{"id":"https://openalex.org/W2162058791","doi":"https://doi.org/10.1109/tbme.2011.2135858","title":"Imaging of Indocyanine Green Perfusion in Mouse Liver With Fluorescence Diffuse Optical Tomography","display_name":"Imaging of Indocyanine Green Perfusion in Mouse Liver With Fluorescence Diffuse Optical Tomography","publication_year":2011,"publication_date":"2011-04-06","ids":{"openalex":"https://openalex.org/W2162058791","doi":"https://doi.org/10.1109/tbme.2011.2135858","mag":"2162058791"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2011.2135858","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2011.2135858","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100352350","display_name":"Xin Liu","orcid":"https://orcid.org/0000-0003-4627-3058"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Liu","raw_affiliation_strings":["Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100838158","display_name":"Xiaolian Guo","orcid":null},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolian Guo","raw_affiliation_strings":["Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103205996","display_name":"Fei Liu","orcid":"https://orcid.org/0009-0003-6901-0661"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Liu","raw_affiliation_strings":["Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100388358","display_name":"Yi Zhang","orcid":"https://orcid.org/0009-0005-4678-7181"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Zhang","raw_affiliation_strings":["Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100626318","display_name":"Hui Zhang","orcid":"https://orcid.org/0000-0001-9476-4244"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Zhang","raw_affiliation_strings":["Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068338144","display_name":"Guangshu Hu","orcid":null},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guangshu Hu","raw_affiliation_strings":["Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101109173","display_name":"Jing Bai","orcid":null},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Bai","raw_affiliation_strings":["Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I99065089"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4165,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.88197244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"58","issue":"8","first_page":"2139","last_page":"2143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/indocyanine-green","display_name":"Indocyanine green","score":0.9474702477455139},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.6761668920516968},{"id":"https://openalex.org/keywords/perfusion","display_name":"Perfusion","score":0.6712715029716492},{"id":"https://openalex.org/keywords/tomography","display_name":"Tomography","score":0.6542314291000366},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.5978952050209045},{"id":"https://openalex.org/keywords/diffuse-optical-imaging","display_name":"Diffuse optical imaging","score":0.576545000076294},{"id":"https://openalex.org/keywords/preclinical-imaging","display_name":"Preclinical imaging","score":0.5099695920944214},{"id":"https://openalex.org/keywords/optical-tomography","display_name":"Optical tomography","score":0.4988856315612793},{"id":"https://openalex.org/keywords/fluorescence-lifetime-imaging-microscopy","display_name":"Fluorescence-lifetime imaging microscopy","score":0.440355509519577},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.43350645899772644},{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"Positron emission tomography","score":0.41195547580718994},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.40077823400497437},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.3921199440956116},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.32905498147010803},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.2785547375679016},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.2524212896823883},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.23025840520858765},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.19808658957481384},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.16896659135818481},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11146727204322815}],"concepts":[{"id":"https://openalex.org/C2781065829","wikidata":"https://www.wikidata.org/wiki/Q905662","display_name":"Indocyanine green","level":2,"score":0.9474702477455139},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6761668920516968},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.6712715029716492},{"id":"https://openalex.org/C163716698","wikidata":"https://www.wikidata.org/wiki/Q841267","display_name":"Tomography","level":2,"score":0.6542314291000366},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5978952050209045},{"id":"https://openalex.org/C145417883","wikidata":"https://www.wikidata.org/wiki/Q5275421","display_name":"Diffuse optical imaging","level":3,"score":0.576545000076294},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.5099695920944214},{"id":"https://openalex.org/C2777413408","wikidata":"https://www.wikidata.org/wiki/Q1968843","display_name":"Optical tomography","level":3,"score":0.4988856315612793},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.440355509519577},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.43350645899772644},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.41195547580718994},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.40077823400497437},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3921199440956116},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32905498147010803},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2785547375679016},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2524212896823883},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.23025840520858765},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19808658957481384},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.16896659135818481},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11146727204322815},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/tbme.2011.2135858","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2011.2135858","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5600000023841858,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1978377658","https://openalex.org/W1995993502","https://openalex.org/W2014359315","https://openalex.org/W2017062848","https://openalex.org/W2031604650","https://openalex.org/W2040703019","https://openalex.org/W2044202315","https://openalex.org/W2081098120","https://openalex.org/W2096130488","https://openalex.org/W2097897435","https://openalex.org/W2110012738","https://openalex.org/W2140041425","https://openalex.org/W2148588305","https://openalex.org/W2397546497","https://openalex.org/W2753504014"],"related_works":["https://openalex.org/W2037916999","https://openalex.org/W1994071027","https://openalex.org/W2073776015","https://openalex.org/W2318737792","https://openalex.org/W2148187845","https://openalex.org/W4385335355","https://openalex.org/W2345318804","https://openalex.org/W3010250986","https://openalex.org/W4253832138","https://openalex.org/W2090799487"],"abstract_inverted_index":{"Dynamic":[0],"fluorescence":[1],"diffuse":[2],"optical":[3],"tomography":[4,48],"(D-FDOT)":[5],"is":[6],"important":[7],"for":[8],"drug":[9],"deliver":[10],"research,":[11],"as":[12],"it":[13],"allows":[14],"to":[15],"image":[16,108],"the":[17,79,85,88,109,127,134],"distribution":[18],"of":[19,37,61,82,111],"fluorescent":[20,112],"biomarkers":[21,113],"over":[22],"time":[23,119],"in":[24,84,114,131],"vivo.":[25],"In":[26,51],"this":[27],"letter,":[28],"we":[29,104],"visualize":[30],"mouse":[31,62],"liver":[32,63],"perfusion":[33,110],"after":[34],"intravenous":[35],"injection":[36],"indocyanine":[38],"green":[39],"(ICG)":[40],"using":[41,66,96,133],"a":[42,68,97],"hybrid":[43,135],"free-space":[44],"FDOT":[45],"and":[46,90],"microcomputed":[47],"(micro-CT)":[49],"system.":[50,138],"vivo":[52,132],"dynamic":[53],"tomographic":[54],"images":[55],"(110":[56],"frames;":[57],"approximately":[58],"120":[59],"min)":[60],"are":[64,94],"reconstructed":[65],"structural":[67],"priori":[69],"information":[70],"provided":[71],"by":[72],"micro-CT,":[73],"incorporating":[74],"heterogeneous":[75],"forward":[76],"model.":[77,99],"Further,":[78],"pharmacokinetic":[80,129],"parameters":[81,130],"ICG":[83],"liver,":[86],"reflecting":[87],"uptake":[89],"excretion":[91],"rate":[92],"constants,":[93],"obtained":[95],"two-compartmental":[98],"The":[100],"results":[101],"show":[102],"that":[103],"cannot":[105],"only":[106],"tomographically":[107],"small":[115],"animals":[116],"on":[117],"minute":[118],"scale":[120],"(approximately":[121],"1.1":[122],"min/frame)":[123],"but":[124],"also":[125],"obtain":[126],"corresponding":[128],"FDOT/micro-CT":[136],"imaging":[137]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}