{"id":"https://openalex.org/W2111390181","doi":"https://doi.org/10.1109/tbme.2015.2399437","title":"32-Channel System to Measure the Electrophysiological Properties of Bioengineered Cardiac Muscle","display_name":"32-Channel System to Measure the Electrophysiological Properties of Bioengineered Cardiac Muscle","publication_year":2015,"publication_date":"2015-02-04","ids":{"openalex":"https://openalex.org/W2111390181","doi":"https://doi.org/10.1109/tbme.2015.2399437","mag":"2111390181","pmid":"https://pubmed.ncbi.nlm.nih.gov/25667345"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2015.2399437","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2015.2399437","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080040967","display_name":"Betsy Salazar","orcid":"https://orcid.org/0000-0002-3626-9349"},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Betsy H. Salazar","raw_affiliation_strings":["Biomedical Engineering Department, University of Houston"],"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Department, University of Houston","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049310026","display_name":"Anilkumar K. Reddy","orcid":null},"institutions":[{"id":"https://openalex.org/I4210089294","display_name":"Indus Instruments (United States)","ror":"https://ror.org/0073h0969","country_code":"US","type":"company","lineage":["https://openalex.org/I4210089294"]},{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anilkumar K. Reddy","raw_affiliation_strings":["Baylor College of Medicine","Indus Instruments"],"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Indus Instruments","institution_ids":["https://openalex.org/I4210089294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102009655","display_name":"Ze\u2010Wei Tao","orcid":"https://orcid.org/0000-0003-0820-3964"},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zewei- Tao","raw_affiliation_strings":["Biomedical Engineering Department, University of Houston"],"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Department, University of Houston","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053456702","display_name":"Sridhar Madala","orcid":null},"institutions":[{"id":"https://openalex.org/I4210089294","display_name":"Indus Instruments (United States)","ror":"https://ror.org/0073h0969","country_code":"US","type":"company","lineage":["https://openalex.org/I4210089294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sridhar Madala","raw_affiliation_strings":["Indus Instruments"],"affiliations":[{"raw_affiliation_string":"Indus Instruments","institution_ids":["https://openalex.org/I4210089294"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056720010","display_name":"Ravi K. Birla","orcid":null},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi K. Birla","raw_affiliation_strings":["Biomedical Engineering Department, University of Houston, Houston, TX, USA"],"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Department, University of Houston, Houston, TX, USA","institution_ids":["https://openalex.org/I44461941"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5080040967"],"corresponding_institution_ids":["https://openalex.org/I44461941"],"apc_list":null,"apc_paid":null,"fwci":1.7271,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.84295589,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"62","issue":"6","first_page":"1614","last_page":"1622"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10338","display_name":"Advanced Sensor and Energy Harvesting Materials","score":0.9629999995231628,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.6782646775245667},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.6763863563537598},{"id":"https://openalex.org/keywords/qrs-complex","display_name":"QRS complex","score":0.5923338532447815},{"id":"https://openalex.org/keywords/cardiac-muscle","display_name":"Cardiac muscle","score":0.4854310154914856},{"id":"https://openalex.org/keywords/fibrin","display_name":"Fibrin","score":0.47895652055740356},{"id":"https://openalex.org/keywords/native-tissue","display_name":"Native tissue","score":0.4427315592765808},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"Tissue engineering","score":0.3714333772659302},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.36813193559646606},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.3344537913799286},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.32605868577957153},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2783031463623047},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2455359399318695}],"concepts":[{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.6782646775245667},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.6763863563537598},{"id":"https://openalex.org/C111773187","wikidata":"https://www.wikidata.org/wiki/Q1969239","display_name":"QRS complex","level":2,"score":0.5923338532447815},{"id":"https://openalex.org/C2778996579","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac muscle","level":2,"score":0.4854310154914856},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.47895652055740356},{"id":"https://openalex.org/C2993784607","wikidata":"https://www.wikidata.org/wiki/Q40397","display_name":"Native tissue","level":3,"score":0.4427315592765808},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.3714333772659302},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.36813193559646606},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3344537913799286},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.32605868577957153},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2783031463623047},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2455359399318695},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022062","descriptor_name":"Electrophysiologic Techniques, Cardiac","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D022062","descriptor_name":"Electrophysiologic Techniques, Cardiac","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D022062","descriptor_name":"Electrophysiologic Techniques, Cardiac","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D022062","descriptor_name":"Electrophysiologic Techniques, Cardiac","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D022062","descriptor_name":"Electrophysiologic Techniques, Cardiac","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D022062","descriptor_name":"Electrophysiologic Techniques, Cardiac","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbme.2015.2399437","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2015.2399437","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:25667345","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25667345","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7717892955","display_name":null,"funder_award_id":"R01-EB011516","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309549","display_name":"University of Houston","ror":"https://ror.org/040vwpm13"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1840520116","https://openalex.org/W1964184143","https://openalex.org/W1965244293","https://openalex.org/W1967589422","https://openalex.org/W1970351990","https://openalex.org/W1976419485","https://openalex.org/W1978055200","https://openalex.org/W1995423354","https://openalex.org/W2014762318","https://openalex.org/W2018474760","https://openalex.org/W2029225855","https://openalex.org/W2033282181","https://openalex.org/W2040341666","https://openalex.org/W2052943522","https://openalex.org/W2058247311","https://openalex.org/W2069058079","https://openalex.org/W2085776993","https://openalex.org/W2091573294","https://openalex.org/W2093337826","https://openalex.org/W2096237299","https://openalex.org/W2125306719","https://openalex.org/W2126051807","https://openalex.org/W2131746030","https://openalex.org/W2134053621","https://openalex.org/W2161118621","https://openalex.org/W2165115062","https://openalex.org/W2170823241","https://openalex.org/W2396413228","https://openalex.org/W4211147424","https://openalex.org/W4236448317","https://openalex.org/W6679490775"],"related_works":["https://openalex.org/W2061245480","https://openalex.org/W2151149598","https://openalex.org/W2359125179","https://openalex.org/W2341518303","https://openalex.org/W2190102455","https://openalex.org/W2110111497","https://openalex.org/W157877078","https://openalex.org/W2078819653","https://openalex.org/W2335634009","https://openalex.org/W2111390181"],"abstract_inverted_index":{"The":[0,151,176],"purpose":[1],"of":[2,20,43,65,79,158,167,190],"this":[3,27,70,180],"study":[4,181,231],"was":[5,57,72],"to":[6,15,39,59,74,85,117,234],"develop,":[7],"assess,":[8],"and":[9,89,101,144,163,206,238,248],"validate":[10],"a":[11,36,183,204],"custom":[12],"32-channel":[13],"system":[14,56,71],"analyze":[16],"the":[17,41,46,51,61,66,76,86,94,112,129,173,187,191,209,240],"electrical":[18,77,224],"properties":[19,78,189,225,237],"3-D":[21],"artificial":[22],"heart":[23,211,217],"muscle":[24,67,212],"(3D-AHM).":[25],"In":[26],"study,":[28],"neonatal":[29],"rat":[30,81],"cardiac":[31,102],"cells":[32],"were":[33,48,134],"cultured":[34],"in":[35,93,125,179],"fibrin":[37],"gel":[38],"drive":[40],"formation":[42],"3D-AHM.":[44,150],"Once":[45],"tissues":[47,88],"fully":[49],"formed,":[50],"customized":[52],"electrocardiogram":[53],"(EKG)":[54],"sensing":[55],"used":[58,73],"obtain":[60],"different":[62],"electrophysiological":[63],"characteristics":[64],"constructs.":[68,175],"Additionally,":[69],"evaluate":[75],"native":[80,90,216],"hearts,":[82],"for":[83,149,172,198,226],"comparison":[84],"fabricated":[87,130],"values":[91],"found":[92],"literature.":[95],"Histological":[96],"evaluation":[97],"showed":[98],"extensive":[99],"cellularization":[100],"tissue":[103,174,218],"formation.":[104],"EKG":[105,199],"data":[106,177,200],"analysis":[107],"yielded":[108],"time":[109],"delays":[110],"between":[111],"signals":[113],"ranging":[114],"from":[115],"0":[116],"7":[118],"ms.":[119],"Optical":[120],"maps":[121],"exhibited":[122,154],"slight":[123],"trends":[124],"impulse":[126],"propagation":[127],"throughout":[128],"tissue.":[131],"Conduction":[132],"velocities":[133],"calculated":[135],"longitudinally":[136],"at":[137,141,146],"277.81":[138],"cm/s,":[139,143],"transversely":[140],"300.79":[142],"diagonally":[145],"285.68":[147],"cm/s":[148],"QRS":[152],"complex":[153],"an":[155,164],"R-wave":[156],"amplitude":[157],"438.42":[159],"\u00b1":[160,169],"36.96":[161],"\u03bcV":[162],"average":[165],"duration":[166],"317.5":[168],"16.5":[170],"ms":[171],"collected":[178],"provide":[182],"clearer":[184],"picture":[185],"about":[186],"intrinsic":[188],"3D-AHM":[192],"while":[193],"proving":[194],"our":[195],"system's":[196],"efficacy":[197],"procurement.":[201],"To":[202],"achieve":[203],"viable":[205],"permanent":[207],"solution,":[208],"bioengineered":[210],"must":[213],"physiologically":[214],"resemble":[215],"as":[219,221],"well":[220],"mimic":[222],"its":[223],"proper":[227],"contractile":[228],"function.":[229,249],"This":[230],"allows":[232],"us":[233],"monitor":[235],"such":[236],"assess":[239],"necessary":[241],"changes":[242],"that":[243],"will":[244],"improve":[245],"construct":[246],"development":[247]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}