{"id":"https://openalex.org/W2004536885","doi":"https://doi.org/10.1109/tbme.2012.2202660","title":"An Integrated Segmentation and Analysis Approach for QCT of the Knee to Determine Subchondral Bone Mineral Density and Texture","display_name":"An Integrated Segmentation and Analysis Approach for QCT of the Knee to Determine Subchondral Bone Mineral Density and Texture","publication_year":2012,"publication_date":"2012-06-05","ids":{"openalex":"https://openalex.org/W2004536885","doi":"https://doi.org/10.1109/tbme.2012.2202660","mag":"2004536885","pmid":"https://pubmed.ncbi.nlm.nih.gov/22692866"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2012.2202660","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2012.2202660","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041365116","display_name":"P. Zerfa\u00df","orcid":null},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"P. Zerfass","raw_affiliation_strings":["Institute of Medical Physics, University of Erlangen-Nuernberg, 91052 Erlangen, Germany. Peter.Zerfass@imp.uni-erlangen.de","Institute of Medical Physics, University of Erlangen-Nuernberg, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Medical Physics, University of Erlangen-Nuernberg, 91052 Erlangen, Germany. Peter.Zerfass@imp.uni-erlangen.de","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Institute of Medical Physics, University of Erlangen-Nuernberg, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040701173","display_name":"T. Lowitz","orcid":null},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Lowitz","raw_affiliation_strings":["Institute of Medical Physics, University of Erlangen-Nuremberg, Erlangen, Germany","Institute of Medical Physics, University of Erlangen-Nuernberg, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Medical Physics, University of Erlangen-Nuremberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Institute of Medical Physics, University of Erlangen-Nuernberg, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083591924","display_name":"Oleg Museyko","orcid":"https://orcid.org/0000-0001-8556-6705"},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"O. Museyko","raw_affiliation_strings":["Institute of Medical Physics, University of Erlangen-Nuremberg, Erlangen, Germany","Institute of Medical Physics, University of Erlangen-Nuernberg, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Medical Physics, University of Erlangen-Nuremberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Institute of Medical Physics, University of Erlangen-Nuernberg, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003931348","display_name":"V. Bousson","orcid":"https://orcid.org/0000-0002-3068-0815"},"institutions":[{"id":"https://openalex.org/I169173203","display_name":"D\u00e9l\u00e9gation Paris 7","ror":"https://ror.org/00bw5n526","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488","https://openalex.org/I169173203"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"funder","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210119095","display_name":"H\u00f4pital Lariboisi\u00e8re","ror":"https://ror.org/02mqtne57","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210119095"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"V. Bousson","raw_affiliation_strings":["Service de Radiologie Ost\u00e9oArticulaire-Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Lariboisi\u00e8re, Paris, France","Universit\u00e9 Paris Diderot-ParisVII, Paris, France","Service de Radiologie Ost\u00e9oArticulaire-Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Lariboisi\u00e8re , France"],"affiliations":[{"raw_affiliation_string":"Service de Radiologie Ost\u00e9oArticulaire-Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Lariboisi\u00e8re, Paris, France","institution_ids":["https://openalex.org/I4210119095","https://openalex.org/I4210097159"]},{"raw_affiliation_string":"Universit\u00e9 Paris Diderot-ParisVII, Paris, France","institution_ids":["https://openalex.org/I169173203","https://openalex.org/I204730241"]},{"raw_affiliation_string":"Service de Radiologie Ost\u00e9oArticulaire-Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Lariboisi\u00e8re , France","institution_ids":["https://openalex.org/I4210119095","https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070836067","display_name":"L. Laouisset","orcid":null},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"funder","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210119095","display_name":"H\u00f4pital Lariboisi\u00e8re","ror":"https://ror.org/02mqtne57","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210119095"]},{"id":"https://openalex.org/I169173203","display_name":"D\u00e9l\u00e9gation Paris 7","ror":"https://ror.org/00bw5n526","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488","https://openalex.org/I169173203"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L. Laouisset","raw_affiliation_strings":["Service de Radiologie Ost\u00e9oArticulaire-Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Lariboisi\u00e8re, Paris, France","Universit\u00e9 Paris Diderot-ParisVII, Paris, France","Service de Radiologie Ost\u00e9oArticulaire-Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Lariboisi\u00e8re , France"],"affiliations":[{"raw_affiliation_string":"Service de Radiologie Ost\u00e9oArticulaire-Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Lariboisi\u00e8re, Paris, France","institution_ids":["https://openalex.org/I4210119095","https://openalex.org/I4210097159"]},{"raw_affiliation_string":"Universit\u00e9 Paris Diderot-ParisVII, Paris, France","institution_ids":["https://openalex.org/I169173203","https://openalex.org/I204730241"]},{"raw_affiliation_string":"Service de Radiologie Ost\u00e9oArticulaire-Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Lariboisi\u00e8re , France","institution_ids":["https://openalex.org/I4210119095","https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109995368","display_name":"Willi A. Kalender","orcid":null},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W. A. Kalender","raw_affiliation_strings":["Institute of Medical Physics, University of Erlangen-Nuremberg, Erlangen, Germany","Institute of Medical Physics, University of Erlangen-Nuernberg, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Medical Physics, University of Erlangen-Nuremberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Institute of Medical Physics, University of Erlangen-Nuernberg, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077532993","display_name":"J.-D. Laredo","orcid":null},"institutions":[{"id":"https://openalex.org/I169173203","display_name":"D\u00e9l\u00e9gation Paris 7","ror":"https://ror.org/00bw5n526","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488","https://openalex.org/I169173203"]},{"id":"https://openalex.org/I4210119095","display_name":"H\u00f4pital Lariboisi\u00e8re","ror":"https://ror.org/02mqtne57","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210119095"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"funder","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J.-D. Laredo","raw_affiliation_strings":["Service de Radiologie Ost\u00e9oArticulaire-Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Lariboisi\u00e8re, Paris, France","Universit\u00e9 Paris Diderot-ParisVII, Paris, France","Service de Radiologie Ost\u00e9oArticulaire-Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Lariboisi\u00e8re , France"],"affiliations":[{"raw_affiliation_string":"Service de Radiologie Ost\u00e9oArticulaire-Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Lariboisi\u00e8re, Paris, France","institution_ids":["https://openalex.org/I4210119095","https://openalex.org/I4210097159"]},{"raw_affiliation_string":"Universit\u00e9 Paris Diderot-ParisVII, Paris, France","institution_ids":["https://openalex.org/I169173203","https://openalex.org/I204730241"]},{"raw_affiliation_string":"Service de Radiologie Ost\u00e9oArticulaire-Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Lariboisi\u00e8re , France","institution_ids":["https://openalex.org/I4210119095","https://openalex.org/I4210097159"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091603719","display_name":"Klaus Engelke","orcid":"https://orcid.org/0000-0001-9875-4123"},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Engelke","raw_affiliation_strings":["Institute of Medical Physics, University of Erlangen-Nuremberg, Erlangen, Germany","Institute of Medical Physics, University of Erlangen-Nuernberg, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Medical Physics, University of Erlangen-Nuremberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Institute of Medical Physics, University of Erlangen-Nuernberg, Germany","institution_ids":["https://openalex.org/I181369854"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5041365116"],"corresponding_institution_ids":["https://openalex.org/I181369854"],"apc_list":null,"apc_paid":null,"fwci":1.4119,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.80251527,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"59","issue":"9","first_page":"2449","last_page":"2458"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14510","display_name":"Medical Imaging and Analysis","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T14510","display_name":"Medical Imaging and Analysis","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12209","display_name":"Bone and Joint Diseases","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9818000197410583,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tibia","display_name":"Tibia","score":0.5969681143760681},{"id":"https://openalex.org/keywords/bone-mineral","display_name":"Bone mineral","score":0.5714957118034363},{"id":"https://openalex.org/keywords/cadaveric-spasm","display_name":"Cadaveric spasm","score":0.5518548488616943},{"id":"https://openalex.org/keywords/quantitative-computed-tomography","display_name":"Quantitative computed tomography","score":0.5514864325523376},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5377730131149292},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4927356541156769},{"id":"https://openalex.org/keywords/subchondral-bone","display_name":"Subchondral bone","score":0.4902632534503937},{"id":"https://openalex.org/keywords/femur","display_name":"Femur","score":0.4641249179840088},{"id":"https://openalex.org/keywords/tomography","display_name":"Tomography","score":0.44517782330513},{"id":"https://openalex.org/keywords/epiphysis","display_name":"Epiphysis","score":0.440021812915802},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.4222003221511841},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.3960230052471161},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.372110515832901},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2643192410469055},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"Osteoarthritis","score":0.25669968128204346},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"Osteoporosis","score":0.24286770820617676},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.21761828660964966},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.18720248341560364},{"id":"https://openalex.org/keywords/articular-cartilage","display_name":"Articular cartilage","score":0.09102985262870789}],"concepts":[{"id":"https://openalex.org/C2777236700","wikidata":"https://www.wikidata.org/wiki/Q178366","display_name":"Tibia","level":2,"score":0.5969681143760681},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.5714957118034363},{"id":"https://openalex.org/C175696284","wikidata":"https://www.wikidata.org/wiki/Q986524","display_name":"Cadaveric spasm","level":2,"score":0.5518548488616943},{"id":"https://openalex.org/C2777425516","wikidata":"https://www.wikidata.org/wiki/Q17083560","display_name":"Quantitative computed tomography","level":4,"score":0.5514864325523376},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5377730131149292},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4927356541156769},{"id":"https://openalex.org/C3018615303","wikidata":"https://www.wikidata.org/wiki/Q1801229","display_name":"Subchondral bone","level":5,"score":0.4902632534503937},{"id":"https://openalex.org/C2780554211","wikidata":"https://www.wikidata.org/wiki/Q176503","display_name":"Femur","level":2,"score":0.4641249179840088},{"id":"https://openalex.org/C163716698","wikidata":"https://www.wikidata.org/wiki/Q841267","display_name":"Tomography","level":2,"score":0.44517782330513},{"id":"https://openalex.org/C2780472225","wikidata":"https://www.wikidata.org/wiki/Q1801229","display_name":"Epiphysis","level":2,"score":0.440021812915802},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4222003221511841},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.3960230052471161},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.372110515832901},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2643192410469055},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.25669968128204346},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.24286770820617676},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.21761828660964966},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.18720248341560364},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.09102985262870789},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006132","descriptor_name":"Growth Plate","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D006132","descriptor_name":"Growth Plate","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D006132","descriptor_name":"Growth Plate","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007719","descriptor_name":"Knee Joint","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D007719","descriptor_name":"Knee Joint","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D007719","descriptor_name":"Knee Joint","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbme.2012.2202660","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2012.2202660","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:22692866","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22692866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1598060457","https://openalex.org/W1982237835","https://openalex.org/W1983545297","https://openalex.org/W1990342901","https://openalex.org/W2004327723","https://openalex.org/W2004806078","https://openalex.org/W2009479693","https://openalex.org/W2013825234","https://openalex.org/W2017426741","https://openalex.org/W2017892632","https://openalex.org/W2018189647","https://openalex.org/W2020497590","https://openalex.org/W2027109535","https://openalex.org/W2029015251","https://openalex.org/W2031323502","https://openalex.org/W2035141079","https://openalex.org/W2035932745","https://openalex.org/W2038384336","https://openalex.org/W2038632684","https://openalex.org/W2041666200","https://openalex.org/W2043232149","https://openalex.org/W2047178252","https://openalex.org/W2060492077","https://openalex.org/W2069537876","https://openalex.org/W2083320055","https://openalex.org/W2084806705","https://openalex.org/W2086830933","https://openalex.org/W2088453390","https://openalex.org/W2091038620","https://openalex.org/W2106018887","https://openalex.org/W2108824264","https://openalex.org/W2125019670","https://openalex.org/W2128215850","https://openalex.org/W2143068928","https://openalex.org/W2149856404","https://openalex.org/W2149879251","https://openalex.org/W2154459079","https://openalex.org/W2156414583","https://openalex.org/W2167367417","https://openalex.org/W2168094725","https://openalex.org/W3171583985"],"related_works":["https://openalex.org/W2373601011","https://openalex.org/W1998726996","https://openalex.org/W2059883365","https://openalex.org/W2182991037","https://openalex.org/W1991336979","https://openalex.org/W2581586035","https://openalex.org/W2515945674","https://openalex.org/W2410533821","https://openalex.org/W2320325195","https://openalex.org/W2162613882"],"abstract_inverted_index":{"We":[0],"have":[1],"developed":[2,55],"a":[3,93,96,107,113],"new":[4],"integrated":[5],"approach":[6],"for":[7,166,181],"quantitative":[8],"computed":[9,115],"tomography":[10,116],"of":[11,30,38,45,48,60,119,150,158],"the":[12,61,66,79,85,120,151,172,177],"knee":[13],"in":[14,84,124,144,171,176],"order":[15,125],"to":[16,56,78,126,193,200],"quantify":[17,127],"bone":[18,24,129],"mineral":[19],"density":[20],"(BMD)":[21],"and":[22,33,42,63,65,95,132,139,174,196],"subchondral":[23,128],"structure.":[25,130],"The":[26],"present":[27],"framework":[28],"consists":[29],"image":[31],"acquisition":[32],"reconstruction,":[34],"3-D":[35],"segmentation,":[36],"determination":[37],"anatomic":[39],"coordinate":[40],"systems,":[41],"reproducible":[43],"positioning":[44],"analysis":[46,109],"volumes":[47],"interest":[49],"(VOI).":[50],"Novel":[51],"segmentation":[52],"algorithms":[53],"were":[54,142,168,183],"identify":[57],"growth":[58],"plates":[59],"tibia":[62],"femur":[64,173],"joint":[67],"space":[68],"with":[69,75],"high":[70],"reproducibility.":[71],"Five":[72],"different":[73],"VOIs":[74],"varying":[76],"distance":[77],"articular":[80],"surface":[81],"are":[82],"defined":[83],"epiphysis.":[86],"Each":[87],"VOI":[88],"is":[89,103,110],"further":[90],"subdivided":[91],"into":[92],"medial":[94],"lateral":[97],"part.":[98],"In":[99,105],"each":[100],"VOI,":[101],"BMD":[102,182],"determined.":[104],"addition,":[106],"texture":[108],"performed":[111],"on":[112],"high-resolution":[114],"(CT)":[117],"reconstruction":[118],"same":[121],"CT":[122],"scan":[123],"Local":[131],"global":[133,140],"homogeneity,":[134],"as":[135,137],"well":[136],"local":[138],"anisotropy":[141,197],"measured":[143],"all":[145],"VOIs.":[146],"Overall":[147],"short-term":[148],"precision":[149,190],"technique":[152],"was":[153],"evaluated":[154],"using":[155],"double":[156],"measurements":[157],"20":[159],"osteoarthritic":[160],"cadaveric":[161],"human":[162],"knees.":[163],"Precision":[164,179],"errors":[165,180,191],"volume":[167],"about":[169,184,194,201],"2-3%":[170],"3-5%":[175],"tibia.":[178],"1-2%":[185],"lower.":[186],"Homogeneity":[187],"parameters":[188,198],"showed":[189],"up":[192,199],"2%":[195],"4%.":[202]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}