{"id":"https://openalex.org/W2288562226","doi":"https://doi.org/10.1109/tbme.2016.2533658","title":"A Personalized Framework for Dynamic Modeling of Disease Trajectories in Chronic Lymphocytic Leukemia","display_name":"A Personalized Framework for Dynamic Modeling of Disease Trajectories in Chronic Lymphocytic Leukemia","publication_year":2016,"publication_date":"2016-02-23","ids":{"openalex":"https://openalex.org/W2288562226","doi":"https://doi.org/10.1109/tbme.2016.2533658","mag":"2288562226","pmid":"https://pubmed.ncbi.nlm.nih.gov/26929022"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2016.2533658","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2016.2533658","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056657814","display_name":"Symeon Savvopoulos","orcid":"https://orcid.org/0000-0003-2092-7041"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Symeon Savvopoulos","raw_affiliation_strings":["Department of Chemical Engineering, Imperial College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Imperial College London","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054244566","display_name":"Ruth Misener","orcid":"https://orcid.org/0000-0001-5612-5417"},"institutions":[{"id":"https://openalex.org/I2800778610","display_name":"Kensington College of Business","ror":"https://ror.org/02bd3qj97","country_code":"GB","type":"education","lineage":["https://openalex.org/I2800778610"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ruth Misener","raw_affiliation_strings":["Department of Computing, Imperial College London, South Kensington Campus, London, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computing, Imperial College London, South Kensington Campus, London, U.K","institution_ids":["https://openalex.org/I2800778610","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042492602","display_name":"Nicki Panoskaltsis","orcid":"https://orcid.org/0000-0001-8972-5697"},"institutions":[{"id":"https://openalex.org/I4210161740","display_name":"St Mark's Hospital","ror":"https://ror.org/05am5g719","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800484787","https://openalex.org/I4210161740"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicki Panoskaltsis","raw_affiliation_strings":["Department of Haematology, Imperial College London, Northwick Park and St.\u00a0Marks Campus, London, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Imperial College London, Northwick Park and St.\u00a0Marks Campus, London, U.K","institution_ids":["https://openalex.org/I4210161740","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115598076","display_name":"Efstratios N. Pistikopoulos","orcid":"https://orcid.org/0000-0001-6220-818X"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Efstratios N. Pistikopoulos","raw_affiliation_strings":["Department of Chemical Engineering, Texas A&M University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Texas A&M University","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048473531","display_name":"Athanasios Mantalaris","orcid":"https://orcid.org/0000-0001-6183-0292"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Athanasios Mantalaris","raw_affiliation_strings":["Department of Chemical Engineering, Imperial College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Imperial College London","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7368,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.71474258,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"63","issue":"11","first_page":"2396","last_page":"2404"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9803000092506409,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9621000289916992,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"Chronic lymphocytic leukemia","score":0.7674865126609802},{"id":"https://openalex.org/keywords/haematopoiesis","display_name":"Haematopoiesis","score":0.6065353155136108},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"Bone marrow","score":0.5994766354560852},{"id":"https://openalex.org/keywords/lymph","display_name":"Lymph","score":0.5124099850654602},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4929654598236084},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.46135565638542175},{"id":"https://openalex.org/keywords/leukemia","display_name":"Leukemia","score":0.4600391983985901},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.43393462896347046},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.38381722569465637},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.35055142641067505},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.320310115814209},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2732250690460205},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.23630276322364807},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.23531511425971985},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.17858374118804932}],"concepts":[{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.7674865126609802},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6065353155136108},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5994766354560852},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.5124099850654602},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4929654598236084},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46135565638542175},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4600391983985901},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43393462896347046},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38381722569465637},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35055142641067505},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.320310115814209},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2732250690460205},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23630276322364807},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.23531511425971985},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17858374118804932},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/tbme.2016.2533658","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2016.2533658","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:26929022","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26929022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/29915","is_oa":false,"landing_page_url":"http://hdl.handle.net/10044/1/29915","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2404","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W9884766","https://openalex.org/W96780237","https://openalex.org/W169626422","https://openalex.org/W603018772","https://openalex.org/W648953716","https://openalex.org/W1484886449","https://openalex.org/W1492263161","https://openalex.org/W1554856540","https://openalex.org/W1556399965","https://openalex.org/W1584870316","https://openalex.org/W1782925843","https://openalex.org/W1965851569","https://openalex.org/W1968793561","https://openalex.org/W1975047856","https://openalex.org/W1988540551","https://openalex.org/W2001838945","https://openalex.org/W2002180682","https://openalex.org/W2011664525","https://openalex.org/W2018488520","https://openalex.org/W2019655196","https://openalex.org/W2033277681","https://openalex.org/W2038881832","https://openalex.org/W2042901488","https://openalex.org/W2048694910","https://openalex.org/W2061351840","https://openalex.org/W2064381013","https://openalex.org/W2068688088","https://openalex.org/W2071601147","https://openalex.org/W2073425532","https://openalex.org/W2075908995","https://openalex.org/W2078161165","https://openalex.org/W2079035972","https://openalex.org/W2079160087","https://openalex.org/W2079373765","https://openalex.org/W2088438813","https://openalex.org/W2088551805","https://openalex.org/W2088872396","https://openalex.org/W2093145699","https://openalex.org/W2095848269","https://openalex.org/W2102552995","https://openalex.org/W2108091955","https://openalex.org/W2116472925","https://openalex.org/W2121510837","https://openalex.org/W2125647853","https://openalex.org/W2126486896","https://openalex.org/W2134139148","https://openalex.org/W2141836356","https://openalex.org/W2161282446","https://openalex.org/W2172293209","https://openalex.org/W2182689298","https://openalex.org/W2217262841","https://openalex.org/W2221262359","https://openalex.org/W2263314433","https://openalex.org/W2477369250","https://openalex.org/W2496101153","https://openalex.org/W2501171240","https://openalex.org/W6637866730","https://openalex.org/W7070625856"],"related_works":["https://openalex.org/W2411759252","https://openalex.org/W2140471736","https://openalex.org/W2112110217","https://openalex.org/W1973406296","https://openalex.org/W2415371794","https://openalex.org/W579273576","https://openalex.org/W2418031697","https://openalex.org/W2100140007","https://openalex.org/W1975353758","https://openalex.org/W2365088567"],"abstract_inverted_index":{"Chronic":[0],"lymphocytic":[1],"leukemia":[2],"(CLL)":[3],"is":[4],"the":[5,15,25,41,68,84,87,96,107,119,128,134,141,169],"most":[6],"common":[7],"peripheral":[8,126],"blood":[9,156,163],"and":[10,65,90,115,136,157,167],"bone":[11,153],"marrow":[12,154],"cancer":[13],"in":[14,38,62,125,187],"developed":[16],"world.":[17],"This":[18],"manuscript":[19],"proposes":[20],"mathematical":[21],"model":[22,71,93,178],"equations":[23],"representing":[24,57],"disease":[26,43,75,100,111],"dynamics":[27],"of":[28,40,86,98,122,130,138,144,158],"B-cell":[29],"CLL.":[30],"We":[31,50,80],"interconnect":[32],"delay":[33],"differential":[34],"cell":[35,48],"cycle":[36],"models":[37],"each":[39],"tumor-involved":[42],"centers":[44],"using":[45,103],"physiologically":[46],"relevant":[47],"migration.":[49],"further":[51],"introduce":[52],"five":[53],"hypothetical":[54],"case":[55],"studies":[56],"CLL":[58,70,99,123,150,160],"heterogeneity":[59,97],"commonly":[60],"seen":[61],"clinical":[63],"practice":[64],"demonstrate":[66],"how":[67],"proposed":[69,88,177],"framework":[72],"may":[73,184],"capture":[74,95],"pathophysiology":[76],"across":[77],"patient":[78,190],"types.":[79],"conclude":[81],"by":[82],"exploring":[83],"capacity":[85],"temporally-":[89],"spatially":[91],"distributed":[92],"to":[94,174],"progression.":[101],"By":[102],"global":[104],"sensitivity":[105],"analysis,":[106],"critical":[108],"parameters":[109,170],"influencing":[110],"trajectory":[112],"over":[113],"space":[114],"time":[116],"are:":[117],"1)":[118],"initial":[120],"number":[121,129],"cells":[124,151,161,173],"blood,":[127],"involved":[131],"lymph":[132,165],"nodes,":[133],"presence":[135],"degree":[137],"splenomegaly;":[139],"2)":[140],"migratory":[142],"fraction":[143],"nonproliferating":[145],"as":[146,148],"well":[147],"proliferating":[149,159],"from":[152,162],"into":[155,164],"nodes;":[166],"3)":[168],"inducing":[171],"nonproliferative":[172],"proliferate.":[175],"The":[176],"offers":[179],"a":[180],"practical":[181],"platform":[182],"that":[183],"be":[185],"explored":[186],"future":[188],"personalized":[189],"protocols":[191],"once":[192],"validated.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}
