{"id":"https://openalex.org/W2032335972","doi":"https://doi.org/10.1109/tbme.2014.2314357","title":"Recent Advances in Thermal Treatment Techniques and Thermally Induced Immune Responses Against Cancer","display_name":"Recent Advances in Thermal Treatment Techniques and Thermally Induced Immune Responses Against Cancer","publication_year":2014,"publication_date":"2014-04-10","ids":{"openalex":"https://openalex.org/W2032335972","doi":"https://doi.org/10.1109/tbme.2014.2314357","mag":"2032335972","pmid":"https://pubmed.ncbi.nlm.nih.gov/24732979"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2014.2314357","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2014.2314357","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036032938","display_name":"Jinfeng Bai","orcid":"https://orcid.org/0000-0001-8940-480X"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"J. F. Bai","raw_affiliation_strings":["Shanghai Jiao Tong University, School of Biomedical Engineering, Shanghai, China","Sch. of Biomed. Eng., Shanghai Jiao Tong Univ., Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Jiao Tong University, School of Biomedical Engineering, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Sch. of Biomed. Eng., Shanghai Jiao Tong Univ., Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100713390","display_name":"Pan Liu","orcid":"https://orcid.org/0000-0002-4063-9605"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"P. Liu","raw_affiliation_strings":["Shanghai Jiao Tong University, School of Biomedical Engineering, Shanghai, China","Sch. of Biomed. Eng., Shanghai Jiao Tong Univ., Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Jiao Tong University, School of Biomedical Engineering, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Sch. of Biomed. Eng., Shanghai Jiao Tong Univ., Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043622943","display_name":"Lisa X. Xu","orcid":"https://orcid.org/0000-0003-2873-3225"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"L. X. Xu","raw_affiliation_strings":["Shanghai Jiao Tong University, School of Biomedical Engineering and Med-X Research Institute, Shanghai, China","Sch. of Biomed. Eng., Shanghai Jiao Tong Univ., Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Jiao Tong University, School of Biomedical Engineering and Med-X Research Institute, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Sch. of Biomed. Eng., Shanghai Jiao Tong Univ., Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5036032938"],"corresponding_institution_ids":["https://openalex.org/I183067930"],"apc_list":null,"apc_paid":null,"fwci":0.854,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.72450493,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"61","issue":"5","first_page":"1497","last_page":"1505"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.9866999983787537,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9807000160217285,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-ablation","display_name":"Tumor ablation","score":0.688856303691864},{"id":"https://openalex.org/keywords/thermal-ablation","display_name":"Thermal ablation","score":0.649347186088562},{"id":"https://openalex.org/keywords/ablation","display_name":"Ablation","score":0.6411715745925903},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.6356333494186401},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5999681949615479},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5489625334739685},{"id":"https://openalex.org/keywords/cancer-treatment","display_name":"Cancer treatment","score":0.45950669050216675},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"Cancer therapy","score":0.4479201138019562},{"id":"https://openalex.org/keywords/treatment-modality","display_name":"Treatment modality","score":0.4406547248363495},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.21340849995613098},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.16799169778823853}],"concepts":[{"id":"https://openalex.org/C3020187634","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Tumor ablation","level":3,"score":0.688856303691864},{"id":"https://openalex.org/C2992234517","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Thermal ablation","level":3,"score":0.649347186088562},{"id":"https://openalex.org/C2778902805","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Ablation","level":2,"score":0.6411715745925903},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6356333494186401},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5999681949615479},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5489625334739685},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.45950669050216675},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.4479201138019562},{"id":"https://openalex.org/C3020606620","wikidata":"https://www.wikidata.org/wiki/Q179661","display_name":"Treatment modality","level":2,"score":0.4406547248363495},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21340849995613098},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16799169778823853}],"mesh":[{"descriptor_ui":"D003452","descriptor_name":"Cryosurgery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003452","descriptor_name":"Cryosurgery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003452","descriptor_name":"Cryosurgery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D055011","descriptor_name":"Ablation Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055011","descriptor_name":"Ablation Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055011","descriptor_name":"Ablation Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057086","descriptor_name":"High-Intensity Focused Ultrasound Ablation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057086","descriptor_name":"High-Intensity Focused Ultrasound Ablation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057086","descriptor_name":"High-Intensity Focused Ultrasound Ablation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbme.2014.2314357","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2014.2314357","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:24732979","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24732979","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9","score":0.5600000023841858}],"awards":[{"id":"https://openalex.org/G8450421888","display_name":null,"funder_award_id":"11275126","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":131,"referenced_works":["https://openalex.org/W24302367","https://openalex.org/W171605292","https://openalex.org/W324120520","https://openalex.org/W1035517807","https://openalex.org/W1441574878","https://openalex.org/W1513881469","https://openalex.org/W1520353258","https://openalex.org/W1523675883","https://openalex.org/W1527151869","https://openalex.org/W1614691964","https://openalex.org/W1892890053","https://openalex.org/W1964009439","https://openalex.org/W1969545795","https://openalex.org/W1970864897","https://openalex.org/W1973100173","https://openalex.org/W1975286129","https://openalex.org/W1977004881","https://openalex.org/W1979238472","https://openalex.org/W1981594234","https://openalex.org/W1983624489","https://openalex.org/W1984453668","https://openalex.org/W1984484036","https://openalex.org/W1988637965","https://openalex.org/W1992555237","https://openalex.org/W1993306984","https://openalex.org/W1995481447","https://openalex.org/W1999289656","https://openalex.org/W2001768920","https://openalex.org/W2001780123","https://openalex.org/W2002771831","https://openalex.org/W2002972840","https://openalex.org/W2003736464","https://openalex.org/W2004085483","https://openalex.org/W2004238611","https://openalex.org/W2004266769","https://openalex.org/W2007091608","https://openalex.org/W2008799640","https://openalex.org/W2011805117","https://openalex.org/W2012674211","https://openalex.org/W2016000295","https://openalex.org/W2017101043","https://openalex.org/W2017410663","https://openalex.org/W2018592534","https://openalex.org/W2018653121","https://openalex.org/W2025191689","https://openalex.org/W2026131421","https://openalex.org/W2027963618","https://openalex.org/W2029628302","https://openalex.org/W2029948407","https://openalex.org/W2029991069","https://openalex.org/W2030694165","https://openalex.org/W2041579416","https://openalex.org/W2042144858","https://openalex.org/W2044657849","https://openalex.org/W2047679945","https://openalex.org/W2051340989","https://openalex.org/W2052569696","https://openalex.org/W2060032703","https://openalex.org/W2061806683","https://openalex.org/W2063172437","https://openalex.org/W2064585996","https://openalex.org/W2064665989","https://openalex.org/W2065685950","https://openalex.org/W2065978997","https://openalex.org/W2067098437","https://openalex.org/W2068613291","https://openalex.org/W2070957683","https://openalex.org/W2071673959","https://openalex.org/W2073956340","https://openalex.org/W2075203722","https://openalex.org/W2077201251","https://openalex.org/W2080645627","https://openalex.org/W2084289098","https://openalex.org/W2087201759","https://openalex.org/W2088604038","https://openalex.org/W2088672140","https://openalex.org/W2089900609","https://openalex.org/W2090172464","https://openalex.org/W2090799771","https://openalex.org/W2091493364","https://openalex.org/W2093545893","https://openalex.org/W2096903762","https://openalex.org/W2097903633","https://openalex.org/W2098793684","https://openalex.org/W2101024100","https://openalex.org/W2101580680","https://openalex.org/W2101859149","https://openalex.org/W2105252803","https://openalex.org/W2105258021","https://openalex.org/W2105607314","https://openalex.org/W2110064348","https://openalex.org/W2111616718","https://openalex.org/W2112820219","https://openalex.org/W2113376628","https://openalex.org/W2113789124","https://openalex.org/W2115306657","https://openalex.org/W2115866604","https://openalex.org/W2116196276","https://openalex.org/W2116220875","https://openalex.org/W2119014922","https://openalex.org/W2119769028","https://openalex.org/W2123250747","https://openalex.org/W2131979090","https://openalex.org/W2132729014","https://openalex.org/W2133202049","https://openalex.org/W2138534590","https://openalex.org/W2140633375","https://openalex.org/W2142627274","https://openalex.org/W2144590010","https://openalex.org/W2148403372","https://openalex.org/W2148880605","https://openalex.org/W2149404987","https://openalex.org/W2156522421","https://openalex.org/W2158332951","https://openalex.org/W2158667855","https://openalex.org/W2158879960","https://openalex.org/W2161650299","https://openalex.org/W2164111677","https://openalex.org/W2169161417","https://openalex.org/W2171214225","https://openalex.org/W2171799893","https://openalex.org/W2260314710","https://openalex.org/W2410544662","https://openalex.org/W2414475182","https://openalex.org/W6607033212","https://openalex.org/W6628362180","https://openalex.org/W6631364512","https://openalex.org/W6636483821","https://openalex.org/W6675844642","https://openalex.org/W6676033066","https://openalex.org/W6716033642"],"related_works":["https://openalex.org/W2069536232","https://openalex.org/W1501570921","https://openalex.org/W1766484949","https://openalex.org/W2067204570","https://openalex.org/W2029679708","https://openalex.org/W2973566442","https://openalex.org/W4394581005","https://openalex.org/W2092807637","https://openalex.org/W2372419336","https://openalex.org/W3164881166"],"abstract_inverted_index":{"In":[0,36],"the":[1,15,62,85],"past":[2],"decades,":[3],"techniques":[4,44],"for":[5,80,89],"tumor":[6],"diagnosis":[7],"and":[8,33,68],"treatment":[9],"have":[10],"been":[11],"significantly":[12],"advanced.":[13],"However,":[14],"five-year":[16],"survival":[17],"rate":[18],"of":[19,41,64],"cancer":[20,82],"patients":[21],"remains":[22],"low.":[23],"New":[24],"modalities":[25],"are":[26,45],"highly":[27,90],"desirable":[28],"based":[29],"on":[30],"technology":[31],"innovation":[32],"translational":[34],"medicine.":[35],"this":[37],"paper,":[38],"recent":[39],"outcomes":[40],"thermal":[42,48,66],"ablation":[43,67],"reviewed,":[46],"including":[47],"energy":[49],"delivery":[50],"methods,":[51],"thermally":[52,69],"induced":[53,70],"immune":[54,73],"responses":[55],"in":[56,84],"depth.":[57],"It":[58],"is":[59],"suggested":[60],"that":[61],"synergy":[63],"local":[65],"whole":[71],"body":[72],"response":[74],"could":[75],"be":[76],"a":[77],"promising":[78],"direction":[79],"effective":[81],"therapy":[83],"near":[86],"future,":[87],"especially":[88],"metastatic":[91],"tumor.":[92]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
