{"id":"https://openalex.org/W2096755293","doi":"https://doi.org/10.1109/tbme.2012.2182995","title":"Three-Dimensional Rotation of Mouse Embryos","display_name":"Three-Dimensional Rotation of Mouse Embryos","publication_year":2012,"publication_date":"2012-01-06","ids":{"openalex":"https://openalex.org/W2096755293","doi":"https://doi.org/10.1109/tbme.2012.2182995","mag":"2096755293","pmid":"https://pubmed.ncbi.nlm.nih.gov/22231670"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2012.2182995","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2012.2182995","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045261921","display_name":"Clement H. C. Leung","orcid":"https://orcid.org/0000-0001-8050-4644"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Clement Leung","raw_affiliation_strings":["Advanced Micro and Nanosystems Laboratory, University of Toronto, Toronto, ON, Canada. clement.leung@utoronto.ca","Adv. Micro & Nanosyst. Lab., Univ. of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Micro and Nanosystems Laboratory, University of Toronto, Toronto, ON, Canada. clement.leung@utoronto.ca","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Adv. Micro & Nanosyst. Lab., Univ. of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101495002","display_name":"Zhe Lu","orcid":"https://orcid.org/0000-0001-6536-9579"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Zhe Lu","raw_affiliation_strings":["Advanced Micro and Nanosystems Laboratory, University of Toronto, Toronto, ONT, Canada","Adv. Micro & Nanosyst. Lab., Univ. of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Micro and Nanosystems Laboratory, University of Toronto, Toronto, ONT, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Adv. Micro & Nanosyst. Lab., Univ. of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100719433","display_name":"Xuping Zhang","orcid":"https://orcid.org/0000-0002-7498-495X"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Xuping P. Zhang","raw_affiliation_strings":["Advanced Micro and Nanosystems Laboratory, University of Toronto, Toronto, ONT, Canada","Adv. Micro & Nanosyst. Lab., Univ. of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Micro and Nanosystems Laboratory, University of Toronto, Toronto, ONT, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Adv. Micro & Nanosyst. Lab., Univ. of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077878309","display_name":"Yu Sun","orcid":"https://orcid.org/0000-0001-7895-0741"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yu Sun","raw_affiliation_strings":["Advanced Micro and Nanosystems Laboratory, University of Toronto, Toronto, ONT, Canada","Adv. Micro & Nanosyst. Lab., Univ. of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Micro and Nanosystems Laboratory, University of Toronto, Toronto, ONT, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Adv. Micro & Nanosyst. Lab., Univ. of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I185261750"],"apc_list":null,"apc_paid":null,"fwci":4.8618,"has_fulltext":false,"cited_by_count":118,"citation_normalized_percentile":{"value":0.95407007,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"59","issue":"4","first_page":"1049","last_page":"1056"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9745000004768372,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9745000004768372,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12976","display_name":"Magnetic and Electromagnetic Effects","score":0.9444000124931335,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9309999942779541,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rotation","display_name":"Rotation (mathematics)","score":0.6441761255264282},{"id":"https://openalex.org/keywords/embryo","display_name":"Embryo","score":0.4484644830226898},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.34674692153930664},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3326171040534973},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2402159571647644},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2351490557193756},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.21964693069458008}],"concepts":[{"id":"https://openalex.org/C74050887","wikidata":"https://www.wikidata.org/wiki/Q848368","display_name":"Rotation (mathematics)","level":2,"score":0.6441761255264282},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.4484644830226898},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.34674692153930664},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3326171040534973},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2402159571647644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2351490557193756},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21964693069458008}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008846","descriptor_name":"Micromanipulation","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D008846","descriptor_name":"Micromanipulation","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D008846","descriptor_name":"Micromanipulation","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D013048","descriptor_name":"Specimen Handling","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D013048","descriptor_name":"Specimen Handling","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D013048","descriptor_name":"Specimen Handling","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D013396","descriptor_name":"Suction","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D013396","descriptor_name":"Suction","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D013396","descriptor_name":"Suction","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D019544","descriptor_name":"Equipment Failure Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019544","descriptor_name":"Equipment Failure Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019544","descriptor_name":"Equipment Failure Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058948","descriptor_name":"Cell Tracking","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D058948","descriptor_name":"Cell Tracking","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D058948","descriptor_name":"Cell Tracking","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/tbme.2012.2182995","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2012.2182995","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:22231670","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22231670","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.653.1339","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.653.1339","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://amnl.mie.utoronto.ca/data/J77.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1509235676","https://openalex.org/W1514419504","https://openalex.org/W1668895383","https://openalex.org/W1967173080","https://openalex.org/W1983016157","https://openalex.org/W1990349160","https://openalex.org/W1996365802","https://openalex.org/W2009948709","https://openalex.org/W2012820889","https://openalex.org/W2041628441","https://openalex.org/W2048943192","https://openalex.org/W2061055915","https://openalex.org/W2067719550","https://openalex.org/W2070004889","https://openalex.org/W2084009843","https://openalex.org/W2113065220","https://openalex.org/W2119156836","https://openalex.org/W2120481893","https://openalex.org/W2121375957","https://openalex.org/W2133059825","https://openalex.org/W2136021986","https://openalex.org/W2144582912","https://openalex.org/W2146368825","https://openalex.org/W2155021219","https://openalex.org/W2160256255","https://openalex.org/W2162038986","https://openalex.org/W2168363176","https://openalex.org/W2168708593","https://openalex.org/W4244934240","https://openalex.org/W4246444165","https://openalex.org/W6681417281","https://openalex.org/W6683808722"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2935759653","https://openalex.org/W3105167352","https://openalex.org/W54078636","https://openalex.org/W2954470139","https://openalex.org/W1501425562","https://openalex.org/W2902782467","https://openalex.org/W3084825885","https://openalex.org/W2298861036","https://openalex.org/W3148032049"],"abstract_inverted_index":{"Research":[0],"and":[1,7,31,50,58,69,102,138],"clinical":[2],"applications,":[3],"such":[4,52],"as":[5,53],"microinjection":[6],"polar-body":[8,124],"biopsy":[9],"involve":[10],"3-D":[11,80,111],"rotation":[12,38],"of":[13,24,62,83,96,114,131,135,142],"mammalian":[14],"oocytes/embryos.":[15],"In":[16],"these":[17],"cell":[18],"manipulation":[19],"tasks,":[20],"the":[21,93,120],"polar":[22,94],"body":[23,95],"an":[25,133,139],"embryo/oocyte":[26],"must":[27],"be":[28],"made":[29],"visible":[30],"properly":[32],"oriented":[33],"under":[34],"optical":[35],"microscopy.":[36],"Cell":[37],"in":[39,99,149],"conventional":[40],"manual":[41,64,150],"operation":[42],"by":[43],"skilled":[44],"professionals":[45],"is":[46],"based":[47],"on":[48],"trial":[49],"error,":[51],"through":[54],"repeated":[55],"vacuum":[56],"aspiration":[57],"release.":[59],"The":[60],"randomness":[61],"this":[63],"procedure,":[65],"its":[66],"poor":[67],"reproducibility,":[68],"inconsistency":[70],"across":[71],"operators":[72],"entail":[73],"a":[74,89,127],"systematic":[75],"technique":[76],"for":[77,123],"automated,":[78],"noninvasive,":[79],"rotational":[81,112],"control":[82,106,113],"single":[84],"cells.":[85],"This":[86],"paper":[87],"reports":[88],"system":[90],"that":[91],"tracks":[92],"mouse":[97,115],"embryos":[98],"real":[100],"time":[101],"controls":[103],"multiple":[104],"motion":[105],"devices":[107],"to":[108],"conduct":[109],"automated":[110],"embryos.":[116],"Experimental":[117],"results":[118],"demonstrated":[119],"system's":[121],"capability":[122],"orientation":[125],"with":[126],"high":[128],"success":[129],"rate":[130],"90%,":[132],"accuracy":[134],"1.9":[136],"\u00b0,":[137],"average":[140],"speed":[141],"22.8":[143],"s/cell":[144,148],"(versus":[145],"averagely":[146],"40":[147],"operation).":[151]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":5}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
