{"id":"https://openalex.org/W2148768059","doi":"https://doi.org/10.1109/tbme.2014.2311118","title":"Segmentation of Renal Perfusion Signals From Laser Speckle Imaging Into Clusters With Phase Synchronized Dynamics","display_name":"Segmentation of Renal Perfusion Signals From Laser Speckle Imaging Into Clusters With Phase Synchronized Dynamics","publication_year":2014,"publication_date":"2014-03-11","ids":{"openalex":"https://openalex.org/W2148768059","doi":"https://doi.org/10.1109/tbme.2014.2311118","mag":"2148768059","pmid":"https://pubmed.ncbi.nlm.nih.gov/24956617"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2014.2311118","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2014.2311118","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079054224","display_name":"Christopher G. Scully","orcid":"https://orcid.org/0000-0001-8244-0832"},"institutions":[{"id":"https://openalex.org/I107077323","display_name":"Worcester Polytechnic Institute","ror":"https://ror.org/05ejpqr48","country_code":"US","type":"education","lineage":["https://openalex.org/I107077323"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher G. Scully","raw_affiliation_strings":["Department of Biomedical Engineering , Worcester Polytechnic Institute, Worcester","Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering , Worcester Polytechnic Institute, Worcester","institution_ids":["https://openalex.org/I107077323"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA","institution_ids":["https://openalex.org/I107077323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032686306","display_name":"Nicholas Mitrou","orcid":null},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nicholas Mitrou","raw_affiliation_strings":["Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada","Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023504201","display_name":"Branko Braam","orcid":"https://orcid.org/0000-0002-7296-1148"},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Branko Braam","raw_affiliation_strings":["Departments of Medicine and Physiology, University of Alberta, Edmonton, Canada","Departments of Medicine and Physiology, University of Alberta, Edmonton, AB, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Physiology, University of Alberta, Edmonton, Canada","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"Departments of Medicine and Physiology, University of Alberta, Edmonton, AB, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110868279","display_name":"William A. Cupples","orcid":null},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"William A. Cupples","raw_affiliation_strings":["Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada","Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032573836","display_name":"Ki H. Chon","orcid":"https://orcid.org/0000-0002-4422-4837"},"institutions":[{"id":"https://openalex.org/I107077323","display_name":"Worcester Polytechnic Institute","ror":"https://ror.org/05ejpqr48","country_code":"US","type":"education","lineage":["https://openalex.org/I107077323"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ki H. Chon","raw_affiliation_strings":["Department of Biomedical Engineering , Worcester Polytechnic Institute, Worcester","Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering , Worcester Polytechnic Institute, Worcester","institution_ids":["https://openalex.org/I107077323"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA","institution_ids":["https://openalex.org/I107077323"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2284,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.795531,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"61","issue":"7","first_page":"1989","last_page":"1997"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.9420999884605408,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9351999759674072,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/speckle-pattern","display_name":"Speckle pattern","score":0.8210088014602661},{"id":"https://openalex.org/keywords/coherence","display_name":"Coherence (philosophical gambling strategy)","score":0.5637807250022888},{"id":"https://openalex.org/keywords/perfusion","display_name":"Perfusion","score":0.5583850741386414},{"id":"https://openalex.org/keywords/renal-cortex","display_name":"Renal cortex","score":0.5453824400901794},{"id":"https://openalex.org/keywords/laser-doppler-velocimetry","display_name":"Laser Doppler velocimetry","score":0.44114816188812256},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.35660070180892944},{"id":"https://openalex.org/keywords/blood-flow","display_name":"Blood flow","score":0.3428194522857666},{"id":"https://openalex.org/keywords/kidney","display_name":"Kidney","score":0.33185985684394836},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3283611536026001},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.31780409812927246},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2470775842666626},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2096402943134308}],"concepts":[{"id":"https://openalex.org/C102290492","wikidata":"https://www.wikidata.org/wiki/Q7575045","display_name":"Speckle pattern","level":2,"score":0.8210088014602661},{"id":"https://openalex.org/C2781181686","wikidata":"https://www.wikidata.org/wiki/Q4226068","display_name":"Coherence (philosophical gambling strategy)","level":2,"score":0.5637807250022888},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.5583850741386414},{"id":"https://openalex.org/C2778577996","wikidata":"https://www.wikidata.org/wiki/Q2307492","display_name":"Renal cortex","level":3,"score":0.5453824400901794},{"id":"https://openalex.org/C52305850","wikidata":"https://www.wikidata.org/wiki/Q1420475","display_name":"Laser Doppler velocimetry","level":3,"score":0.44114816188812256},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.35660070180892944},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.3428194522857666},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.33185985684394836},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3283611536026001},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.31780409812927246},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2470775842666626},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2096402943134308},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007672","descriptor_name":"Kidney Cortex","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D007672","descriptor_name":"Kidney Cortex","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D007672","descriptor_name":"Kidney Cortex","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D012079","descriptor_name":"Renal Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012079","descriptor_name":"Renal Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012079","descriptor_name":"Renal Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020318","descriptor_name":"Rats, Long-Evans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020318","descriptor_name":"Rats, Long-Evans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020318","descriptor_name":"Rats, Long-Evans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbme.2014.2311118","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2014.2311118","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:24956617","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24956617","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7073502274","display_name":null,"funder_award_id":"MOP-102694","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W184847470","https://openalex.org/W195078343","https://openalex.org/W1525465974","https://openalex.org/W1902027874","https://openalex.org/W1967448769","https://openalex.org/W1968898826","https://openalex.org/W1969829606","https://openalex.org/W1975642440","https://openalex.org/W1983356028","https://openalex.org/W1993780889","https://openalex.org/W2000157495","https://openalex.org/W2017288758","https://openalex.org/W2019412778","https://openalex.org/W2045755323","https://openalex.org/W2054845099","https://openalex.org/W2063503589","https://openalex.org/W2071582757","https://openalex.org/W2080164391","https://openalex.org/W2095814115","https://openalex.org/W2123209321","https://openalex.org/W2123404055","https://openalex.org/W2132692097","https://openalex.org/W2134164118","https://openalex.org/W2136787567","https://openalex.org/W2138383114","https://openalex.org/W2138742704","https://openalex.org/W2147182902","https://openalex.org/W2154870960","https://openalex.org/W2157991072","https://openalex.org/W2177560687","https://openalex.org/W2313019537","https://openalex.org/W2407650814","https://openalex.org/W2417794721","https://openalex.org/W2419587543","https://openalex.org/W3104214844","https://openalex.org/W4241980096"],"related_works":["https://openalex.org/W2053540276","https://openalex.org/W3043482392","https://openalex.org/W2079028290","https://openalex.org/W2161552906","https://openalex.org/W2093574757","https://openalex.org/W2059121517","https://openalex.org/W2140375333","https://openalex.org/W2029916769","https://openalex.org/W2064858779","https://openalex.org/W1983257187"],"abstract_inverted_index":{"Renal":[0],"perfusion":[1,166],"signals":[2],"contain":[3],"dynamics":[4,27,182],"arising":[5],"from":[6],"the":[7,13,25,31,44,94,104,127,152,184],"renal":[8,32,45,95,105,128,180,185],"autoregulation":[9,181],"feedback":[10],"mechanisms":[11],"as":[12],"contraction":[14],"and":[15],"dilation":[16],"of":[17,43,93,97,115,122],"vessels":[18],"alter":[19],"flow":[20],"patterns.":[21],"We":[22,38],"can":[23,173],"capture":[24],"time-varying":[26],"at":[28],"points":[29],"across":[30,183],"surface":[33,106,165],"using":[34],"laser":[35,90],"speckle":[36,91],"imaging.":[37],"segment":[39,77],"an":[40],"imaged":[41,118],"area":[42],"cortex":[46,96],"into":[47,81,132],"clusters":[48,133,142],"with":[49,59,107,134],"phase":[50,57,78,82,108,136],"synchronized":[51,67,83,109],"dynamics.":[52],"Our":[53],"approach":[54],"first":[55],"uses":[56],"coherence":[58,79],"a":[60,156],"surrogate":[61],"data":[62],"derived":[63],"threshold":[64],"to":[65,76,89,100,176],"identify":[66,101,177],"pixel":[68],"pairs.":[69],"Non-negative":[70],"matrix":[71],"factorization":[72],"is":[73,87],"then":[74],"applied":[75,88],"estimates":[80],"regions.":[84],"The":[85],"method":[86,172],"imaging":[92],"anaesthetized":[98],"rats":[99],"regions":[102],"on":[103],"myogenic":[110,158],"activity.":[111],"In":[112,151],"three":[113,154],"out":[114],"six":[116],"animals":[117],"after":[119],"bolus":[120],"infusion":[121],"N(\u03c9)-nitro-l-arginine":[123],"methyl":[124],"ester":[125],"(NAM),":[126],"surfaces":[129],"are":[130],"segmented":[131],"high":[135],"coherence.":[137],"No":[138],"more":[139],"than":[140],"two":[141],"were":[143],"identified":[144],"during":[145,167],"control":[146,168],"period":[147],"for":[148],"any":[149],"animal.":[150],"remaining":[153],"animals,":[155],"strong":[157],"signal":[159],"could":[160],"not":[161],"be":[162,174],"detected":[163],"in":[164,179],"or":[169],"NAM.":[170],"This":[171],"used":[175],"synchronization":[178],"surface.":[186]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}