure.amsterdamumc.nl/files/178266110/Contrast-enhanced-ultrasound-angiogenesis-imaging-by-mutual-information-analysis-for-prostate-cancer-localization.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Schalk, S G, Demi, L, Bouhouch, N, Kuenen, M P J, Postema, A W, de La Rosette, J J M C H, Wijkstra, H, Tjalkens, T J & Mischi, M 2017, 'Contrast-Enhanced Ultrasound Angiogenesis Imaging by Mutual Information Analysis for Prostate Cancer Localization', IEEE transactions on bio-medical engineering, vol. 64, no. 3, pp. 661-670. https://doi.org/10.1109/TBME.2016.2571624","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1006053003","display_name":null,"funder_award_id":"VIDI Grant #10769","funder_id":"https://openalex.org/F4320334893","funder_display_name":"Stichting voor de Technische Wetenschappen"},{"id":"https://openalex.org/G298890089","display_name":null,"funder_award_id":"10769","funder_id":"https://openalex.org/F4320334893","funder_display_name":"Stichting voor de Technische Wetenschappen"}],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320334893","display_name":"Stichting voor de Technische Wetenschappen","ror":"https://ror.org/057tq3593"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2396959751.pdf","grobid_xml":"https://content.openalex.org/works/W2396959751.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W153934429","https://openalex.org/W1563825794","https://openalex.org/W1810166418","https://openalex.org/W1826073797","https://openalex.org/W1827310843","https://openalex.org/W1974422184","https://openalex.org/W1993978830","https://openalex.org/W1995246862","https://openalex.org/W2000000541","https://openalex.org/W2002365996","https://openalex.org/W2005711928","https://openalex.org/W2006115709","https://openalex.org/W2010987628","https://openalex.org/W2014858450","https://openalex.org/W2024359532","https://openalex.org/W2035809577","https://openalex.org/W2039138053","https://openalex.org/W2041404167","https://openalex.org/W2042098439","https://openalex.org/W2062287598","https://openalex.org/W2072733003","https://openalex.org/W2075880681","https://openalex.org/W2077937721","https://openalex.org/W2086619383","https://openalex.org/W2096352263","https://openalex.org/W2096359889","https://openalex.org/W2096949472","https://openalex.org/W2105986437","https://openalex.org/W2111866018","https://openalex.org/W2116175191","https://openalex.org/W2126935672","https://openalex.org/W2127343074","https://openalex.org/W2130622335","https://openalex.org/W2148468651","https://openalex.org/W2150414251","https://openalex.org/W2157825442","https://openalex.org/W2159395257","https://openalex.org/W2170552969","https://openalex.org/W2171449887","https://openalex.org/W2171857449","https://openalex.org/W2210387432","https://openalex.org/W2978725006","https://openalex.org/W4245727854","https://openalex.org/W6606306761","https://openalex.org/W6638555172","https://openalex.org/W6638760006"],"related_works":["https://openalex.org/W2466816617","https://openalex.org/W4385649027","https://openalex.org/W1970834875","https://openalex.org/W3174028392","https://openalex.org/W842936808","https://openalex.org/W2000517284","https://openalex.org/W2136503713","https://openalex.org/W2365318811","https://openalex.org/W4239222040","https://openalex.org/W2789762029"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,157],"role":[2],"of":[3,38,75,235,244,250],"angiogenesis":[4,32],"in":[5,78,131,133,158,162,247],"cancer":[6,14,80,252],"growth":[7],"has":[8],"stimulated":[9],"research":[10],"aimed":[11],"at":[12],"noninvasive":[13],"detection":[15],"by":[16,57,71,142,182,193],"blood":[17],"perfusion":[18,195],"imaging.":[19,33,59],"Recently,":[20],"contrast":[21,211],"ultrasound":[22,58],"dispersion":[23,42,86,118,151,212],"imaging":[24],"was":[25,110,129,155,174],"proposed":[26],"as":[27],"an":[28,39],"alternative":[29],"method":[30,88,226,246],"for":[31,139],"After":[34],"the":[35,48,72,114,123,245],"intravenous":[36],"injection":[37],"ultrasound-contrast-agent":[40],"bolus,":[41],"can":[43,205,214,227,253],"be":[44,206,254],"indirectly":[45,209],"estimated":[46],"from":[47],"local":[49],"similarity":[50,65,184],"between":[51,117,150,201],"neighboring":[52,202],"time-intensity":[53,203],"curves":[54,204],"(TICs)":[55],"measured":[56],"Up":[60],"until":[61],"now,":[62],"only":[63],"linear":[64,183],"measures":[66,185],"have":[67],"been":[68],"investigated.":[69],"Motivated":[70],"promising":[73],"results":[74],"this":[76],"approach":[77],"prostate":[79],"(PCa),":[81],"we":[82],"developed":[83],"a":[84,107,163],"novel":[85],"estimation":[87],"based":[89],"on":[90],"mutual":[91,120,153],"information,":[92],"thus":[93],"including":[94],"nonlinear":[95],"similarity,":[96],"to":[97,102,112,126,171,179,191,208,216,230],"further":[98],"improve":[99],"its":[100],"ability":[101,125],"localize":[103,127],"PCa.":[104],"METHODS:":[105],"First,":[106],"simulation":[108],"study":[109,160],"performed":[111],"establish":[113],"theoretical":[115],"link":[116],"and":[119,152,187,213,233,237],"information.":[121],"Next,":[122],"method's":[124],"PCa":[128,219,224],"validated":[130],"vivo":[132,159],"23":[134],"patients":[135],"(58":[136],"datasets)":[137],"referred":[138],"radical":[140],"prostatectomy":[141],"comparison":[143],"with":[144],"histology.":[145],"RESULTS:":[146],"A":[147],"monotonic":[148],"relationship":[149],"information":[154,200],"demonstrated.":[156],"resulted":[161],"receiver":[164],"operating":[165],"characteristic":[166],"(ROC)":[167],"curve":[168],"area":[169],"equal":[170],"0.77,":[172],"which":[173],"superior":[175],"(p":[176,188],"=":[177],"0.21-0.24)":[178],"that":[180,192],"obtained":[181],"(0.74-0.75)":[186],"<;":[189],"0.05)":[190],"conventional":[194],"parameters":[196],"(\u22640.70).":[197],"CONCLUSION:":[198],"Mutual":[199],"used":[207],"estimate":[210],"lead":[215,229],"more":[217],"accurate":[218],"localization.":[220],"SIGNIFICANCE:":[221],"An":[222],"improved":[223],"localization":[225],"possibly":[228],"better":[231],"grading":[232],"staging":[234],"tumors,":[236],"support":[238],"focal-treatment":[239],"guidance.":[240],"Moreover,":[241],"future":[242],"employment":[243],"other":[248],"types":[249],"angiogenic":[251],"considered.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4}],"updated_date":"2026-08-02T14:50:37.381335","created_date":"2025-10-10T00:00:00"}