{"id":"https://openalex.org/W2122789959","doi":"https://doi.org/10.1109/tbme.2013.2237906","title":"Segmentation of Choroidal Neovascularization in Fundus Fluorescein Angiograms","display_name":"Segmentation of Choroidal Neovascularization in Fundus Fluorescein Angiograms","publication_year":2013,"publication_date":"2013-01-09","ids":{"openalex":"https://openalex.org/W2122789959","doi":"https://doi.org/10.1109/tbme.2013.2237906","mag":"2122789959","pmid":"https://pubmed.ncbi.nlm.nih.gov/23314765"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2013.2237906","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2013.2237906","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077410286","display_name":"Walid M. Abdelmoula","orcid":"https://orcid.org/0000-0003-3117-7389"},"institutions":[{"id":"https://openalex.org/I57629906","display_name":"Nile University","ror":"https://ror.org/03cg7cp61","country_code":"EG","type":"education","lineage":["https://openalex.org/I57629906"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"W. M. Abdelmoula","raw_affiliation_strings":["Center for Informatics Science, Nile University, Cairo 12677, Egypt","Center for Inf. Sci., Nile Univ., Cairo, Egypt"],"affiliations":[{"raw_affiliation_string":"Center for Informatics Science, Nile University, Cairo 12677, Egypt","institution_ids":[]},{"raw_affiliation_string":"Center for Inf. Sci., Nile Univ., Cairo, Egypt","institution_ids":["https://openalex.org/I57629906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088380787","display_name":"Syed Mahmood Shah","orcid":"https://orcid.org/0000-0002-5262-3563"},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. M. Shah","raw_affiliation_strings":["Flaum Eye Institute, University of Rochester, New York, USA","Flaum Eye Institute, University of Rochester, Rochester, NY, USA"],"affiliations":[{"raw_affiliation_string":"Flaum Eye Institute, University of Rochester, New York, USA","institution_ids":["https://openalex.org/I5388228"]},{"raw_affiliation_string":"Flaum Eye Institute, University of Rochester, Rochester, NY, USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112368923","display_name":"Ahmed S. Fahmy","orcid":null},"institutions":[{"id":"https://openalex.org/I57629906","display_name":"Nile University","ror":"https://ror.org/03cg7cp61","country_code":"EG","type":"education","lineage":["https://openalex.org/I57629906"]},{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"A. S. Fahmy","raw_affiliation_strings":["Center for Informatics science, Nile University, Cairo, Egypt","Department of Systems and Biomedical Engineering, Cairo University, Cairo, Egypt","Center for Inf. Sci., Nile Univ., Cairo, Egypt"],"affiliations":[{"raw_affiliation_string":"Center for Informatics science, Nile University, Cairo, Egypt","institution_ids":["https://openalex.org/I57629906"]},{"raw_affiliation_string":"Department of Systems and Biomedical Engineering, Cairo University, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]},{"raw_affiliation_string":"Center for Inf. Sci., Nile Univ., Cairo, Egypt","institution_ids":["https://openalex.org/I57629906"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5077410286"],"corresponding_institution_ids":["https://openalex.org/I57629906"],"apc_list":null,"apc_paid":null,"fwci":1.0326,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.78003244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"60","issue":"5","first_page":"1439","last_page":"1445"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/choroidal-neovascularization","display_name":"Choroidal neovascularization","score":0.8209617137908936},{"id":"https://openalex.org/keywords/macular-degeneration","display_name":"Macular degeneration","score":0.7263486385345459},{"id":"https://openalex.org/keywords/fundus","display_name":"Fundus (uterus)","score":0.7166275978088379},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.6166208982467651},{"id":"https://openalex.org/keywords/fluorescein-angiography","display_name":"Fluorescein angiography","score":0.5777631402015686},{"id":"https://openalex.org/keywords/retinal","display_name":"Retinal","score":0.5188630819320679},{"id":"https://openalex.org/keywords/choroid","display_name":"Choroid","score":0.5015394687652588},{"id":"https://openalex.org/keywords/ophthalmology","display_name":"Ophthalmology","score":0.4814838171005249},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.44490674138069153},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4211372435092926},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.3979921340942383},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.33212339878082275},{"id":"https://openalex.org/keywords/retina","display_name":"Retina","score":0.30326753854751587},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.12420937418937683}],"concepts":[{"id":"https://openalex.org/C2781359195","wikidata":"https://www.wikidata.org/wiki/Q5105209","display_name":"Choroidal neovascularization","level":3,"score":0.8209617137908936},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.7263486385345459},{"id":"https://openalex.org/C2776391266","wikidata":"https://www.wikidata.org/wiki/Q9612","display_name":"Fundus (uterus)","level":2,"score":0.7166275978088379},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6166208982467651},{"id":"https://openalex.org/C2780248432","wikidata":"https://www.wikidata.org/wiki/Q1434206","display_name":"Fluorescein angiography","level":3,"score":0.5777631402015686},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5188630819320679},{"id":"https://openalex.org/C2776694393","wikidata":"https://www.wikidata.org/wiki/Q271762","display_name":"Choroid","level":3,"score":0.5015394687652588},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4814838171005249},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.44490674138069153},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4211372435092926},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.3979921340942383},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33212339878082275},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.30326753854751587},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.12420937418937683},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005451","descriptor_name":"Fluorescein Angiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005451","descriptor_name":"Fluorescein Angiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005451","descriptor_name":"Fluorescein Angiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020256","descriptor_name":"Choroidal Neovascularization","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020256","descriptor_name":"Choroidal Neovascularization","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020256","descriptor_name":"Choroidal Neovascularization","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbme.2013.2237906","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2013.2237906","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:23314765","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23314765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W24556047","https://openalex.org/W1644997609","https://openalex.org/W1923645765","https://openalex.org/W1985623028","https://openalex.org/W1985801721","https://openalex.org/W1990254675","https://openalex.org/W1991736297","https://openalex.org/W2017545736","https://openalex.org/W2058189916","https://openalex.org/W2068250244","https://openalex.org/W2108789326","https://openalex.org/W2124415048","https://openalex.org/W2143711534","https://openalex.org/W2432517183","https://openalex.org/W2800394774","https://openalex.org/W2981264952","https://openalex.org/W3017143921","https://openalex.org/W3097169496","https://openalex.org/W6601031210","https://openalex.org/W6640531724","https://openalex.org/W6676560373"],"related_works":["https://openalex.org/W3027684582","https://openalex.org/W2993662524","https://openalex.org/W3149813528","https://openalex.org/W2076711558","https://openalex.org/W2616362931","https://openalex.org/W2991715136","https://openalex.org/W2991939470","https://openalex.org/W4251170123","https://openalex.org/W2278521924","https://openalex.org/W4200284702"],"abstract_inverted_index":{"Choroidal":[0],"neovascularization":[1],"(CNV)":[2],"is":[3,13,62,77,123],"a":[4,101,120],"common":[5],"manifestation":[6],"of":[7,18,30,47,69,85,111,143,157,172],"age-related":[8],"macular":[9],"degeneration":[10],"(AMD).":[11],"It":[12],"characterized":[14],"by":[15,138],"the":[16,23,31,41,50,54,70,83,112,127,153,170,173,183],"growth":[17],"abnormal":[19,37],"blood":[20],"vessels":[21,38],"in":[22,59,115,134,179],"choroidal":[24],"layer":[25],"causing":[26,44],"blurring":[27],"and":[28,57,67,93],"deterioration":[29],"vision.":[32],"In":[33,96],"late":[34],"stages,":[35],"these":[36],"can":[39],"rupture":[40],"retinal":[42],"layers":[43],"complete":[45],"loss":[46],"vision":[48],"at":[49,131,146],"affected":[51],"regions.":[52],"Determining":[53],"CNV":[55,75,105,177],"size":[56],"type":[58],"fluorescein":[60,117,139],"angiograms":[61],"required":[63],"for":[64,74,103],"proper":[65],"treatment":[66],"prognosis":[68],"disease.":[71],"Computer-aided":[72],"methods":[73],"segmentation":[76,87],"needed":[78],"not":[79],"only":[80],"to":[81,90,125,151,175],"reduce":[82,91],"burden":[84],"manual":[86,184],"but":[88],"also":[89],"inter-":[92],"intraobserver":[94],"variability.":[95],"this":[97],"paper,":[98],"we":[99],"present":[100],"framework":[102],"segmenting":[104],"lesions":[106,178],"based":[107],"on":[108,162],"parametric":[109],"modeling":[110],"intensity":[113,129],"variation":[114,130],"fundus":[116],"angiograms.":[118],"First,":[119],"novel":[121],"model":[122,144],"proposed":[124],"describe":[126],"temporal":[128],"each":[132,147],"pixel":[133,148],"image":[135,154],"sequences":[136],"acquired":[137],"angiography.":[140],"The":[141],"set":[142],"parameters":[145],"are":[149],"used":[150],"segment":[152,176],"into":[155],"regions":[156],"homogeneous":[158],"parameters.":[159],"Preliminary":[160],"results":[161],"datasets":[163],"from":[164],"21":[165],"patients":[166],"with":[167,182],"Wet-AMD":[168],"show":[169],"potential":[171],"method":[174],"close":[180],"agreement":[181],"segmentation.":[185]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}