{"id":"https://openalex.org/W1984045811","doi":"https://doi.org/10.1109/tbme.2012.2187785","title":"Fractal Dimension as a Measure of Altered Actin Cytoskeleton in MC3T3-E1 Cells Under Simulated Microgravity Using 3-D/2-D Clinostats","display_name":"Fractal Dimension as a Measure of Altered Actin Cytoskeleton in MC3T3-E1 Cells Under Simulated Microgravity Using 3-D/2-D Clinostats","publication_year":2012,"publication_date":"2012-02-13","ids":{"openalex":"https://openalex.org/W1984045811","doi":"https://doi.org/10.1109/tbme.2012.2187785","mag":"1984045811","pmid":"https://pubmed.ncbi.nlm.nih.gov/22345524"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2012.2187785","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2012.2187785","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027693027","display_name":"Airong Qian","orcid":"https://orcid.org/0000-0002-0740-9218"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"A. R. Qian","raw_affiliation_strings":["Key Laboratory for Space Biosciences and Biotechnology, Faculty of Life Sciences, Northwestern Polytechnical University, Xi\u2019an 710072, China. qianair@nwpu.edu.cn","Key Lab. for Space Biosci. & Biotechnol., Northwestern Polytech. Univ., Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Space Biosciences and Biotechnology, Faculty of Life Sciences, Northwestern Polytechnical University, Xi\u2019an 710072, China. qianair@nwpu.edu.cn","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"Key Lab. for Space Biosci. & Biotechnol., Northwestern Polytech. Univ., Xi'an, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018414077","display_name":"Dongdong Li","orcid":"https://orcid.org/0000-0001-9000-7158"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"D. Li","raw_affiliation_strings":["Key Laboratory for Space Biosciences and Biotechnology Faculty of Life Sciences, Northwestern Polytechnical University, Xi'an, China","Key Lab. for Space Biosci. & Biotechnol., Northwestern Polytech. Univ., Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Space Biosciences and Biotechnology Faculty of Life Sciences, Northwestern Polytechnical University, Xi'an, China","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"Key Lab. for Space Biosci. & Biotechnol., Northwestern Polytech. Univ., Xi'an, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035464114","display_name":"Jian Han","orcid":"https://orcid.org/0000-0002-3800-9436"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J. Han","raw_affiliation_strings":["Key Laboratory for Space Biosciences and Biotechnology Faculty of Life Sciences, Northwestern Polytechnical University, Xi'an, China","Key Lab. for Space Biosci. & Biotechnol., Northwestern Polytech. Univ., Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Space Biosciences and Biotechnology Faculty of Life Sciences, Northwestern Polytechnical University, Xi'an, China","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"Key Lab. for Space Biosci. & Biotechnol., Northwestern Polytech. Univ., Xi'an, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032169838","display_name":"Xiang Gao","orcid":"https://orcid.org/0000-0003-0699-0351"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"X. Gao","raw_affiliation_strings":["Key Laboratory for Space Biosciences and Biotechnology Faculty of Life Sciences, Northwestern Polytechnical University, Xi'an, China","Key Lab. for Space Biosci. & Biotechnol., Northwestern Polytech. Univ., Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Space Biosciences and Biotechnology Faculty of Life Sciences, Northwestern Polytechnical University, Xi'an, China","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"Key Lab. for Space Biosci. & Biotechnol., Northwestern Polytech. Univ., Xi'an, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108502849","display_name":"S.M. Di","orcid":null},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"S. M. Di","raw_affiliation_strings":["Key Laboratory for Space Biosciences and Biotechnology Faculty of Life Sciences, Northwestern Polytechnical University, Xi'an, China","Key Lab. for Space Biosci. & Biotechnol., Northwestern Polytech. Univ., Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Space Biosciences and Biotechnology Faculty of Life Sciences, Northwestern Polytechnical University, Xi'an, China","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"Key Lab. for Space Biosci. & Biotechnol., Northwestern Polytech. Univ., Xi'an, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100444422","display_name":"Wen Zhang","orcid":"https://orcid.org/0000-0003-2293-099X"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"W. Zhang","raw_affiliation_strings":["Key Laboratory for Space Biosciences and Biotechnology Faculty of Life Sciences, Northwestern Polytechnical University, Xi'an, China","Key Lab. for Space Biosci. & Biotechnol., Northwestern Polytech. Univ., Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Space Biosciences and Biotechnology Faculty of Life Sciences, Northwestern Polytechnical University, Xi'an, China","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"Key Lab. for Space Biosci. & Biotechnol., Northwestern Polytech. Univ., Xi'an, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101529753","display_name":"Lifang Hu","orcid":"https://orcid.org/0000-0003-1648-4428"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"L. F. Hu","raw_affiliation_strings":["Key Laboratory for Space Biosciences and Biotechnology Faculty of Life Sciences, Northwestern Polytechnical University, Xi'an, China","Key Lab. for Space Biosci. & Biotechnol., Northwestern Polytech. Univ., Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Space Biosciences and Biotechnology Faculty of Life Sciences, Northwestern Polytechnical University, Xi'an, China","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"Key Lab. for Space Biosci. & Biotechnol., Northwestern Polytech. Univ., Xi'an, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078166119","display_name":"Peng Shang","orcid":"https://orcid.org/0000-0001-5418-6240"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Shang","raw_affiliation_strings":["Key Laboratory for Space Biosciences and Biotechnology Faculty of Life Sciences, Northwestern Polytechnical University, Xi'an, China","Key Lab. for Space Biosci. & Biotechnol., Northwestern Polytech. Univ., Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Space Biosciences and Biotechnology Faculty of Life Sciences, Northwestern Polytechnical University, Xi'an, China","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"Key Lab. for Space Biosci. & Biotechnol., Northwestern Polytech. Univ., Xi'an, China","institution_ids":["https://openalex.org/I17145004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I17145004"],"apc_list":{"value":2645,"currency":"USD","value_usd":2645},"apc_paid":null,"fwci":2.5419,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.88866644,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"59","issue":"5","first_page":"1374","last_page":"1380"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14214","display_name":"Space Exploration and Technology","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/2202","display_name":"Aerospace Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12788","display_name":"Space Science and Extraterrestrial Life","score":0.9103999733924866,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"Cytoskeleton","score":0.8850796222686768},{"id":"https://openalex.org/keywords/fractal-dimension","display_name":"Fractal dimension","score":0.6365088820457458},{"id":"https://openalex.org/keywords/actin","display_name":"Actin","score":0.6134921312332153},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"Actin cytoskeleton","score":0.5978491306304932},{"id":"https://openalex.org/keywords/actin-remodeling-of-neurons","display_name":"Actin remodeling of neurons","score":0.44807836413383484},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4331085681915283},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3537682592868805},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.32899221777915955},{"id":"https://openalex.org/keywords/fractal","display_name":"Fractal","score":0.31505030393600464},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.17989230155944824},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.11781343817710876},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.08073174953460693}],"concepts":[{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.8850796222686768},{"id":"https://openalex.org/C26546657","wikidata":"https://www.wikidata.org/wiki/Q1412452","display_name":"Fractal dimension","level":3,"score":0.6365088820457458},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.6134921312332153},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.5978491306304932},{"id":"https://openalex.org/C151000934","wikidata":"https://www.wikidata.org/wiki/Q4676834","display_name":"Actin remodeling of neurons","level":5,"score":0.44807836413383484},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4331085681915283},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3537682592868805},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32899221777915955},{"id":"https://openalex.org/C40636538","wikidata":"https://www.wikidata.org/wiki/Q81392","display_name":"Fractal","level":2,"score":0.31505030393600464},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.17989230155944824},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11781343817710876},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.08073174953460693},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014893","descriptor_name":"Weightlessness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014893","descriptor_name":"Weightlessness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014893","descriptor_name":"Weightlessness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017709","descriptor_name":"Fractals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017709","descriptor_name":"Fractals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017709","descriptor_name":"Fractals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tbme.2012.2187785","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2012.2187785","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:22345524","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22345524","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W243287661","https://openalex.org/W391584246","https://openalex.org/W1174047713","https://openalex.org/W1725789807","https://openalex.org/W1769105382","https://openalex.org/W1824966615","https://openalex.org/W1921515041","https://openalex.org/W1966392462","https://openalex.org/W1970239007","https://openalex.org/W1971394744","https://openalex.org/W1984801751","https://openalex.org/W1986080495","https://openalex.org/W1988518409","https://openalex.org/W1988998651","https://openalex.org/W2004646107","https://openalex.org/W2013862371","https://openalex.org/W2018458970","https://openalex.org/W2019260509","https://openalex.org/W2020851500","https://openalex.org/W2035409006","https://openalex.org/W2036404408","https://openalex.org/W2069292190","https://openalex.org/W2069850637","https://openalex.org/W2083960671","https://openalex.org/W2091477255","https://openalex.org/W2096292802","https://openalex.org/W2101174085","https://openalex.org/W2102592206","https://openalex.org/W2105525226","https://openalex.org/W2107277218","https://openalex.org/W2108966129","https://openalex.org/W2123207395","https://openalex.org/W2123436811","https://openalex.org/W2126087366","https://openalex.org/W2137166343","https://openalex.org/W2140741294","https://openalex.org/W2152505742","https://openalex.org/W2156289700","https://openalex.org/W2156750625","https://openalex.org/W2413571687","https://openalex.org/W6609272459","https://openalex.org/W6613453305","https://openalex.org/W6715969054"],"related_works":["https://openalex.org/W2904912999","https://openalex.org/W1908941310","https://openalex.org/W197432475","https://openalex.org/W4303449254","https://openalex.org/W4311957677","https://openalex.org/W2594707584","https://openalex.org/W2032946496","https://openalex.org/W3005684111","https://openalex.org/W2056665186","https://openalex.org/W2099875681"],"abstract_inverted_index":{"Osteoblasts,":[0],"the":[1,23,27,37,59,65,89,93,113,132,154,202],"bone-forming":[2],"cells,":[3],"respond":[4],"to":[5,31,52,87,111,129],"various":[6],"mechanical":[7],"forces,":[8],"such":[9],"as":[10,22],"stretch":[11],"and":[12,46,124,153,188,191],"fluid":[13],"shear":[14],"force":[15],"in":[16,41,68,92,144,160,204,206],"essentially":[17],"similar":[18],"ways.":[19],"The":[20,106,139,177],"cytoskeleton,":[21,149],"load-bearing":[24],"architecture":[25,187],"of":[26,36,43,58,61,96,116,147,158,168,201],"cell,":[28],"is":[29,50],"sensitive":[30],"altered":[32],"inertial":[33],"forces.":[34],"Disruption":[35],"cytoskeleton":[38,95,118,186,205],"will":[39],"result":[40],"alteration":[42],"cellular":[44],"structure":[45],"function.":[47],"However,":[48],"it":[49],"difficult":[51],"quantitatively":[53],"illustrate":[54],"cytoskeletal":[55,62],"rearrangement":[56],"because":[57],"complexity":[60],"structure.":[63],"Usually,":[64],"morphological":[66,90],"changes":[67,91,203],"actin":[69,94,117,148,185],"organization":[70],"caused":[71],"by":[72,119,135],"external":[73],"stimulus":[74],"are":[75],"basically":[76],"descriptive.":[77],"In":[78],"this":[79],"study,":[80],"fractal":[81,114,136,192],"dimensions":[82],"(D)":[83],"analysis":[84,200],"was":[85,109],"used":[86,110,128],"quantify":[88],"osteoblast-like":[97,161],"cells":[98,162],"(MC3T3-E1)":[99],"under":[100,170],"simulated":[101],"microgravity":[102],"using":[103],"3-D/2-D":[104,171,181],"clinostats.":[105],"ImageJ":[107],"software":[108],"count":[112],"dimension":[115,137],"box-counting":[120],"methods.":[121],"Real-time":[122],"PCR":[123],"immunofluroscent":[125],"assays":[126],"were":[127],"further":[130],"confirm":[131],"results":[133,140],"obtained":[134],"analysis.":[138],"showed":[141],"significant":[142],"decreases":[143],"D":[145],"value":[146],"\u03b2-actin":[150],"mRNA":[151,189],"expression,":[152,190],"mean":[155],"fluorescence":[156],"intensity":[157],"F-actin":[159],"after":[163],"24":[164],"or":[165],"48":[166],"h":[167],"incubation":[169],"clinorotation":[172,182],"condition":[173],"compared":[174],"with":[175],"control.":[176],"findings":[178],"indicate":[179],"that":[180],"affects":[183],"both":[184],"may":[193],"be":[194],"a":[195],"promising":[196],"approach":[197],"for":[198],"quantitative":[199],"different":[207],"environments.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":4}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}