{"id":"https://openalex.org/W2161637076","doi":"https://doi.org/10.1109/tbme.2015.2400631","title":"Molecular Communication Modeling of Antibody-Mediated Drug Delivery Systems","display_name":"Molecular Communication Modeling of Antibody-Mediated Drug Delivery Systems","publication_year":2015,"publication_date":"2015-02-05","ids":{"openalex":"https://openalex.org/W2161637076","doi":"https://doi.org/10.1109/tbme.2015.2400631","mag":"2161637076","pmid":"https://pubmed.ncbi.nlm.nih.gov/25675450"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2015.2400631","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2015.2400631","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036102259","display_name":"Youssef Chahibi","orcid":"https://orcid.org/0000-0001-9141-9111"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Youssef Chahibi","raw_affiliation_strings":["Broadband Wireless Networking Laboratory, School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broadband Wireless Networking Laboratory, School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044396726","display_name":"Ian F. Akyildiz","orcid":"https://orcid.org/0000-0002-8099-3529"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I4210133110","display_name":"Tampere University","ror":null,"country_code":"FI","type":null,"lineage":["https://openalex.org/I4210133110"]}],"countries":["FI","US"],"is_corresponding":false,"raw_author_name":"Ian F. Akyildiz","raw_affiliation_strings":["Broadband Wireless Networking Laboratory, School of Electrical and Computer Engineering, Georgia Institute of Technology","Department of Electronics and Communication Engineering, Tampere University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broadband Wireless Networking Laboratory, School of Electrical and Computer Engineering, Georgia Institute of Technology","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"Department of Electronics and Communication Engineering, Tampere University of Technology","institution_ids":["https://openalex.org/I4210133110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077005247","display_name":"Sasitharan Balasubramaniam","orcid":"https://orcid.org/0000-0003-4022-3615"},"institutions":[{"id":"https://openalex.org/I4210133110","display_name":"Tampere University","ror":null,"country_code":"FI","type":null,"lineage":["https://openalex.org/I4210133110"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Sasitharan Balasubramaniam","raw_affiliation_strings":["Nano Communication Centre (NC2), Tampere University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nano Communication Centre (NC2), Tampere University of Technology","institution_ids":["https://openalex.org/I4210133110"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015032841","display_name":"Yevgeni Koucheryavy","orcid":"https://orcid.org/0000-0003-3976-297X"},"institutions":[{"id":"https://openalex.org/I4210133110","display_name":"Tampere University","ror":null,"country_code":"FI","type":null,"lineage":["https://openalex.org/I4210133110"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Yevgeni Koucheryavy","raw_affiliation_strings":["Nano Communication Centre (NC2), Tampere University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nano Communication Centre (NC2), Tampere University of Technology","institution_ids":["https://openalex.org/I4210133110"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2645,"currency":"USD","value_usd":2645},"apc_paid":null,"fwci":3.5716,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.92974685,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"62","issue":"7","first_page":"1683","last_page":"1695"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10913","display_name":"Molecular Junctions and Nanostructures","score":0.9866999983787537,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-delivery","display_name":"Drug delivery","score":0.5795667767524719},{"id":"https://openalex.org/keywords/molecular-communication","display_name":"Molecular communication","score":0.550600528717041},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.5033988356590271},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48503464460372925},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.4658205509185791},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4449024796485901},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.424014151096344},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.42006051540374756},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.40116214752197266},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3784014582633972},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3393442630767822},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3251548409461975},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.32116198539733887},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.2358662188053131},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.2309829592704773},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22866293787956238},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.14057862758636475}],"concepts":[{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5795667767524719},{"id":"https://openalex.org/C2779767902","wikidata":"https://www.wikidata.org/wiki/Q17037278","display_name":"Molecular communication","level":4,"score":0.550600528717041},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5033988356590271},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48503464460372925},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4658205509185791},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4449024796485901},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.424014151096344},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.42006051540374756},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.40116214752197266},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3784014582633972},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3393442630767822},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3251548409461975},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32116198539733887},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2358662188053131},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2309829592704773},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22866293787956238},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.14057862758636475},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.0},{"id":"https://openalex.org/C47798520","wikidata":"https://www.wikidata.org/wiki/Q190157","display_name":"Transmitter","level":3,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001808","descriptor_name":"Blood Vessels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001808","descriptor_name":"Blood Vessels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001808","descriptor_name":"Blood Vessels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020342","descriptor_name":"Finite Element Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020342","descriptor_name":"Finite Element Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020342","descriptor_name":"Finite Element Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbme.2015.2400631","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2015.2400631","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:25675450","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25675450","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8100000023841858,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1552826555","https://openalex.org/W1557718589","https://openalex.org/W1602790144","https://openalex.org/W1966122087","https://openalex.org/W1971242419","https://openalex.org/W1973699894","https://openalex.org/W1991671533","https://openalex.org/W1993626874","https://openalex.org/W1995842573","https://openalex.org/W2002029014","https://openalex.org/W2002765161","https://openalex.org/W2019574809","https://openalex.org/W2022045967","https://openalex.org/W2034426095","https://openalex.org/W2037525504","https://openalex.org/W2043228552","https://openalex.org/W2044905081","https://openalex.org/W2047167799","https://openalex.org/W2047730466","https://openalex.org/W2054939724","https://openalex.org/W2068846148","https://openalex.org/W2073090918","https://openalex.org/W2078317394","https://openalex.org/W2080313971","https://openalex.org/W2100627342","https://openalex.org/W2104039052","https://openalex.org/W2104558356","https://openalex.org/W2116194016","https://openalex.org/W2125863473","https://openalex.org/W2134348941","https://openalex.org/W2149283799","https://openalex.org/W2149974024","https://openalex.org/W2159529419","https://openalex.org/W2169083304","https://openalex.org/W2171125625","https://openalex.org/W4234914623"],"related_works":["https://openalex.org/W2163496989","https://openalex.org/W2054910325","https://openalex.org/W3135645983","https://openalex.org/W3000508184","https://openalex.org/W2554633690","https://openalex.org/W2283480350","https://openalex.org/W1493890705","https://openalex.org/W2782595656","https://openalex.org/W2052126869","https://openalex.org/W2610758737"],"abstract_inverted_index":{"Antibody-mediated":[0],"Drug":[1],"Delivery":[2],"Systems":[3],"(ADDS)":[4],"are":[5,108,190],"emerging":[6],"as":[7,20],"one":[8],"of":[9,45,64,71,86,93,98,117,127,144,151,158,163,175,188,201,209],"the":[10,31,43,46,52,62,69,84,91,118,130,134,142,145,148,152,156,159,164,176,180,186,194,205],"most":[11],"encouraging":[12],"therapeutic":[13],"solutions":[14],"for":[15,68],"treating":[16],"several":[17],"diseases":[18],"such":[19],"human":[21],"cancers.":[22],"ADDS":[23,72,119,189,202],"use":[24],"small":[25],"molecules":[26],"(antibodies)":[27],"that":[28],"propagate":[29],"in":[30,211],"body":[32],"and":[33,73,90,104,121,155,182,207,215],"bind":[34],"selectively":[35],"to":[36,78,112,133],"their":[37,75,101],"corresponding":[38],"receptors":[39],"(antigens)":[40],"expressed":[41],"at":[42],"surface":[44],"diseased":[47],"cells.":[48],"In":[49],"this":[50],"paper,":[51],"Molecular":[53],"Communication":[54],"(MC)":[55],"paradigm,":[56],"where":[57],"information":[58],"is":[59,66,137,167],"conveyed":[60],"through":[61],"concentration":[63],"molecules,":[65],"advocated":[67],"engineering":[70],"modeling":[74],"complex":[76,105,177],"behavior,":[77],"provide":[79],"a":[80,212],"realistic":[81],"model":[82,116,166,200],"without":[83],"over-complication":[85],"system":[87],"biology":[88],"models,":[89],"limitations":[92],"experimental":[94],"approaches.":[95],"The":[96,124,161,173,198],"peculiarities":[97],"antibodies,":[99],"including":[100],"anisotropic":[102],"transport":[103,120,181],"electrochemical":[106,149],"structure,":[107],"taken":[109],"into":[110],"account":[111],"develop":[113],"an":[114],"analytical":[115],"antigen-binding":[122],"kinetics.":[123],"end-to-end":[125],"response":[126],"ADDS,":[128],"from":[129],"drug":[131,135],"injection":[132],"absorption,":[136],"mathematically":[138],"derived":[139],"based":[140],"on":[141,185],"geometry":[143],"antibody":[146],"molecule,":[147],"structure":[150],"antibody-antigen":[153],"complex,":[154],"physiology":[157],"patient.":[160],"accuracy":[162],"MC":[165,196,199],"validated":[168],"by":[169,193],"finite-element":[170],"(COMSOL)":[171],"simulations.":[172],"implications":[174],"interplay":[178],"between":[179],"kinetics":[183],"parameters":[184],"performance":[187],"effectively":[191],"captured":[192],"proposed":[195],"model.":[197],"will":[203],"enable":[204],"discovery":[206],"optimization":[208],"drugs":[210],"versatile,":[213],"cost-efficient,":[214],"reliable":[216],"manner.":[217]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}
