{"id":"https://openalex.org/W2010765996","doi":"https://doi.org/10.1109/tbme.2012.2225834","title":"Assessing the Effects of Pharmacological Agents on Respiratory Dynamics Using Time-Series Modeling","display_name":"Assessing the Effects of Pharmacological Agents on Respiratory Dynamics Using Time-Series Modeling","publication_year":2012,"publication_date":"2012-10-25","ids":{"openalex":"https://openalex.org/W2010765996","doi":"https://doi.org/10.1109/tbme.2012.2225834","mag":"2010765996","pmid":"https://pubmed.ncbi.nlm.nih.gov/23193230"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2012.2225834","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2012.2225834","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100516914","display_name":"K. F. K. Wong","orcid":null},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"K. F. K. Wong","raw_affiliation_strings":["Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02129, USA. kfwong@partners.org","Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02129, USA. kfwong@partners.org","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041515359","display_name":"Jen J. Gong","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. J. Gong","raw_affiliation_strings":["Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA","Massachusetts Institute of Technology, Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007052039","display_name":"Joseph F. Cotten","orcid":"https://orcid.org/0000-0002-3526-0908"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. F. Cotten","raw_affiliation_strings":["Department of Anaesthesia, Harvard Medical School, Boston, MA, USA","Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Anaesthesia, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008583793","display_name":"Ken Solt","orcid":"https://orcid.org/0000-0001-5328-2062"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Solt","raw_affiliation_strings":["Department of Anaesthesia, Harvard Medical School, Boston, MA, USA","Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA","Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Anaesthesia, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109283352","display_name":"E. N. Brown","orcid":null},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. N. Brown","raw_affiliation_strings":["Department of Anaesthesia, Harvard Medical School, Boston, MA, USA","Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA","Department of Brain and Cognitive Sciences, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Anaesthesia, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Brain and Cognitive Sciences, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100516914"],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":0.1178,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.41383671,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"60","issue":"4","first_page":"1118","last_page":"1125"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.9919000267982483,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9782999753952026,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/respiratory-rate","display_name":"Respiratory rate","score":0.6897488236427307},{"id":"https://openalex.org/keywords/akaike-information-criterion","display_name":"Akaike information criterion","score":0.683161735534668},{"id":"https://openalex.org/keywords/autoregressive-model","display_name":"Autoregressive model","score":0.5882755517959595},{"id":"https://openalex.org/keywords/respiratory-system","display_name":"Respiratory system","score":0.5626989603042603},{"id":"https://openalex.org/keywords/respiratory-minute-volume","display_name":"Respiratory minute volume","score":0.5152133107185364},{"id":"https://openalex.org/keywords/tidal-volume","display_name":"Tidal volume","score":0.45832645893096924},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.38917624950408936},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.38833847641944885},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3214922547340393},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2539764642715454},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.16977375745773315},{"id":"https://openalex.org/keywords/heart-rate","display_name":"Heart rate","score":0.14028504490852356}],"concepts":[{"id":"https://openalex.org/C8213797","wikidata":"https://www.wikidata.org/wiki/Q754250","display_name":"Respiratory rate","level":4,"score":0.6897488236427307},{"id":"https://openalex.org/C126674687","wikidata":"https://www.wikidata.org/wiki/Q1662573","display_name":"Akaike information criterion","level":2,"score":0.683161735534668},{"id":"https://openalex.org/C159877910","wikidata":"https://www.wikidata.org/wiki/Q2202883","display_name":"Autoregressive model","level":2,"score":0.5882755517959595},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.5626989603042603},{"id":"https://openalex.org/C79959777","wikidata":"https://www.wikidata.org/wiki/Q754333","display_name":"Respiratory minute volume","level":3,"score":0.5152133107185364},{"id":"https://openalex.org/C2777257755","wikidata":"https://www.wikidata.org/wiki/Q3493813","display_name":"Tidal volume","level":3,"score":0.45832645893096924},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.38917624950408936},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.38833847641944885},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3214922547340393},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2539764642715454},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16977375745773315},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.14028504490852356},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007530","descriptor_name":"Isoflurane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007530","descriptor_name":"Isoflurane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007530","descriptor_name":"Isoflurane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007530","descriptor_name":"Isoflurane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008774","descriptor_name":"Methylphenidate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008774","descriptor_name":"Methylphenidate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008774","descriptor_name":"Methylphenidate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008774","descriptor_name":"Methylphenidate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010991","descriptor_name":"Plethysmography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010991","descriptor_name":"Plethysmography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010991","descriptor_name":"Plethysmography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010991","descriptor_name":"Plethysmography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013990","descriptor_name":"Tidal Volume","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013990","descriptor_name":"Tidal Volume","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013990","descriptor_name":"Tidal Volume","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013990","descriptor_name":"Tidal Volume","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018685","descriptor_name":"Anesthetics, Inhalation","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018685","descriptor_name":"Anesthetics, Inhalation","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018685","descriptor_name":"Anesthetics, Inhalation","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018685","descriptor_name":"Anesthetics, Inhalation","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056152","descriptor_name":"Respiratory Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D056152","descriptor_name":"Respiratory Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D056152","descriptor_name":"Respiratory Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D056152","descriptor_name":"Respiratory Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/tbme.2012.2225834","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2012.2225834","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:23193230","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23193230","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:europepmc.org:5364285","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6376979","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6899999976158142,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1490229695","https://openalex.org/W1976861790","https://openalex.org/W1979575715","https://openalex.org/W1980169864","https://openalex.org/W1986986486","https://openalex.org/W1995945562","https://openalex.org/W1999996900","https://openalex.org/W2023614680","https://openalex.org/W2025696947","https://openalex.org/W2031323283","https://openalex.org/W2035454507","https://openalex.org/W2039527771","https://openalex.org/W2043587412","https://openalex.org/W2066026676","https://openalex.org/W2088715256","https://openalex.org/W2111095535","https://openalex.org/W2119774025","https://openalex.org/W2126116691","https://openalex.org/W2129401965","https://openalex.org/W2135338737","https://openalex.org/W2146805593","https://openalex.org/W2159028173","https://openalex.org/W2159669477","https://openalex.org/W2171126132","https://openalex.org/W2249364916","https://openalex.org/W2269515678","https://openalex.org/W2477834368","https://openalex.org/W2798056406","https://openalex.org/W3106889297","https://openalex.org/W4246061069","https://openalex.org/W4292024691","https://openalex.org/W4293223245","https://openalex.org/W4388322985"],"related_works":["https://openalex.org/W3032736716","https://openalex.org/W1996447318","https://openalex.org/W2239550753","https://openalex.org/W1983647495","https://openalex.org/W1732138557","https://openalex.org/W2032936085","https://openalex.org/W2144328154","https://openalex.org/W2072898286","https://openalex.org/W2083596363","https://openalex.org/W2086261615"],"abstract_inverted_index":{"Developing":[0],"quantitative":[1],"descriptions":[2],"of":[3,50,65,82,96,106,117,130,137,141,158,211],"how":[4],"stimulant":[5,120],"and":[6,25,85,99,114,146,178,195,216],"depressant":[7],"drugs":[8],"affect":[9],"the":[10,48,78,83,86,94,97,100,118,124,131,138,142,147,156,171,188,209],"respiratory":[11,68,107,119,144,175,193,196,213],"system":[12],"is":[13],"an":[14,104],"important":[15],"focus":[16],"in":[17,150,174,191],"medical":[18],"research.":[19],"Respiratory":[20],"variables-respiratory":[21],"rate,":[22],"tidal":[23,27],"volume,":[24],"end":[26],"carbon":[28],"dioxide-have":[29],"prominent":[30],"temporal":[31],"dynamics":[32,197,210],"that":[33,42,134],"make":[34],"it":[35],"inappropriate":[36],"to":[37,46,76,91,126,207],"use":[38,71,123],"standard":[39],"hypothesis-testing":[40],"methods":[41],"assume":[43],"independent":[44],"observations":[45],"assess":[47],"effects":[49],"these":[51],"pharmacological":[52],"agents.":[53],"We":[54,70,153],"present":[55],"a":[56,72],"polynomial":[57,98],"signal":[58],"plus":[59],"autoregressive":[60,101],"noise":[61],"model":[62,125,159],"for":[63,155,170],"analysis":[64,105],"continuously":[66],"recorded":[67,109],"variables.":[69],"cyclic":[73],"descent":[74],"algorithm":[75],"maximize":[77],"conditional":[79],"log":[80],"likelihood":[81],"parameters":[84],"corrected":[87],"Akaike's":[88],"information":[89],"criterion":[90],"choose":[92],"simultaneously":[93],"orders":[95],"models.":[102],"In":[103],"rates":[108],"from":[110],"anesthetized":[111],"rats":[112],"before":[113,215],"after":[115,217],"administration":[116],"methylphenidate,":[121],"we":[122],"construct":[127],"within-animal":[128],"z-tests":[129],"drug":[132],"effect":[133,157],"take":[135],"account":[136],"time-varying":[139],"nature":[140],"mean":[143,192],"rate":[145,151,176,194],"serial":[148],"dependence":[149],"measurements.":[152],"correct":[154],"lack-of-fit":[160],"on":[161],"our":[162],"inferences":[163],"by":[164],"also":[165],"computing":[166],"bootstrap":[167],"confidence":[168],"intervals":[169],"average":[172],"difference":[173],"pre-":[177],"postmethylphenidate":[179],"treatment.":[180],"Our":[181],"time-series":[182],"modeling":[183],"quantifies":[184],"within":[185],"each":[186],"animal":[187],"substantial":[189],"increase":[190],"following":[198],"methylphenidate":[199],"administration.":[200],"This":[201],"paradigm":[202],"can":[203],"be":[204],"readily":[205],"adapted":[206],"analyze":[208],"other":[212],"variables":[214],"pharmacologic":[218],"treatments.":[219]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}