{"id":"https://openalex.org/W2071557586","doi":"https://doi.org/10.1109/tbme.2013.2244598","title":"Bridging Paradigms: Hybrid Mechanistic-Discriminative Predictive Models","display_name":"Bridging Paradigms: Hybrid Mechanistic-Discriminative Predictive Models","publication_year":2013,"publication_date":"2013-02-04","ids":{"openalex":"https://openalex.org/W2071557586","doi":"https://doi.org/10.1109/tbme.2013.2244598","mag":"2071557586","pmid":"https://pubmed.ncbi.nlm.nih.gov/23392334"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2013.2244598","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2013.2244598","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://durham-repository.worktribe.com/output/1489871","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064274203","display_name":"Orla Doyle","orcid":"https://orcid.org/0000-0002-6964-0140"},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I165524941","display_name":"Wellcome Centre for Human Neuroimaging","ror":"https://ror.org/02704qw51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I165524941","https://openalex.org/I45129253","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"O. M. Doyle","raw_affiliation_strings":["Department of Neuroimaging, Institute of Psychiatry, King's College London, London, UK. orla.doyle@kcl.ac.uk","Dept. of Neuroimaging, Inst. of Psychiatry, London, UK"],"affiliations":[{"raw_affiliation_string":"Department of Neuroimaging, Institute of Psychiatry, King's College London, London, UK. orla.doyle@kcl.ac.uk","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Dept. of Neuroimaging, Inst. of Psychiatry, London, UK","institution_ids":["https://openalex.org/I165524941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109184290","display_name":"K. Tsaneva-Atansaova","orcid":null},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K. Tsaneva-Atansaova","raw_affiliation_strings":["Department of Engineering Mathematics, University of Bristol, Bristol, U.K","Dept. of Eng. Math., Univ. of Bristol, Bristol, UK#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Engineering Mathematics, University of Bristol, Bristol, U.K","institution_ids":["https://openalex.org/I36234482"]},{"raw_affiliation_string":"Dept. of Eng. Math., Univ. of Bristol, Bristol, UK#TAB#","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070997192","display_name":"James M. Harte","orcid":"https://orcid.org/0000-0003-0785-5450"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Harte","raw_affiliation_strings":["Institute of Digital Healthcare, University of Warwick, Coventry, U.K","Inst. of Digital Healthcare, Univ. of Warwick, Coventry, UK"],"affiliations":[{"raw_affiliation_string":"Institute of Digital Healthcare, University of Warwick, Coventry, U.K","institution_ids":[]},{"raw_affiliation_string":"Inst. of Digital Healthcare, Univ. of Warwick, Coventry, UK","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052868041","display_name":"Paul A. Tiffin","orcid":"https://orcid.org/0000-0003-1770-5034"},"institutions":[{"id":"https://openalex.org/I190082696","display_name":"Durham University","ror":"https://ror.org/01v29qb04","country_code":"GB","type":"education","lineage":["https://openalex.org/I190082696"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. A. Tiffin","raw_affiliation_strings":["School for Medicine Pharmacy and Health, Durham University, Durham, U.K","School for Medicine, Pharmacy and Health, Durham University, Durham, UK"],"affiliations":[{"raw_affiliation_string":"School for Medicine Pharmacy and Health, Durham University, Durham, U.K","institution_ids":[]},{"raw_affiliation_string":"School for Medicine, Pharmacy and Health, Durham University, Durham, UK","institution_ids":["https://openalex.org/I190082696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051182859","display_name":"Peter Ti\u0148o","orcid":"https://orcid.org/0000-0003-2330-128X"},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. Tino","raw_affiliation_strings":["School of Computer Science, University of Birmingham, Edgbaston, UK","School of Computer Science, University of Birmingham, Birmingham, UK"],"affiliations":[{"raw_affiliation_string":"School of Computer Science, University of Birmingham, Edgbaston, UK","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"School of Computer Science, University of Birmingham, Birmingham, UK","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026601290","display_name":"Vanessa D\u00edaz\u2010Zuccarini","orcid":"https://orcid.org/0000-0003-3183-7463"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vanessa Diaz-Zuccarini","raw_affiliation_strings":["Department of Mechanical Engineering, University College London, London, UK","Dept. of Mech. Eng., Univ. Coll. London, London, UK"],"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Dept. of Mech. Eng., Univ. Coll. London, London, UK","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5064274203"],"corresponding_institution_ids":["https://openalex.org/I165524941","https://openalex.org/I183935753"],"apc_list":null,"apc_paid":null,"fwci":0.8984,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.7431536,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"60","issue":"3","first_page":"735","last_page":"742"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/viewpoints","display_name":"Viewpoints","score":0.7568975687026978},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6623525619506836},{"id":"https://openalex.org/keywords/bridging","display_name":"Bridging (networking)","score":0.6607893705368042},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5601617097854614},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.546038031578064},{"id":"https://openalex.org/keywords/discriminative-model","display_name":"Discriminative model","score":0.48045843839645386},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3541472554206848}],"concepts":[{"id":"https://openalex.org/C2776035091","wikidata":"https://www.wikidata.org/wiki/Q7928819","display_name":"Viewpoints","level":2,"score":0.7568975687026978},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6623525619506836},{"id":"https://openalex.org/C174348530","wikidata":"https://www.wikidata.org/wiki/Q188635","display_name":"Bridging (networking)","level":2,"score":0.6607893705368042},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5601617097854614},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.546038031578064},{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.48045843839645386},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3541472554206848},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.0},{"id":"https://openalex.org/C153349607","wikidata":"https://www.wikidata.org/wiki/Q36649","display_name":"Visual arts","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035843","descriptor_name":"Biomedical Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035843","descriptor_name":"Biomedical Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035843","descriptor_name":"Biomedical Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1109/tbme.2013.2244598","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2013.2244598","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:23392334","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23392334","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:research-information.bris.ac.uk:openaire_cris_publications/03eb7aa5-7be8-4a8c-9704-539283f46884","is_oa":false,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/03eb7aa5-7be8-4a8c-9704-539283f46884","pdf_url":null,"source":{"id":"https://openalex.org/S7407055359","display_name":"Explore Bristol Research","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Doyle, O, Tsaneva-Atanasova, K, Harte, J, Tiffin, P, Tino, P & Diaz-Zuccarini, V 2013, 'Bridging Paradigms : Hybrid Mechanistic-Discriminative Predictive Models', IEEE Transactions on Biomedical Engineering. https://doi.org/10.1109/TBME.2013.2244598","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:dro.dur.ac.uk.OAI2:13284","is_oa":false,"landing_page_url":"http://dro.dur.ac.uk/13284/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196258","display_name":"Durham Research Online (Durham University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I190082696","host_organization_name":"Durham University","host_organization_lineage":["https://openalex.org/I190082696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"IEEE transactions on biomedical engineering, 2013, Vol.60(3), pp.735-742 [Peer Reviewed Journal]","raw_type":"Article"},{"id":"pmh:oai:durham-repository.worktribe.com:1489871","is_oa":true,"landing_page_url":"https://durham-repository.worktribe.com/output/1489871","pdf_url":null,"source":{"id":"https://openalex.org/S4306400188","display_name":"Durham Research Online (Durham University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I190082696","host_organization_name":"Durham University","host_organization_lineage":["https://openalex.org/I190082696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1394039","is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1394039/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING , 60  (3)   pp. 735-742.   (2013)      ","raw_type":"Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/f3e378ac-f4e5-4319-8a7d-fde46ec701af","is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/f3e378ac-f4e5-4319-8a7d-fde46ec701af","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doyle , O M , Tsaneva-Atansaova , K , Harte , J , Tiffin , P A , Tino , P & D\u00edaz-Zuccarini , V 2013 , ' Bridging paradigms : hybrid mechanistic-discriminative predictive models ' , IEEE Transactions on Biomedical Engineering , vol. 60 , no. 3 , pp. 735-742 . https://doi.org/10.1109/TBME.2013.2244598","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:durham-repository.worktribe.com:1489871","is_oa":true,"landing_page_url":"https://durham-repository.worktribe.com/output/1489871","pdf_url":null,"source":{"id":"https://openalex.org/S4306400188","display_name":"Durham Research Online (Durham University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I190082696","host_organization_name":"Durham University","host_organization_lineage":["https://openalex.org/I190082696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","score":0.7900000214576721,"display_name":"Reduced inequalities"}],"awards":[{"id":"https://openalex.org/G2377813503","display_name":null,"funder_award_id":"BB/J014699/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2627452405","display_name":null,"funder_award_id":"BB/H012508/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6840695367","display_name":null,"funder_award_id":"EP/I018638/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W135014142","https://openalex.org/W173906397","https://openalex.org/W1540155273","https://openalex.org/W1750536449","https://openalex.org/W1820772924","https://openalex.org/W1967541074","https://openalex.org/W1969959732","https://openalex.org/W1976044168","https://openalex.org/W1979289529","https://openalex.org/W1980062933","https://openalex.org/W1983147519","https://openalex.org/W1986397618","https://openalex.org/W1987652216","https://openalex.org/W1997864710","https://openalex.org/W2000292092","https://openalex.org/W2007804187","https://openalex.org/W2011430131","https://openalex.org/W2012470375","https://openalex.org/W2018116321","https://openalex.org/W2018545641","https://openalex.org/W2022763971","https://openalex.org/W2025786233","https://openalex.org/W2035720196","https://openalex.org/W2040545532","https://openalex.org/W2047066646","https://openalex.org/W2047555270","https://openalex.org/W2048631316","https://openalex.org/W2053559585","https://openalex.org/W2053821121","https://openalex.org/W2054987174","https://openalex.org/W2064314501","https://openalex.org/W2065180801","https://openalex.org/W2066861429","https://openalex.org/W2079458462","https://openalex.org/W2081535035","https://openalex.org/W2082475952","https://openalex.org/W2083465881","https://openalex.org/W2092318512","https://openalex.org/W2092587625","https://openalex.org/W2093693172","https://openalex.org/W2095692398","https://openalex.org/W2096283457","https://openalex.org/W2101183614","https://openalex.org/W2102125248","https://openalex.org/W2104787607","https://openalex.org/W2106952837","https://openalex.org/W2115242586","https://openalex.org/W2115632542","https://openalex.org/W2116728999","https://openalex.org/W2121156246","https://openalex.org/W2126892270","https://openalex.org/W2131962222","https://openalex.org/W2132026986","https://openalex.org/W2132557820","https://openalex.org/W2132954395","https://openalex.org/W2137705650","https://openalex.org/W2138321569","https://openalex.org/W2139333781","https://openalex.org/W2141773277","https://openalex.org/W2142170450","https://openalex.org/W2143426320","https://openalex.org/W2144354855","https://openalex.org/W2149489749","https://openalex.org/W2149649894","https://openalex.org/W2151182412","https://openalex.org/W2151531457","https://openalex.org/W2153592242","https://openalex.org/W2153939756","https://openalex.org/W2155369224","https://openalex.org/W2156230353","https://openalex.org/W2161064815","https://openalex.org/W2166473218","https://openalex.org/W2171831801","https://openalex.org/W3003413895","https://openalex.org/W3036588604","https://openalex.org/W3139884153","https://openalex.org/W4240172095","https://openalex.org/W4241820278","https://openalex.org/W4256475235","https://openalex.org/W6646187470","https://openalex.org/W6663437110","https://openalex.org/W6682443497","https://openalex.org/W6684116732"],"related_works":["https://openalex.org/W2385368906","https://openalex.org/W2902924992","https://openalex.org/W2626642044","https://openalex.org/W2619807045","https://openalex.org/W2388758053","https://openalex.org/W93537448","https://openalex.org/W2949734191","https://openalex.org/W2017333877","https://openalex.org/W2048332520","https://openalex.org/W4233821346"],"abstract_inverted_index":{"Many":[0],"disease":[1],"processes":[2,11],"are":[3,26,63],"extremely":[4],"complex":[5],"and":[6,21,52,66],"characterized":[7],"by":[8],"multiple":[9],"stochastic":[10],"interacting":[12],"simultaneously.":[13],"Current":[14],"analytical":[15],"approaches":[16],"have":[17],"included":[18],"mechanistic":[19,50],"models":[20,51],"machine":[22],"learning":[23],"(ML),":[24],"which":[25,62],"often":[27],"treated":[28],"as":[29,56,58],"orthogonal":[30],"viewpoints.":[31],"However,":[32],"to":[33],"facilitate":[34],"truly":[35],"personalized":[36],"medicine,":[37],"new":[38],"perspectives":[39],"may":[40],"be":[41],"required.":[42],"This":[43],"paper":[44],"reviews":[45],"the":[46],"use":[47],"of":[48],"both":[49],"ML":[53],"in":[54],"healthcare":[55],"well":[57],"emerging":[59],"hybrid":[60],"methods,":[61],"an":[64],"exciting":[65],"promising":[67],"approach":[68],"for":[69],"biologically":[70],"based,":[71],"yet":[72],"data-driven":[73],"advanced":[74],"intelligent":[75],"systems.":[76]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}