{"id":"https://openalex.org/W1968219825","doi":"https://doi.org/10.1109/tbme.2015.2405549","title":"Conceptual Network Model From Sensory Neurons to Astrocytes of the Human Nervous System","display_name":"Conceptual Network Model From Sensory Neurons to Astrocytes of the Human Nervous System","publication_year":2015,"publication_date":"2015-02-19","ids":{"openalex":"https://openalex.org/W1968219825","doi":"https://doi.org/10.1109/tbme.2015.2405549","mag":"1968219825","pmid":"https://pubmed.ncbi.nlm.nih.gov/25706505"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2015.2405549","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2015.2405549","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101611828","display_name":"Yiqun Yang","orcid":"https://orcid.org/0000-0001-5212-0854"},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yiqun Yang","raw_affiliation_strings":["School of Computer Engineering, Nanyang Technological University, Singapore","School of Computer Engineering, Nanyang Technological University,,Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Engineering, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"School of Computer Engineering, Nanyang Technological University,,Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006146465","display_name":"Chai Kiat Yeo","orcid":"https://orcid.org/0000-0002-7618-1472"},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Chai Kiat Yeo","raw_affiliation_strings":["Nanyang Technological University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanyang Technological University","institution_ids":["https://openalex.org/I172675005"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I172675005"],"apc_list":null,"apc_paid":null,"fwci":0.8156,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.71314725,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"62","issue":"7","first_page":"1843","last_page":"1852"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.8298307061195374},{"id":"https://openalex.org/keywords/nervous-system","display_name":"Nervous system","score":0.7339383363723755},{"id":"https://openalex.org/keywords/astrocyte","display_name":"Astrocyte","score":0.6346684694290161},{"id":"https://openalex.org/keywords/sensory-system","display_name":"Sensory system","score":0.5424202084541321},{"id":"https://openalex.org/keywords/stimulus","display_name":"Stimulus (psychology)","score":0.5164885520935059},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4743470251560211},{"id":"https://openalex.org/keywords/neurophysiology","display_name":"Neurophysiology","score":0.4552158713340759},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.4215499758720398},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.40768134593963623},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.12703770399093628}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.8298307061195374},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.7339383363723755},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.6346684694290161},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.5424202084541321},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.5164885520935059},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4743470251560211},{"id":"https://openalex.org/C152478114","wikidata":"https://www.wikidata.org/wiki/Q660910","display_name":"Neurophysiology","level":2,"score":0.4552158713340759},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.4215499758720398},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40768134593963623},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.12703770399093628},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbme.2015.2405549","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2015.2405549","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:25706505","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25706505","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W115296240","https://openalex.org/W1969111489","https://openalex.org/W1971125401","https://openalex.org/W1972077052","https://openalex.org/W1985943544","https://openalex.org/W1986312757","https://openalex.org/W1987688067","https://openalex.org/W1988761152","https://openalex.org/W1988878611","https://openalex.org/W2006338283","https://openalex.org/W2030787126","https://openalex.org/W2032803618","https://openalex.org/W2042681276","https://openalex.org/W2044730840","https://openalex.org/W2052665251","https://openalex.org/W2057020589","https://openalex.org/W2058288195","https://openalex.org/W2065349788","https://openalex.org/W2070408678","https://openalex.org/W2071900171","https://openalex.org/W2076790692","https://openalex.org/W2086351296","https://openalex.org/W2094205031","https://openalex.org/W2118661818","https://openalex.org/W2118788831","https://openalex.org/W2126928912","https://openalex.org/W2129896258","https://openalex.org/W2132266804","https://openalex.org/W2143120360","https://openalex.org/W2147270524","https://openalex.org/W2147372806","https://openalex.org/W2152137672","https://openalex.org/W2158116085","https://openalex.org/W2410864140","https://openalex.org/W6714673050"],"related_works":["https://openalex.org/W4285022297","https://openalex.org/W2026577098","https://openalex.org/W2375663469","https://openalex.org/W2901448111","https://openalex.org/W4389691107","https://openalex.org/W2264335418","https://openalex.org/W2773348616","https://openalex.org/W3142601694","https://openalex.org/W4247372324","https://openalex.org/W2132261450"],"abstract_inverted_index":{"From":[0],"a":[1,160,206,233],"single-cell":[2],"animal":[3],"like":[4,8],"paramecium":[5],"to":[6,19,26,93,119,131,158,186,236],"vertebrates":[7],"ape,":[9],"the":[10,20,23,28,32,50,53,64,68,78,87,94,97,105,110,114,120,124,127,132,144,155,165,177,197,210,214,220],"nervous":[11,29,42,167,222],"system":[12,30,43,223],"plays":[13],"an":[14,70],"important":[15],"role":[16],"in":[17,31,77,96,104,151,219,245],"responding":[18],"variations":[21],"of":[22,107,123,154,173,180,209,216],"environment.":[24],"Compared":[25],"animals,":[27],"human":[33,166,221,246],"body":[34],"possesses":[35],"more":[36],"intricate":[37],"organization":[38],"and":[39,81,148,176,201,204,239,242],"utility.":[40],"The":[41,169],"anatomy":[44],"has":[45],"been":[46],"understood":[47],"progressively,":[48],"yet":[49],"explanation":[51],"at":[52,109],"cell":[54],"level":[55],"regarding":[56],"complete":[57],"information":[58],"transmission":[59],"is":[60,102,171,224],"still":[61,225],"lacking.":[62],"Along":[63],"signal":[65,156],"pathway":[66],"toward":[67],"brain,":[69],"external":[71],"stimulus":[72],"first":[73],"activates":[74],"action":[75],"potentials":[76],"sensing":[79],"neuron":[80],"these":[82],"electric":[83],"pulses":[84],"transmit":[85],"along":[86],"spinal":[88],"nerve":[89,92],"or":[90],"cranial":[91],"neurons":[95],"brain.":[98],"Second,":[99],"calcium":[100,116,128],"elevation":[101],"triggered":[103],"branch":[106],"astrocyte":[108,134],"tripartite":[111],"synapse.":[112],"Third,":[113],"local":[115],"wave":[117,129],"expands":[118],"entire":[121],"territory":[122],"astrocyte.":[125],"Finally,":[126],"propagates":[130],"neighboring":[133],"via":[135],"gap":[136],"junction":[137],"channel.":[138],"In":[139],"our":[140,193,229],"study,":[141],"we":[142],"integrate":[143],"existing":[145],"mathematical":[146,202],"model":[147,163,230],"biological":[149,199],"experiments":[150,200],"each":[152,181],"step":[153],"transduction":[157],"establish":[159],"conceptual":[161],"network":[162,170],"for":[164],"system.":[168],"composed":[172],"four":[174],"layers":[175],"communication":[178],"protocols":[179],"layer":[182],"could":[183],"be":[184],"adapted":[185],"entities":[187],"with":[188],"different":[189],"characterizations.":[190],"We":[191],"verify":[192,240],"simulation":[194],"results":[195],"against":[196],"available":[198],"models":[203],"provide":[205],"test":[207],"case":[208],"integrated":[211],"network.":[212],"As":[213],"production":[215],"conscious":[217],"episode":[218],"under":[226],"intense":[227],"research,":[228],"serves":[231],"as":[232],"useful":[234],"tool":[235],"facilitate,":[237],"complement":[238],"current":[241],"future":[243],"study":[244],"cognition.":[247]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}