{"id":"https://openalex.org/W2167885523","doi":"https://doi.org/10.1109/tbme.2012.2192733","title":"A Class of Monte-Carlo-Based Statistical Algorithms for Efficient Detection of Repolarization Alternans","display_name":"A Class of Monte-Carlo-Based Statistical Algorithms for Efficient Detection of Repolarization Alternans","publication_year":2012,"publication_date":"2012-04-11","ids":{"openalex":"https://openalex.org/W2167885523","doi":"https://doi.org/10.1109/tbme.2012.2192733","mag":"2167885523","pmid":"https://pubmed.ncbi.nlm.nih.gov/22481808"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2012.2192733","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2012.2192733","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038294812","display_name":"Shahriar Iravanian","orcid":"https://orcid.org/0000-0003-2132-1543"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Iravanian","raw_affiliation_strings":["Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA. shahriar.x.iravanian@kp.org","Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA; Southeast Permanente Medical Group, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA. shahriar.x.iravanian@kp.org","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA; Southeast Permanente Medical Group, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064931531","display_name":"Uche B Kanu","orcid":null},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"U. B. Kanu","raw_affiliation_strings":["Greenberg Division of Cardiology, Weill Medical College of Cornell University, New York, NY, USA","Greenberg Div. of Cardiology, Weill Cornell Med. Coll., New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Greenberg Division of Cardiology, Weill Medical College of Cornell University, New York, NY, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Greenberg Div. of Cardiology, Weill Cornell Med. Coll., New York, NY, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035862691","display_name":"David J. Christini","orcid":"https://orcid.org/0000-0003-0852-2922"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. J. Christini","raw_affiliation_strings":["Greenberg Division of Cardiology, Department of Medicine, and the Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY, USA","Weill Cornell Med. Coll., Dept. of Med., Greenberg Div. of Cardiology, Cornell Univ., Ithaca, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Greenberg Division of Cardiology, Department of Medicine, and the Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Weill Cornell Med. Coll., Dept. of Med., Greenberg Div. of Cardiology, Cornell Univ., Ithaca, NY, USA","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2645,"currency":"USD","value_usd":2645},"apc_paid":null,"fwci":0.7031,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.75413665,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"59","issue":"7","first_page":"1882","last_page":"1891"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11021","display_name":"ECG Monitoring and Analysis","score":0.9868999719619751,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.9165999889373779,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.7424279451370239},{"id":"https://openalex.org/keywords/monte-carlo-method","display_name":"Monte Carlo method","score":0.5797110795974731},{"id":"https://openalex.org/keywords/repolarization","display_name":"Repolarization","score":0.5306267738342285},{"id":"https://openalex.org/keywords/optical-mapping","display_name":"Optical mapping","score":0.4543634057044983},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4438972771167755},{"id":"https://openalex.org/keywords/t-wave-alternans","display_name":"T wave alternans","score":0.439137727022171},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3121154308319092},{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"Sudden cardiac death","score":0.2931198477745056},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.09423214197158813}],"concepts":[{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.7424279451370239},{"id":"https://openalex.org/C19499675","wikidata":"https://www.wikidata.org/wiki/Q232207","display_name":"Monte Carlo method","level":2,"score":0.5797110795974731},{"id":"https://openalex.org/C146403970","wikidata":"https://www.wikidata.org/wiki/Q205729","display_name":"Repolarization","level":3,"score":0.5306267738342285},{"id":"https://openalex.org/C28289500","wikidata":"https://www.wikidata.org/wiki/Q7098868","display_name":"Optical mapping","level":2,"score":0.4543634057044983},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4438972771167755},{"id":"https://openalex.org/C2777325121","wikidata":"https://www.wikidata.org/wiki/Q3613169","display_name":"T wave alternans","level":3,"score":0.439137727022171},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3121154308319092},{"id":"https://openalex.org/C2775935837","wikidata":"https://www.wikidata.org/wiki/Q202837","display_name":"Sudden cardiac death","level":2,"score":0.2931198477745056},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.09423214197158813},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1109/tbme.2012.2192733","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2012.2192733","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:22481808","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22481808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2522804","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3524270","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:null:20.500.12648/15779","is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.12648/15779","pdf_url":null,"source":{"id":"https://openalex.org/S4306400078","display_name":"SUNY Digital Repository Support (State University of New York System)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I63190737","host_organization_name":"University at Buffalo, State University of New York","host_organization_lineage":["https://openalex.org/I63190737"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"1891","raw_type":"Article/Review"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5799999833106995,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G3976246576","display_name":null,"funder_award_id":"R01-HL094620","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1489387013","https://openalex.org/W1889104906","https://openalex.org/W1975840526","https://openalex.org/W1976086141","https://openalex.org/W1982210904","https://openalex.org/W1988280325","https://openalex.org/W1996033332","https://openalex.org/W1998730638","https://openalex.org/W2009775227","https://openalex.org/W2013157031","https://openalex.org/W2017095658","https://openalex.org/W2023903233","https://openalex.org/W2027945578","https://openalex.org/W2052868286","https://openalex.org/W2056183107","https://openalex.org/W2056370815","https://openalex.org/W2056513081","https://openalex.org/W2061973954","https://openalex.org/W2065246793","https://openalex.org/W2073287324","https://openalex.org/W2074739150","https://openalex.org/W2077129671","https://openalex.org/W2082279182","https://openalex.org/W2084807631","https://openalex.org/W2086258274","https://openalex.org/W2086527071","https://openalex.org/W2094886506","https://openalex.org/W2095602565","https://openalex.org/W2096778977","https://openalex.org/W2098441159","https://openalex.org/W2112713043","https://openalex.org/W2115928923","https://openalex.org/W2121325549","https://openalex.org/W2127154973","https://openalex.org/W2133148854","https://openalex.org/W2133291632","https://openalex.org/W2142775879","https://openalex.org/W2145767991","https://openalex.org/W2146637030","https://openalex.org/W2152502128","https://openalex.org/W2162718501","https://openalex.org/W2163951418","https://openalex.org/W2165111060","https://openalex.org/W2170014849","https://openalex.org/W2334859129","https://openalex.org/W4238772239"],"related_works":["https://openalex.org/W2046243719","https://openalex.org/W2134638952","https://openalex.org/W2898950838","https://openalex.org/W2077129671","https://openalex.org/W2009775227","https://openalex.org/W4390542021","https://openalex.org/W2127154973","https://openalex.org/W60020221","https://openalex.org/W2334859129","https://openalex.org/W2001326242"],"abstract_inverted_index":{"Cardiac":[0],"repolarization":[1],"alternans":[2,47,95,166],"is":[3],"an":[4,130,165],"electrophysiologic":[5],"condition":[6],"identified":[7],"by":[8],"a":[9,26,92,103,125],"beat-to-beat":[10],"fluctuation":[11],"in":[12,31,53,177],"action":[13],"potential":[14,69,209],"waveform.":[15],"It":[16],"has":[17],"been":[18,51,60],"mechanistically":[19],"linked":[20],"to":[21],"instances":[22],"of":[23,39,91,106,120,127,136,173,180],"T-wave":[24,32,66],"alternans,":[25],"clinically":[27],"defined":[28],"ECG":[29],"alternation":[30],"morphology,":[33],"and":[34,42,89,117,132,139,148,159,182,185,197,202],"associated":[35],"with":[36,65,143,211],"the":[37,54,57,87,110,115,137,144,149,171,174,178],"onset":[38],"cardiac":[40,44,213],"reentry":[41],"sudden":[43],"death.":[45],"Many":[46],"detection":[48,96,116],"algorithms":[49,128,190],"have":[50,59,199],"proposed":[52,189],"past,":[55],"but":[56],"majority":[58],"designed":[61],"specifically":[62],"for":[63,114,194],"use":[64,90,210],"alternans.":[67,121],"Action":[68],"duration":[70],"(APD)":[71],"signals":[72],"obtained":[73,163],"from":[74,79,164],"experiments":[75],"(especially":[76],"those":[77],"derived":[78],"optical":[80,160],"mapping)":[81],"possess":[82],"unique":[83],"characteristics,":[84],"which":[85],"requires":[86],"development":[88],"more":[93,133],"appropriate":[94],"method.":[97],"In":[98],"this":[99],"paper,":[100],"we":[101,123],"present":[102],"new":[104,175],"class":[105],"algorithms,":[107],"based":[108],"on":[109],"Monte":[111],"Carlo":[112],"method,":[113],"quantitative":[118],"measurement":[119],"Specifically,":[122],"derive":[124],"set":[126],"(one":[129],"analytical":[131],"efficient":[134],"version":[135],"other)":[138],"compare":[140],"its":[141],"performance":[142],"standard":[145],"spectral":[146],"method":[147],"generalized":[150],"likelihood":[151],"ratio":[152],"test":[153],"algorithm":[154,176],"using":[155,205],"synthetic":[156],"APD":[157],"sequences":[158],"mapping":[161],"data":[162],"control":[167],"experiment.":[168],"We":[169],"demonstrate":[170],"benefits":[172],"presence":[179],"Gaussian":[181],"Laplacian":[183],"noise":[184],"frame-shift":[186],"errors.":[187],"The":[188],"are":[191,203],"well":[192],"suited":[193],"experimental":[195],"applications,":[196],"furthermore,":[198],"low":[200],"complexity":[201],"implementable":[204],"fixed-point":[206],"arithmetic,":[207],"enabling":[208],"implantable":[212],"devices.":[214]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2025-10-10T00:00:00"}